Finasteride_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Finasteride perturbation in SW 1088 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Finasteride_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.203011
MYH9 myosin, heavy chain 9, non-muscle 0.112371
ERRFI1 ERBB receptor feedback inhibitor 1 0.0853626
AKAP9 A kinase (PRKA) anchor protein 9 0.082181
VEGFA vascular endothelial growth factor A 0.082007
TMSB10 thymosin beta 10 0.0817474
DSCAM Down syndrome cell adhesion molecule 0.0784693
RPL23 ribosomal protein L23 0.0774961
VIM vimentin 0.0751595
COL5A1 collagen, type V, alpha 1 0.0749107
FAM13A family with sequence similarity 13, member A 0.0727362
PDE4D phosphodiesterase 4D, cAMP-specific 0.0700084
EGFR epidermal growth factor receptor 0.0644888
COL7A1 collagen, type VII, alpha 1 0.0637284
RPS3 ribosomal protein S3 0.0614808
TRIO trio Rho guanine nucleotide exchange factor 0.0601706
SBF2 SET binding factor 2 0.0601298
COPA coatomer protein complex, subunit alpha 0.0598461
COL6A3 collagen, type VI, alpha 3 0.0594322
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0593442
MACF1 microtubule-actin crosslinking factor 1 0.0587875
ANXA2 annexin A2 0.0586836
UBA6 ubiquitin-like modifier activating enzyme 6 0.0582943
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0575473
RPL37A ribosomal protein L37a 0.0574406
EIF1 eukaryotic translation initiation factor 1 0.0550022
LOXL2 lysyl oxidase-like 2 0.0517121
ZMYND8 zinc finger, MYND-type containing 8 0.0510602
C1D C1D nuclear receptor corepressor 0.050719
PRKCSH protein kinase C substrate 80K-H 0.0493558
PDIA6 protein disulfide isomerase family A, member 6 0.0488581
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0488342
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0484256
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0481356
RPS12 ribosomal protein S12 0.047869
NAMPT nicotinamide phosphoribosyltransferase 0.0444293
SQSTM1 sequestosome 1 0.0443467
EEF2 eukaryotic translation elongation factor 2 0.0438171
RUNX1 runt-related transcription factor 1 0.0431386
RPS14 ribosomal protein S14 0.0425143
FLOT1 flotillin 1 0.0422335
NLGN1 neuroligin 1 0.0419366
TM4SF1 transmembrane 4 L six family member 1 0.0419104
PCBP2 poly(rC) binding protein 2 0.040268
PGK1 phosphoglycerate kinase 1 0.0401286
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0387912
PHIP pleckstrin homology domain interacting protein 0.0380009
CANX calnexin 0.0378869
ACTN1 actinin, alpha 1 0.0377916
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0376598
FSCN1 fascin actin-bundling protein 1 0.0374816
RAD23B RAD23 homolog B (S. cerevisiae) 0.0373996
RPL5 ribosomal protein L5 0.0368111
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0366788
CALR calreticulin 0.0360732
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0358235
WDFY2 WD repeat and FYVE domain containing 2 0.0350938
YBX1 Y box binding protein 1 0.0350903
NAV1 neuron navigator 1 0.0350872
SRRM2 serine/arginine repetitive matrix 2 0.0348453
FNDC3B fibronectin type III domain containing 3B 0.034787
SERTAD2 SERTA domain containing 2 0.0347588
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0345872
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0343054
MLEC malectin 0.0340631
RPL28 ribosomal protein L28 0.0337212
ADGRB3 adhesion G protein-coupled receptor B3 0.033443
SEPTIN2 septin 2 0.0333423
GPC6 glypican 6 0.0332141
ANO6 anoctamin 6 0.0331559
RRBP1 ribosome binding protein 1 0.033095
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0330202
PARP4 poly (ADP-ribose) polymerase family, member 4 0.03292
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0328839
IFI16 interferon, gamma-inducible protein 16 0.0326691
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0322768
TNIP1 TNFAIP3 interacting protein 1 0.0322641
MBNL2 muscleblind-like splicing regulator 2 0.0318646
SENP6 SUMO1/sentrin specific peptidase 6 0.031675
PDE8A phosphodiesterase 8A 0.0316211
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0315775
RPS17 ribosomal protein S17 0.0312905
RAB7A RAB7A, member RAS oncogene family 0.0312711
MATR3 matrin 3 0.0311772
TENT5A terminal nucleotidyltransferase 5A 0.0311758
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0311168
ADAR adenosine deaminase, RNA-specific 0.0310823
NEK7 NIMA-related kinase 7 0.031071
ARRDC3 arrestin domain containing 3 0.0307716
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0302933
NUCB2 nucleobindin 2 0.0301992
FNBP4 formin binding protein 4 0.0299757
SAMD4A sterile alpha motif domain containing 4A 0.0299328
RBM5 RNA binding motif protein 5 0.0297952
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0297425
NCOA3 nuclear receptor coactivator 3 0.0291854
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0290856
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0289124
FNDC3A fibronectin type III domain containing 3A 0.028575
TPR translocated promoter region, nuclear basket protein 0.0285711

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.198284
