Fingolimod (hydrochloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.118591
COL6A3 collagen, type VI, alpha 3 0.0939008
ATP13A3 ATPase type 13A3 0.073609
TRIO trio Rho guanine nucleotide exchange factor 0.0658385
MYH9 myosin, heavy chain 9, non-muscle 0.0475811
VEGFA vascular endothelial growth factor A 0.0439682
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.038173
SPAG9 sperm associated antigen 9 0.0336219
FNDC3B fibronectin type III domain containing 3B 0.0326575
CADM1 cell adhesion molecule 1 0.0302089
GOLGA4 golgin A4 0.0293688
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0263292
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0262743
SQLE squalene epoxidase 0.0259781
ERRFI1 ERBB receptor feedback inhibitor 1 0.0251322
PDE10A phosphodiesterase 10A 0.024852
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0247957
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0246724
ELL2 elongation factor, RNA polymerase II, 2 0.0246337
ZNF292 zinc finger protein 292 0.0228444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0227049
POSTN periostin, osteoblast specific factor 0.0225269
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0224988
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0221198
NAMPT nicotinamide phosphoribosyltransferase 0.0218811
UBA6 ubiquitin-like modifier activating enzyme 6 0.0216504
TNIP1 TNFAIP3 interacting protein 1 0.0215773
RASA2 RAS p21 protein activator 2 0.0214908
KMT2E lysine (K)-specific methyltransferase 2E 0.0213667
RPS2 ribosomal protein S2 0.0210643
FXR1 fragile X mental retardation, autosomal homolog 1 0.0199219
TFG TRK-fused gene 0.0192564
ZFAND3 zinc finger, AN1-type domain 3 0.0191456
TSC22D2 TSC22 domain family, member 2 0.0189005
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0187428
ARRDC3 arrestin domain containing 3 0.018368
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0183549
MSN moesin 0.0182234
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0179966
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0176276
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0170091
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0167321
ADAM17 ADAM metallopeptidase domain 17 0.0166803
IL6ST interleukin 6 signal transducer 0.0166438
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0163852
SKIC3 SKI3 subunit of superkiller complex 0.0161459
MAP1B microtubule-associated protein 1B 0.0160933
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0158444
RICTOR RPTOR independent companion of MTOR, complex 2 0.0158322
CANX calnexin 0.0156297
TMF1 TATA element modulatory factor 1 0.0153016
ESYT2 extended synaptotagmin-like protein 2 0.0152565
PICALM phosphatidylinositol binding clathrin assembly protein 0.0152451
SETD5 SET domain containing 5 0.0151171
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0150987
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0150554
ADAM9 ADAM metallopeptidase domain 9 0.0149028
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0148553
QKI QKI, KH domain containing, RNA binding 0.014835
RLF rearranged L-myc fusion 0.0146762
FOXJ3 forkhead box J3 0.0145936
RNF145 ring finger protein 145 0.0144102
USP3 ubiquitin specific peptidase 3 0.0142051
DPYSL3 dihydropyrimidinase-like 3 0.0140671
VCAN versican 0.0140261
RPL3 ribosomal protein L3 0.0139587
CLINT1 clathrin interactor 1 0.0137758
MACF1 microtubule-actin crosslinking factor 1 0.0137027
SMAD3 SMAD family member 3 0.0136905
VEGFC vascular endothelial growth factor C 0.013675
WAC WW domain containing adaptor with coiled-coil 0.0133452
SBF2 SET binding factor 2 0.01321
GOLT1B golgi transport 1B 0.0131922
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0131375
APP amyloid beta (A4) precursor protein 0.0131179
SOD2 superoxide dismutase 2, mitochondrial 0.0130673
TMEM39A transmembrane protein 39A 0.0129288
RAB8B RAB8B, member RAS oncogene family 0.0129202
KDM7A lysine (K)-specific demethylase 7A 0.0128365
MRTFA myocardin related transcription factor A 0.0127182
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0127137
NCKAP1 NCK-associated protein 1 0.012587
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0125796
GRB10 growth factor receptor-bound protein 10 0.0125381
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0124673
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0123654
AZIN1 antizyme inhibitor 1 0.0121852
SUCO SUN domain containing ossification factor 0.012108
DST dystonin 0.0120108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0120074
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0119246
YEATS2 YEATS domain containing 2 0.0119171
PTK2 protein tyrosine kinase 2 0.011865
JARID2 jumonji, AT rich interactive domain 2 0.0117147
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0116742
