Fingolimod (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0662094
MYH9 myosin, heavy chain 9, non-muscle 0.0640838
RPS2 ribosomal protein S2 0.0490368
SPAG9 sperm associated antigen 9 0.0478622
MSN moesin 0.0476421
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0471014
TRIO trio Rho guanine nucleotide exchange factor 0.0466424
ATP13A3 ATPase type 13A3 0.0458378
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0446051
GLS2 glutaminase 2 (liver, mitochondrial) 0.0438599
PLK2 polo-like kinase 2 0.039665
SOD2 superoxide dismutase 2, mitochondrial 0.0391156
CADM1 cell adhesion molecule 1 0.0387503
UBA6 ubiquitin-like modifier activating enzyme 6 0.036853
TPM3 tropomyosin 3 0.0367992
DDIT4 DNA-damage-inducible transcript 4 0.0367019
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0363859
PTBP3 polypyrimidine tract binding protein 3 0.0345401
ANKRD33B ankyrin repeat domain 33B 0.0344212
CSF1 colony stimulating factor 1 (macrophage) 0.0343348
FNDC3B fibronectin type III domain containing 3B 0.0328961
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326324
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320085
POTEF POTE ankyrin domain family, member F 0.031225
ZFAND3 zinc finger, AN1-type domain 3 0.0310095
WAC WW domain containing adaptor with coiled-coil 0.030032
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0298894
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0291537
WDR43 WD repeat domain 43 0.0289911
ICAM1 intercellular adhesion molecule 1 0.0287753
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0279658
FXR1 fragile X mental retardation, autosomal homolog 1 0.0279275
HELZ helicase with zinc finger 0.0278366
TFG TRK-fused gene 0.0277977
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0276916
VCAM1 vascular cell adhesion molecule 1 0.0271602
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0269794
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0263434
SUCO SUN domain containing ossification factor 0.026112
APP amyloid beta (A4) precursor protein 0.0259937
RHEB Ras homolog enriched in brain 0.0256048
ZCCHC7 zinc finger, CCHC domain containing 7 0.0256028
KMT2E lysine (K)-specific methyltransferase 2E 0.0253977
P3H2 prolyl 3-hydroxylase 2 0.0253971
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0253372
COPA coatomer protein complex, subunit alpha 0.0251038
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0250369
XPO1 exportin 1 0.025033
UBQLN1 ubiquilin 1 0.0250249
GOLGA4 golgin A4 0.0249909
NAMPT nicotinamide phosphoribosyltransferase 0.0249792
TNIP1 TNFAIP3 interacting protein 1 0.0248159
NOP58 NOP58 ribonucleoprotein 0.024588
CLTC clathrin, heavy chain (Hc) 0.0244131
KDM6A lysine (K)-specific demethylase 6A 0.0241534
ADAM9 ADAM metallopeptidase domain 9 0.0239982
FMNL2 formin-like 2 0.0237218
CXCL8 chemokine (C-X-C motif) ligand 8 0.0235299
ADAM17 ADAM metallopeptidase domain 17 0.0234097
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0232195
G0S2 G0/G1 switch 2 0.0229768
KMT2C lysine (K)-specific methyltransferase 2C 0.0229422
RBM39 RNA binding motif protein 39 0.0228497
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0228086
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0226612
RPL3 ribosomal protein L3 0.0223924
USP3 ubiquitin specific peptidase 3 0.0221835
ANXA5 annexin A5 0.022089
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0220757
TSC22D2 TSC22 domain family, member 2 0.0219365
CXCL2 chemokine (C-X-C motif) ligand 2 0.0218284
UGCG UDP-glucose ceramide glucosyltransferase 0.0213219
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0213043
MYO10 myosin X 0.0209492
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0209393
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0209253
DENND4A DENN/MADD domain containing 4A 0.0209155
QKI QKI, KH domain containing, RNA binding 0.0208257
FAT1 FAT atypical cadherin 1 0.0208152
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0207367
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0206847
MARCHF6 membrane associated ring-CH-type finger 6 0.0206679
PTK2 protein tyrosine kinase 2 0.0204596
ECPAS Ecm29 proteasome adaptor and scaffold 0.0204168
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.020223
PCBP2 poly(rC) binding protein 2 0.020195
ZFP36L1 ZFP36 ring finger protein-like 1 0.0201686
CCL2 chemokine (C-C motif) ligand 2 0.0200762
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0200377
VEGFA vascular endothelial growth factor A 0.0200363
SRPK2 SRSF protein kinase 2 0.0199943
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0198122
NCKAP1 NCK-associated protein 1 0.0197342
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0196919
RAI14 retinoic acid induced 14 0.0196535
