Finasteride_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.125015
ERRFI1 ERBB receptor feedback inhibitor 1 0.107324
RAD51B RAD51 paralog B 0.0720955
TRIO trio Rho guanine nucleotide exchange factor 0.0702509
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0655858
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0636403
GRAMD1B GRAM domain containing 1B 0.0616871
EEF2 eukaryotic translation elongation factor 2 0.0579648
TPM3 tropomyosin 3 0.0538506
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0500012
THSD4 thrombospondin, type I, domain containing 4 0.0481278
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0476475
MACF1 microtubule-actin crosslinking factor 1 0.0469518
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0458042
MYH9 myosin, heavy chain 9, non-muscle 0.0435715
TXNRD1 thioredoxin reductase 1 0.0389762
ZCCHC7 zinc finger, CCHC domain containing 7 0.0364057
ANKRD36 ankyrin repeat domain 36 0.0362184
EIF4B eukaryotic translation initiation factor 4B 0.0355153
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0345952
ANO6 anoctamin 6 0.0331148
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0324455
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0322399
ZFAND3 zinc finger, AN1-type domain 3 0.0317711
ZNF638 zinc finger protein 638 0.0315429
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0313704
EXOC4 exocyst complex component 4 0.0312815
ATP11A ATPase, class VI, type 11A 0.0311376
FAF1 Fas (TNFRSF6) associated factor 1 0.0307994
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0306599
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0306061
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0297903
PTK2 protein tyrosine kinase 2 0.0295401
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0286834
RPS18 ribosomal protein S18 0.0278032
DOCK5 dedicator of cytokinesis 5 0.0276929
HSPA8 heat shock 70kDa protein 8 0.0272747
SMAD3 SMAD family member 3 0.0270928
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0270739
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269292
KDM2A lysine (K)-specific demethylase 2A 0.0268806
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0268034
SAMD4A sterile alpha motif domain containing 4A 0.0265304
CAMTA1 calmodulin binding transcription activator 1 0.0264676
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0264369
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0261763
MARCHF4 membrane associated ring-CH-type finger 4 0.0261483
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0260857
KRT18 keratin 18, type I 0.0255843
DENND1A DENN/MADD domain containing 1A 0.0253281
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0251152
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0250459
SFPQ splicing factor proline/glutamine-rich 0.0246956
PNN pinin, desmosome associated protein 0.0246689
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0246196
SET SET nuclear proto-oncogene 0.024215
SMYD3 SET and MYND domain containing 3 0.0240567
FXR1 fragile X mental retardation, autosomal homolog 1 0.0239397
BBX bobby sox homolog (Drosophila) 0.0238864
PRPF8 pre-mRNA processing factor 8 0.0238764
CEP192 centrosomal protein 192kDa 0.0238736
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0233834
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0233595
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0233431
DCAF8 DDB1 and CUL4 associated factor 8 0.0233354
SRRM2 serine/arginine repetitive matrix 2 0.0228083
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0227364
PLEC plectin 0.0220872
CEP250 centrosomal protein 250kDa 0.0220133
GIGYF2 GRB10 interacting GYF protein 2 0.0218553
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0218467
PDIA6 protein disulfide isomerase family A, member 6 0.0216931
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0216307
ADAR adenosine deaminase, RNA-specific 0.021485
RPL3 ribosomal protein L3 0.0214242
FMNL2 formin-like 2 0.0213845
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0213561
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0213349
USP9X ubiquitin specific peptidase 9, X-linked 0.0212643
OGA O-GlcNAcase 0.0212536
WDR43 WD repeat domain 43 0.0212116
ANKRD11 ankyrin repeat domain 11 0.0209764
TLN1 talin 1 0.0208721
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.020762
CKAP5 cytoskeleton associated protein 5 0.0206911
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0206758
JMJD1C jumonji domain containing 1C 0.0206081
BIRC6 baculoviral IAP repeat containing 6 0.0205309
CTTN cortactin 0.0204933
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0204735
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0200952
COPA coatomer protein complex, subunit alpha 0.0200641
VMP1 vacuole membrane protein 1 0.0199929
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0199767