LAMB1 laminin, beta 1 0.0116623
CD109 CD109 molecule 0.0114814
COL4A1 collagen, type IV, alpha 1 0.0114278
BHLHE40 basic helix-loop-helix family, member e40 0.0113868
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0113257

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.236204
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173039
MT2A metallothionein 2A -0.158956
COL1A1 collagen, type I, alpha 1 -0.136968
TMSB10 thymosin beta 10 -0.12409
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0941746
RPL35A ribosomal protein L35a -0.0829193
RPS8 ribosomal protein S8 -0.0648141
FTL ferritin, light polypeptide -0.0592058
HLA-B major histocompatibility complex, class I, B -0.0578967
IER3 immediate early response 3 -0.0539827
COL1A2 collagen, type I, alpha 2 -0.0506734
ACTG1 actin gamma 1 -0.0484857
PTMA prothymosin, alpha -0.0483492
TGFBI transforming growth factor, beta-induced, 68kDa -0.0447349
TPT1 tumor protein, translationally-controlled 1 -0.044505
RPLP1 ribosomal protein, large, P1 -0.0409312
LGALS1 lectin, galactoside-binding, soluble, 1 -0.039794
S100A9 S100 calcium binding protein A9 -0.0387728
NDRG1 N-myc downstream regulated 1 -0.0376519
RPS19 ribosomal protein S19 -0.0370497
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0369082
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0365507
RPL37A ribosomal protein L37a -0.0361227
CDH13 cadherin 13 -0.0359843
RPL23 ribosomal protein L23 -0.035079
ENO1 enolase 1, (alpha) -0.0349312
RPS6 ribosomal protein S6 -0.0336491
EXT1 exostosin glycosyltransferase 1 -0.0331364
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0328657
EIF1 eukaryotic translation initiation factor 1 -0.032436
RPLP2 ribosomal protein, large, P2 -0.0323711
CALR calreticulin -0.0307804
RPL11 ribosomal protein L11 -0.0302796
RPL28 ribosomal protein L28 -0.0298306
RPL34 ribosomal protein L34 -0.0294157
RPL31 ribosomal protein L31 -0.0290473
CAVIN1 caveolae associated protein 1 -0.0290443
ZBTB20 zinc finger and BTB domain containing 20 -0.0281449
RPS13 ribosomal protein S13 -0.0281092
TIMP1 TIMP metallopeptidase inhibitor 1 -0.027706
RPL30 ribosomal protein L30 -0.0267039
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0265303
RPL36 ribosomal protein L36 -0.0264666
RPS20 ribosomal protein S20 -0.026387
RPS24 ribosomal protein S24 -0.0263573
IFI6 interferon, alpha-inducible protein 6 -0.0258324
RPS21 ribosomal protein S21 -0.0255205
TM4SF1 transmembrane 4 L six family member 1 -0.0250945
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0250252
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0249258
HLA-A major histocompatibility complex, class I, A -0.0247007
RPS3 ribosomal protein S3 -0.0244433
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0244252
TPM4 tropomyosin 4 -0.0243986
B2M beta-2-microglobulin -0.0240829
IFITM3 interferon induced transmembrane protein 3 -0.0237753
RPS25 ribosomal protein S25 -0.0235874
RPL8 ribosomal protein L8 -0.023439
RPL37 ribosomal protein L37 -0.0229273
RRBP1 ribosome binding protein 1 -0.022333
RPS15 ribosomal protein S15 -0.0221847
RPS11 ribosomal protein S11 -0.022155
RPS14 ribosomal protein S14 -0.0221096
RPL26 ribosomal protein L26 -0.021938
RPL12 ribosomal protein L12 -0.0217608
RPL9 ribosomal protein L9 -0.021707
RACK1 receptor for activated C kinase 1 -0.0211778
RPL19 ribosomal protein L19 -0.0211764
RPS23 ribosomal protein S23 -0.0211472
RPS16 ribosomal protein S16 -0.020966
S100A10 S100 calcium binding protein A10 -0.0207275
EGR1 early growth response 1 -0.0201321
RPS27A ribosomal protein S27a -0.02013
RPS29 ribosomal protein S29 -0.0199329
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0193057
SEC61G Sec61 gamma subunit -0.0192709
RPS5 ribosomal protein S5 -0.0188644
VDAC1 voltage-dependent anion channel 1 -0.0186261
MT1X metallothionein 1X -0.01814
ALCAM activated leukocyte cell adhesion molecule -0.017958
MTDH metadherin -0.0176266
S100A6 S100 calcium binding protein A6 -0.017198
RPL32 ribosomal protein L32 -0.0169912
SLC38A2 solute carrier family 38, member 2 -0.016847
F3 coagulation factor III (thromboplastin, tissue factor) -0.0168144
KPNB1 karyopherin (importin) beta 1 -0.0167653
RPS12 ribosomal protein S12 -0.0166574
RPLP0 ribosomal protein, large, P0 -0.0165118
RPL5 ribosomal protein L5 -0.0164915
RPL27 ribosomal protein L27 -0.0163677
RPL38 ribosomal protein L38 -0.0161144
RPS10 ribosomal protein S10 -0.0153774
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0149881
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0148897
MYDGF myeloid-derived growth factor -0.0147751
CD44 CD44 molecule (Indian blood group) -0.0147358
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0147067
ISG15 ISG15 ubiquitin-like modifier -0.0146209
RPL7A ribosomal protein L7a -0.0145302