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.156781
HLA-B major histocompatibility complex, class I, B -0.136007
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0953692
ANLN anillin, actin binding protein -0.0896097
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0883286
IGFBP7 insulin-like growth factor binding protein 7 -0.086648
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0793627
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0736419
ACTG1 actin gamma 1 -0.0675794
GLIS3 GLIS family zinc finger 3 -0.0653144
SMYD3 SET and MYND domain containing 3 -0.0633021
CDK6 cyclin-dependent kinase 6 -0.0623555
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0592737
EXT1 exostosin glycosyltransferase 1 -0.0582414
MT1X metallothionein 1X -0.0570653
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0550679
CALD1 caldesmon 1 -0.0541743
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0534407
FN1 fibronectin 1 -0.0532463
COL6A1 collagen, type VI, alpha 1 -0.0525239
H3-3B H3.3 histone B -0.0516956
PDIA4 protein disulfide isomerase family A, member 4 -0.0504413
SEPTIN7 septin 7 -0.0501993
AFF4 AF4/FMR2 family, member 4 -0.0495307
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0489832
SDC4 syndecan 4 -0.0487834
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0476859
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0474032
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.047184
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0468372
PTGES2 prostaglandin E synthase 2 -0.0464978
RAD51B RAD51 paralog B -0.0445682
SDK1 sidekick cell adhesion molecule 1 -0.0442956
SFXN1 sideroflexin 1 -0.0436391
IGFBP3 insulin-like growth factor binding protein 3 -0.0436153
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0433754
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0431208
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0428552
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.042763
TGFBI transforming growth factor, beta-induced, 68kDa -0.0423215
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0421243
HOOK2 hook microtubule-tethering protein 2 -0.0418534
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.041565
FUS FUS RNA binding protein -0.0411722
CALU calumenin -0.0409677
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.040724
COL4A1 collagen, type IV, alpha 1 -0.0406347
COL3A1 collagen, type III, alpha 1 -0.0405765
JAZF1 JAZF zinc finger 1 -0.0404301
LOX lysyl oxidase -0.0402986
TMEM131 transmembrane protein 131 -0.0402329
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0400965
GLG1 golgi glycoprotein 1 -0.0399048
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0394919
IARS1 isoleucyl-tRNA synthetase 1 -0.0390336
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0388922
LCORL ligand dependent nuclear receptor corepressor-like -0.038722
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0383675
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0380708
IL6ST interleukin 6 signal transducer -0.037822
TENT4A terminal nucleotidyltransferase 4A -0.0378189
FER fer (fps/fes related) tyrosine kinase -0.0374368
MAPK8 mitogen-activated protein kinase 8 -0.037025
CCNI cyclin I -0.0368818
SEC24D SEC24 family member D -0.0366554
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0363405
PDIA3 protein disulfide isomerase family A, member 3 -0.0362421
SETD5 SET domain containing 5 -0.0361345
WDR45B WD repeat domain 45B -0.0359669
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0357273
HIP1 huntingtin interacting protein 1 -0.0355463
MARCHF7 membrane associated ring-CH-type finger 7 -0.035509
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0353051
SCLT1 sodium channel and clathrin linker 1 -0.0351682
CKAP2 cytoskeleton associated protein 2 -0.0351125
PAIP2 poly(A) binding protein interacting protein 2 -0.0350812
KMT2E lysine (K)-specific methyltransferase 2E -0.0347238
ANAPC10 anaphase promoting complex subunit 10 -0.0347024
HPCAL1 hippocalcin-like 1 -0.0346889
ANKRD28 ankyrin repeat domain 28 -0.0344674
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0343694
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0341367
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0339965
RPL11 ribosomal protein L11 -0.0339781
SUB1 SUB1 homolog (S. cerevisiae) -0.033543
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0334743
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0331101
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0327872
MYO9B myosin IXB -0.0326347
PDS5B PDS5 cohesin associated factor B -0.0325536
SERINC3 serine incorporator 3 -0.0325357
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0324977
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314985
RDX radixin -0.0314966
RNF130 ring finger protein 130 -0.0314257
RASAL2 RAS protein activator like 2 -0.0313464
MRTFA myocardin related transcription factor A -0.0313084
TGFB1 transforming growth factor, beta 1 -0.0311611
AKAP12 A kinase (PRKA) anchor protein 12 -0.031136