Fingolimod (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.124569
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.112918
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.102616
FBN1 fibrillin 1 0.0917158
TRIO trio Rho guanine nucleotide exchange factor 0.0898031
LOXL2 lysyl oxidase-like 2 0.0804309
LOX lysyl oxidase 0.0804005
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0681472
COL8A1 collagen, type VIII, alpha 1 0.0599624
FNDC3B fibronectin type III domain containing 3B 0.0559226
DLG1 discs, large homolog 1 (Drosophila) 0.0543646
IQGAP1 IQ motif containing GTPase activating protein 1 0.0540712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0539446
OGA O-GlcNAcase 0.0500255
MYOF myoferlin 0.0488507
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0473211
COL5A2 collagen, type V, alpha 2 0.0472307
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0472288
ELL2 elongation factor, RNA polymerase II, 2 0.0471018
COL3A1 collagen, type III, alpha 1 0.0464702
FLNB filamin B, beta 0.0462026
TNIP1 TNFAIP3 interacting protein 1 0.0455548
APP amyloid beta (A4) precursor protein 0.0450016
DST dystonin 0.0447853
UBC ubiquitin C 0.0435101
AHNAK AHNAK nucleoprotein 0.0406967
ANXA2 annexin A2 0.0402851
SBF2 SET binding factor 2 0.0402412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0390351
RUNX1 runt-related transcription factor 1 0.0387087
AUTS2 autism susceptibility candidate 2 0.0385074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0377833
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0368627
ERRFI1 ERBB receptor feedback inhibitor 1 0.0365376
GPC6 glypican 6 0.036422
SOD2 superoxide dismutase 2, mitochondrial 0.0356455
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0351055
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.034826
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0341855
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0333259
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0333101
KDM3A lysine (K)-specific demethylase 3A 0.0324077
MYH9 myosin, heavy chain 9, non-muscle 0.0315173
MAP4 microtubule-associated protein 4 0.030858
THBS2 thrombospondin 2 0.0297222
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0297035
CANX calnexin 0.0296436
LDHA lactate dehydrogenase A 0.0290525
COL1A2 collagen, type I, alpha 2 0.0288203
MB21D2 Mab-21 domain containing 2 0.0287806
NAP1L1 nucleosome assembly protein 1-like 1 0.0285259
CD44 CD44 molecule (Indian blood group) 0.0283277
ZEB1 zinc finger E-box binding homeobox 1 0.0281661
XPO1 exportin 1 0.0281216
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278599
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0277916
SPAG9 sperm associated antigen 9 0.027347
ATP13A3 ATPase type 13A3 0.0273125
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0272931
MXI1 MAX interactor 1, dimerization protein 0.0272218
DPYSL3 dihydropyrimidinase-like 3 0.0271173
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.026762
OPTN optineurin 0.0267317
MBNL2 muscleblind-like splicing regulator 2 0.026615
PICALM phosphatidylinositol binding clathrin assembly protein 0.0263313
SQSTM1 sequestosome 1 0.0259087
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0257503
STC1 stanniocalcin 1 0.025451
SEPTIN9 septin 9 0.0254244
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252882
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0246221
HELZ helicase with zinc finger 0.0241516
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0241186
YEATS2 YEATS domain containing 2 0.0240882
PSD3 pleckstrin and Sec7 domain containing 3 0.0239937
RAI14 retinoic acid induced 14 0.0239906
SFTPA2 surfactant protein A2 0.0238912
PGK1 phosphoglycerate kinase 1 0.0238777
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0237753
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0235748
ADM adrenomedullin 0.0230195
ESYT2 extended synaptotagmin-like protein 2 0.0229631
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0228516
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0224961
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0224211
GOLGA4 golgin A4 0.0220215
DCAF6 DDB1 and CUL4 associated factor 6 0.0219175
SLC22A23 solute carrier family 22, member 23 0.0218652
ARRDC3 arrestin domain containing 3 0.0216278
AFF4 AF4/FMR2 family, member 4 0.0215271
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0214954
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0210962
PLAT plasminogen activator, tissue 0.0209001
CYLD cylindromatosis (turban tumor syndrome) 0.0208807
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.020811
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0207957
SOX9 SRY (sex determining region Y)-box 9 0.0203274
HIP1 huntingtin interacting protein 1 0.0202878
