Finasteride_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.279381
TXNRD1 thioredoxin reductase 1 0.162436
LAMC2 laminin, gamma 2 0.104933
ASPH aspartate beta-hydroxylase 0.099778
TBC1D22A TBC1 domain family, member 22A 0.082281
THSD4 thrombospondin, type I, domain containing 4 0.0698703
MYH9 myosin, heavy chain 9, non-muscle 0.0675333
SOD2 superoxide dismutase 2, mitochondrial 0.065547
CES1 carboxylesterase 1 0.0643101
SMAD3 SMAD family member 3 0.0633657
LAMB3 laminin, beta 3 0.060019
ERRFI1 ERBB receptor feedback inhibitor 1 0.0553028
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0541956
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0538693
PLEC plectin 0.0533909
SLTM SAFB-like, transcription modulator 0.0533836
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0519459
PTPRM protein tyrosine phosphatase, receptor type, M 0.0510812
GRB10 growth factor receptor-bound protein 10 0.0493912
MACF1 microtubule-actin crosslinking factor 1 0.0482767
CEMIP cell migration inducing protein, hyaluronan binding 0.0468441
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0460845
GCLC glutamate-cysteine ligase, catalytic subunit 0.0457112
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0445022
AGO2 argonaute RISC catalytic component 2 0.0418741
ANXA2 annexin A2 0.0418273
NAMPT nicotinamide phosphoribosyltransferase 0.0409101
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0403106
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0400856
LDHA lactate dehydrogenase A 0.0396434
CAMTA1 calmodulin binding transcription activator 1 0.0393648
MKI67 marker of proliferation Ki-67 0.0390751
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0387665
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0386545
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0386264
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0381583
GSK3B glycogen synthase kinase 3 beta 0.0380975
ENO1 enolase 1, (alpha) 0.0369099
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0365786
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0364839
TES testin LIM domain protein 0.0364799
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0363686
ZC3H11A zinc finger CCCH-type containing 11A 0.0361323
NPAS2 neuronal PAS domain protein 2 0.0357229
RUNX1 runt-related transcription factor 1 0.0355767
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0342241
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0338194
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0335907
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0334968
FAM13A family with sequence similarity 13, member A 0.0334646
HOOK2 hook microtubule-tethering protein 2 0.033188
FNDC3B fibronectin type III domain containing 3B 0.033091
USP34 ubiquitin specific peptidase 34 0.0327613
LOC112694756 uncharaterized LOC112694756 0.0326599
LMO7 LIM domain 7 0.0325494
BZW1 basic leucine zipper and W2 domains 1 0.0323366
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0322419
APP amyloid beta (A4) precursor protein 0.0321948
NGLY1 N-glycanase 1 0.0321251
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0314318
AHNAK AHNAK nucleoprotein 0.0313165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0312929
KIAA1217 KIAA1217 0.0312763
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0312118
HDLBP high density lipoprotein binding protein 0.0311785
ATP13A3 ATPase type 13A3 0.0309796
AKAP13 A kinase (PRKA) anchor protein 13 0.0309395
FAT1 FAT atypical cadherin 1 0.030927
SPAG9 sperm associated antigen 9 0.0306644
DSPP dentin sialophosphoprotein 0.0303964
PTK2 protein tyrosine kinase 2 0.029936
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0299181
STC1 stanniocalcin 1 0.0293195
BCAR3 breast cancer anti-estrogen resistance 3 0.0292439
ARHGAP32 Rho GTPase activating protein 32 0.0290437
ARRDC3 arrestin domain containing 3 0.0276717
ANO6 anoctamin 6 0.0276433
RNF169 ring finger protein 169 0.0275945
EPAS1 endothelial PAS domain protein 1 0.0274462
ELL2 elongation factor, RNA polymerase II, 2 0.0270209
LRP1B low density lipoprotein receptor-related protein 1B 0.0268057
RAB7A RAB7A, member RAS oncogene family 0.0267833
GLS2 glutaminase 2 (liver, mitochondrial) 0.0267224
PRRC2C proline-rich coiled-coil 2C 0.0262019
FNIP1 folliculin interacting protein 1 0.0260405
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0258256
VMP1 vacuole membrane protein 1 0.0257906
TRIP12 thyroid hormone receptor interactor 12 0.0254827
UBC ubiquitin C 0.0252319
SPTBN1 spectrin, beta, non-erythrocytic 1 0.025226
UBA6 ubiquitin-like modifier activating enzyme 6 0.0251543
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0251383
EIF4B eukaryotic translation initiation factor 4B 0.024891
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248158
ZFC3H1 zinc finger, C3H1-type containing 0.0248056
