Fingolimod (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.163002
FAM13A family with sequence similarity 13, member A 0.0735496
HELZ helicase with zinc finger 0.063388
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0561933
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0532414
FNBP1 formin binding protein 1 0.0492317
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0462749
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0445862
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413264
MAP1B microtubule-associated protein 1B 0.0404057
CD36 CD36 molecule (thrombospondin receptor) 0.0376214
ITPRID2 ITPR interacting domain containing 2 0.0373743
CENPF centromere protein F, 350/400kDa 0.0368806
ZNF292 zinc finger protein 292 0.0364017
DST dystonin 0.0363964
KMT2C lysine (K)-specific methyltransferase 2C 0.0320571
NAMPT nicotinamide phosphoribosyltransferase 0.0317967
KDM3A lysine (K)-specific demethylase 3A 0.0315337
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0310477
XPO1 exportin 1 0.0309373
HMGB2 high mobility group box 2 0.0295041
WDR45B WD repeat domain 45B 0.0289854
MEF2A myocyte enhancer factor 2A 0.0284656
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281635
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0280853
GOLGA4 golgin A4 0.0277943
ZNF148 zinc finger protein 148 0.0277941
ERRFI1 ERBB receptor feedback inhibitor 1 0.0273592
SOS1 son of sevenless homolog 1 (Drosophila) 0.0272242
LPIN1 lipin 1 0.0265032
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0264365
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0261073
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0252507
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0249162
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0249092
NDRG1 N-myc downstream regulated 1 0.0247608
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0243928
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0243909
OGA O-GlcNAcase 0.0243158
CKAP5 cytoskeleton associated protein 5 0.0241991
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0238556
KMT2E lysine (K)-specific methyltransferase 2E 0.0237147
SEPTIN9 septin 9 0.0236513
APP amyloid beta (A4) precursor protein 0.0236282
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0235626
UBE2O ubiquitin-conjugating enzyme E2O 0.0230655
MATR3 matrin 3 0.0220625
ZNF654 zinc finger protein 654 0.021775
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.021659
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0215778
NPEPPS aminopeptidase puromycin sensitive 0.0215231
NCKAP1 NCK-associated protein 1 0.0214395
RNF145 ring finger protein 145 0.0212167
TCERG1 transcription elongation regulator 1 0.0211688
DSCAM Down syndrome cell adhesion molecule 0.0209336
VEGFA vascular endothelial growth factor A 0.0208911
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0207751
AKAP12 A kinase (PRKA) anchor protein 12 0.0207411
PRPF3 pre-mRNA processing factor 3 0.0207141
CD46 CD46 molecule, complement regulatory protein 0.0206457
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.020555
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.020552
USP9Y ubiquitin specific peptidase 9, Y-linked 0.020471
NFE2L1 nuclear factor, erythroid 2-like 1 0.020467
ADGRG6 adhesion G protein-coupled receptor G6 0.0201236
RIOK3 RIO kinase 3 0.0200747
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0199804
ZMIZ1 zinc finger, MIZ-type containing 1 0.0199458
RAB6A RAB6A, member RAS oncogene family 0.019798
DENND4C DENN/MADD domain containing 4C 0.0197681
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0197523
NCOR1 nuclear receptor corepressor 1 0.0195058
KDM5B lysine (K)-specific demethylase 5B 0.0193072
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0189277
MIS18BP1 MIS18 binding protein 1 0.0184736
KIF5B kinesin family member 5B 0.0184703
YEATS2 YEATS domain containing 2 0.0183663
DDIT4 DNA-damage-inducible transcript 4 0.0182184
PICALM phosphatidylinositol binding clathrin assembly protein 0.0182132
NUP58 nucleoporin 58 0.0178861
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0177004
TPR translocated promoter region, nuclear basket protein 0.0175437
CLTC clathrin, heavy chain (Hc) 0.017481
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0173944
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0173535
SRP54 signal recognition particle 54kDa 0.0172987
CDK19 cyclin-dependent kinase 19 0.0170702
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0170405
YTHDC1 YTH domain containing 1 0.016914
SPAG9 sperm associated antigen 9 0.0169125
ESYT2 extended synaptotagmin-like protein 2 0.016893
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0168862
PAPOLA poly(A) polymerase alpha 0.0168288
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.016759
PTK2 protein tyrosine kinase 2 0.0166654
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0166615
