| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.200771 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.128816 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.111244 |
| NTM | neurotrimin | 0.0985615 |
| ZNF292 | zinc finger protein 292 | 0.0923973 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0916344 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0747484 |
| COL5A2 | collagen, type V, alpha 2 | 0.0707942 |
| PDGFC | platelet derived growth factor C | 0.0684374 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0640971 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0636219 |
| SHROOM3 | shroom family member 3 | 0.06333 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0631282 |
| PLPP1 | phospholipid phosphatase 1 | 0.0599376 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0593342 |
| PRTG | protogenin | 0.0579997 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0570601 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0565152 |
| DST | dystonin | 0.0559017 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0551897 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0502247 |
| ANK2 | ankyrin 2, neuronal | 0.0496651 |
| WDR43 | WD repeat domain 43 | 0.0493944 |
| METAP2 | methionyl aminopeptidase 2 | 0.0481424 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0475884 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.045807 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0457865 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0457017 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0455794 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0443076 |
| TENM3 | teneurin transmembrane protein 3 | 0.043839 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0431877 |
| MTF2 | metal response element binding transcription factor 2 | 0.0429773 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0429118 |
| MATR3 | matrin 3 | 0.0427564 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0425397 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0422906 |
| CENPF | centromere protein F, 350/400kDa | 0.0413306 |
| ZNF608 | zinc finger protein 608 | 0.0409341 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.03906 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0388642 |
| CDC73 | cell division cycle 73 | 0.0386124 |
| SRP54 | signal recognition particle 54kDa | 0.0385185 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0370594 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.036658 |
| NOP58 | NOP58 ribonucleoprotein | 0.0366308 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0361973 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0361716 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0359255 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0358518 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0352423 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0351076 |
| THBS1 | thrombospondin 1 | 0.0350988 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0349849 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0349014 |
| SETD5 | SET domain containing 5 | 0.0348176 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0347509 |
| TOX | thymocyte selection-associated high mobility group box | 0.0342378 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0342036 |
| FIGN | fidgetin | 0.0341723 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0334159 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0333828 |
| MPG | N-methylpurine-DNA glycosylase | 0.0328796 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0324181 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0323743 |
| NHSL1 | NHS-like 1 | 0.0323193 |
| APP | amyloid beta (A4) precursor protein | 0.0319559 |
| PCDH9 | protocadherin 9 | 0.0314319 |
| FBXO11 | F-box protein 11 | 0.0309458 |
| GPC3 | glypican 3 | 0.030941 |
| MEIS2 | Meis homeobox 2 | 0.0308568 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0306918 |
| ZFHX4 | zinc finger homeobox 4 | 0.0306266 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0305834 |
| STAG2 | stromal antigen 2 | 0.0305066 |
| RTN4 | reticulon 4 | 0.0304881 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0301671 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0301022 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.030011 |
| RBM33 | RNA binding motif protein 33 | 0.0298855 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0296427 |
| ZNF385D | zinc finger protein 385D | 0.0294273 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0290209 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.0289698 |
| RYBP | RING1 and YY1 binding protein | 0.0287036 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0285766 |
| LRRC4C | leucine rich repeat containing 4C | 0.0284317 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0278783 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0277532 |
| PDS5B | PDS5 cohesin associated factor B | 0.0276512 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0275326 |
| PRR16 | proline rich 16 | 0.0274349 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0273265 |
| RAD51B | RAD51 paralog B | 0.0271095 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0270613 |
| HMGA2 | high mobility group AT-hook 2 | 0.0270187 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0269393 |
