| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Filgotinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.161265 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.124955 |
| TJP1 | tight junction protein 1 | 0.0996665 |
| PKM | pyruvate kinase, muscle | 0.0967427 |
| VCL | vinculin | 0.0913214 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0890627 |
| GOLGA4 | golgin A4 | 0.0849672 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0848621 |
| LDHA | lactate dehydrogenase A | 0.079295 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0786363 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.07319 |
| EGFR | epidermal growth factor receptor | 0.0714071 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0705678 |
| EZR | ezrin | 0.067963 |
| ZNF292 | zinc finger protein 292 | 0.0650351 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0649209 |
| PDGFC | platelet derived growth factor C | 0.06422 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.062466 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.059836 |
| HDAC9 | histone deacetylase 9 | 0.0597093 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.05532 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0542799 |
| ZNF608 | zinc finger protein 608 | 0.0535138 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0522876 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0516535 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0505097 |
| RTN4 | reticulon 4 | 0.0499461 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0493078 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0487797 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0480458 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0450123 |
| EVI5 | ecotropic viral integration site 5 | 0.0433836 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0432201 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0428402 |
| FOXP1 | forkhead box P1 | 0.0417455 |
| JMJD1C | jumonji domain containing 1C | 0.0415838 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.0410281 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0407469 |
| SMYD3 | SET and MYND domain containing 3 | 0.0406122 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0403013 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0396472 |
| PGK1 | phosphoglycerate kinase 1 | 0.0390076 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0388818 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0382602 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.037697 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0372195 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.03715 |
| S100A6 | S100 calcium binding protein A6 | 0.0371145 |
| TXNRD1 | thioredoxin reductase 1 | 0.0370567 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.036814 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0366792 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0365964 |
| PCBP2 | poly(rC) binding protein 2 | 0.0364655 |
| NBAS | neuroblastoma amplified sequence | 0.0361805 |
| RHOA | ras homolog family member A | 0.0360194 |
| RPL3 | ribosomal protein L3 | 0.0353389 |
| CANX | calnexin | 0.0350001 |
| TXNIP | thioredoxin interacting protein | 0.0349451 |
| ENO1 | enolase 1, (alpha) | 0.03475 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0345839 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0344144 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0340088 |
| SETD5 | SET domain containing 5 | 0.0334297 |
| PHF3 | PHD finger protein 3 | 0.0333933 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0331227 |
| SBF2 | SET binding factor 2 | 0.0331022 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0330735 |
| POTEF | POTE ankyrin domain family, member F | 0.0324645 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0323072 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0322586 |
| TMEM65 | transmembrane protein 65 | 0.0315469 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0314462 |
| METTL15 | methyltransferase like 15 | 0.0311621 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0311253 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0310493 |
| SQSTM1 | sequestosome 1 | 0.0307357 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0306647 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0305076 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0304784 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0304265 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.0304249 |
| ANK2 | ankyrin 2, neuronal | 0.0302688 |
| DUSP4 | dual specificity phosphatase 4 | 0.0302255 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0297584 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0295368 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0294343 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0292063 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0290827 |
| EFNA5 | ephrin-A5 | 0.0290494 |
| CALR | calreticulin | 0.028953 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0288624 |
| DSTN | destrin (actin depolymerizing factor) | 0.0286282 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0283239 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0281776 |
| RNF145 | ring finger protein 145 | 0.0281561 |
| LATS2 | large tumor suppressor kinase 2 | 0.0280123 |
| YAP1 | Yes-associated protein 1 | 0.0275827 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0273887 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.027227 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0268927 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BMP10 | bone morphogenetic protein 10 | -0.125668 |
