Finasteride_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.27279
APOB apolipoprotein B 0.229133
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.140933
C3 complement component 3 0.125616
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.119781
LRMDA leucine rich melanocyte differentiation associated 0.0894618
FN1 fibronectin 1 0.0861021
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0768146
NKD1 naked cuticle homolog 1 (Drosophila) 0.0643971
FNDC3B fibronectin type III domain containing 3B 0.0573905
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0532732
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0526709
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0462537
ITGAV integrin, alpha V 0.0445606
DST dystonin 0.0431282
DSPP dentin sialophosphoprotein 0.0415626
GPC6 glypican 6 0.0415137
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0411389
VCL vinculin 0.0409006
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0397685
LCOR ligand dependent nuclear receptor corepressor 0.039629
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0382457
MAML2 mastermind-like 2 (Drosophila) 0.0377606
ELL2 elongation factor, RNA polymerase II, 2 0.0371935
ARHGAP9 Rho GTPase activating protein 9 0.0370156
DOCK4 dedicator of cytokinesis 4 0.0364593
JMJD1C jumonji domain containing 1C 0.0350872
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0350213
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0336136
ERRFI1 ERBB receptor feedback inhibitor 1 0.0335616
A2M alpha-2-macroglobulin 0.0326881
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0323195
GPC3 glypican 3 0.0318428
SAMD4A sterile alpha motif domain containing 4A 0.0313062
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0307541
MSI2 musashi RNA-binding protein 2 0.0307446
MALT1 MALT1 paracaspase 0.0299487
TRIM26 tripartite motif containing 26 0.0298576
RBM39 RNA binding motif protein 39 0.0296067
KIAA1217 KIAA1217 0.02906
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0289237
DSCAM Down syndrome cell adhesion molecule 0.0285462
CFB complement factor B 0.0280614
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0277351
HLF hepatic leukemia factor 0.0275277
SVIL supervillin 0.0272279
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0270502
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0261438
AHR aryl hydrocarbon receptor 0.0257318
YAP1 Yes-associated protein 1 0.0253717
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.025276
ACTN4 actinin, alpha 4 0.0252718
SOX5 SRY (sex determining region Y)-box 5 0.025058
MBNL3 muscleblind-like splicing regulator 3 0.0248802
PUM2 pumilio RNA-binding family member 2 0.0240007
MRTFA myocardin related transcription factor A 0.0235952
KDM7A lysine (K)-specific demethylase 7A 0.0235342
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0229162
ACSS3 acyl-CoA synthetase short-chain family member 3 0.021841
FBF1 Fas (TNFRSF6) binding factor 1 0.0212945
CD46 CD46 molecule, complement regulatory protein 0.0212034
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0209277
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0209193
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0207252
CDK19 cyclin-dependent kinase 19 0.0206748
ACTN1 actinin, alpha 1 0.0205694
PTBP2 polypyrimidine tract binding protein 2 0.0205228
TIMP1 TIMP metallopeptidase inhibitor 1 0.0205139
CRLS1 cardiolipin synthase 1 0.0203766
MAPK8 mitogen-activated protein kinase 8 0.0203149
PCBP2 poly(rC) binding protein 2 0.0201978
AFF4 AF4/FMR2 family, member 4 0.0200717
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0200225
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0198565
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0198395
BCL2L1 BCL2-like 1 0.0197179
ICAM1 intercellular adhesion molecule 1 0.019526
MYH9 myosin, heavy chain 9, non-muscle 0.019485
ZNF644 zinc finger protein 644 0.01941
SESTD1 SEC14 and spectrin domains 1 0.0193535
DOCK5 dedicator of cytokinesis 5 0.0193517
CORO1C coronin, actin binding protein, 1C 0.0193317
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0192179
FAT1 FAT atypical cadherin 1 0.0191706
AFDN afadin, adherens junction formation factor 0.0191489
MYO1B myosin IB 0.0191411
TXNRD1 thioredoxin reductase 1 0.0188194
ZFAND3 zinc finger, AN1-type domain 3 0.0188117
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0186813
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.0186674
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186204
TM9SF3 transmembrane 9 superfamily member 3 0.0185753
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0183296
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0183192
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0183135