GRAMD1B GRAM domain containing 1B 0.0247376
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0247251
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0247225
CDCP1 CUB domain containing protein 1 0.0245739
ANXA5 annexin A5 0.0245616

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259934
TMSB10 thymosin beta 10 -0.111871
MT2A metallothionein 2A -0.0760729
FTL ferritin, light polypeptide -0.0673767
PTMA prothymosin, alpha -0.0497802
EGR1 early growth response 1 -0.0454542
RPL35A ribosomal protein L35a -0.0439922
NDRG1 N-myc downstream regulated 1 -0.042053
RPLP1 ribosomal protein, large, P1 -0.0410122
SEC61G Sec61 gamma subunit -0.0395952
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0394797
TPT1 tumor protein, translationally-controlled 1 -0.0345442
RPS6 ribosomal protein S6 -0.0341715
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0340194
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0328412
RPL37A ribosomal protein L37a -0.0321315
RPL31 ribosomal protein L31 -0.0296355
RPS12 ribosomal protein S12 -0.0269651
RPL12 ribosomal protein L12 -0.0263816
RPS3 ribosomal protein S3 -0.0260721
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0258953
RPS27 ribosomal protein S27 -0.0241095
P4HB prolyl 4-hydroxylase, beta polypeptide -0.02396
RPS19 ribosomal protein S19 -0.0226551
WSB1 WD repeat and SOCS box containing 1 -0.0225794
RPS8 ribosomal protein S8 -0.0225766
RPS24 ribosomal protein S24 -0.0216356
RPL19 ribosomal protein L19 -0.0213305
RPS29 ribosomal protein S29 -0.0213293
CST3 cystatin C -0.0208126
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0205298
MT1X metallothionein 1X -0.0202084
RPLP0 ribosomal protein, large, P0 -0.0195237
RPS23 ribosomal protein S23 -0.0194746
RPS27A ribosomal protein S27a -0.0193897
RPL34 ribosomal protein L34 -0.0191658
RPL36 ribosomal protein L36 -0.0190774
RPS17 ribosomal protein S17 -0.0181198
RPLP2 ribosomal protein, large, P2 -0.0169869
RPL9 ribosomal protein L9 -0.0167785
UBE2B ubiquitin-conjugating enzyme E2B -0.0165254
S100A10 S100 calcium binding protein A10 -0.0162206
RPS25 ribosomal protein S25 -0.0161279
HMGA1 high mobility group AT-hook 1 -0.0160183
S100P S100 calcium binding protein P -0.0159073
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0158557
RPS14 ribosomal protein S14 -0.0157907
RPL37 ribosomal protein L37 -0.0157286
RPL11 ribosomal protein L11 -0.0156456
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0156099
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0152876
ANKRD37 ankyrin repeat domain 37 -0.0147152
RPS10 ribosomal protein S10 -0.0146767
RPS13 ribosomal protein S13 -0.0146238
RPS21 ribosomal protein S21 -0.014577
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0144122
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0143284
RPS11 ribosomal protein S11 -0.0141698
IFI6 interferon, alpha-inducible protein 6 -0.0139512
RPL8 ribosomal protein L8 -0.0138857
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0138463
RPL5 ribosomal protein L5 -0.0136677
RACK1 receptor for activated C kinase 1 -0.0136329
RPL28 ribosomal protein L28 -0.0136171
RPL23 ribosomal protein L23 -0.0133844
GNAS GNAS complex locus -0.0133373
NSUN6 NOP2/Sun domain family, member 6 -0.0129345
RPL18 ribosomal protein L18 -0.0123393
S100A11 S100 calcium binding protein A11 -0.0123349
S100A9 S100 calcium binding protein A9 -0.0120573
MYOF myoferlin -0.0119678
LOC102724023 ES1 protein homolog, mitochondrial -0.0117709
CIB1 calcium and integrin binding 1 (calmyrin) -0.0116537
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0115071
RPL30 ribosomal protein L30 -0.01144
AREG amphiregulin -0.0113526
WASF2 WAS protein family, member 2 -0.0113032
COX7C cytochrome c oxidase subunit VIIc -0.0112596
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0111016
OFD1 oral-facial-digital syndrome 1 -0.0110178
RPL27 ribosomal protein L27 -0.0109582
PKM pyruvate kinase, muscle -0.0108749
HMGN5 high mobility group nucleosome binding domain 5 -0.0107299
ASTN2 astrotactin 2 -0.0106286
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0104288
BLZF1 basic leucine zipper nuclear factor 1 -0.0104045
RPS16 ribosomal protein S16 -0.0102955
RPL36AL ribosomal protein L36a-like -0.0102943
VIM vimentin -0.0102908
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0101805
ENO2 enolase 2 (gamma, neuronal) -0.0101394
RAP2B RAP2B, member of RAS oncogene family -0.0100483
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.00998807
GUK1 guanylate kinase 1 -0.00992828
RPL32 ribosomal protein L32 -0.00992509
S100A6 S100 calcium binding protein A6 -0.009845
IER3 immediate early response 3 -0.00980317
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00973281
FOXP1 forkhead box P1 -0.00971616
C15ORF48 chromosome 15 open reading frame 48 -0.00969823