Fingolimod (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.141541
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.111134
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0948275
PRELID2 PRELI domain containing 2 0.081885
DSCAM Down syndrome cell adhesion molecule 0.0790729
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0778564
GOLGA4 golgin A4 0.0715411
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0655446
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0641828
TTC3 tetratricopeptide repeat domain 3 0.0640551
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0594343
ZNF638 zinc finger protein 638 0.0555768
AKAP9 A kinase (PRKA) anchor protein 9 0.0553395
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0529385
ZNF292 zinc finger protein 292 0.0527887
KDM4C lysine (K)-specific demethylase 4C 0.0525561
TMF1 TATA element modulatory factor 1 0.0517931
HELZ helicase with zinc finger 0.0483879
YEATS2 YEATS domain containing 2 0.048266
SEC31A SEC31 homolog A (S. cerevisiae) 0.0478031
GOLGB1 golgin B1 0.0469224
COPB1 coatomer protein complex, subunit beta 1 0.046206
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0457043
CANX calnexin 0.0444948
MYH9 myosin, heavy chain 9, non-muscle 0.0431592
TBC1D22A TBC1 domain family, member 22A 0.0426145
DSPP dentin sialophosphoprotein 0.0410687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0405463
OGA O-GlcNAcase 0.0402563
ERRFI1 ERBB receptor feedback inhibitor 1 0.0401339
KMT2C lysine (K)-specific methyltransferase 2C 0.0386745
RBM39 RNA binding motif protein 39 0.0382172
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0379804
ARF4 ADP-ribosylation factor 4 0.0378758
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.03773
KIAA1217 KIAA1217 0.0376832
TXNRD1 thioredoxin reductase 1 0.0376794
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0376454
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.037266
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0369558
KDM2A lysine (K)-specific demethylase 2A 0.0364057
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0361511
CDK19 cyclin-dependent kinase 19 0.0360888
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0359791
MBD5 methyl-CpG binding domain protein 5 0.0358973
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0354551
HDLBP high density lipoprotein binding protein 0.0346189
SRP54 signal recognition particle 54kDa 0.034438
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0342189
SUCO SUN domain containing ossification factor 0.0339651
USP34 ubiquitin specific peptidase 34 0.0339578
MON2 MON2 homolog (S. cerevisiae) 0.0337639
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0336354
COPA coatomer protein complex, subunit alpha 0.0332991
ZC3H11A zinc finger CCCH-type containing 11A 0.03317
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322271
SEC24A SEC24 family member A 0.0321618
PAPOLA poly(A) polymerase alpha 0.0319003
PCBP2 poly(rC) binding protein 2 0.0318313
CLTC clathrin, heavy chain (Hc) 0.0316171
NDRG1 N-myc downstream regulated 1 0.0313713
SETD5 SET domain containing 5 0.0313251
PATJ PATJ crumbs cell polarity complex component 0.0311634
NBAS neuroblastoma amplified sequence 0.0308847
NEBL nebulette 0.0300605
BRWD3 bromodomain and WD repeat domain containing 3 0.0299223
MORF4L2 mortality factor 4 like 2 0.0296687
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0293052
PHF3 PHD finger protein 3 0.0292389
ACBD3 acyl-CoA binding domain containing 3 0.0292076
NUP58 nucleoporin 58 0.0291623
PNISR PNN-interacting serine/arginine-rich protein 0.0289378
ARL5B ADP-ribosylation factor-like 5B 0.028803
EEF2 eukaryotic translation elongation factor 2 0.0286784
KMT2E lysine (K)-specific methyltransferase 2E 0.0286021
ARFGEF3 ARFGEF family member 3 0.0283385
ANKRD12 ankyrin repeat domain 12 0.0283303
COG6 component of oligomeric golgi complex 6 0.0279748
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0278822
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0277688
VMP1 vacuole membrane protein 1 0.0273626
PLAUR plasminogen activator, urokinase receptor 0.0273558
ZNF654 zinc finger protein 654 0.0270926
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0269715
FDPS farnesyl diphosphate synthase 0.026774
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.026358
FNIP1 folliculin interacting protein 1 0.02631
N4BP2L2 NEDD4 binding protein 2-like 2 0.0262488
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0258855
WWC2 WW and C2 domain containing 2 0.0257358
WSB1 WD repeat and SOCS box containing 1 0.0256413
INSIG2 insulin induced gene 2 0.0254194
SBF2 SET binding factor 2 0.0252679
TOR1AIP2 torsin A interacting protein 2 0.0252552
LCOR ligand dependent nuclear receptor corepressor 0.0251899
