Finasteride_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Finasteride_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.159922
COL11A1 collagen, type XI, alpha 1 0.128517
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0978547
KDM3A lysine (K)-specific demethylase 3A 0.0881338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0850521
TMSB4X thymosin beta 4, X-linked 0.0835162
THBS1 thrombospondin 1 0.0807434
HDAC9 histone deacetylase 9 0.0782313
NTM neurotrimin 0.0777936
SRRM2 serine/arginine repetitive matrix 2 0.0657651
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0653424
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0643267
FNDC3B fibronectin type III domain containing 3B 0.0628507
ZFAND3 zinc finger, AN1-type domain 3 0.0588551
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0583198
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0568583
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0564661
EEF2 eukaryotic translation elongation factor 2 0.0556653
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0534099
MACF1 microtubule-actin crosslinking factor 1 0.0532027
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0529385
CALR calreticulin 0.0520071
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0513203
ANXA1 annexin A1 0.0509432
ZNF292 zinc finger protein 292 0.0499539
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0484482
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0481047
ADAM9 ADAM metallopeptidase domain 9 0.0479407
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0478854
ITGAV integrin, alpha V 0.0470611
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0453671
TPM3 tropomyosin 3 0.045183
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0449727
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0445059
KMT2E lysine (K)-specific methyltransferase 2E 0.0434655
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0431755
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0425217
CCN2 cellular communication network factor 2 0.0419354
AKAP9 A kinase (PRKA) anchor protein 9 0.0419056
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0418274
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0411107
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0410479
MYH9 myosin, heavy chain 9, non-muscle 0.0410063
ANKRD33B ankyrin repeat domain 33B 0.0405652
EIF4B eukaryotic translation initiation factor 4B 0.0404471
CSDE1 cold shock domain containing E1, RNA-binding 0.0397802
NCKAP1 NCK-associated protein 1 0.0390221
PDIA6 protein disulfide isomerase family A, member 6 0.0387021
WDR43 WD repeat domain 43 0.0386114
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0381716
USP9X ubiquitin specific peptidase 9, X-linked 0.0374992
TSC22D2 TSC22 domain family, member 2 0.037471
PRPF8 pre-mRNA processing factor 8 0.0371892
NCOR1 nuclear receptor corepressor 1 0.0371806
CANX calnexin 0.0367738
RPS2 ribosomal protein S2 0.0364054
USP15 ubiquitin specific peptidase 15 0.0360991
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.036073
SFRP4 secreted frizzled-related protein 4 0.0357911
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0356096
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0354172
MEF2A myocyte enhancer factor 2A 0.0349814
CECR2 cat eye syndrome chromosome region, candidate 2 0.0349791
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0347551
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0347503
H1-4 H1.4 linker histone, cluster member 0.0346034
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0345983
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0343377
AKAP12 A kinase (PRKA) anchor protein 12 0.0341575
QKI QKI, KH domain containing, RNA binding 0.0339885
PARD3B par-3 family cell polarity regulator beta 0.0339534
PGAP1 post-GPI attachment to proteins 1 0.0334726
B2M beta-2-microglobulin 0.033209
PICALM phosphatidylinositol binding clathrin assembly protein 0.0331674
ZNF217 zinc finger protein 217 0.0328998
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0326489
UPP1 uridine phosphorylase 1 0.0322892
RPS18 ribosomal protein S18 0.032127
KMT2C lysine (K)-specific methyltransferase 2C 0.0320593
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0319474
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0317275
OSBPL9 oxysterol binding protein-like 9 0.0313501
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0313121
RPL11 ribosomal protein L11 0.031274
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0311533
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0310682
FNBP1L formin binding protein 1-like 0.0310004
PDS5B PDS5 cohesin associated factor B 0.0308121
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0305849
YAP1 Yes-associated protein 1 0.0302597
BCLAF1 BCL2-associated transcription factor 1 0.030222
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0300911
PNN pinin, desmosome associated protein 0.0300377
TPR translocated promoter region, nuclear basket protein 0.029922
NAMPT nicotinamide phosphoribosyltransferase 0.029807
NFE2L1 nuclear factor, erythroid 2-like 1 0.0294955
