| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia. (Chemical Entities of Biological Interest Ontology, CHEBI_5062) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/57363 |
| Similar Terms | |
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199 proteins with high or low expression in Finasteride relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNB2 | ephrin-B2 | 2.18 |
| ZG16B | zymogen granule protein 16B | 1.83 |
| TC2N | tandem C2 domains, nuclear | 0.68 |
| PRR3 | proline rich 3 | 0.56 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.56 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | 0.53 |
| MYLK | myosin light chain kinase | 0.5 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.41 |
| FGB | fibrinogen beta chain | 0.41 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.41 |
| ATG12 | autophagy related 12 | 0.39 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.38 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.38 |
| COL6A6 | collagen, type VI, alpha 6 | 0.37 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.35 |
| TTYH3 | tweety family member 3 | 0.35 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.34 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.33 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.33 |
| FOXO1 | forkhead box O1 | 0.33 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.33 |
| STX1A | syntaxin 1A (brain) | 0.33 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.32 |
| ZNF410 | zinc finger protein 410 | 0.32 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.32 |
| MST1R | macrophage stimulating 1 receptor | 0.32 |
| MYZAP | myocardial zonula adherens protein | 0.31 |
| SNTA1 | syntrophin, alpha 1 | 0.31 |
| RMI2 | RecQ mediated genome instability 2 | 0.3 |
| NEB | nebulin | 0.3 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 0.3 |
| CXCL16 | chemokine (C-X-C motif) ligand 16 | 0.3 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.29 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.29 |
| ZNF417 | zinc finger protein 417 | 0.29 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | 0.29 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.29 |
| PMPCB | peptidase (mitochondrial processing) beta | 0.28 |
| ZNF100 | zinc finger protein 100 | 0.28 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.28 |
| B2M | beta-2-microglobulin | 0.28 |
| CLGN | calmegin | 0.28 |
| NKAPD1 | NKAP domain containing 1 | 0.28 |
| TBC1D30 | TBC1 domain family, member 30 | 0.28 |
| FAT3 | FAT atypical cadherin 3 | 0.28 |
| RPS21 | ribosomal protein S21 | 0.28 |
| SGMS1 | sphingomyelin synthase 1 | 0.28 |
| PPT2 | palmitoyl-protein thioesterase 2 | 0.28 |
| HEMK1 | HemK methyltransferase family member 1 | 0.27 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.27 |
| HMGB2 | high mobility group box 2 | 0.26 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.26 |
| MIEF2 | mitochondrial elongation factor 2 | 0.26 |
| KIAA1958 | KIAA1958 | 0.26 |
| SNX29 | sorting nexin 29 | 0.25 |
| ZNF597 | zinc finger protein 597 | 0.25 |
| PMPCA | peptidase (mitochondrial processing) alpha | 0.25 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.25 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.25 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.25 |
| COMMD2 | COMM domain containing 2 | 0.25 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.25 |
| ZNF776 | zinc finger protein 776 | 0.25 |
| FAM133B | family with sequence similarity 133, member B | 0.25 |
| DNPEP | aspartyl aminopeptidase | 0.24 |
| NMU | neuromedin U | 0.24 |
| GGACT | gamma-glutamylamine cyclotransferase | 0.23 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.23 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.23 |
| CDON | cell adhesion associated, oncogene regulated | 0.23 |
| FGA | fibrinogen alpha chain | 0.23 |
| SPOPL | speckle-type POZ protein-like | 0.23 |
| CISD3 | CDGSH iron sulfur domain 3 | 0.23 |
| GAS8 | growth arrest-specific 8 | 0.22 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.22 |
| ITGA6 | integrin, alpha 6 | 0.22 |
| MLF1 | myeloid leukemia factor 1 | 0.22 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.22 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.22 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.22 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.21 |
| LRRC45 | leucine rich repeat containing 45 | 0.21 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.21 |
| SF3B6 | splicing factor 3b, subunit 6, 14kDa | 0.21 |
| ZFAND2A | zinc finger, AN1-type domain 2A | 0.21 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.21 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.21 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.21 |
| ANGPTL4 | angiopoietin-like 4 | 0.21 |
| RPL37A | ribosomal protein L37a | 0.21 |
| ATXN1 | ataxin 1 | 0.21 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.21 |
| SLX4 | SLX4 structure-specific endonuclease subunit | 0.21 |
| UCK1 | uridine-cytidine kinase 1 | 0.21 |
| CDCA4 | cell division cycle associated 4 | 0.2 |
| CCN1 | cellular communication network factor 1 | 0.2 |
| COL1A1 | collagen, type I, alpha 1 | 0.2 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | 0.2 |
