| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Filgotinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Filgotinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.108428 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.097471 |
| EXT1 | exostosin glycosyltransferase 1 | 0.096984 |
| VCL | vinculin | 0.0962107 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0943842 |
| GLIS3 | GLIS family zinc finger 3 | 0.0868027 |
| AHR | aryl hydrocarbon receptor | 0.0816851 |
| TMEM156 | transmembrane protein 156 | 0.0782118 |
| OSMR | oncostatin M receptor | 0.0676243 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0656961 |
| NRP1 | neuropilin 1 | 0.0650101 |
| ASPH | aspartate beta-hydroxylase | 0.0595622 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0591493 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0529546 |
| SMOX | spermine oxidase | 0.05066 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0462117 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0459746 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0450664 |
| SMYD3 | SET and MYND domain containing 3 | 0.0442422 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0427631 |
| SMAD3 | SMAD family member 3 | 0.0426986 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0422249 |
| DST | dystonin | 0.0418119 |
| ETNK1 | ethanolamine kinase 1 | 0.0416036 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0411371 |
| SEPTIN9 | septin 9 | 0.0409919 |
| ADD3 | adducin 3 (gamma) | 0.0408234 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.040326 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0401688 |
| ETV6 | ets variant 6 | 0.0398527 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0391201 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0387802 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0381656 |
| FOXP1 | forkhead box P1 | 0.037475 |
| CAB39 | calcium binding protein 39 | 0.0362129 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0360636 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0358597 |
| TOP1 | topoisomerase (DNA) I | 0.0347496 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0346276 |
| IL6ST | interleukin 6 signal transducer | 0.0344676 |
| RUNX2 | runt-related transcription factor 2 | 0.0343547 |
| CENPF | centromere protein F, 350/400kDa | 0.0338887 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0338293 |
| SVIL | supervillin | 0.033607 |
| ITGA1 | integrin, alpha 1 | 0.0335436 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0333106 |
| WDR26 | WD repeat domain 26 | 0.0325485 |
| ITGB5 | integrin, beta 5 | 0.0319606 |
| PRELID2 | PRELI domain containing 2 | 0.0316783 |
| PELO | pelota homolog (Drosophila) | 0.0309428 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0305229 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0302772 |
| MYO10 | myosin X | 0.0301285 |
| RAB31 | RAB31, member RAS oncogene family | 0.0300612 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0299018 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0295327 |
| SSH1 | slingshot protein phosphatase 1 | 0.0287174 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0286932 |
| ACTN4 | actinin, alpha 4 | 0.028666 |
| NTN4 | netrin 4 | 0.0285657 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0284226 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0282143 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0281866 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0280706 |
| SP3 | Sp3 transcription factor | 0.0277558 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0275911 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.027183 |
| FNBP1 | formin binding protein 1 | 0.0271055 |
| RO60 | Ro60, Y RNA binding protein | 0.026764 |
| FAF2 | Fas associated factor family member 2 | 0.0263448 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.026307 |
| VMP1 | vacuole membrane protein 1 | 0.0262281 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0260727 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0260638 |
| ETV1 | ets variant 1 | 0.0260346 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0260278 |
| CANX | calnexin | 0.025952 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0256942 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0256544 |
| KLHL5 | kelch-like family member 5 | 0.0256142 |
| MKI67 | marker of proliferation Ki-67 | 0.0255364 |
| FAM3C | family with sequence similarity 3, member C | 0.025483 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0253618 |
| CD44 | CD44 molecule (Indian blood group) | 0.0253378 |
| CORO1C | coronin, actin binding protein, 1C | 0.0249191 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0249092 |
| CDCP1 | CUB domain containing protein 1 | 0.024777 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0247535 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0242783 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0241592 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0239708 |
| KSR1 | kinase suppressor of ras 1 | 0.0238869 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0233056 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0229547 |
| OGA | O-GlcNAcase | 0.0229189 |
| PLPP6 | phospholipid phosphatase 6 | 0.0229159 |
| PHF3 | PHD finger protein 3 | 0.0228886 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0228315 |
