Filgotinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Filgotinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Filgotinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.112904
FNDC3B fibronectin type III domain containing 3B 0.107599
DST dystonin 0.0774031
SMYD3 SET and MYND domain containing 3 0.0716966
MACF1 microtubule-actin crosslinking factor 1 0.0704377
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0693081
LDHA lactate dehydrogenase A 0.0626283
ANKRD28 ankyrin repeat domain 28 0.062238
CD44 CD44 molecule (Indian blood group) 0.059119
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0543934
OSMR oncostatin M receptor 0.0543837
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0542056
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0536722
MBNL1 muscleblind-like splicing regulator 1 0.050267
ERRFI1 ERBB receptor feedback inhibitor 1 0.0500271
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0485523
NT5E 5'-nucleotidase, ecto (CD73) 0.0483925
DSCAM Down syndrome cell adhesion molecule 0.047234
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.046489
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0455457
RORA RAR-related orphan receptor A 0.0449872
PDE4D phosphodiesterase 4D, cAMP-specific 0.0443192
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0438856
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0429736
RAD51B RAD51 paralog B 0.0425226
AHNAK AHNAK nucleoprotein 0.0420974
ZBTB20 zinc finger and BTB domain containing 20 0.0403715
ELL2 elongation factor, RNA polymerase II, 2 0.0401702
CENPF centromere protein F, 350/400kDa 0.0399482
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0394848
CANX calnexin 0.0392934
SVIL supervillin 0.0385423
FMN1 formin 1 0.0384821
FMNL2 formin-like 2 0.03841
PDE8A phosphodiesterase 8A 0.0382939
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0381519
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0381518
ZMYND8 zinc finger, MYND-type containing 8 0.0373751
ATXN1 ataxin 1 0.0371132
YAP1 Yes-associated protein 1 0.0370629
MBD5 methyl-CpG binding domain protein 5 0.0362308
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0362301
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0358065
TBC1D5 TBC1 domain family, member 5 0.0352993
IQGAP1 IQ motif containing GTPase activating protein 1 0.0342417
DERA deoxyribose-phosphate aldolase (putative) 0.0341334
ATM ATM serine/threonine kinase 0.0335639
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0331535
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0327668
DGKD diacylglycerol kinase, delta 130kDa 0.0323597
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0321342
CEP250 centrosomal protein 250kDa 0.0320248
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0319635
RTN4 reticulon 4 0.0318763
TRIO trio Rho guanine nucleotide exchange factor 0.0317916
BCAR3 breast cancer anti-estrogen resistance 3 0.030821
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.030792
PHF3 PHD finger protein 3 0.0307642
BIRC6 baculoviral IAP repeat containing 6 0.0306652
VMP1 vacuole membrane protein 1 0.030053
NAV2 neuron navigator 2 0.0297084
BICD1 bicaudal D homolog 1 (Drosophila) 0.0293547
CCDC91 coiled-coil domain containing 91 0.0288212
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0287981
CDCP1 CUB domain containing protein 1 0.0287761
ASPH aspartate beta-hydroxylase 0.0287158
NCOA6 nuclear receptor coactivator 6 0.0286467
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284065
ERBIN erbb2 interacting protein 0.0278629
PRELID2 PRELI domain containing 2 0.0276469
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0275195
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0272513
SLC38A2 solute carrier family 38, member 2 0.0271006
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.026993
LPP LIM domain containing preferred translocation partner in lipoma 0.0269411
THSD4 thrombospondin, type I, domain containing 4 0.026937
PICALM phosphatidylinositol binding clathrin assembly protein 0.0268172
DPYD dihydropyrimidine dehydrogenase 0.0267848
EFNA5 ephrin-A5 0.0266287
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0263194
MSN moesin 0.0255164
PCNX4 pecanex 4 0.0254942
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0254775
ANKRD11 ankyrin repeat domain 11 0.0254267
ZSWIM6 zinc finger, SWIM-type containing 6 0.0253543
ZBTB38 zinc finger and BTB domain containing 38 0.0250847
DENND5B DENN/MADD domain containing 5B 0.0247813
AKAP13 A kinase (PRKA) anchor protein 13 0.0246415
BPTF bromodomain PHD finger transcription factor 0.0244365
FBXL17 F-box and leucine-rich repeat protein 17 0.0243852
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0240268
VCL vinculin 0.023997
NBEA neurobeachin 0.0237814
AFF4 AF4/FMR2 family, member 4 0.0237747
