Finasteride_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.174404
FLNB filamin B, beta 0.127979
MEF2A myocyte enhancer factor 2A 0.126008
MTSS1 metastasis suppressor 1 0.0914646
MYH9 myosin, heavy chain 9, non-muscle 0.0878474
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0832029
RAI14 retinoic acid induced 14 0.0810219
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0788368
KIAA1217 KIAA1217 0.0780825
NAMPT nicotinamide phosphoribosyltransferase 0.0735289
BHLHE40 basic helix-loop-helix family, member e40 0.0732596
NAV2 neuron navigator 2 0.0716748
ITCH itchy E3 ubiquitin protein ligase 0.0681202
CANX calnexin 0.0675852
KRT6A keratin 6A, type II 0.0672513
MYOF myoferlin 0.0664025
GRB10 growth factor receptor-bound protein 10 0.0646498
CEMIP cell migration inducing protein, hyaluronan binding 0.064572
ESYT2 extended synaptotagmin-like protein 2 0.0617524
FTH1 ferritin, heavy polypeptide 1 0.0602966
NRIP1 nuclear receptor interacting protein 1 0.0558773
MBNL2 muscleblind-like splicing regulator 2 0.0537474
GOLGA4 golgin A4 0.0508394
KRT17 keratin 17, type I 0.0491837
PODXL podocalyxin-like 0.0484056
RBM39 RNA binding motif protein 39 0.0473488
SUCO SUN domain containing ossification factor 0.0466302
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.045946
RICTOR RPTOR independent companion of MTOR, complex 2 0.0452871
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0449312
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0444974
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0440304
TPM3 tropomyosin 3 0.043658
ANXA2 annexin A2 0.0432972
ANKRD33B ankyrin repeat domain 33B 0.0424647
OGA O-GlcNAcase 0.0421499
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0417572
BZW1 basic leucine zipper and W2 domains 1 0.0415759
PLEC plectin 0.041444
ANXA1 annexin A1 0.0414153
PRELID2 PRELI domain containing 2 0.0410175
ARRDC3 arrestin domain containing 3 0.0406425
KDM3A lysine (K)-specific demethylase 3A 0.040549
KDM6A lysine (K)-specific demethylase 6A 0.0399855
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.039615
DLG1 discs, large homolog 1 (Drosophila) 0.0394397
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0393752
FLNA filamin A, alpha 0.0393563
FNIP1 folliculin interacting protein 1 0.0385102
MSN moesin 0.0375803
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0375511
COPB1 coatomer protein complex, subunit beta 1 0.0370976
SPAG9 sperm associated antigen 9 0.0367907
DSCAM Down syndrome cell adhesion molecule 0.0362935
RASA3 RAS p21 protein activator 3 0.035622
COPA coatomer protein complex, subunit alpha 0.0356015
CUL4B cullin 4B 0.0355584
DSTN destrin (actin depolymerizing factor) 0.0353541
CALU calumenin 0.035203
EMP1 epithelial membrane protein 1 0.0348197
TNIP1 TNFAIP3 interacting protein 1 0.0347441
SEC31A SEC31 homolog A (S. cerevisiae) 0.0345492
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0341319
SBF2 SET binding factor 2 0.0339413
AHNAK AHNAK nucleoprotein 0.0338175
NCOA3 nuclear receptor coactivator 3 0.0334737
KMT2C lysine (K)-specific methyltransferase 2C 0.033419
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0331911
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0328062
TRA2A transformer 2 alpha homolog (Drosophila) 0.032789
ACBD3 acyl-CoA binding domain containing 3 0.0324427
ARF4 ADP-ribosylation factor 4 0.032392
MYO10 myosin X 0.0316478
NCOR2 nuclear receptor corepressor 2 0.0316342
KDM7A lysine (K)-specific demethylase 7A 0.0314432
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0312815
SMAD3 SMAD family member 3 0.0311117
KIF16B kinesin family member 16B 0.030675
APP amyloid beta (A4) precursor protein 0.0306403
TMEM165 transmembrane protein 165 0.0305972
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0305384
PMM2 phosphomannomutase 2 0.0304269
ARHGAP21 Rho GTPase activating protein 21 0.0303366
RNF19B ring finger protein 19B 0.0303073
KLF7 Kruppel-like factor 7 (ubiquitous) 0.030281
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.030177
SQLE squalene epoxidase 0.0299891
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0295451
PTK2 protein tyrosine kinase 2 0.0295153
LOXL2 lysyl oxidase-like 2 0.0294608
GOLGB1 golgin B1 0.0292896
GARS1 glycyl-tRNA synthetase 1 0.0292167
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0289782
NAP1L1 nucleosome assembly protein 1-like 1 0.0289358
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0288964
CLU clusterin 0.028638
FNDC3B fibronectin type III domain containing 3B 0.0282621
SLMAP sarcolemma associated protein 0.0281544
CD44 CD44 molecule (Indian blood group) 0.0279129
UBA6 ubiquitin-like modifier activating enzyme 6 0.0275549

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.185977