SAMD4A sterile alpha motif domain containing 4A 0.0294817
PHF3 PHD finger protein 3 0.0293907
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0288949
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0286133

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.185588
TOP2A topoisomerase (DNA) II alpha 170kDa -0.086893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0763582
FOXP2 forkhead box P2 -0.0731245
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0728742
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0714798
TMSB10 thymosin beta 10 -0.0680624
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0659455
CADM2 cell adhesion molecule 2 -0.0641053
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0591745
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0579831
PFN1 profilin 1 -0.0558766
GPC3 glypican 3 -0.0510285
MEIS2 Meis homeobox 2 -0.0507155
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0506941
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.048879
ACTG1 actin gamma 1 -0.0461333
RPS6 ribosomal protein S6 -0.0461074
BPTF bromodomain PHD finger transcription factor -0.0453404
RAB31 RAB31, member RAS oncogene family -0.0445597
FTL ferritin, light polypeptide -0.043994
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0432682
TENM3 teneurin transmembrane protein 3 -0.0420386
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0406186
CENPE centromere protein E, 312kDa -0.0389427
ADNP activity-dependent neuroprotector homeobox -0.0383717
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.038069
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0377312
RPS16 ribosomal protein S16 -0.0366002
RPLP0 ribosomal protein, large, P0 -0.0363506
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0356826
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0355625
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0346401
RPLP1 ribosomal protein, large, P1 -0.0342108
RPS27A ribosomal protein S27a -0.0336731
ACTN4 actinin, alpha 4 -0.0329088
NUSAP1 nucleolar and spindle associated protein 1 -0.0321394
FN1 fibronectin 1 -0.0316981
FBXO17 F-box protein 17 -0.0315538
ZNF385D zinc finger protein 385D -0.0313356
HMGB1 high mobility group box 1 -0.0310715
PCDH7 protocadherin 7 -0.0308063
PBX3 pre-B-cell leukemia homeobox 3 -0.030589
VCL vinculin -0.0305824
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.030296
CAVIN1 caveolae associated protein 1 -0.0301029
OGA O-GlcNAcase -0.0300593
TPX2 TPX2, microtubule-associated -0.029828
RHOBTB3 Rho-related BTB domain containing 3 -0.0297453
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291828
CKAP2 cytoskeleton associated protein 2 -0.0289964
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0288064
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0286661
TUBA1B tubulin, alpha 1b -0.0285976
PEG10 paternally expressed 10 -0.0283981
SOX5 SRY (sex determining region Y)-box 5 -0.0283871
RBBP4 retinoblastoma binding protein 4 -0.0283174
WDR45B WD repeat domain 45B -0.0278533
MAP1B microtubule-associated protein 1B -0.0274613
RPL30 ribosomal protein L30 -0.0269058
ARHGAP24 Rho GTPase activating protein 24 -0.0268488
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0268106
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0265922
RPL35A ribosomal protein L35a -0.0263686
LOC102724023 ES1 protein homolog, mitochondrial -0.0263277
SGO2 shugoshin 2 -0.0262196
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0261379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0260626
RPL23 ribosomal protein L23 -0.0260025
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0258264
RAB7A RAB7A, member RAS oncogene family -0.0257753
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.025686
ZBTB20 zinc finger and BTB domain containing 20 -0.0256426
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0255974
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0254576
GNAS GNAS complex locus -0.0254336
AK1 adenylate kinase 1 -0.0254276
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0252732
N4BP2L2 NEDD4 binding protein 2-like 2 -0.025217
SEPTIN7 septin 7 -0.0251509
HMGA1 high mobility group AT-hook 1 -0.0250836
URI1 URI1, prefoldin-like chaperone -0.0249938
RTN4 reticulon 4 -0.024709
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0246565
SNX6 sorting nexin 6 -0.0241667
WSB1 WD repeat and SOCS box containing 1 -0.0241395
SIK2 salt-inducible kinase 2 -0.0240917
RAB2A RAB2A, member RAS oncogene family -0.0240603
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0239444
SPTSSA serine palmitoyltransferase, small subunit A -0.0233346
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.023315
DEK DEK proto-oncogene -0.0231155
ARHGAP15 Rho GTPase activating protein 15 -0.0230343
CEP350 centrosomal protein 350kDa -0.0230337
LRMDA leucine rich melanocyte differentiation associated -0.0227126
ENO1 enolase 1, (alpha) -0.022678
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0223987
MT2A metallothionein 2A -0.0223832
SOX2 SRY (sex determining region Y)-box 2 -0.02235
CCNI cyclin I -0.0222869