Fingolimod (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.106627
CXCL8 chemokine (C-X-C motif) ligand 8 0.100159
EGFR epidermal growth factor receptor 0.0874551
CANX calnexin 0.0757324
ERRFI1 ERBB receptor feedback inhibitor 1 0.0713411
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0698334
DGKD diacylglycerol kinase, delta 130kDa 0.0677344
AKAP12 A kinase (PRKA) anchor protein 12 0.0655996
FNDC3B fibronectin type III domain containing 3B 0.0636645
STC1 stanniocalcin 1 0.0617232
TTC3 tetratricopeptide repeat domain 3 0.0600623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.059632
GOLGB1 golgin B1 0.0586712
COL6A3 collagen, type VI, alpha 3 0.0508293
ASPH aspartate beta-hydroxylase 0.05049
TRIO trio Rho guanine nucleotide exchange factor 0.047725
DST dystonin 0.047218
SBF2 SET binding factor 2 0.0465452
ATP13A3 ATPase type 13A3 0.0458137
CALD1 caldesmon 1 0.0456386
CLTC clathrin, heavy chain (Hc) 0.0455323
NAMPT nicotinamide phosphoribosyltransferase 0.044727
MACF1 microtubule-actin crosslinking factor 1 0.0432104
COPB1 coatomer protein complex, subunit beta 1 0.0416473
COPA coatomer protein complex, subunit alpha 0.0405357
LOX lysyl oxidase 0.0404348
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0392076
MYH9 myosin, heavy chain 9, non-muscle 0.0377961
SAMD4A sterile alpha motif domain containing 4A 0.0368042
VMP1 vacuole membrane protein 1 0.0366328
HDAC9 histone deacetylase 9 0.0365639
SMAD3 SMAD family member 3 0.0364477
SPAG9 sperm associated antigen 9 0.0362905
CADM1 cell adhesion molecule 1 0.0358677
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0356042
ANKRD17 ankyrin repeat domain 17 0.0352612
FNIP1 folliculin interacting protein 1 0.0350721
SRP54 signal recognition particle 54kDa 0.0348055
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0345608
ZCCHC7 zinc finger, CCHC domain containing 7 0.0342608
HELZ helicase with zinc finger 0.0341646
ANO6 anoctamin 6 0.0330445
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0327317
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0312218
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0305839
LMAN1 lectin, mannose-binding, 1 0.0303295
ELL2 elongation factor, RNA polymerase II, 2 0.0296591
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0295975
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0289447
MBD5 methyl-CpG binding domain protein 5 0.0285576
LOXL2 lysyl oxidase-like 2 0.0285073
PMM2 phosphomannomutase 2 0.0284866
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0284646
PABPC1 poly(A) binding protein, cytoplasmic 1 0.028415
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0283608
RASA2 RAS p21 protein activator 2 0.0283122
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0281279
TMEM39A transmembrane protein 39A 0.0278949
GOLGA4 golgin A4 0.027883
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0278487
AHNAK AHNAK nucleoprotein 0.0276
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0270714
FAM13A family with sequence similarity 13, member A 0.0269563
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0269501
COG6 component of oligomeric golgi complex 6 0.0264872
CLINT1 clathrin interactor 1 0.0261112
BACE2 beta-site APP-cleaving enzyme 2 0.0259674
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0256099
MORF4L2 mortality factor 4 like 2 0.0256066
SEC24D SEC24 family member D 0.0255627
LCORL ligand dependent nuclear receptor corepressor-like 0.0254821
ATM ATM serine/threonine kinase 0.0252769
YEATS2 YEATS domain containing 2 0.0252498
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0251857
PYGL phosphorylase, glycogen, liver 0.0250081
SEC31A SEC31 homolog A (S. cerevisiae) 0.0249403
MAST4 microtubule associated serine/threonine kinase family member 4 0.0247265
RAB1A RAB1A, member RAS oncogene family 0.024645
ANKRD28 ankyrin repeat domain 28 0.0245951
LRRC49 leucine rich repeat containing 49 0.0243831
COG5 component of oligomeric golgi complex 5 0.0242234
HDLBP high density lipoprotein binding protein 0.0241485
SCFD1 sec1 family domain containing 1 0.0240971
TMF1 TATA element modulatory factor 1 0.0239711
EXT1 exostosin glycosyltransferase 1 0.0239342
TMEM263 transmembrane protein 263 0.0239287
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0238514
ZNF841 zinc finger protein 841 0.0236384
NBEAL1 neurobeachin-like 1 0.0233055
RARS1 arginyl-tRNA synthetase 1 0.0232288
COL5A1 collagen, type V, alpha 1 0.0232089
ZNF638 zinc finger protein 638 0.0230674
MSN moesin 0.0229305
USP34 ubiquitin specific peptidase 34 0.0228247
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0227479
SEC23A Sec23 homolog A (S. cerevisiae) 0.0226662
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.022589
AVL9 AVL9 homolog (S. cerevisiase) 0.0225153
