Fingolimod (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.167888
NDRG1 N-myc downstream regulated 1 0.140653
AKAP12 A kinase (PRKA) anchor protein 12 0.139512
SPAG9 sperm associated antigen 9 0.0872339
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.084151
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0815852
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0801431
GOLGA4 golgin A4 0.078309
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.073165
SMAD3 SMAD family member 3 0.0688779
ANKRD11 ankyrin repeat domain 11 0.067979
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0657394
PCBP2 poly(rC) binding protein 2 0.0637035
USP3 ubiquitin specific peptidase 3 0.0623176
HELZ helicase with zinc finger 0.0616404
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0611751
MSN moesin 0.0602466
FMNL2 formin-like 2 0.0601996
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0599504
IGFBP3 insulin-like growth factor binding protein 3 0.0595056
MYH9 myosin, heavy chain 9, non-muscle 0.0544838
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0540785
RPS2 ribosomal protein S2 0.0535825
PKM pyruvate kinase, muscle 0.0533904
GRB10 growth factor receptor-bound protein 10 0.0528367
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0516224
TNIP1 TNFAIP3 interacting protein 1 0.0509343
FNDC3B fibronectin type III domain containing 3B 0.0486278
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0479727
FAM13A family with sequence similarity 13, member A 0.0476021
PRRC2C proline-rich coiled-coil 2C 0.0469614
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.046251
ECT2 epithelial cell transforming 2 0.0454612
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0445659
KTN1 kinectin 1 (kinesin receptor) 0.0433936
WAC WW domain containing adaptor with coiled-coil 0.0426521
PUM2 pumilio RNA-binding family member 2 0.0423347
FLNB filamin B, beta 0.0418027
CA12 carbonic anhydrase XII 0.0407985
ADAM17 ADAM metallopeptidase domain 17 0.0407354
WDR43 WD repeat domain 43 0.0405482
KDM3A lysine (K)-specific demethylase 3A 0.0402743
NUP58 nucleoporin 58 0.0402482
DGKD diacylglycerol kinase, delta 130kDa 0.0399995
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0379523
MYO1B myosin IB 0.0378216
PICALM phosphatidylinositol binding clathrin assembly protein 0.0376452
CCNL1 cyclin L1 0.0369525
MYO1E myosin IE 0.036279
FA2H fatty acid 2-hydroxylase 0.0361004
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0359885
SBF2 SET binding factor 2 0.0358988
ERRFI1 ERBB receptor feedback inhibitor 1 0.0358622
ZNF292 zinc finger protein 292 0.0358445
UBA6 ubiquitin-like modifier activating enzyme 6 0.0353514
RB1CC1 RB1-inducible coiled-coil 1 0.0352973
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0352771
AUTS2 autism susceptibility candidate 2 0.0351451
BIRC6 baculoviral IAP repeat containing 6 0.0350599
RICTOR RPTOR independent companion of MTOR, complex 2 0.0348968
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0348334
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0343516
LDHA lactate dehydrogenase A 0.0338404
SETD5 SET domain containing 5 0.0337393
NAMPT nicotinamide phosphoribosyltransferase 0.0337309
EGFR epidermal growth factor receptor 0.0336998
ARHGAP26 Rho GTPase activating protein 26 0.0335602
SHB Src homology 2 domain containing adaptor protein B 0.0332816
ESYT2 extended synaptotagmin-like protein 2 0.0327938
CENPF centromere protein F, 350/400kDa 0.0326849
KCTD9 potassium channel tetramerization domain containing 9 0.0325748
PGK1 phosphoglycerate kinase 1 0.0322952
AKAP13 A kinase (PRKA) anchor protein 13 0.0321984
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0320709
MYOF myoferlin 0.0320449
RIN2 Ras and Rab interactor 2 0.0320264
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0318725
ADAM9 ADAM metallopeptidase domain 9 0.0318596
PSD3 pleckstrin and Sec7 domain containing 3 0.0318001
KMT2C lysine (K)-specific methyltransferase 2C 0.0317747
SUCO SUN domain containing ossification factor 0.0310444
MCL1 myeloid cell leukemia 1 0.0310399
XPO1 exportin 1 0.0307476
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0306293
RNF145 ring finger protein 145 0.0304763
RPL3 ribosomal protein L3 0.0304669
PTBP3 polypyrimidine tract binding protein 3 0.03021
SEC24A SEC24 family member A 0.0301207
SRRM2 serine/arginine repetitive matrix 2 0.0298949
LIMCH1 LIM and calponin homology domains 1 0.0295894
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0293811
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0292733
KMT2E lysine (K)-specific methyltransferase 2E 0.0292684
SEPTIN9 septin 9 0.0292632
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0292314
