Finasteride_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0783919
VEGFA vascular endothelial growth factor A 0.0691595
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0607692
MYH9 myosin, heavy chain 9, non-muscle 0.0589283
ZFAND3 zinc finger, AN1-type domain 3 0.0564872
BCL2L1 BCL2-like 1 0.0554604
GOLGA4 golgin A4 0.0539127
HYOU1 hypoxia up-regulated 1 0.0528585
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0512916
DSPP dentin sialophosphoprotein 0.0507181
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0501539
ZNF292 zinc finger protein 292 0.0501339
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0494417
KMT2C lysine (K)-specific methyltransferase 2C 0.0492379
MBNL2 muscleblind-like splicing regulator 2 0.0477226
CTNND1 catenin (cadherin-associated protein), delta 1 0.0475892
VMP1 vacuole membrane protein 1 0.0470216
AVL9 AVL9 homolog (S. cerevisiase) 0.0468561
ARHGAP32 Rho GTPase activating protein 32 0.0459724
AKAP13 A kinase (PRKA) anchor protein 13 0.0439933
CCNL1 cyclin L1 0.0421687
TXNRD1 thioredoxin reductase 1 0.0418143
AKAP9 A kinase (PRKA) anchor protein 9 0.041022
ATXN1 ataxin 1 0.0402165
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0401484
EXT1 exostosin glycosyltransferase 1 0.039856
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0396982
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0396286
ANXA11 annexin A11 0.039606
FAT1 FAT atypical cadherin 1 0.0392373
TRIM2 tripartite motif containing 2 0.0390182
MACF1 microtubule-actin crosslinking factor 1 0.0378582
KDM6A lysine (K)-specific demethylase 6A 0.0376167
PICALM phosphatidylinositol binding clathrin assembly protein 0.0375028
STK24 serine/threonine kinase 24 0.0372909
BIRC6 baculoviral IAP repeat containing 6 0.036514
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.035678
COG5 component of oligomeric golgi complex 5 0.0352695
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0351509
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0346511
SNX13 sorting nexin 13 0.0343986
USP9X ubiquitin specific peptidase 9, X-linked 0.0341355
RB1CC1 RB1-inducible coiled-coil 1 0.0340298
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.033978
WWC1 WW and C2 domain containing 1 0.0333251
FAM13A family with sequence similarity 13, member A 0.0331816
MYOF myoferlin 0.0331792
SNX9 sorting nexin 9 0.0330525
YAP1 Yes-associated protein 1 0.0329975
NBAS neuroblastoma amplified sequence 0.0328724
NEK7 NIMA-related kinase 7 0.0326715
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0324986
JMJD1C jumonji domain containing 1C 0.0322613
CUL3 cullin 3 0.0318906
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0318075
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0317618
PTEN phosphatase and tensin homolog 0.0315887
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0313611
CCNY cyclin Y 0.0313448
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0313101
UBE2H ubiquitin-conjugating enzyme E2H 0.0312845
KMT2E lysine (K)-specific methyltransferase 2E 0.0312439
ITCH itchy E3 ubiquitin protein ligase 0.0311217
SRRM2 serine/arginine repetitive matrix 2 0.0310882
ADAM9 ADAM metallopeptidase domain 9 0.0310704
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0306224
KDM4C lysine (K)-specific demethylase 4C 0.030342
CEMIP2 cell migration inducing hyaluronidase 2 0.029866
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0291373
KDM3A lysine (K)-specific demethylase 3A 0.0289263
ESRP1 epithelial splicing regulatory protein 1 0.0288712
CADPS2 Ca++-dependent secretion activator 2 0.0287429
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0287143
ARHGAP42 Rho GTPase activating protein 42 0.0285713
ALPK1 alpha-kinase 1 0.02809
SEPTIN9 septin 9 0.0279568
ANKRD11 ankyrin repeat domain 11 0.0279432
DSCAM Down syndrome cell adhesion molecule 0.0279292
TES testin LIM domain protein 0.0277097
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0276023
FNDC3A fibronectin type III domain containing 3A 0.0274141
KDM2A lysine (K)-specific demethylase 2A 0.0273055
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272075
YEATS2 YEATS domain containing 2 0.0268148
FTH1 ferritin, heavy polypeptide 1 0.0267527
MON2 MON2 homolog (S. cerevisiae) 0.0266275
ARF4 ADP-ribosylation factor 4 0.0265591
SH3RF1 SH3 domain containing ring finger 1 0.0265453
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0261464
TNRC18 trinucleotide repeat containing 18 0.0261265
MED13L mediator complex subunit 13-like 0.0261155
CLTC clathrin, heavy chain (Hc) 0.0260115
HELZ helicase with zinc finger 0.0260076
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0259735
USP34 ubiquitin specific peptidase 34 0.0258623
TMF1 TATA element modulatory factor 1 0.0258242
LPP LIM domain containing preferred translocation partner in lipoma 0.0255938