| LPIN2 | lipin 2 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMOD1 | leiomodin 1 (smooth muscle) | -1.74 |
| ABHD2 | abhydrolase domain containing 2 | -1.13 |
| DENND5A | DENN/MADD domain containing 5A | -0.86 |
| SELENOF | selenoprotein F | -0.84 |
| TRIB3 | tribbles pseudokinase 3 | -0.69 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.67 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.62 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.61 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.6 |
| DMD | dystrophin | -0.58 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.57 |
| PIP | prolactin-induced protein | -0.57 |
| CBY1 | chibby homolog 1 (Drosophila) | -0.56 |
| PLSCR3 | phospholipid scramblase 3 | -0.55 |
| DMTN | dematin actin binding protein | -0.55 |
| ATF3 | activating transcription factor 3 | -0.55 |
| MZT2A | mitotic spindle organizing protein 2A | -0.54 |
| CEP85L | centrosomal protein 85kDa-like | -0.53 |
| CDC42SE2 | CDC42 small effector 2 | -0.49 |
| ZNF749 | zinc finger protein 749 | -0.49 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | -0.48 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.48 |
| TMTC4 | transmembrane and tetratricopeptide repeat containing 4 | -0.47 |
| ZBTB2 | zinc finger and BTB domain containing 2 | -0.46 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.45 |
| PRMT2 | protein arginine methyltransferase 2 | -0.45 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.45 |
| MEGF6 | multiple EGF-like-domains 6 | -0.45 |
| GON7 | GON7 subunit of KEOPS complex | -0.45 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.44 |
| STMN1 | stathmin 1 | -0.44 |
| CNTRL | centriolin | -0.44 |
| KIAA0513 | KIAA0513 | -0.44 |
| LYSMD1 | LysM, putative peptidoglycan-binding, domain containing 1 | -0.44 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.43 |
| MYO15B | myosin XVB | -0.43 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.43 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.43 |
| TEN1 | TEN1 CST complex subunit | -0.42 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.42 |
| PCBP4 | poly(rC) binding protein 4 | -0.42 |
| FNIP1 | folliculin interacting protein 1 | -0.42 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.42 |
| PALB2 | partner and localizer of BRCA2 | -0.41 |
| MTRES1 | mitochondrial transcription rescue factor 1 | -0.41 |
| CBWD1 | COBW domain containing 1 | -0.41 |
| HFM1 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | -0.4 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.4 |
| TSPOAP1 | TSPO associated protein 1 | -0.39 |
| LDHD | lactate dehydrogenase D | -0.39 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.38 |
| RNF170 | ring finger protein 170 | -0.38 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.38 |
| ZNF484 | zinc finger protein 484 | -0.38 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.37 |
| RNF146 | ring finger protein 146 | -0.37 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.37 |
| TTC8 | tetratricopeptide repeat domain 8 | -0.37 |
| ZNF451 | zinc finger protein 451 | -0.36 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.36 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | -0.36 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.36 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.36 |
| FAM102A | family with sequence similarity 102, member A | -0.36 |
| HLA-F | major histocompatibility complex, class I, F | -0.36 |
| GGT1 | gamma-glutamyltransferase 1 | -0.35 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.35 |
| ZNF33A | zinc finger protein 33A | -0.35 |
| LRRC49 | leucine rich repeat containing 49 | -0.35 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | -0.35 |
| GGT2 | gamma-glutamyltransferase 2 | -0.34 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.34 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.34 |
| HGFAC | HGF activator | -0.34 |
| ZNF672 | zinc finger protein 672 | -0.33 |
| MANEA | mannosidase, endo-alpha | -0.33 |
| RAB8B | RAB8B, member RAS oncogene family | -0.33 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.33 |
| CMIP | c-Maf inducing protein | -0.32 |
| MBIP | MAP3K12 binding inhibitory protein 1 | -0.32 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | -0.32 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | -0.32 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.32 |
| TMOD1 | tropomodulin 1 | -0.31 |
| ANKRD10 | ankyrin repeat domain 10 | -0.31 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.31 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.31 |
| IRX4 | iroquois homeobox 4 | -0.31 |
| FRMD6 | FERM domain containing 6 | -0.31 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.31 |
| SH3D19 | SH3 domain containing 19 | -0.31 |
| OXNAD1 | oxidoreductase NAD-binding domain containing 1 | -0.31 |
| ZNF777 | zinc finger protein 777 | -0.31 |
| OTX1 | orthodenticle homeobox 1 | -0.3 |
| FABP6 | fatty acid binding protein 6, ileal | -0.3 |
| ANXA6 | annexin A6 | -0.3 |
| BAIAP2 | BAI1-associated protein 2 | -0.3 |
| KIAA1107 | KIAA1107 | -0.3 |
| BORCS6 | BLOC-1 related complex subunit 6 | -0.3 |
| FAM120C | family with sequence similarity 120C | -0.3 |