FER fer (fps/fes related) tyrosine kinase 0.0237088
TCF12 transcription factor 12 0.0236443
BASP1 brain abundant, membrane attached signal protein 1 0.0233694
FBXL7 F-box and leucine-rich repeat protein 7 0.0228404
EGFR epidermal growth factor receptor 0.0226271
RSRC1 arginine/serine-rich coiled-coil 1 0.0225249

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.101637
TMSB10 thymosin beta 10 -0.0723541
MT2A metallothionein 2A -0.0721131
PTMA prothymosin, alpha -0.0682324
TPT1 tumor protein, translationally-controlled 1 -0.0575467
RPLP1 ribosomal protein, large, P1 -0.05716
RPL35A ribosomal protein L35a -0.0525475
HILPDA hypoxia inducible lipid droplet-associated -0.0481821
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.046697
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0422938
RPS17 ribosomal protein S17 -0.0409249
RPL23 ribosomal protein L23 -0.0401701
RPS8 ribosomal protein S8 -0.0400373
RPL36 ribosomal protein L36 -0.0395975
RPL32 ribosomal protein L32 -0.0369496
RPL12 ribosomal protein L12 -0.036607
RPS12 ribosomal protein S12 -0.0360933
FTL ferritin, light polypeptide -0.0359416
RPL15 ribosomal protein L15 -0.0358598
RPL19 ribosomal protein L19 -0.035832
RPL31 ribosomal protein L31 -0.0347178
RPS27A ribosomal protein S27a -0.0339366
RPS25 ribosomal protein S25 -0.033539
RPL37A ribosomal protein L37a -0.0333429
RPS19 ribosomal protein S19 -0.0327838
RPS3 ribosomal protein S3 -0.0318056
RPL7A ribosomal protein L7a -0.0308882
RPS13 ribosomal protein S13 -0.0306368
RPL9 ribosomal protein L9 -0.0305711
EGR1 early growth response 1 -0.0302873
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293003
RPS23 ribosomal protein S23 -0.0287204
B2M beta-2-microglobulin -0.0286494
H3-3B H3.3 histone B -0.0285814
EIF1 eukaryotic translation initiation factor 1 -0.0284314
RPL28 ribosomal protein L28 -0.0283743
RPL37 ribosomal protein L37 -0.0279116
RPS15 ribosomal protein S15 -0.027781
S100A9 S100 calcium binding protein A9 -0.0276386
RPL35 ribosomal protein L35 -0.0274511
RACK1 receptor for activated C kinase 1 -0.0271531
RPL26 ribosomal protein L26 -0.0271183
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0270551
RPS14 ribosomal protein S14 -0.0268935
RPS28 ribosomal protein S28 -0.0265847
FUS FUS RNA binding protein -0.0263815
RPS29 ribosomal protein S29 -0.0253059
RPLP2 ribosomal protein, large, P2 -0.0252386
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0251468
RPS20 ribosomal protein S20 -0.0242871
IFITM3 interferon induced transmembrane protein 3 -0.0241054
RPL34 ribosomal protein L34 -0.0236075
SMC4 structural maintenance of chromosomes 4 -0.0233034
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0230447
GNAS GNAS complex locus -0.0229755
RPS11 ribosomal protein S11 -0.0224514
GOLGA4 golgin A4 -0.0216227
RPL30 ribosomal protein L30 -0.0215585
WSB1 WD repeat and SOCS box containing 1 -0.021226
IGF2 insulin-like growth factor 2 -0.0212175
RPS27 ribosomal protein S27 -0.0210966
RPS10 ribosomal protein S10 -0.0209312
ATP5F1E ATP synthase F1 subunit epsilon -0.0208814
RPS6 ribosomal protein S6 -0.0208792
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0203357
RPS21 ribosomal protein S21 -0.0200268
ANKRD37 ankyrin repeat domain 37 -0.019681
HLA-B major histocompatibility complex, class I, B -0.0195893
BTG1 B-cell translocation gene 1, anti-proliferative -0.0194831
RPS24 ribosomal protein S24 -0.0193772
BRD4 bromodomain containing 4 -0.0192903
SQSTM1 sequestosome 1 -0.0189972
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0189668
RAB7A RAB7A, member RAS oncogene family -0.018924
IER3 immediate early response 3 -0.0184036
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0183194
RPL18 ribosomal protein L18 -0.0179603
RPL7 ribosomal protein L7 -0.0176652
RPL5 ribosomal protein L5 -0.0176195
RPL11 ribosomal protein L11 -0.0176187
RPL8 ribosomal protein L8 -0.0173334
DDIT3 DNA-damage-inducible transcript 3 -0.0172934
NAP1L1 nucleosome assembly protein 1-like 1 -0.0172607
NOP58 NOP58 ribonucleoprotein -0.017247
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0170889
POMP proteasome maturation protein -0.0170775
HLA-A major histocompatibility complex, class I, A -0.0170515
EIF4A1 eukaryotic translation initiation factor 4A1 -0.017046
RPS16 ribosomal protein S16 -0.0169954
UQCRB ubiquinol-cytochrome c reductase binding protein -0.016915
RPL27A ribosomal protein L27a -0.0168317
RAB1A RAB1A, member RAS oncogene family -0.0165444
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0165035
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0164496
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0163763
WDR45B WD repeat domain 45B -0.0161933
ENO2 enolase 2 (gamma, neuronal) -0.0159314
ADM adrenomedullin -0.0158218
HMGB2 high mobility group box 2 -0.0158191
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0156704