Finasteride_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.150371
LSAMP limbic system-associated membrane protein 0.116972
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0819996
FMN1 formin 1 0.0783175
TRIB2 tribbles pseudokinase 2 0.0729499
TRIO trio Rho guanine nucleotide exchange factor 0.0644054
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0531428
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0501374
PTPRD protein tyrosine phosphatase, receptor type, D 0.0499702
MEIS2 Meis homeobox 2 0.0494054
FNDC3B fibronectin type III domain containing 3B 0.0481356
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0476645
FAM13A family with sequence similarity 13, member A 0.0468334
SEPTIN9 septin 9 0.0468304
PDE4D phosphodiesterase 4D, cAMP-specific 0.0446248
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0441401
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0438234
SMYD3 SET and MYND domain containing 3 0.042029
NALF1 NALCN channel auxiliary factor 1 0.0414453
ZBTB20 zinc finger and BTB domain containing 20 0.0407107
ANTXR1 anthrax toxin receptor 1 0.039253
VEGFA vascular endothelial growth factor A 0.0386655
DSCAM Down syndrome cell adhesion molecule 0.0378659
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.037424
ARHGAP9 Rho GTPase activating protein 9 0.0371356
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0369095
TENM4 teneurin transmembrane protein 4 0.0365146
AHNAK AHNAK nucleoprotein 0.0364803
PSD3 pleckstrin and Sec7 domain containing 3 0.0361957
MSI2 musashi RNA-binding protein 2 0.0354665
DST dystonin 0.0346648
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0335913
RNF213 ring finger protein 213 0.0324083
NREP neuronal regeneration related protein 0.0322274
MYH9 myosin, heavy chain 9, non-muscle 0.0319353
ZMIZ1 zinc finger, MIZ-type containing 1 0.0318998
ITPRID2 ITPR interacting domain containing 2 0.0309779
CADM2 cell adhesion molecule 2 0.0308757
PRRC2B proline-rich coiled-coil 2B 0.0308532
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0307425
BCAS3 breast carcinoma amplified sequence 3 0.030078
PTEN phosphatase and tensin homolog 0.030077
CDH10 cadherin 10, type 2 (T2-cadherin) 0.029842
PRRC2C proline-rich coiled-coil 2C 0.0297308
UNC5C unc-5 homolog C (C. elegans) 0.0295675
ZNF292 zinc finger protein 292 0.0293105
TENT5A terminal nucleotidyltransferase 5A 0.0292321
FHIT fragile histidine triad 0.0291147
JMJD1C jumonji domain containing 1C 0.0289496
SRRM2 serine/arginine repetitive matrix 2 0.0289071
NRIP1 nuclear receptor interacting protein 1 0.0288341
PTPRE protein tyrosine phosphatase, receptor type, E 0.028662
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0285651
SOS1 son of sevenless homolog 1 (Drosophila) 0.0274141
MACF1 microtubule-actin crosslinking factor 1 0.0272735
IGF1R insulin-like growth factor 1 receptor 0.0272026
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0270025
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0267039
TPST1 tyrosylprotein sulfotransferase 1 0.0266541
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0265385
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.026052
PHF3 PHD finger protein 3 0.0258733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0257492
MED13L mediator complex subunit 13-like 0.0257167
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0255891
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0255729
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.02551
ADAR adenosine deaminase, RNA-specific 0.0254005
AOPEP aminopeptidase O (putative) 0.025129
NF1 neurofibromin 1 0.0250842
DNAH14 dynein, axonemal, heavy chain 14 0.0249877
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0248943
CENPF centromere protein F, 350/400kDa 0.0248549
RPTOR regulatory associated protein of MTOR, complex 1 0.024792
NAMPT nicotinamide phosphoribosyltransferase 0.0242803
NPAS2 neuronal PAS domain protein 2 0.0239521
VCAN versican 0.0238686
EXT1 exostosin glycosyltransferase 1 0.0236739
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.023349
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0233084
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0231205
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0230262
EIF4B eukaryotic translation initiation factor 4B 0.0224865
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.022434
KLHL13 kelch-like family member 13 0.0223335
GRK5 G protein-coupled receptor kinase 5 0.0221977
KMT2C lysine (K)-specific methyltransferase 2C 0.0221602
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.022139
RIGI RNA sensor RIG-I 0.0221028
DPH6 diphthamine biosynthesis 6 0.0220689
AQR aquarius intron-binding spliceosomal factor 0.0220053
EEF2 eukaryotic translation elongation factor 2 0.0219504
PELI1 pellino E3 ubiquitin protein ligase 1 0.0219311
CEP95 centrosomal protein 95kDa 0.0219185
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0217186
ADGRG6 adhesion G protein-coupled receptor G6 0.0217109