| AHNAK | AHNAK nucleoprotein | -0.0832268 |
| PTMA | prothymosin, alpha | -0.0782493 |
| MKI67 | marker of proliferation Ki-67 | -0.0728772 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.063847 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0542405 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0523181 |
| DIAPH3 | diaphanous-related formin 3 | -0.0515785 |
| NAV2 | neuron navigator 2 | -0.0466161 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.043307 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349551 |
| RPLP1 | ribosomal protein, large, P1 | -0.0339748 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0326881 |
| RIGI | RNA sensor RIG-I | -0.0323092 |
| HJURP | Holliday junction recognition protein | -0.0313942 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0309449 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0309186 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0302071 |
| RPS21 | ribosomal protein S21 | -0.0289873 |
| RPL26 | ribosomal protein L26 | -0.0287948 |
| RPL35A | ribosomal protein L35a | -0.0287343 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0286596 |
| RPL34 | ribosomal protein L34 | -0.0270289 |
| RPS8 | ribosomal protein S8 | -0.02508 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0244589 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0237379 |
| TPX2 | TPX2, microtubule-associated | -0.0233896 |
| SP100 | SP100 nuclear antigen | -0.0230569 |
| RRM2 | ribonucleotide reductase M2 | -0.0227581 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0226549 |
| HMGB1 | high mobility group box 1 | -0.0226319 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.022348 |
| RPL38 | ribosomal protein L38 | -0.0220867 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0219044 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.021877 |
| CENPF | centromere protein F, 350/400kDa | -0.0218083 |
| RPS24 | ribosomal protein S24 | -0.021799 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0210658 |
| RPLP2 | ribosomal protein, large, P2 | -0.0207017 |
| S100A4 | S100 calcium binding protein A4 | -0.0206945 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0206726 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0206462 |
| BCOR | BCL6 corepressor | -0.0206231 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.020564 |
| ZNF438 | zinc finger protein 438 | -0.0203718 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0203047 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0201418 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0201177 |
| CENPE | centromere protein E, 312kDa | -0.0198988 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0198014 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0191453 |
| PLSCR1 | phospholipid scramblase 1 | -0.0186222 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0184347 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0181632 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0179208 |
| HMGB2 | high mobility group box 2 | -0.0174401 |
| XXYLT1 | xyloside xylosyltransferase 1 | -0.0172803 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0172078 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0171443 |
| GSE1 | Gse1 coiled-coil protein | -0.0171312 |
| PDE7B | phosphodiesterase 7B | -0.0170155 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0170123 |
| EMP3 | epithelial membrane protein 3 | -0.0170095 |
| TUBB | tubulin, beta class I | -0.0167755 |
| CUX1 | cut-like homeobox 1 | -0.016633 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0165847 |
| ANLN | anillin, actin binding protein | -0.0164906 |
| THBD | thrombomodulin | -0.0163795 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0163558 |
| RPL23 | ribosomal protein L23 | -0.0161359 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0160234 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0159908 |
| RPL31 | ribosomal protein L31 | -0.0159487 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0157398 |
| PMP22 | peripheral myelin protein 22 | -0.0156912 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0156413 |
| RPL36 | ribosomal protein L36 | -0.0154163 |
| RPS25 | ribosomal protein S25 | -0.0153793 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0152645 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0151052 |
| NOP56 | NOP56 ribonucleoprotein | -0.0146219 |
| RPS27A | ribosomal protein S27a | -0.0145585 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0142105 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0141261 |
| MYOF | myoferlin | -0.0137569 |
| RBL1 | retinoblastoma-like 1 | -0.0136879 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.0135789 |
| KNL1 | kinetochore scaffold 1 | -0.0135481 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0135335 |
| FUS | FUS RNA binding protein | -0.0134074 |
| KIF18B | kinesin family member 18B | -0.0130735 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0129957 |
| RPL19 | ribosomal protein L19 | -0.0129342 |
| APLF | aprataxin and PNKP like factor | -0.0126711 |
| CEP112 | centrosomal protein 112kDa | -0.0126234 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0125141 |
| TMSB10 | thymosin beta 10 | -0.0124978 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0123835 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0123726 |
| RPS11 | ribosomal protein S11 | -0.0123226 |