| CDH19 | cadherin 19, type 2 | 0.0267904 |
| RBM25 | RNA binding motif protein 25 | 0.0267861 |
| TCF12 | transcription factor 12 | 0.0267363 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.186957 |
| PTMA | prothymosin, alpha | -0.146521 |
| TMSB10 | thymosin beta 10 | -0.13062 |
| RPS16 | ribosomal protein S16 | -0.103851 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0947366 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0798356 |
| RPS6 | ribosomal protein S6 | -0.0783261 |
| RPL35A | ribosomal protein L35a | -0.0746046 |
| RPS8 | ribosomal protein S8 | -0.0706785 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.068399 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0645426 |
| RPL37A | ribosomal protein L37a | -0.0559167 |
| RPLP1 | ribosomal protein, large, P1 | -0.055701 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0533648 |
| RPL37 | ribosomal protein L37 | -0.0531462 |
| B2M | beta-2-microglobulin | -0.0519507 |
| RPS27A | ribosomal protein S27a | -0.0519401 |
| RPL11 | ribosomal protein L11 | -0.0510396 |
| COL1A2 | collagen, type I, alpha 2 | -0.0479922 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0479128 |
| RPL12 | ribosomal protein L12 | -0.0463534 |
| RPS19 | ribosomal protein S19 | -0.0463476 |
| ACTG1 | actin gamma 1 | -0.0451654 |
| RPL31 | ribosomal protein L31 | -0.0450791 |
| CAVIN1 | caveolae associated protein 1 | -0.0437872 |
| RPS12 | ribosomal protein S12 | -0.0408768 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.038927 |
| RPL19 | ribosomal protein L19 | -0.0386226 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0385753 |
| RPL9 | ribosomal protein L9 | -0.0379047 |
| RIGI | RNA sensor RIG-I | -0.0378369 |
| RPL7A | ribosomal protein L7a | -0.0376793 |
| RPS13 | ribosomal protein S13 | -0.03711 |
| RPLP2 | ribosomal protein, large, P2 | -0.0370314 |
| RPL23 | ribosomal protein L23 | -0.036873 |
| S100A10 | S100 calcium binding protein A10 | -0.0356674 |
| RPL26 | ribosomal protein L26 | -0.0349391 |
| ENO1 | enolase 1, (alpha) | -0.0347914 |
| FTL | ferritin, light polypeptide | -0.0346344 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0332938 |
| RPS29 | ribosomal protein S29 | -0.0331669 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0330592 |
| ATF4 | activating transcription factor 4 | -0.0324937 |
| RPS17 | ribosomal protein S17 | -0.0320749 |
| GNAS | GNAS complex locus | -0.0316039 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0311507 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.030472 |
| RPL5 | ribosomal protein L5 | -0.0301594 |
| APOE | apolipoprotein E | -0.0300424 |
| RPS3 | ribosomal protein S3 | -0.0299991 |
| RPL28 | ribosomal protein L28 | -0.0298585 |
| SQSTM1 | sequestosome 1 | -0.0298192 |
| RACK1 | receptor for activated C kinase 1 | -0.0295265 |
| SPAG9 | sperm associated antigen 9 | -0.0289008 |
| RPL34 | ribosomal protein L34 | -0.0282863 |
| RPS24 | ribosomal protein S24 | -0.0282569 |
| RPS10 | ribosomal protein S10 | -0.0281095 |
| RPS21 | ribosomal protein S21 | -0.0279643 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.027739 |
| RPL27 | ribosomal protein L27 | -0.0265639 |
| RPL38 | ribosomal protein L38 | -0.0257661 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0257483 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0251318 |
| RPL36A | ribosomal protein L36a | -0.0244046 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0243927 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0237532 |
| RPL30 | ribosomal protein L30 | -0.0237102 |
| RPS15 | ribosomal protein S15 | -0.0233633 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.023178 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0231683 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0230829 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0228312 |
| RPS23 | ribosomal protein S23 | -0.0227877 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.022674 |
| ASPH | aspartate beta-hydroxylase | -0.0224793 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0224643 |
| FGF13 | fibroblast growth factor 13 | -0.0224612 |
| RPL8 | ribosomal protein L8 | -0.0220387 |
| RPLP0 | ribosomal protein, large, P0 | -0.0219263 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0218812 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0218789 |
| COL3A1 | collagen, type III, alpha 1 | -0.0218502 |
| PGK1 | phosphoglycerate kinase 1 | -0.021702 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0216362 |
| RPS25 | ribosomal protein S25 | -0.0216287 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0215264 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0214908 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0214094 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0210883 |
| HMGA1 | high mobility group AT-hook 1 | -0.0208611 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.020684 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0205908 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0204981 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0204027 |
| RPS27 | ribosomal protein S27 | -0.0202631 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0201698 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0199463 |
| UBB | ubiquitin B | -0.0198414 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0198155 |
| RPL7 | ribosomal protein L7 | -0.019364 |