TIMP3 TIMP metallopeptidase inhibitor 3 -0.151488
MT2A metallothionein 2A -0.125128
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118137
TMSB10 thymosin beta 10 -0.0901726
IFITM1 interferon induced transmembrane protein 1 -0.0732503
IFITM3 interferon induced transmembrane protein 3 -0.067682
IFI6 interferon, alpha-inducible protein 6 -0.0531875
DPYD dihydropyrimidine dehydrogenase -0.0514253
RPLP1 ribosomal protein, large, P1 -0.0475706
IGF2 insulin-like growth factor 2 -0.0472482
CYB5R3 cytochrome b5 reductase 3 -0.0468626
POTEF POTE ankyrin domain family, member F -0.0457497
RPLP2 ribosomal protein, large, P2 -0.0453064
PLAT plasminogen activator, tissue -0.0446782
SAMD9 sterile alpha motif domain containing 9 -0.0431684
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0425651
FTL ferritin, light polypeptide -0.0419652
RPS19 ribosomal protein S19 -0.0416161
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0388161
FOXP1 forkhead box P1 -0.0384024
HLA-B major histocompatibility complex, class I, B -0.0383252
RPS21 ribosomal protein S21 -0.0374945
S100A10 S100 calcium binding protein A10 -0.0373621
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0368783
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0363908
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0344984
ACTN4 actinin, alpha 4 -0.0333075
IFI27 interferon, alpha-inducible protein 27 -0.0325506
IGFBP4 insulin-like growth factor binding protein 4 -0.032389
SULF2 sulfatase 2 -0.0323776
PALLD palladin, cytoskeletal associated protein -0.0322043
GNAS GNAS complex locus -0.031869
MT1X metallothionein 1X -0.031588
RPL8 ribosomal protein L8 -0.0308926
RPS6 ribosomal protein S6 -0.0303366
RPL32 ribosomal protein L32 -0.0301892
RPL36 ribosomal protein L36 -0.0299553
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0294668
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0293595
S100A6 S100 calcium binding protein A6 -0.0289111
RPL34 ribosomal protein L34 -0.0283232
RIGI RNA sensor RIG-I -0.0281755
MKI67 marker of proliferation Ki-67 -0.0278934
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0273161
TXNRD1 thioredoxin reductase 1 -0.0268202
RPS13 ribosomal protein S13 -0.0267398
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0262379
MT1E metallothionein 1E -0.0261359
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0260465
PRSS23 protease, serine, 23 -0.0250917
PKM pyruvate kinase, muscle -0.0248432
RPL35A ribosomal protein L35a -0.0248109
MECOM MDS1 and EVI1 complex locus -0.0246415
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0244154
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242016
OSMR oncostatin M receptor -0.0236269
IFI44L interferon-induced protein 44-like -0.0234762
CENPF centromere protein F, 350/400kDa -0.0225825
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0225707
S100A11 S100 calcium binding protein A11 -0.0225059
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0222938
CNRIP1 cannabinoid receptor interacting protein 1 -0.0222225
RPS29 ribosomal protein S29 -0.0221548
RPS8 ribosomal protein S8 -0.0219055
RPS23 ribosomal protein S23 -0.0218762
ALCAM activated leukocyte cell adhesion molecule -0.0218103
IFI16 interferon, gamma-inducible protein 16 -0.0217576
RPL19 ribosomal protein L19 -0.0215969
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0213497
RPL31 ribosomal protein L31 -0.0213277
LMO7 LIM domain 7 -0.0209834
UQCRB ubiquinol-cytochrome c reductase binding protein -0.020901
SOX5 SRY (sex determining region Y)-box 5 -0.0205967
NDRG1 N-myc downstream regulated 1 -0.0205937
ZMYND8 zinc finger, MYND-type containing 8 -0.0205096
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0204471
EGR1 early growth response 1 -0.020384
RPL36A ribosomal protein L36a -0.0202589
LY6E lymphocyte antigen 6 complex, locus E -0.020242
ACTG1 actin gamma 1 -0.0202108
TNS4 tensin 4 -0.0200586
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0199635
MRPS6 mitochondrial ribosomal protein S6 -0.0199475
RPS25 ribosomal protein S25 -0.0199453
MTAP methylthioadenosine phosphorylase -0.0199318
TXNIP thioredoxin interacting protein -0.0196985
ATP5F1E ATP synthase F1 subunit epsilon -0.0193953
RPL30 ribosomal protein L30 -0.019204
MDK midkine (neurite growth-promoting factor 2) -0.0191823
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0191637
CST3 cystatin C -0.0191591
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0189563
SP100 SP100 nuclear antigen -0.0188608
MEIS2 Meis homeobox 2 -0.0188159
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0185881
PFN1 profilin 1 -0.0184919
TRIM56 tripartite motif containing 56 -0.0182494
S100A9 S100 calcium binding protein A9 -0.0182296
RPL35 ribosomal protein L35 -0.0181446