SND1 staphylococcal nuclease and tudor domain containing 1 0.0199566
MKI67 marker of proliferation Ki-67 0.0197722
YAP1 Yes-associated protein 1 0.0194609
RHOA ras homolog family member A 0.0193913
RBM33 RNA binding motif protein 33 0.0192686
SHB Src homology 2 domain containing adaptor protein B 0.0192245

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.285801
TMSB10 thymosin beta 10 -0.133468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0798326
VIM vimentin -0.0755482
PTMA prothymosin, alpha -0.0740552
EGR1 early growth response 1 -0.0535757
RPS8 ribosomal protein S8 -0.0504768
RPLP1 ribosomal protein, large, P1 -0.0503206
RPL35A ribosomal protein L35a -0.0472666
TPT1 tumor protein, translationally-controlled 1 -0.0455346
FTL ferritin, light polypeptide -0.0447527
RPS19 ribosomal protein S19 -0.0438239
MT2A metallothionein 2A -0.0415477
RPL23 ribosomal protein L23 -0.0414098
RPL12 ribosomal protein L12 -0.0398652
RPL34 ribosomal protein L34 -0.039635
PFN1 profilin 1 -0.0392698
TFPI2 tissue factor pathway inhibitor 2 -0.0392472
RPS21 ribosomal protein S21 -0.0390736
GNAS GNAS complex locus -0.0375286
RPS29 ribosomal protein S29 -0.0374368
RPL19 ribosomal protein L19 -0.0372442
RPS27 ribosomal protein S27 -0.0372282
YBX3 Y box binding protein 3 -0.0341219
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0335986
MYL12B myosin, light chain 12B, regulatory -0.0335269
ACTG1 actin gamma 1 -0.0334018
RPL8 ribosomal protein L8 -0.0332788
RPLP0 ribosomal protein, large, P0 -0.0328797
RPS15 ribosomal protein S15 -0.0311961
WSB1 WD repeat and SOCS box containing 1 -0.0310412
RPL37 ribosomal protein L37 -0.0303137
RPL32 ribosomal protein L32 -0.0300536
RPL31 ribosomal protein L31 -0.0297063
HLA-B major histocompatibility complex, class I, B -0.0295904
RPLP2 ribosomal protein, large, P2 -0.027392
RPL36 ribosomal protein L36 -0.0273661
S100A6 S100 calcium binding protein A6 -0.0271983
RPL38 ribosomal protein L38 -0.0263257
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0262037
TUBA1B tubulin, alpha 1b -0.0255949
S100A10 S100 calcium binding protein A10 -0.0246958
RPL5 ribosomal protein L5 -0.0245956
IFI6 interferon, alpha-inducible protein 6 -0.0245602
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0244615
MT1X metallothionein 1X -0.0241703
RPS25 ribosomal protein S25 -0.0237527
TPI1 triosephosphate isomerase 1 -0.0236094
RPS6 ribosomal protein S6 -0.0233055
RPS14 ribosomal protein S14 -0.0230209
RPS13 ribosomal protein S13 -0.0221549
RPS24 ribosomal protein S24 -0.0218198
RPS4X ribosomal protein S4, X-linked -0.0214007
RPL37A ribosomal protein L37a -0.0209909
HMGA1 high mobility group AT-hook 1 -0.0207942
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0206448
RPS10 ribosomal protein S10 -0.0201482
RPS27A ribosomal protein S27a -0.0197797
RPL27 ribosomal protein L27 -0.0197132
LOC102724023 ES1 protein homolog, mitochondrial -0.0194304
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.019425
RPL9 ribosomal protein L9 -0.0192018
RPL36A ribosomal protein L36a -0.0189215
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0188996
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.018898
GSTP1 glutathione S-transferase pi 1 -0.0180648
RPS16 ribosomal protein S16 -0.0179637
VDAC1 voltage-dependent anion channel 1 -0.0170682
RPS3 ribosomal protein S3 -0.0164327
RPL18 ribosomal protein L18 -0.0164016
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0162595
MARCKS myristoylated alanine-rich protein kinase C substrate -0.016079
TPM2 tropomyosin 2 (beta) -0.0157444
IER3 immediate early response 3 -0.0155263
LDHB lactate dehydrogenase B -0.0154737
OSMR oncostatin M receptor -0.0154371
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0152869
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0152183
SEC61G Sec61 gamma subunit -0.0151804
S100A9 S100 calcium binding protein A9 -0.0149018
RPS23 ribosomal protein S23 -0.0148951
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0147514
IGF2 insulin-like growth factor 2 -0.0146753
ATP5F1E ATP synthase F1 subunit epsilon -0.014575
RPL35 ribosomal protein L35 -0.0144197
RPL27A ribosomal protein L27a -0.0143926
POTEF POTE ankyrin domain family, member F -0.0143592
H1-0 H1.0 linker histone -0.0142183
S100A11 S100 calcium binding protein A11 -0.0142179
EML4 echinoderm microtubule associated protein like 4 -0.013968
RPS11 ribosomal protein S11 -0.0139489
TM4SF1 transmembrane 4 L six family member 1 -0.0139204
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0137786
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0136622
AHCYL1 adenosylhomocysteinase-like 1 -0.0134975
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0133233
ASTN2 astrotactin 2 -0.0132619
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0132503
WASF2 WAS protein family, member 2 -0.0131828
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0131034