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0251526
RARS1 arginyl-tRNA synthetase 1 0.0251129
ZCCHC7 zinc finger, CCHC domain containing 7 0.0248985
RNF24 ring finger protein 24 0.0248815
BBX bobby sox homolog (Drosophila) 0.0247834

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.220037
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.193477
TMSB10 thymosin beta 10 -0.143682
TPT1 tumor protein, translationally-controlled 1 -0.09586
FAT1 FAT atypical cadherin 1 -0.0935104
RPL35A ribosomal protein L35a -0.061588
ACTG1 actin gamma 1 -0.0559723
MT2A metallothionein 2A -0.0542176
RPS8 ribosomal protein S8 -0.0508962
POTEF POTE ankyrin domain family, member F -0.0415439
RPS6 ribosomal protein S6 -0.0413801
TUBA1B tubulin, alpha 1b -0.0410982
S100A10 S100 calcium binding protein A10 -0.0410915
KRT8 keratin 8, type II -0.0380687
HMGB1 high mobility group box 1 -0.0356989
KRT18 keratin 18, type I -0.034661
S100A9 S100 calcium binding protein A9 -0.0342985
RPL23 ribosomal protein L23 -0.0330119
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.03292
RPS24 ribosomal protein S24 -0.0326955
RPLP1 ribosomal protein, large, P1 -0.0326044
RPLP2 ribosomal protein, large, P2 -0.0323011
CCND1 cyclin D1 -0.0321664
RPLP0 ribosomal protein, large, P0 -0.0317523
EGR1 early growth response 1 -0.0313418
RPL26 ribosomal protein L26 -0.0307619
RPS27A ribosomal protein S27a -0.0292345
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0290409
WWOX WW domain containing oxidoreductase -0.0287298
RPS21 ribosomal protein S21 -0.0286865
RPS19 ribosomal protein S19 -0.0285478
RPL34 ribosomal protein L34 -0.0285031
HMGA2 high mobility group AT-hook 2 -0.0282707
RPS12 ribosomal protein S12 -0.0271487
PA2G4 proliferation-associated 2G4, 38kDa -0.0266212
HMGA1 high mobility group AT-hook 1 -0.0263646
S100A6 S100 calcium binding protein A6 -0.0262151
CADPS Ca++-dependent secretion activator -0.0260219
RPS25 ribosomal protein S25 -0.0257403
EIF5B eukaryotic translation initiation factor 5B -0.0256561
RPS17 ribosomal protein S17 -0.0250769
SERINC5 serine incorporator 5 -0.0249702
RPL37A ribosomal protein L37a -0.0249234
RPL31 ribosomal protein L31 -0.0241042
RPL8 ribosomal protein L8 -0.0240152
TUBB tubulin, beta class I -0.0238235
RPL11 ribosomal protein L11 -0.0237398
TPI1 triosephosphate isomerase 1 -0.0236229
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0234127
RPL19 ribosomal protein L19 -0.0233349
RPS15 ribosomal protein S15 -0.0231413
NOP56 NOP56 ribonucleoprotein -0.0230475
TUBB4B tubulin, beta 4B class IVb -0.0229596
HLA-A major histocompatibility complex, class I, A -0.0224347
PFN1 profilin 1 -0.0220863
LMNA lamin A/C -0.0219152
RPL36A ribosomal protein L36a -0.0212537
RPS13 ribosomal protein S13 -0.0211091
IFITM3 interferon induced transmembrane protein 3 -0.021069
RPS3 ribosomal protein S3 -0.0207037
RPL35 ribosomal protein L35 -0.0205824
RACK1 receptor for activated C kinase 1 -0.020283
MYL12B myosin, light chain 12B, regulatory -0.0201176
RPL12 ribosomal protein L12 -0.0200469
RPS16 ribosomal protein S16 -0.0194782
LDHB lactate dehydrogenase B -0.0191292
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0189972
HELLS helicase, lymphoid-specific -0.0189571
IGFBP4 insulin-like growth factor binding protein 4 -0.0189054
RPL30 ribosomal protein L30 -0.0187498
RPL9 ribosomal protein L9 -0.0186241
RPS29 ribosomal protein S29 -0.0186088
RPS23 ribosomal protein S23 -0.0185417
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0185066
RPS14 ribosomal protein S14 -0.0183371
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0182056
MKI67 marker of proliferation Ki-67 -0.0181551
DEK DEK proto-oncogene -0.0179927
RPS10 ribosomal protein S10 -0.0179648
HLA-B major histocompatibility complex, class I, B -0.0177875
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0176064
PRDX2 peroxiredoxin 2 -0.0175137
FAF1 Fas (TNFRSF6) associated factor 1 -0.0175091
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0173631
RPS5 ribosomal protein S5 -0.0173391
RPL38 ribosomal protein L38 -0.0173305
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0172081
AKAP12 A kinase (PRKA) anchor protein 12 -0.0171703
RPL28 ribosomal protein L28 -0.0171097
FHIT fragile histidine triad -0.0169539
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0169291
RPL27 ribosomal protein L27 -0.01687
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0168219
RAN RAN, member RAS oncogene family -0.016653
KPNB1 karyopherin (importin) beta 1 -0.0165816
CBX3 chromobox homolog 3 -0.0162802
RPS11 ribosomal protein S11 -0.0162685
RPL7A ribosomal protein L7a -0.0160522
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0160074
MORC4 MORC family CW-type zinc finger 4 -0.015853