ASPH aspartate beta-hydroxylase 0.0291899
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0289538
NOP58 NOP58 ribonucleoprotein 0.0288981
NGLY1 N-glycanase 1 0.0288925
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0288752

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193714
TMSB10 thymosin beta 10 -0.16726
FTL ferritin, light polypeptide -0.140519
VIM vimentin -0.123996
ACTG1 actin gamma 1 -0.0972762
RPLP1 ribosomal protein, large, P1 -0.0970108
TPT1 tumor protein, translationally-controlled 1 -0.0908884
FTH1 ferritin, heavy polypeptide 1 -0.0836741
RPS19 ribosomal protein S19 -0.0674127
KYNU kynureninase -0.0652945
ANXA2 annexin A2 -0.0647326
RPL23 ribosomal protein L23 -0.0612513
RPS16 ribosomal protein S16 -0.0600591
MT2A metallothionein 2A -0.0577057
RPS24 ribosomal protein S24 -0.0564478
RPL12 ribosomal protein L12 -0.053508
TM4SF1 transmembrane 4 L six family member 1 -0.0528715
S100A10 S100 calcium binding protein A10 -0.0504733
RPLP0 ribosomal protein, large, P0 -0.0488204
RPL35A ribosomal protein L35a -0.048482
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0477286
MT1X metallothionein 1X -0.0456135
EIF1 eukaryotic translation initiation factor 1 -0.0452388
RPL26 ribosomal protein L26 -0.044295
RPS27A ribosomal protein S27a -0.0398478
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0386573
S100A6 S100 calcium binding protein A6 -0.0383528
RPLP2 ribosomal protein, large, P2 -0.0380556
RPS8 ribosomal protein S8 -0.0359865
RPL34 ribosomal protein L34 -0.0353469
RPL36A ribosomal protein L36a -0.0347383
C15ORF48 chromosome 15 open reading frame 48 -0.0345849
KRT81 keratin 81, type II -0.033693
RPL31 ribosomal protein L31 -0.0334932
RPS6 ribosomal protein S6 -0.0325887
RPS21 ribosomal protein S21 -0.032324
KLF6 Kruppel-like factor 6 -0.031697
RPS4X ribosomal protein S4, X-linked -0.0301369
RPL11 ribosomal protein L11 -0.0281299
RPS5 ribosomal protein S5 -0.0279572
RACK1 receptor for activated C kinase 1 -0.0275591
RPL19 ribosomal protein L19 -0.0268405
LOC112694756 uncharaterized LOC112694756 -0.0267308
RPS12 ribosomal protein S12 -0.0266983
OSMR oncostatin M receptor -0.0265426
RPS27 ribosomal protein S27 -0.0263118
RPS14 ribosomal protein S14 -0.0256342
RPL18 ribosomal protein L18 -0.0255
RPL9 ribosomal protein L9 -0.0252463
VDAC1 voltage-dependent anion channel 1 -0.025243
TKT transketolase -0.024788
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0242993
RPL37A ribosomal protein L37a -0.0241811
RPL8 ribosomal protein L8 -0.0237784
RPL35 ribosomal protein L35 -0.0235316
ARHGAP5 Rho GTPase activating protein 5 -0.0228768
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0225228
KRT18 keratin 18, type I -0.0223619
FBXL2 F-box and leucine-rich repeat protein 2 -0.022231
RPL36 ribosomal protein L36 -0.0220293
RPL37 ribosomal protein L37 -0.02151
NPC1 Niemann-Pick disease, type C1 -0.0212879
AHNAK AHNAK nucleoprotein -0.021106
RPS23 ribosomal protein S23 -0.0209986
RPS3 ribosomal protein S3 -0.0209556
UBB ubiquitin B -0.020929
MYO9A myosin IXA -0.0208604
WDFY1 WD repeat and FYVE domain containing 1 -0.0207411
KRT7 keratin 7, type II -0.0206116
IFI6 interferon, alpha-inducible protein 6 -0.0205786
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0201072
RPS11 ribosomal protein S11 -0.0197257
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0194759
RPS17 ribosomal protein S17 -0.0194611
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0193188
RPS13 ribosomal protein S13 -0.0192075
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0191222
RPL28 ribosomal protein L28 -0.0189306
LASP1 LIM and SH3 protein 1 -0.0187303
BMAL2 basic helix-loop-helix ARNT like 2 -0.0186022
IGFBP4 insulin-like growth factor binding protein 4 -0.0184608
GSTP1 glutathione S-transferase pi 1 -0.0182995
RPL7A ribosomal protein L7a -0.0181538
RPL32 ribosomal protein L32 -0.0181182
NLK nemo-like kinase -0.0180635
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0180288
ARF1 ADP-ribosylation factor 1 -0.0180253
IER3 immediate early response 3 -0.0179339
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0178498
RPL27A ribosomal protein L27a -0.0178247
RPL27 ribosomal protein L27 -0.0175757
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0174365
DOCK4 dedicator of cytokinesis 4 -0.0172272
RSPO3 R-spondin 3 -0.0171217
COTL1 coactosin-like F-actin binding protein 1 -0.0170222
RPS29 ribosomal protein S29 -0.0169874
RAB7A RAB7A, member RAS oncogene family -0.0161888
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0161667
UGDH UDP-glucose 6-dehydrogenase -0.0160909
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0157425