ACBD3 acyl-CoA binding domain containing 3 0.0192739
HBP1 HMG-box transcription factor 1 0.0192709
SBF2 SET binding factor 2 0.0191494
CCNL1 cyclin L1 0.0191362
RAB8B RAB8B, member RAS oncogene family 0.0190156

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.151155
VIM vimentin -0.126893
FTL ferritin, light polypeptide -0.110894
HLA-B major histocompatibility complex, class I, B -0.0958549
RPL35A ribosomal protein L35a -0.0740612
TPT1 tumor protein, translationally-controlled 1 -0.0719401
MT2A metallothionein 2A -0.0694018
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0689538
ASPH aspartate beta-hydroxylase -0.0687135
RPL23 ribosomal protein L23 -0.0527401
RPLP1 ribosomal protein, large, P1 -0.0512042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0492431
CP ceruloplasmin (ferroxidase) -0.0463257
RPS8 ribosomal protein S8 -0.0461204
FRMD4A FERM domain containing 4A -0.0439299
RPL34 ribosomal protein L34 -0.043834
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0418913
IFI16 interferon, gamma-inducible protein 16 -0.0410917
RPS24 ribosomal protein S24 -0.0407135
RPS19 ribosomal protein S19 -0.0405258
EIF1 eukaryotic translation initiation factor 1 -0.0396594
RPL12 ribosomal protein L12 -0.0383659
TXNRD1 thioredoxin reductase 1 -0.0383422
B2M beta-2-microglobulin -0.0379188
RPLP2 ribosomal protein, large, P2 -0.037758
PTMA prothymosin, alpha -0.0348613
RPL31 ribosomal protein L31 -0.034715
EXT1 exostosin glycosyltransferase 1 -0.0342806
RPS4X ribosomal protein S4, X-linked -0.0339476
RPL28 ribosomal protein L28 -0.0337569
HLA-C major histocompatibility complex, class I, C -0.0328763
HMGB1 high mobility group box 1 -0.0328653
RRBP1 ribosome binding protein 1 -0.0318851
RPL26 ribosomal protein L26 -0.0317289
RPL19 ribosomal protein L19 -0.0316588
RPS21 ribosomal protein S21 -0.0316421
RPL37A ribosomal protein L37a -0.031578
S100A10 S100 calcium binding protein A10 -0.0309745
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0304588
ZBTB20 zinc finger and BTB domain containing 20 -0.0302158
RPL9 ribosomal protein L9 -0.0297027
HLA-A major histocompatibility complex, class I, A -0.0286768
OSMR oncostatin M receptor -0.0280575
RNF213 ring finger protein 213 -0.0275936
RPS6 ribosomal protein S6 -0.0275791
RPL35 ribosomal protein L35 -0.0275376
TSHZ2 teashirt zinc finger homeobox 2 -0.0268727
RPS27A ribosomal protein S27a -0.0264941
IFITM3 interferon induced transmembrane protein 3 -0.0263242
IFIH1 interferon induced with helicase C domain 1 -0.026223
RPS13 ribosomal protein S13 -0.0261103
KPNB1 karyopherin (importin) beta 1 -0.0258115
VCL vinculin -0.0255281
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0246146
RPS23 ribosomal protein S23 -0.0244327
ZMYND8 zinc finger, MYND-type containing 8 -0.0240373
RPL30 ribosomal protein L30 -0.0239694
RPL36 ribosomal protein L36 -0.023891
PFN1 profilin 1 -0.0238813
CTSD cathepsin D -0.0236124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0234653
GLIS3 GLIS family zinc finger 3 -0.0231352
IFI6 interferon, alpha-inducible protein 6 -0.0229871
SP100 SP100 nuclear antigen -0.0229418
APOL1 apolipoprotein L, 1 -0.0225108
LMNA lamin A/C -0.0224643
RPS20 ribosomal protein S20 -0.022419
RPL8 ribosomal protein L8 -0.0224054
S100A6 S100 calcium binding protein A6 -0.0220942
RPL36A ribosomal protein L36a -0.0218691
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0217736
CAVIN1 caveolae associated protein 1 -0.0217652
CA12 carbonic anhydrase XII -0.0216539
RPL27 ribosomal protein L27 -0.0213851
RPL37 ribosomal protein L37 -0.0213393
RIGI RNA sensor RIG-I -0.0211594
MGST1 microsomal glutathione S-transferase 1 -0.0209715
RPLP0 ribosomal protein, large, P0 -0.0209259
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0209025
PLIN2 perilipin 2 -0.0206615
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0205386
CD44 CD44 molecule (Indian blood group) -0.0201694
ACTG1 actin gamma 1 -0.0201633
PDE4D phosphodiesterase 4D, cAMP-specific -0.0199713
RBBP6 retinoblastoma binding protein 6 -0.0197545
RPS5 ribosomal protein S5 -0.0196449
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0195976
GCC2 GRIP and coiled-coil domain containing 2 -0.0195017
RPL7A ribosomal protein L7a -0.0194365
RPS14 ribosomal protein S14 -0.019266
RPS27 ribosomal protein S27 -0.0192507
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0190774
RPS17 ribosomal protein S17 -0.0190474
RPL27A ribosomal protein L27a -0.0189271
RPS16 ribosomal protein S16 -0.0188652
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0188322
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0188121
RPL11 ribosomal protein L11 -0.0186537
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0185646
GNAS GNAS complex locus -0.0183518