THSD4 thrombospondin, type I, domain containing 4 0.021586
RPS18 ribosomal protein S18 0.0214054
AUTS2 autism susceptibility candidate 2 0.0213801
CHD9 chromodomain helicase DNA binding protein 9 0.0213338

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.492067
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208122
PTMA prothymosin, alpha -0.116424
VIM vimentin -0.109568
AKAP12 A kinase (PRKA) anchor protein 12 -0.0809756
RPL35A ribosomal protein L35a -0.0749009
ACTG1 actin gamma 1 -0.0700074
RPL19 ribosomal protein L19 -0.0665102
TMSB10 thymosin beta 10 -0.0655715
RPLP1 ribosomal protein, large, P1 -0.0641617
RPL23 ribosomal protein L23 -0.0619364
RPS6 ribosomal protein S6 -0.0616489
PKM pyruvate kinase, muscle -0.0542514
NDRG1 N-myc downstream regulated 1 -0.053054
WDR45B WD repeat domain 45B -0.0522154
RPL34 ribosomal protein L34 -0.0519753
FTL ferritin, light polypeptide -0.0506603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0487432
EIF1 eukaryotic translation initiation factor 1 -0.0427202
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0422318
LMNA lamin A/C -0.0421297
GDF15 growth differentiation factor 15 -0.041514
TPT1 tumor protein, translationally-controlled 1 -0.0408574
COL1A1 collagen, type I, alpha 1 -0.0377857
S100A6 S100 calcium binding protein A6 -0.0368514
EGR1 early growth response 1 -0.0361983
RPS19 ribosomal protein S19 -0.0359939
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.035823
IER3 immediate early response 3 -0.0355272
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.034758
RPS24 ribosomal protein S24 -0.0343368
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0328879
RPL36 ribosomal protein L36 -0.0327479
WSB1 WD repeat and SOCS box containing 1 -0.0320874
RPS11 ribosomal protein S11 -0.0315426
RPL38 ribosomal protein L38 -0.0312799
HILPDA hypoxia inducible lipid droplet-associated -0.0310008
RPS29 ribosomal protein S29 -0.0300541
RAB7A RAB7A, member RAS oncogene family -0.0297015
RPL12 ribosomal protein L12 -0.0294352
RPL31 ribosomal protein L31 -0.0292161
RPS8 ribosomal protein S8 -0.029136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0284238
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0283216
RPL37 ribosomal protein L37 -0.0280027
HMGA1 high mobility group AT-hook 1 -0.0278991
RPL37A ribosomal protein L37a -0.0278337
DCAF7 DDB1 and CUL4 associated factor 7 -0.0277412
BSG basigin (Ok blood group) -0.0267481
RPS23 ribosomal protein S23 -0.0262454
RPL8 ribosomal protein L8 -0.0262215
DDIT4 DNA-damage-inducible transcript 4 -0.0254042
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0252936
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0252066
RPS14 ribosomal protein S14 -0.0250567
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0247565
RPL30 ribosomal protein L30 -0.024574
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.024425
RACK1 receptor for activated C kinase 1 -0.0240354
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0239446
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0238063
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0237856
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0232399
UBE2B ubiquitin-conjugating enzyme E2B -0.0231913
PFN1 profilin 1 -0.0231433
CDC27 cell division cycle 27 -0.0230011
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0228422
VDAC1 voltage-dependent anion channel 1 -0.0220934
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218033
RPL9 ribosomal protein L9 -0.0216187
KDM2A lysine (K)-specific demethylase 2A -0.0214134
RPS25 ribosomal protein S25 -0.0211569
RPL27 ribosomal protein L27 -0.021103
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.020845
SQSTM1 sequestosome 1 -0.020784
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0206463
NPEPPS aminopeptidase puromycin sensitive -0.0205629
FAM162A family with sequence similarity 162, member A -0.020372
SPAG9 sperm associated antigen 9 -0.0200542
RPL28 ribosomal protein L28 -0.0200252
RPL32 ribosomal protein L32 -0.0200149
RPS27 ribosomal protein S27 -0.0200095
RAB6A RAB6A, member RAS oncogene family -0.0197674
CLINT1 clathrin interactor 1 -0.0197297
TPI1 triosephosphate isomerase 1 -0.0196005
MDK midkine (neurite growth-promoting factor 2) -0.0195756
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0190791
KPNB1 karyopherin (importin) beta 1 -0.0189024
IGFBP4 insulin-like growth factor binding protein 4 -0.018854
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0187707
RPLP0 ribosomal protein, large, P0 -0.0181415
TRIM56 tripartite motif containing 56 -0.0181128
SEC24A SEC24 family member A -0.0179976
RPS21 ribosomal protein S21 -0.0178667
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.017738
KDM3A lysine (K)-specific demethylase 3A -0.0177053
RPL35 ribosomal protein L35 -0.0176659
VCL vinculin -0.017596
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0175796
MCL1 myeloid cell leukemia 1 -0.017525