DOCK5 dedicator of cytokinesis 5 0.0225016
LPP LIM domain containing preferred translocation partner in lipoma 0.0222557

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102422
IGFBP3 insulin-like growth factor binding protein 3 -0.101154
TMSB10 thymosin beta 10 -0.0947035
VIM vimentin -0.0884773
MT2A metallothionein 2A -0.066972
NALF1 NALCN channel auxiliary factor 1 -0.0668815
FN1 fibronectin 1 -0.0645319
RPS6 ribosomal protein S6 -0.0601638
HLA-B major histocompatibility complex, class I, B -0.052496
FTL ferritin, light polypeptide -0.0520927
RPL35A ribosomal protein L35a -0.0455585
PTMA prothymosin, alpha -0.0438252
RPLP1 ribosomal protein, large, P1 -0.0431139
RPS8 ribosomal protein S8 -0.0418779
TPT1 tumor protein, translationally-controlled 1 -0.0407147
B2M beta-2-microglobulin -0.0400476
HLA-A major histocompatibility complex, class I, A -0.0394056
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0376517
RPLP2 ribosomal protein, large, P2 -0.0356873
RPS19 ribosomal protein S19 -0.0347891
RPL37A ribosomal protein L37a -0.0334211
RPL23 ribosomal protein L23 -0.0315002
IGFBP5 insulin-like growth factor binding protein 5 -0.0314098
RPL9 ribosomal protein L9 -0.0292247
POTEF POTE ankyrin domain family, member F -0.0291994
RPL34 ribosomal protein L34 -0.0288424
TGFBI transforming growth factor, beta-induced, 68kDa -0.0279042
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0274217
RPL28 ribosomal protein L28 -0.0269652
GRB10 growth factor receptor-bound protein 10 -0.0266871
ACTG1 actin gamma 1 -0.0245977
RPS13 ribosomal protein S13 -0.0235512
RPS27 ribosomal protein S27 -0.022814
RPS25 ribosomal protein S25 -0.0225201
RPL36 ribosomal protein L36 -0.0218644
S100A10 S100 calcium binding protein A10 -0.0216025
RPL31 ribosomal protein L31 -0.0212875
IGF2 insulin-like growth factor 2 -0.0206794
SEC61G Sec61 gamma subunit -0.0205985
RPL12 ribosomal protein L12 -0.0204177
RPS16 ribosomal protein S16 -0.0203807
YBX1 Y box binding protein 1 -0.0202872
WSB1 WD repeat and SOCS box containing 1 -0.0194018
CBX3 chromobox homolog 3 -0.0190714
S100A9 S100 calcium binding protein A9 -0.0190239
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0188224
RPS17 ribosomal protein S17 -0.0188051
RPS23 ribosomal protein S23 -0.0187181
RPS11 ribosomal protein S11 -0.0184229
PDE4D phosphodiesterase 4D, cAMP-specific -0.0184061
LMNA lamin A/C -0.0178772
EGR1 early growth response 1 -0.0175142
RPL11 ribosomal protein L11 -0.0174937
FTH1 ferritin, heavy polypeptide 1 -0.0173548
NLGN1 neuroligin 1 -0.016969
CLMP CXADR-like membrane protein -0.0167371
RPL37 ribosomal protein L37 -0.016481
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0162879
RPL19 ribosomal protein L19 -0.01617
DEK DEK proto-oncogene -0.0160913
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0160438
RPS12 ribosomal protein S12 -0.0160317
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0159388
HMGA1 high mobility group AT-hook 1 -0.0158766
PFN1 profilin 1 -0.0157278
PRSS23 protease, serine, 23 -0.0151769
RPL35 ribosomal protein L35 -0.0151598
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0150745
RPS20 ribosomal protein S20 -0.0149398
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0146412
S100A6 S100 calcium binding protein A6 -0.0146159
HLA-C major histocompatibility complex, class I, C -0.0145932
RPS29 ribosomal protein S29 -0.0144259
RPS24 ribosomal protein S24 -0.0143601
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0143242
CYB5R3 cytochrome b5 reductase 3 -0.0142189
RACK1 receptor for activated C kinase 1 -0.0139761
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0139486
RPS14 ribosomal protein S14 -0.0138641
HMGB1 high mobility group box 1 -0.0138227
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0136174
ENO2 enolase 2 (gamma, neuronal) -0.0134696
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0133892
RPL26 ribosomal protein L26 -0.013205
RPS3 ribosomal protein S3 -0.0129819
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0127509
RPS21 ribosomal protein S21 -0.0127339
RPL5 ribosomal protein L5 -0.0126282
AHR aryl hydrocarbon receptor -0.0124555
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0123272
NAP1L1 nucleosome assembly protein 1-like 1 -0.0121272
PABPN1 poly(A) binding protein, nuclear 1 -0.0118539
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0117806
GDF15 growth differentiation factor 15 -0.0117705
RPL36A ribosomal protein L36a -0.01162
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0115922
PSD3 pleckstrin and Sec7 domain containing 3 -0.0115901
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0113637
SNED1 sushi, nidogen and EGF-like domains 1 -0.0113496
RPS4X ribosomal protein S4, X-linked -0.0111523