| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Filgotinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.158891 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.148719 |
| COL6A3 | collagen, type VI, alpha 3 | 0.141912 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0851834 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0691956 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0676677 |
| IL6 | interleukin 6 | 0.0664634 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0582281 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0573255 |
| CDH13 | cadherin 13 | 0.0560463 |
| POTEF | POTE ankyrin domain family, member F | 0.0526317 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0458148 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0457877 |
| NRXN3 | neurexin 3 | 0.0436336 |
| ENO1 | enolase 1, (alpha) | 0.0418812 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0415135 |
| VEGFC | vascular endothelial growth factor C | 0.0394992 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0383513 |
| EGFR | epidermal growth factor receptor | 0.0363263 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0353303 |
| SEPTIN9 | septin 9 | 0.034657 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0299579 |
| FAM13A | family with sequence similarity 13, member A | 0.0296979 |
| COG6 | component of oligomeric golgi complex 6 | 0.0295889 |
| VEGFA | vascular endothelial growth factor A | 0.0292392 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0285756 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0273839 |
| HMGA2 | high mobility group AT-hook 2 | 0.0264121 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0261229 |
| LDHA | lactate dehydrogenase A | 0.0259505 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0258985 |
| EXOC4 | exocyst complex component 4 | 0.0256996 |
| MSN | moesin | 0.0256749 |
| ASPH | aspartate beta-hydroxylase | 0.0256716 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0255663 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0252944 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0251318 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0250799 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0238421 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0236121 |
| CALR | calreticulin | 0.0233704 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0232929 |
| COL5A1 | collagen, type V, alpha 1 | 0.0229464 |
| SYNPO | synaptopodin | 0.0228972 |
| EFNA5 | ephrin-A5 | 0.0228686 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0221342 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0221222 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0218186 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0217614 |
| STC1 | stanniocalcin 1 | 0.0216634 |
| CLIC4 | chloride intracellular channel 4 | 0.0213719 |
| C1D | C1D nuclear receptor corepressor | 0.0213701 |
| GLIS3 | GLIS family zinc finger 3 | 0.0212368 |
| CDK6 | cyclin-dependent kinase 6 | 0.0209181 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0208933 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0207492 |
| COPA | coatomer protein complex, subunit alpha | 0.0203155 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0202534 |
| NDRG1 | N-myc downstream regulated 1 | 0.0199173 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0198568 |
| UBC | ubiquitin C | 0.0192817 |
| FTO | fat mass and obesity associated | 0.0192775 |
| ATP13A3 | ATPase type 13A3 | 0.01899 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0189796 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.018935 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.018846 |
| ACTN1 | actinin, alpha 1 | 0.0186556 |
| LOXL2 | lysyl oxidase-like 2 | 0.0186435 |
| STC2 | stanniocalcin 2 | 0.0184702 |
| GOLGB1 | golgin B1 | 0.0184011 |
| FOSL1 | FOS-like antigen 1 | 0.0183687 |
| YBX1 | Y box binding protein 1 | 0.0182841 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0181732 |
| SH3RF3 | SH3 domain containing ring finger 3 | 0.0179207 |
| SNX13 | sorting nexin 13 | 0.0176224 |
| HDAC9 | histone deacetylase 9 | 0.0175971 |
| WASF2 | WAS protein family, member 2 | 0.0174518 |
| HLA-A | major histocompatibility complex, class I, A | 0.017377 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0173188 |
| PKM | pyruvate kinase, muscle | 0.0171333 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.016922 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.016808 |
| RUNX1 | runt-related transcription factor 1 | 0.0168073 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0166742 |
| TNS3 | tensin 3 | 0.0163101 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0162408 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0160553 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0159906 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0159573 |
| ETV6 | ets variant 6 | 0.0158842 |
| CALU | calumenin | 0.0158681 |
| ANO6 | anoctamin 6 | 0.0158635 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0157632 |
| TAGLN2 | transgelin 2 | 0.015736 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0153598 |
| ECE1 | endothelin converting enzyme 1 | 0.0151854 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0150097 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0149147 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0148795 |