LAMB1 laminin, beta 1 0.0201958
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0201898

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.116989
TMSB10 thymosin beta 10 -0.0834384
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0632264
SUCNR1 succinate receptor 1 -0.0400409
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0325422
CDH13 cadherin 13 -0.0311319
RPL35A ribosomal protein L35a -0.0291288
S100A10 S100 calcium binding protein A10 -0.0285711
RPL37A ribosomal protein L37a -0.0259853
TPT1 tumor protein, translationally-controlled 1 -0.0251118
LMNA lamin A/C -0.0239258
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0231405
RPS8 ribosomal protein S8 -0.022482
ACTG1 actin gamma 1 -0.0219752
S100A6 S100 calcium binding protein A6 -0.0218744
FTL ferritin, light polypeptide -0.0206462
CSTB cystatin B (stefin B) -0.0200878
IFITM3 interferon induced transmembrane protein 3 -0.0190875
RPLP2 ribosomal protein, large, P2 -0.018944
RPLP1 ribosomal protein, large, P1 -0.0188473
RPL23 ribosomal protein L23 -0.0188036
MT2A metallothionein 2A -0.0167111
RPL28 ribosomal protein L28 -0.0166827
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0166018
PFN1 profilin 1 -0.016208
RPL31 ribosomal protein L31 -0.0161515
ISG15 ISG15 ubiquitin-like modifier -0.0159246
TIMP2 TIMP metallopeptidase inhibitor 2 -0.015414
ABI3BP ABI family, member 3 (NESH) binding protein -0.0151329
S100A11 S100 calcium binding protein A11 -0.0149985
RPS19 ribosomal protein S19 -0.0146281
SEC61G Sec61 gamma subunit -0.014296
RPL9 ribosomal protein L9 -0.0141351
RPS23 ribosomal protein S23 -0.0139212
RPS27 ribosomal protein S27 -0.0138585
POTEF POTE ankyrin domain family, member F -0.0136378
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0136102
RPS27A ribosomal protein S27a -0.0135235
IFI6 interferon, alpha-inducible protein 6 -0.0134119
INTS6 integrator complex subunit 6 -0.0133706
PTMA prothymosin, alpha -0.0133581
RPS13 ribosomal protein S13 -0.0133094
SLC39A11 solute carrier family 39, member 11 -0.0130762
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.012985
PEA15 phosphoprotein enriched in astrocytes 15 -0.0129533
HLA-B major histocompatibility complex, class I, B -0.0127691
SLC38A2 solute carrier family 38, member 2 -0.0126567
PBX3 pre-B-cell leukemia homeobox 3 -0.0126496
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0125027
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0124845
FN1 fibronectin 1 -0.0123431
RPL37 ribosomal protein L37 -0.0122491
RPS17 ribosomal protein S17 -0.0119504
TBCA tubulin folding cofactor A -0.0118649
RPS24 ribosomal protein S24 -0.0118559
RPS12 ribosomal protein S12 -0.011791
SORBS2 sorbin and SH3 domain containing 2 -0.0116913
RACK1 receptor for activated C kinase 1 -0.0115564
KRT81 keratin 81, type II -0.0114324
RPL36 ribosomal protein L36 -0.0113901
RPL26 ribosomal protein L26 -0.011357
RPL19 ribosomal protein L19 -0.0112781
PLXNA2 plexin A2 -0.0111029
FLT1 fms-related tyrosine kinase 1 -0.0109288
RPS11 ribosomal protein S11 -0.010926
RPS15 ribosomal protein S15 -0.0108335
HLA-C major histocompatibility complex, class I, C -0.0107966
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0107177
RPS21 ribosomal protein S21 -0.0106998
CYB5R3 cytochrome b5 reductase 3 -0.0106955
HM13 histocompatibility (minor) 13 -0.0106423
RPS6 ribosomal protein S6 -0.0105215
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.010463
CD81 CD81 molecule -0.0104287
RPS14 ribosomal protein S14 -0.0103618
RPS16 ribosomal protein S16 -0.0103116
EFNA5 ephrin-A5 -0.0102611
RPS29 ribosomal protein S29 -0.010225
NOG noggin -0.00993589
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.00978728
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00971507
RPS25 ribosomal protein S25 -0.009589
EIF5B eukaryotic translation initiation factor 5B -0.00953035
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00944602
TUBB4B tubulin, beta 4B class IVb -0.00940339
SLC38A1 solute carrier family 38, member 1 -0.00938118
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00922465
IFI27 interferon, alpha-inducible protein 27 -0.00916645
RPL34 ribosomal protein L34 -0.00910347
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.00909191
RPL27 ribosomal protein L27 -0.00904524
CCND1 cyclin D1 -0.00899118
PDCD5 programmed cell death 5 -0.00857084
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.00851523
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.00846157
ADAM32 ADAM metallopeptidase domain 32 -0.00842827
ENO2 enolase 2 (gamma, neuronal) -0.00838358
NDUFA4 NDUFA4, mitochondrial complex associated -0.00835904
BICD1 bicaudal D homolog 1 (Drosophila) -0.00818864
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00809467