Finasteride_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.169445
DST dystonin 0.124778
FTH1 ferritin, heavy polypeptide 1 0.119538
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.109703
TMSB4X thymosin beta 4, X-linked 0.095037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0945072
MACF1 microtubule-actin crosslinking factor 1 0.0808249
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0719808
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0692157
EEF2 eukaryotic translation elongation factor 2 0.0631752
APP amyloid beta (A4) precursor protein 0.0603751
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0598137
PSD3 pleckstrin and Sec7 domain containing 3 0.0583656
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0581222
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.055874
CANX calnexin 0.053368
EHBP1 EH domain binding protein 1 0.0528794
DLG1 discs, large homolog 1 (Drosophila) 0.052678
EZR ezrin 0.0513866
CD44 CD44 molecule (Indian blood group) 0.0513076
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0500548
MYOF myoferlin 0.0490327
TRIO trio Rho guanine nucleotide exchange factor 0.048104
YEATS2 YEATS domain containing 2 0.047422
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0465488
TNS3 tensin 3 0.0456694
MYH9 myosin, heavy chain 9, non-muscle 0.0455597
FNIP1 folliculin interacting protein 1 0.0449884
FMNL2 formin-like 2 0.0446265
EFNA5 ephrin-A5 0.0443209
TSC22D1 TSC22 domain family, member 1 0.043932
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0438024
DENND1A DENN/MADD domain containing 1A 0.0431665
RUNX1 runt-related transcription factor 1 0.0430857
EXOC4 exocyst complex component 4 0.0412912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0410998
LOXL2 lysyl oxidase-like 2 0.0408257
RPL26 ribosomal protein L26 0.040596
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0404158
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0403374
SET SET nuclear proto-oncogene 0.0403306
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0401545
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0400697
PDE10A phosphodiesterase 10A 0.0394795
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0392758
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0390815
CALR calreticulin 0.0381325
DOCK11 dedicator of cytokinesis 11 0.0375978
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0375676
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0373862
AHNAK AHNAK nucleoprotein 0.036899
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0361816
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0350732
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0348399
BCAR3 breast cancer anti-estrogen resistance 3 0.0347934
HDAC9 histone deacetylase 9 0.0346204
RAI1 retinoic acid induced 1 0.0344582
RPS18 ribosomal protein S18 0.0343306
PIAS2 protein inhibitor of activated STAT, 2 0.0339831
PTK2 protein tyrosine kinase 2 0.0339696
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0329576
ARHGAP5 Rho GTPase activating protein 5 0.0329231
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0324756
CSMD3 CUB and Sushi multiple domains 3 0.0324179
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0316796
TPM3 tropomyosin 3 0.0315572
LPP LIM domain containing preferred translocation partner in lipoma 0.0314373
TXNRD1 thioredoxin reductase 1 0.0314017
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0311994
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0307811
PDIA6 protein disulfide isomerase family A, member 6 0.0307462
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0304612
HOOK2 hook microtubule-tethering protein 2 0.030441
ANXA1 annexin A1 0.0298175
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0298124
ESYT2 extended synaptotagmin-like protein 2 0.0297466
TBC1D22A TBC1 domain family, member 22A 0.0295138
PTPRF protein tyrosine phosphatase, receptor type, F 0.0294356
HDLBP high density lipoprotein binding protein 0.0290099
ANKRD11 ankyrin repeat domain 11 0.0289511
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0287814
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0285361
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0283897
HSPA8 heat shock 70kDa protein 8 0.0281092
CFAP299 cilia and flagella associated protein 299 0.0279795
KDM4C lysine (K)-specific demethylase 4C 0.0278245
PRELID2 PRELI domain containing 2 0.0278071
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0276405
ZDHHC14 zinc finger, DHHC-type containing 14 0.0275056
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0274282
CADM2 cell adhesion molecule 2 0.0272606
MBNL2 muscleblind-like splicing regulator 2 0.0270438
PODXL podocalyxin-like 0.0270268
GIGYF2 GRB10 interacting GYF protein 2 0.0268721
OGA O-GlcNAcase 0.0268393
SRRM2 serine/arginine repetitive matrix 2 0.0264702