SEC31A SEC31 homolog A (S. cerevisiae) 0.0166133
WSB1 WD repeat and SOCS box containing 1 0.0165902
SETD5 SET domain containing 5 0.0165675
MXI1 MAX interactor 1, dimerization protein 0.0165337

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.166092
NRG1 neuregulin 1 -0.136217
NALF1 NALCN channel auxiliary factor 1 -0.109322
EXT1 exostosin glycosyltransferase 1 -0.0981277
VCL vinculin -0.0942305
FMN1 formin 1 -0.0780189
THSD4 thrombospondin, type I, domain containing 4 -0.0716305
PTPRD protein tyrosine phosphatase, receptor type, D -0.0670456
RPL23 ribosomal protein L23 -0.0594284
SYT1 synaptotagmin I -0.0568417
BCAS3 breast carcinoma amplified sequence 3 -0.0554677
RPL35A ribosomal protein L35a -0.0541951
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0508735
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0477125
TMSB10 thymosin beta 10 -0.0475612
ACTG1 actin gamma 1 -0.0467638
VIM vimentin -0.0464554
ZNF804A zinc finger protein 804A -0.0450452
SLIT2 slit homolog 2 (Drosophila) -0.0449997
COL1A1 collagen, type I, alpha 1 -0.0431675
RPS24 ribosomal protein S24 -0.0417133
TPT1 tumor protein, translationally-controlled 1 -0.04101
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0402259
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0398749
ZBTB20 zinc finger and BTB domain containing 20 -0.0394256
RPLP1 ribosomal protein, large, P1 -0.0389671
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0386265
FRMD4A FERM domain containing 4A -0.0386151
PRKCA protein kinase C, alpha -0.0380587
EGR1 early growth response 1 -0.0379348
RPL34 ribosomal protein L34 -0.0378043
IGF2 insulin-like growth factor 2 -0.0368331
RPL19 ribosomal protein L19 -0.0364751
DNAH14 dynein, axonemal, heavy chain 14 -0.0361906
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.035544
RNF213 ring finger protein 213 -0.0349237
BPTF bromodomain PHD finger transcription factor -0.0343022
GLCCI1 glucocorticoid induced 1 -0.0339842
PTMA prothymosin, alpha -0.0336388
CADM2 cell adhesion molecule 2 -0.033515
RAD51B RAD51 paralog B -0.0326981
MAPK10 mitogen-activated protein kinase 10 -0.0316858
NPAS2 neuronal PAS domain protein 2 -0.0312648
RPL26 ribosomal protein L26 -0.0298255
PTPRG protein tyrosine phosphatase, receptor type, G -0.0295965
TPM1 tropomyosin 1 (alpha) -0.0294763
SP100 SP100 nuclear antigen -0.0294657
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0290008
RPS6 ribosomal protein S6 -0.0288058
CUX1 cut-like homeobox 1 -0.0286819
GREM2 gremlin 2, DAN family BMP antagonist -0.0285909
ANTXR1 anthrax toxin receptor 1 -0.0285118
RPS19 ribosomal protein S19 -0.0284945
CNTN4 contactin 4 -0.0284521
CRH corticotropin releasing hormone -0.0280303
RPL9 ribosomal protein L9 -0.0275047
KLHL13 kelch-like family member 13 -0.0274248
RPS8 ribosomal protein S8 -0.0272298
BICD1 bicaudal D homolog 1 (Drosophila) -0.0268282
NREP neuronal regeneration related protein -0.0267395
RIGI RNA sensor RIG-I -0.0266926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0264703
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0262122
LRP1B low density lipoprotein receptor-related protein 1B -0.026136
SLC39A11 solute carrier family 39, member 11 -0.0259896
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0257001
RPS27A ribosomal protein S27a -0.0256129
RPL37 ribosomal protein L37 -0.0247233
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0246906
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0241548
UNC5C unc-5 homolog C (C. elegans) -0.0240307
SOX4 SRY (sex determining region Y)-box 4 -0.0238508
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0236929
RPS12 ribosomal protein S12 -0.0235418
PBX1 pre-B-cell leukemia homeobox 1 -0.0233546
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0232279
RPS17 ribosomal protein S17 -0.0230862
DACH2 dachshund family transcription factor 2 -0.023018
TENM4 teneurin transmembrane protein 4 -0.0229695
IGFBP3 insulin-like growth factor binding protein 3 -0.0224707
MX2 MX dynamin-like GTPase 2 -0.0224285
RPL31 ribosomal protein L31 -0.022301
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0221098
TBX2 T-box 2 -0.021963
RPS23 ribosomal protein S23 -0.021612
MTAP methylthioadenosine phosphorylase -0.0214504
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0211155
DNM3 dynamin 3 -0.0207472
PTPRK protein tyrosine phosphatase, receptor type, K -0.0204716
SIK2 salt-inducible kinase 2 -0.0204171
ZNF609 zinc finger protein 609 -0.0202234
PTPRM protein tyrosine phosphatase, receptor type, M -0.0201679
COL4A5 collagen, type IV, alpha 5 -0.0200942
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0198875
MCL1 myeloid cell leukemia 1 -0.0198733
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0197166
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0196645
ITGA1 integrin, alpha 1 -0.0195486
S100A9 S100 calcium binding protein A9 -0.0193963
KCNIP4 Kv channel interacting protein 4 -0.0192851