SPAG9 sperm associated antigen 9 0.0255031
KLHL29 kelch-like family member 29 0.0251092
XRN1 5'-3' exoribonuclease 1 0.0250982

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.202198
TPT1 tumor protein, translationally-controlled 1 -0.140692
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136103
PTMA prothymosin, alpha -0.108703
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100438
RPL35A ribosomal protein L35a -0.0995357
AGR2 anterior gradient 2 -0.0944695
FTL ferritin, light polypeptide -0.0876928
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0844973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0800086
NPSR1 neuropeptide S receptor 1 -0.0782242
RPS6 ribosomal protein S6 -0.0780303
RPL23 ribosomal protein L23 -0.0777192
S100A6 S100 calcium binding protein A6 -0.0764096
EIF1 eukaryotic translation initiation factor 1 -0.0747118
RPLP1 ribosomal protein, large, P1 -0.0723399
S100A10 S100 calcium binding protein A10 -0.0722888
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0694807
RPS19 ribosomal protein S19 -0.0683524
HLA-A major histocompatibility complex, class I, A -0.0635342
RPS21 ribosomal protein S21 -0.0610166
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0605639
RPS8 ribosomal protein S8 -0.058459
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0582265
RPL19 ribosomal protein L19 -0.0576504
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0565736
RPL34 ribosomal protein L34 -0.0560794
ACTG1 actin gamma 1 -0.0551847
PGK1 phosphoglycerate kinase 1 -0.0527684
RPS25 ribosomal protein S25 -0.0516185
RPS3 ribosomal protein S3 -0.051434
S100P S100 calcium binding protein P -0.0495671
FGFR2 fibroblast growth factor receptor 2 -0.049375
IFI27 interferon, alpha-inducible protein 27 -0.0487108
RPL12 ribosomal protein L12 -0.0478235
ATF5 activating transcription factor 5 -0.0476526
GNAS GNAS complex locus -0.0472318
RPS16 ribosomal protein S16 -0.0458583
B2M beta-2-microglobulin -0.0457675
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.045311
S100A9 S100 calcium binding protein A9 -0.043297
LCN2 lipocalin 2 -0.0424343
RPL8 ribosomal protein L8 -0.041925
RPS24 ribosomal protein S24 -0.0412682
LMNA lamin A/C -0.0411355
IFI6 interferon, alpha-inducible protein 6 -0.0405011
RPL26 ribosomal protein L26 -0.0400903
RPS27A ribosomal protein S27a -0.03987
EMP1 epithelial membrane protein 1 -0.0398027
RPL18 ribosomal protein L18 -0.0393886
EPCAM epithelial cell adhesion molecule -0.0393382
PKM pyruvate kinase, muscle -0.039074
RPL38 ribosomal protein L38 -0.0390537
TM4SF1 transmembrane 4 L six family member 1 -0.0383018
RPL9 ribosomal protein L9 -0.0381855
KLF5 Kruppel-like factor 5 (intestinal) -0.0380979
RPL37A ribosomal protein L37a -0.0373891
AREG amphiregulin -0.0368444
SOX4 SRY (sex determining region Y)-box 4 -0.0367789
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0366655
RPL11 ribosomal protein L11 -0.0358567
RPL36A ribosomal protein L36a -0.0358481
S100A11 S100 calcium binding protein A11 -0.0353727
HLA-E major histocompatibility complex, class I, E -0.0352534
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.034748
RPS29 ribosomal protein S29 -0.0343453
RPL32 ribosomal protein L32 -0.0341136
INSIG1 insulin induced gene 1 -0.0340017
LOC112694756 uncharaterized LOC112694756 -0.0336057
HLA-B major histocompatibility complex, class I, B -0.0334571
GSTP1 glutathione S-transferase pi 1 -0.0333897
HMGB1 high mobility group box 1 -0.0333118
RPL28 ribosomal protein L28 -0.033251
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0328044
LOC102724023 ES1 protein homolog, mitochondrial -0.032618
RPL27 ribosomal protein L27 -0.0324188
RPS12 ribosomal protein S12 -0.0323945
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0323891
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0322643
RPL35 ribosomal protein L35 -0.0322004
INTS6 integrator complex subunit 6 -0.031849
RPLP2 ribosomal protein, large, P2 -0.0316895
RPLP0 ribosomal protein, large, P0 -0.0316812
SEC61G Sec61 gamma subunit -0.0316733
KRT19 keratin 19, type I -0.031526
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0313344
UBB ubiquitin B -0.0311853
HMGA1 high mobility group AT-hook 1 -0.0311736
RPL5 ribosomal protein L5 -0.0309402
RPS14 ribosomal protein S14 -0.0304466
SLC38A1 solute carrier family 38, member 1 -0.0303156
CALR calreticulin -0.0300052
RPS5 ribosomal protein S5 -0.0295712
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0294262
MYL12B myosin, light chain 12B, regulatory -0.0293334
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0292065
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0284611
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0282034
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0281307
RRBP1 ribosome binding protein 1 -0.027995