Finasteride_NCI-H596 Gene Set
Genes
54 genes differentially expressed following the Finasteride_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
NDRG1
|
N-myc downstream regulated 1
|
0.240429
|
|
EGFR
|
epidermal growth factor receptor
|
0.207533
|
|
GBE1
|
glucan (1,4-alpha-), branching enzyme 1
|
0.167332
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
0.140747
|
|
JMJD1C
|
jumonji domain containing 1C
|
0.137914
|
|
ITGB1
|
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
|
0.123751
|
|
HERC4
|
HECT and RLD domain containing E3 ubiquitin protein ligase 4
|
0.118239
|
|
SAMD4A
|
sterile alpha motif domain containing 4A
|
0.118199
|
|
RCOR1
|
REST corepressor 1
|
0.108105
|
|
FN1
|
fibronectin 1
|
0.107191
|
|
PDE4D
|
phosphodiesterase 4D, cAMP-specific
|
0.0909159
|
|
PMEPA1
|
prostate transmembrane protein, androgen induced 1
|
0.083034
|
|
SBF2
|
SET binding factor 2
|
0.0665917
|
|
TRIO
|
trio Rho guanine nucleotide exchange factor
|
0.0633179
|
|
VIM
|
vimentin
|
0.060074
|
|
MKLN1
|
muskelin 1, intracellular mediator containing kelch motifs
|
0.0568415
|
|
NPAS2
|
neuronal PAS domain protein 2
|
0.0561536
|
|
PALM2AKAP2
|
PALM2 and AKAP2 fusion
|
0.0457105
|
|
HSP90B1
|
heat shock protein 90kDa beta (Grp94), member 1
|
0.0408384
|
|
INPP4B
|
inositol polyphosphate-4-phosphatase, type II, 105kDa
|
0.0349288
|
|
DSCAM
|
Down syndrome cell adhesion molecule
|
0.0322503
|
|
ZFAND3
|
zinc finger, AN1-type domain 3
|
0.0249361
|
|
KMT2C
|
lysine (K)-specific methyltransferase 2C
|
0.0248772
|
|
IMMP2L
|
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
|
0.0217924
|
|
PTK2
|
protein tyrosine kinase 2
|
0.0011234
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.220599
|
|
PDE10A
|
phosphodiesterase 10A
|
-0.174702
|
|
DST
|
dystonin
|
-0.172349
|
|
UBC
|
ubiquitin C
|
-0.16107
|
|
PTMA
|
prothymosin, alpha
|
-0.137511
|
|
CD55
|
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
|
-0.131005
|
|
RPL23
|
ribosomal protein L23
|
-0.119428
|
|
LDHA
|
lactate dehydrogenase A
|
-0.117692
|
|
ACTN4
|
actinin, alpha 4
|
-0.106699
|
|
ZNF292
|
zinc finger protein 292
|
-0.100569
|
|
SMYD3
|
SET and MYND domain containing 3
|
-0.0911218
|
|
PARD3
|
par-3 family cell polarity regulator
|
-0.0886938
|
|
ANXA2
|
annexin A2
|
-0.0835248
|
|
SLC2A3
|
solute carrier family 2 (facilitated glucose transporter), member 3
|
-0.0723719
|
|
RPS3
|
ribosomal protein S3
|
-0.0715702
|
|
NUP58
|
nucleoporin 58
|
-0.0657391
|
|
ASPH
|
aspartate beta-hydroxylase
|
-0.0522515
|
|
ZBTB20
|
zinc finger and BTB domain containing 20
|
-0.0513325
|
|
SEMA3A
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
|
-0.0440067
|
|
HSP90AA1
|
heat shock protein 90kDa alpha (cytosolic), class A member 1
|
-0.0410787
|
|
IGFBP5
|
insulin-like growth factor binding protein 5
|
-0.0391988
|
|
AGAP1
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
|
-0.0378921
|
|
EFNA5
|
ephrin-A5
|
-0.0366925
|
|
ITCH
|
itchy E3 ubiquitin protein ligase
|
-0.0361034
|
|
EXT1
|
exostosin glycosyltransferase 1
|
-0.0339466
|
|
GPC6
|
glypican 6
|
-0.0324246
|
|
RTN4
|
reticulon 4
|
-0.0258269
|
|
PGK1
|
phosphoglycerate kinase 1
|
-0.0188219
|
|
ERO1A
|
endoplasmic reticulum oxidoreductase 1 alpha
|
-0.00987543
|