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0260596
ANKRD36 ankyrin repeat domain 36 0.0258543
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0257688
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0256653

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.317886
MT2A metallothionein 2A -0.310664
VIM vimentin -0.177123
TMSB10 thymosin beta 10 -0.113831
FTL ferritin, light polypeptide -0.106234
MT1X metallothionein 1X -0.0938663
MT1E metallothionein 1E -0.0754737
HMGA1 high mobility group AT-hook 1 -0.047013
RPL35A ribosomal protein L35a -0.041992
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0418336
RPLP1 ribosomal protein, large, P1 -0.041571
TM4SF1 transmembrane 4 L six family member 1 -0.0386182
POTEF POTE ankyrin domain family, member F -0.0384817
RPS19 ribosomal protein S19 -0.0370152
PTMA prothymosin, alpha -0.0363234
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0348201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345574
ACTG1 actin gamma 1 -0.0344184
EGR1 early growth response 1 -0.0332989
IFITM1 interferon induced transmembrane protein 1 -0.0313012
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0306821
S100A6 S100 calcium binding protein A6 -0.030474
RPS8 ribosomal protein S8 -0.0295692
RPLP2 ribosomal protein, large, P2 -0.0295289
KMT2E lysine (K)-specific methyltransferase 2E -0.0292468
RPL36 ribosomal protein L36 -0.0289978
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0268174
RPL34 ribosomal protein L34 -0.0266866
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0264912
RPL19 ribosomal protein L19 -0.0264685
TPT1 tumor protein, translationally-controlled 1 -0.025127
RPS24 ribosomal protein S24 -0.0249831
RPL31 ribosomal protein L31 -0.023795
SRGN serglycin -0.0234136
PFN1 profilin 1 -0.0231088
S100A10 S100 calcium binding protein A10 -0.0227979
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0227912
RPLP0 ribosomal protein, large, P0 -0.0221669
EMP1 epithelial membrane protein 1 -0.0219121
RPL32 ribosomal protein L32 -0.0216239
RPS13 ribosomal protein S13 -0.0211596
GCLM glutamate-cysteine ligase, modifier subunit -0.0209268
WSB1 WD repeat and SOCS box containing 1 -0.02082
RPS14 ribosomal protein S14 -0.0207914
YBX3 Y box binding protein 3 -0.0205519
RPS11 ribosomal protein S11 -0.0205011
AREG amphiregulin -0.019912
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198443
RPL5 ribosomal protein L5 -0.0195925
DEK DEK proto-oncogene -0.0190418
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0186653
RPS4X ribosomal protein S4, X-linked -0.0186243
RPS23 ribosomal protein S23 -0.0181995
RPS21 ribosomal protein S21 -0.0181446
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0180168
RPL23 ribosomal protein L23 -0.0179003
FOSL1 FOS-like antigen 1 -0.0176662
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0176395
IFITM3 interferon induced transmembrane protein 3 -0.0176297
RPS25 ribosomal protein S25 -0.0171784
RPL38 ribosomal protein L38 -0.017172
HMGB1 high mobility group box 1 -0.0170923
PRDX1 peroxiredoxin 1 -0.0169169
MYL12B myosin, light chain 12B, regulatory -0.016855
SEPTIN7 septin 7 -0.0168414
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0167161
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0166995
IFI6 interferon, alpha-inducible protein 6 -0.0165961
VDAC1 voltage-dependent anion channel 1 -0.0165954
H1-0 H1.0 linker histone -0.0165398
RPS27 ribosomal protein S27 -0.0164791
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0163735
S100A11 S100 calcium binding protein A11 -0.0160325
ANGPTL4 angiopoietin-like 4 -0.0160213
RPL8 ribosomal protein L8 -0.015868
BSG basigin (Ok blood group) -0.015818
RPL27 ribosomal protein L27 -0.0152901
GNAS GNAS complex locus -0.0147506
RPL28 ribosomal protein L28 -0.0145675
LOC102724023 ES1 protein homolog, mitochondrial -0.0143712
SPRY4 sprouty homolog 4 (Drosophila) -0.0142317
RPS6 ribosomal protein S6 -0.0141707
S100A9 S100 calcium binding protein A9 -0.0140661
RPS29 ribosomal protein S29 -0.0139741
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0137731
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0137141
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0133701
TAPBP TAP binding protein (tapasin) -0.0132978
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0130251
WDR45B WD repeat domain 45B -0.0129641
IER3 immediate early response 3 -0.012895
KLF6 Kruppel-like factor 6 -0.0126982
RPL27A ribosomal protein L27a -0.0126525
H3-3B H3.3 histone B -0.0123409
RPS5 ribosomal protein S5 -0.0121951
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0120225
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0118189
SEC61G Sec61 gamma subunit -0.0113402
HSPB1 heat shock 27kDa protein 1 -0.0112928
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0112492