YME1L1 YME1-like 1 ATPase 0.0180615
DIAPH1 diaphanous-related formin 1 0.0179339
WAC WW domain containing adaptor with coiled-coil 0.0178679
FRMD5 FERM domain containing 5 0.0176678
PPARD peroxisome proliferator-activated receptor delta 0.0176465

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.566036
AKAP12 A kinase (PRKA) anchor protein 12 -0.152571
RPS6 ribosomal protein S6 -0.0913899
RPL37A ribosomal protein L37a -0.0825214
RPS8 ribosomal protein S8 -0.0796771
MT2A metallothionein 2A -0.0750482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0634102
FTL ferritin, light polypeptide -0.0605984
RPLP1 ribosomal protein, large, P1 -0.0556795
TPT1 tumor protein, translationally-controlled 1 -0.0546918
RPS19 ribosomal protein S19 -0.0544115
RPS12 ribosomal protein S12 -0.0524512
CCL20 chemokine (C-C motif) ligand 20 -0.0514908
RPL11 ribosomal protein L11 -0.0514285
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502207
RPL9 ribosomal protein L9 -0.0492202
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0490904
RPL23 ribosomal protein L23 -0.0461164
RPS24 ribosomal protein S24 -0.0460708
RPL12 ribosomal protein L12 -0.0457001
RPS29 ribosomal protein S29 -0.0451117
RPS3 ribosomal protein S3 -0.0450357
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0446022
APOA2 apolipoprotein A-II -0.0442652
RPL35A ribosomal protein L35a -0.0428626
INTS6 integrator complex subunit 6 -0.0415927
RPS27A ribosomal protein S27a -0.0405689
GMDS GDP-mannose 4,6-dehydratase -0.0399648
RPL5 ribosomal protein L5 -0.0398927
GK glycerol kinase -0.0398168
RACK1 receptor for activated C kinase 1 -0.0372668
RPL31 ribosomal protein L31 -0.0369009
RPL34 ribosomal protein L34 -0.0356521
NAP1L1 nucleosome assembly protein 1-like 1 -0.0338683
RPS14 ribosomal protein S14 -0.0333425
PLIN2 perilipin 2 -0.0333077
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0332035
PTMA prothymosin, alpha -0.0331806
CP ceruloplasmin (ferroxidase) -0.0330786
AHSG alpha-2-HS-glycoprotein -0.0328776
RPL26 ribosomal protein L26 -0.0322484
PDLIM5 PDZ and LIM domain 5 -0.0315401
RPL38 ribosomal protein L38 -0.0291741
RPLP2 ribosomal protein, large, P2 -0.0285008
RPS13 ribosomal protein S13 -0.0280523
RPL32 ribosomal protein L32 -0.0273588
RPS23 ribosomal protein S23 -0.027181
RPL7A ribosomal protein L7a -0.026515
RPL19 ribosomal protein L19 -0.0262192
ENO1 enolase 1, (alpha) -0.0258508
RPS10 ribosomal protein S10 -0.0256351
HMGA1 high mobility group AT-hook 1 -0.0254117
RPLP0 ribosomal protein, large, P0 -0.0245915
CANX calnexin -0.024409
ACTG1 actin gamma 1 -0.0240753
RPS17 ribosomal protein S17 -0.0239338
EHBP1 EH domain binding protein 1 -0.0239263
RPS27 ribosomal protein S27 -0.0238733
SLC38A1 solute carrier family 38, member 1 -0.0238326
ASPH aspartate beta-hydroxylase -0.0235406
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0235392
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0235003
RPS11 ribosomal protein S11 -0.0233275
RPL13A ribosomal protein L13a -0.0228636
RPL10A ribosomal protein L10a -0.0228148
GNAS GNAS complex locus -0.0226517
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0222794
NDRG1 N-myc downstream regulated 1 -0.0219092
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0217502
RPS25 ribosomal protein S25 -0.0212453
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0209107
TMSB10 thymosin beta 10 -0.0207138
FLNB filamin B, beta -0.0206554
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.020322
RPS21 ribosomal protein S21 -0.0201556
RPL8 ribosomal protein L8 -0.0199231
PALLD palladin, cytoskeletal associated protein -0.0199128
EIF1 eukaryotic translation initiation factor 1 -0.0190557
APOE apolipoprotein E -0.0189325
WSB1 WD repeat and SOCS box containing 1 -0.0188764
RPS16 ribosomal protein S16 -0.0187811
MCL1 myeloid cell leukemia 1 -0.0187005
DDIT4 DNA-damage-inducible transcript 4 -0.0186581
GCLC glutamate-cysteine ligase, catalytic subunit -0.0186247
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0181587
NPR2 natriuretic peptide receptor 2 -0.0181116
RPS5 ribosomal protein S5 -0.0178623
RPL37 ribosomal protein L37 -0.0177867
ARHGAP21 Rho GTPase activating protein 21 -0.0176487
RPL28 ribosomal protein L28 -0.0175768
RPL27A ribosomal protein L27a -0.0174927
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.01744
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0173919
RPL14 ribosomal protein L14 -0.0173795
FTH1 ferritin, heavy polypeptide 1 -0.0171776
CALR calreticulin -0.017096
HM13 histocompatibility (minor) 13 -0.0170772
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0170412
MAP1B microtubule-associated protein 1B -0.017022
RPL36A ribosomal protein L36a -0.0169584