| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fingolimod (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fingolimod (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.270589 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.241465 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.146311 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.134412 |
| C3 | complement component 3 | 0.107601 |
| RPS6 | ribosomal protein S6 | 0.0927473 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0893449 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0809915 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0799137 |
| ENO1 | enolase 1, (alpha) | 0.0773301 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0724709 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0716097 |
| DSPP | dentin sialophosphoprotein | 0.0700553 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.069171 |
| MT2A | metallothionein 2A | 0.0661643 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0620056 |
| APOA2 | apolipoprotein A-II | 0.0579693 |
| FTL | ferritin, light polypeptide | 0.0509452 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0507425 |
| RPL11 | ribosomal protein L11 | 0.0503482 |
| VEGFA | vascular endothelial growth factor A | 0.0493938 |
| RPS12 | ribosomal protein S12 | 0.047064 |
| NDRG1 | N-myc downstream regulated 1 | 0.0460002 |
| CPE | carboxypeptidase E | 0.0427412 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0412702 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0410156 |
| RPS8 | ribosomal protein S8 | 0.0382473 |
| AHSG | alpha-2-HS-glycoprotein | 0.0373101 |
| ZNF292 | zinc finger protein 292 | 0.0368581 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0367477 |
| RPL37A | ribosomal protein L37a | 0.036406 |
| GOLGA4 | golgin A4 | 0.0361392 |
| APOE | apolipoprotein E | 0.0359985 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0359951 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0351441 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0343345 |
| PCBP2 | poly(rC) binding protein 2 | 0.0343061 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0342522 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0341613 |
| INSIG2 | insulin induced gene 2 | 0.0333479 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0332392 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0332133 |
| HMGA1 | high mobility group AT-hook 1 | 0.0331558 |
| LDHA | lactate dehydrogenase A | 0.0329844 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0318536 |
| RPS19 | ribosomal protein S19 | 0.031196 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0307374 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0304257 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0304105 |
| RPL7 | ribosomal protein L7 | 0.0302394 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0301573 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0300052 |
| FMNL2 | formin-like 2 | 0.029828 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0294375 |
| AFDN | afadin, adherens junction formation factor | 0.0292086 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0291708 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0291577 |
| ARFGEF3 | ARFGEF family member 3 | 0.0287256 |
| RPS3 | ribosomal protein S3 | 0.0286385 |
| RPL3 | ribosomal protein L3 | 0.0282658 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0277927 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0277798 |
| RPL5 | ribosomal protein L5 | 0.0265885 |
| RPS2 | ribosomal protein S2 | 0.0263593 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0261051 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0259941 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0256737 |
| KIF1B | kinesin family member 1B | 0.0256523 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250351 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0249525 |
| RPS27A | ribosomal protein S27a | 0.0244191 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0244137 |
| PLIN2 | perilipin 2 | 0.0240507 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0236951 |
| WDR45B | WD repeat domain 45B | 0.0234598 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0233872 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0228815 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0221955 |
| PKM | pyruvate kinase, muscle | 0.0221807 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0219877 |
| SMAP1 | small ArfGAP 1 | 0.0217305 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0215646 |
| RPL12 | ribosomal protein L12 | 0.0214741 |
| SET | SET nuclear proto-oncogene | 0.0213606 |
| MATR3 | matrin 3 | 0.0213511 |
| TPD52 | tumor protein D52 | 0.0209882 |
| NGLY1 | N-glycanase 1 | 0.02071 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0204335 |
| RPL26 | ribosomal protein L26 | 0.0203183 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0201717 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0199788 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0199112 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0198633 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0196119 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0195979 |
| RPS14 | ribosomal protein S14 | 0.0195762 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0195569 |
| RPLP0 | ribosomal protein, large, P0 | 0.0194578 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.019453 |
| B2M | beta-2-microglobulin | 0.0193687 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0764735 |
| ITGAV | integrin, alpha V | -0.066427 |
| GPC6 | glypican 6 | -0.0646148 |
| VCL | vinculin | -0.0577659 |
| APOB | apolipoprotein B | -0.0510095 |
| EHBP1 | EH domain binding protein 1 | -0.0498118 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0465423 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0442831 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0405445 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0396628 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.038999 |
| BCL2L1 | BCL2-like 1 | -0.0385428 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0363856 |
| PTCHD4 | patched domain containing 4 | -0.0340257 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.03336 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0325095 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0317097 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0310637 |
| EGR1 | early growth response 1 | -0.0306358 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0295536 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0290171 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0286144 |
| FAT1 | FAT atypical cadherin 1 | -0.0285224 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0284429 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.027833 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0277728 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0274941 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.02658 |
| FAM135A | family with sequence similarity 135, member A | -0.0254508 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0253597 |
| FN1 | fibronectin 1 | -0.0247722 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0245031 |
| RIGI | RNA sensor RIG-I | -0.024044 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.02381 |
| FOXP1 | forkhead box P1 | -0.0232818 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0231353 |
| RNF213 | ring finger protein 213 | -0.0228443 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.022835 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0225797 |
| ENAH | enabled homolog (Drosophila) | -0.0221512 |
| MYO1E | myosin IE | -0.0216867 |
| MRTFA | myocardin related transcription factor A | -0.0214869 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.020519 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0197567 |
| FAM107B | family with sequence similarity 107, member B | -0.0197331 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0196715 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0196467 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0195301 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0193326 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0186181 |
| ATP11A | ATPase, class VI, type 11A | -0.0185955 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0184976 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0184534 |
| ZNF644 | zinc finger protein 644 | -0.0182693 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0180066 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.017932 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0178744 |
| ZFHX3 | zinc finger homeobox 3 | -0.0177706 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0176103 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0174903 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0174344 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0173181 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0171693 |
| RHOB | ras homolog family member B | -0.016971 |
| TRIM26 | tripartite motif containing 26 | -0.0168942 |
| TPM1 | tropomyosin 1 (alpha) | -0.016791 |
| KLF6 | Kruppel-like factor 6 | -0.0166311 |
| THBS1 | thrombospondin 1 | -0.0161441 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0161399 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0161362 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0160968 |
| AHNAK | AHNAK nucleoprotein | -0.016082 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0158382 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.015495 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0152653 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0148735 |
| SLC38A2 | solute carrier family 38, member 2 | -0.01486 |
| RSU1 | Ras suppressor protein 1 | -0.0146518 |
| FILIP1L | filamin A interacting protein 1-like | -0.0146196 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0145486 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0143106 |
| HDAC4 | histone deacetylase 4 | -0.0141105 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0140848 |
| CP | ceruloplasmin (ferroxidase) | -0.0140521 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -0.0140418 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0140264 |
| SMYD3 | SET and MYND domain containing 3 | -0.0138429 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.0138409 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0138248 |
| VIL1 | villin 1 | -0.0138086 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0136515 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0136098 |
| ATXN1 | ataxin 1 | -0.0135587 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.013497 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0134902 |
| SP100 | SP100 nuclear antigen | -0.0133368 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0132133 |
| RASA2 | RAS p21 protein activator 2 | -0.013169 |
| FERMT1 | fermitin family member 1 | -0.0131195 |
| SMAD3 | SMAD family member 3 | -0.0130348 |