| MAGT1 | magnesium transporter 1 | 0.0147623 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0713884 |
| MT2A | metallothionein 2A | -0.0642651 |
| PTMA | prothymosin, alpha | -0.0583834 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0573848 |
| TMSB10 | thymosin beta 10 | -0.0422067 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0370127 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.036448 |
| B2M | beta-2-microglobulin | -0.0344103 |
| HLA-B | major histocompatibility complex, class I, B | -0.0335195 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0317184 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.026544 |
| RPL34 | ribosomal protein L34 | -0.0263952 |
| VCL | vinculin | -0.0261881 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0249102 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0246864 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246663 |
| RPL11 | ribosomal protein L11 | -0.0244129 |
| COL3A1 | collagen, type III, alpha 1 | -0.0241069 |
| TMSB4X | thymosin beta 4, X-linked | -0.0237612 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0221209 |
| ACTG1 | actin gamma 1 | -0.0220974 |
| WDR45B | WD repeat domain 45B | -0.0215254 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0212601 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0209243 |
| RPS2 | ribosomal protein S2 | -0.0208556 |
| SPAG9 | sperm associated antigen 9 | -0.0207906 |
| NOP58 | NOP58 ribonucleoprotein | -0.0201587 |
| RAB10 | RAB10, member RAS oncogene family | -0.0201057 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0200054 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0199459 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0198818 |
| RPS24 | ribosomal protein S24 | -0.0194872 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0194717 |
| OGA | O-GlcNAcase | -0.0194419 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0192236 |
| PRKCA | protein kinase C, alpha | -0.0190824 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0189283 |
| ZNF292 | zinc finger protein 292 | -0.0188436 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0185295 |
| RPLP1 | ribosomal protein, large, P1 | -0.0183755 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0183613 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0179458 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0179307 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0177598 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.017749 |
| ANKRD17 | ankyrin repeat domain 17 | -0.017744 |
| H3-3B | H3.3 histone B | -0.0177202 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0171816 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0171542 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0170362 |
| RPL35A | ribosomal protein L35a | -0.0170318 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0169911 |
| TFG | TRK-fused gene | -0.0169751 |
| RSF1 | remodeling and spacing factor 1 | -0.016786 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0167229 |
| RPL31 | ribosomal protein L31 | -0.0166896 |
| SETD5 | SET domain containing 5 | -0.016678 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0165982 |
| RPL26 | ribosomal protein L26 | -0.0165631 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0165198 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0164696 |
| JAK1 | Janus kinase 1 | -0.0164341 |
| PDE10A | phosphodiesterase 10A | -0.0163854 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0162993 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0162669 |
| LMO7 | LIM domain 7 | -0.016224 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0161807 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0161477 |
| MTPN | myotrophin | -0.0160573 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0160182 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0159924 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0159593 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0158832 |
| RPS8 | ribosomal protein S8 | -0.0157761 |
| GNAS | GNAS complex locus | -0.0155533 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.01534 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0150728 |
| SYNRG | synergin, gamma | -0.0150467 |
| CST3 | cystatin C | -0.015034 |
| GLG1 | golgi glycoprotein 1 | -0.014824 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.014768 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0147574 |
| RPL32 | ribosomal protein L32 | -0.0147516 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0146922 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0146729 |
| RPL38 | ribosomal protein L38 | -0.0145826 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0145616 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.014507 |
| SEM1 | SEM1 26S proteasome subunit | -0.0144889 |
| DENND4C | DENN/MADD domain containing 4C | -0.0144331 |
| PTGES2 | prostaglandin E synthase 2 | -0.0143848 |
| FTL | ferritin, light polypeptide | -0.0143362 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0141292 |
| TNPO1 | transportin 1 | -0.0141046 |
| RPL15 | ribosomal protein L15 | -0.0140924 |
| RPL37 | ribosomal protein L37 | -0.0140798 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.013658 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0136046 |
| MT1E | metallothionein 1E | -0.0135902 |
| ECHDC1 | ethylmalonyl-CoA decarboxylase 1 | -0.0135399 |