| CUL3 | cullin 3 | 0.0226452 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0223877 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.182302 |
| PTMA | prothymosin, alpha | -0.179928 |
| NDRG1 | N-myc downstream regulated 1 | -0.150007 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126194 |
| MT2A | metallothionein 2A | -0.122099 |
| FTL | ferritin, light polypeptide | -0.120757 |
| TMSB10 | thymosin beta 10 | -0.119795 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.115401 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.108716 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.099865 |
| VIM | vimentin | -0.0944808 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0864858 |
| HLA-B | major histocompatibility complex, class I, B | -0.0806228 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0780702 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.076921 |
| LMNA | lamin A/C | -0.0714948 |
| S100A6 | S100 calcium binding protein A6 | -0.0709902 |
| STC2 | stanniocalcin 2 | -0.0674438 |
| RPL35A | ribosomal protein L35a | -0.0665563 |
| NRG1 | neuregulin 1 | -0.0637126 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0630356 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0619089 |
| RPS6 | ribosomal protein S6 | -0.0613618 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0588944 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0564332 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0548258 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0546617 |
| PLIN2 | perilipin 2 | -0.0546267 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.054347 |
| ACTG1 | actin gamma 1 | -0.0520644 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.051727 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0515326 |
| RPL37A | ribosomal protein L37a | -0.051084 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0509077 |
| B2M | beta-2-microglobulin | -0.0508928 |
| S100A10 | S100 calcium binding protein A10 | -0.050688 |
| CADM1 | cell adhesion molecule 1 | -0.0494401 |
| TMSB4X | thymosin beta 4, X-linked | -0.0488552 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0471298 |
| RPL9 | ribosomal protein L9 | -0.0469419 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0467155 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0464496 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0463104 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0452114 |
| RPS27 | ribosomal protein S27 | -0.0442308 |
| RPS8 | ribosomal protein S8 | -0.0432521 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0432117 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0431703 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0430752 |
| FAM13A | family with sequence similarity 13, member A | -0.0416814 |
| IER3 | immediate early response 3 | -0.0402683 |
| POTEF | POTE ankyrin domain family, member F | -0.0400517 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0397441 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0385354 |
| RPLP1 | ribosomal protein, large, P1 | -0.0382164 |
| RPS29 | ribosomal protein S29 | -0.0379399 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0374916 |
| RPL31 | ribosomal protein L31 | -0.0373602 |
| RPL23 | ribosomal protein L23 | -0.0370387 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0362951 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0359738 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0355161 |
| RPS12 | ribosomal protein S12 | -0.0352105 |
| SPAG9 | sperm associated antigen 9 | -0.0351352 |
| RPS25 | ribosomal protein S25 | -0.0350312 |
| RAI14 | retinoic acid induced 14 | -0.0347543 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0346378 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0344005 |
| RPS19 | ribosomal protein S19 | -0.033773 |
| RPS3 | ribosomal protein S3 | -0.0334034 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0332337 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0331322 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0330977 |
| HLA-A | major histocompatibility complex, class I, A | -0.0330098 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0327972 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0327204 |
| RPL36 | ribosomal protein L36 | -0.0324321 |
| RACK1 | receptor for activated C kinase 1 | -0.0324309 |
| WDR45B | WD repeat domain 45B | -0.0322913 |
| RPL34 | ribosomal protein L34 | -0.0320073 |
| RPS24 | ribosomal protein S24 | -0.0318487 |
| S100A9 | S100 calcium binding protein A9 | -0.0317899 |
| MYOF | myoferlin | -0.0316739 |
| HMGA2 | high mobility group AT-hook 2 | -0.0313092 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0310306 |
| RPL12 | ribosomal protein L12 | -0.0308881 |
| SQSTM1 | sequestosome 1 | -0.0307183 |
| HMGA1 | high mobility group AT-hook 1 | -0.0298732 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0298146 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0297959 |
| JUN | jun proto-oncogene | -0.029662 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0294607 |
| IL6 | interleukin 6 | -0.0291741 |
| RPL26 | ribosomal protein L26 | -0.0290491 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0289142 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0288808 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0288464 |
| RPS11 | ribosomal protein S11 | -0.0287964 |
| RPL37 | ribosomal protein L37 | -0.028795 |
| UBC | ubiquitin C | -0.0287425 |
