Fingolimod (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.147321
PTMA prothymosin, alpha 0.128388
TXNIP thioredoxin interacting protein 0.114787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.1107
NDRG1 N-myc downstream regulated 1 0.106534
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0993133
DSPP dentin sialophosphoprotein 0.0991333
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0975436
GOLGA4 golgin A4 0.0941641
LMO7 LIM domain 7 0.0926987
FAM13A family with sequence similarity 13, member A 0.084462
LDHA lactate dehydrogenase A 0.0840406
EZR ezrin 0.0820003
ANXA2 annexin A2 0.0816792
ITGA6 integrin, alpha 6 0.0810834
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0791232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0789293
EREG epiregulin 0.0776123
KIF5B kinesin family member 5B 0.0723909
ESYT2 extended synaptotagmin-like protein 2 0.0714016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0680243
NCOR1 nuclear receptor corepressor 1 0.066801
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0643551
FAT1 FAT atypical cadherin 1 0.0629269
MACF1 microtubule-actin crosslinking factor 1 0.0628337
VEGFA vascular endothelial growth factor A 0.0603912
KRT18 keratin 18, type I 0.0600445
KDM7A lysine (K)-specific demethylase 7A 0.0594423
PIGR polymeric immunoglobulin receptor 0.0592708
ABHD2 abhydrolase domain containing 2 0.056854
EEF2 eukaryotic translation elongation factor 2 0.0561664
ENO1 enolase 1, (alpha) 0.0559694
PTPRR protein tyrosine phosphatase, receptor type, R 0.0550745
DSG2 desmoglein 2 0.0520488
EPCAM epithelial cell adhesion molecule 0.0519731
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0514984
ITPRID2 ITPR interacting domain containing 2 0.0486417
ZFAND3 zinc finger, AN1-type domain 3 0.0481962
RNF145 ring finger protein 145 0.0477778
CANX calnexin 0.0456102
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0455289
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0455001
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0454125
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.045403
TMF1 TATA element modulatory factor 1 0.0453447
DSCAM Down syndrome cell adhesion molecule 0.0453055
UBA6 ubiquitin-like modifier activating enzyme 6 0.0450108
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.04493
KDM3A lysine (K)-specific demethylase 3A 0.0442717
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0440919
GCC2 GRIP and coiled-coil domain containing 2 0.0437895
RPS2 ribosomal protein S2 0.0429195
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0426628
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0426091
FNBP1L formin binding protein 1-like 0.0421232
PGK1 phosphoglycerate kinase 1 0.0411688
WDR45B WD repeat domain 45B 0.0407881
UBE2H ubiquitin-conjugating enzyme E2H 0.0407095
OGA O-GlcNAcase 0.0406725
MED13L mediator complex subunit 13-like 0.0406577
PPARG peroxisome proliferator-activated receptor gamma 0.0402813
TRIM2 tripartite motif containing 2 0.0402682
TPD52 tumor protein D52 0.0397474
PKM pyruvate kinase, muscle 0.0392595
SETD5 SET domain containing 5 0.0392397
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0389723
ARHGAP5 Rho GTPase activating protein 5 0.0385555
USP34 ubiquitin specific peptidase 34 0.0381708
KMT2E lysine (K)-specific methyltransferase 2E 0.0381097
PTBP3 polypyrimidine tract binding protein 3 0.0379559
ADD3 adducin 3 (gamma) 0.0375765
RNF43 ring finger protein 43 0.0374989
MBNL2 muscleblind-like splicing regulator 2 0.0373065
MLEC malectin 0.0370952
TTC3 tetratricopeptide repeat domain 3 0.0368629
CCNY cyclin Y 0.0368133
EIF1 eukaryotic translation initiation factor 1 0.0360392
EXOC1 exocyst complex component 1 0.0357682
CLTC clathrin, heavy chain (Hc) 0.035746
BAIAP2L1 BAI1-associated protein 2-like 1 0.0356928
RPS6 ribosomal protein S6 0.0354116
EHF ets homologous factor 0.0353564
SPAG9 sperm associated antigen 9 0.0352441
PLS1 plastin 1 0.0351886
KMT2C lysine (K)-specific methyltransferase 2C 0.0348725
PTEN phosphatase and tensin homolog 0.0345153
CSNK1A1 casein kinase 1, alpha 1 0.0345086
UBC ubiquitin C 0.0342001
USP6NL USP6 N-terminal like 0.0340368
KLF3 Kruppel-like factor 3 (basic) 0.0339493
MXI1 MAX interactor 1, dimerization protein 0.0338627
GSK3B glycogen synthase kinase 3 beta 0.0338295
SHROOM3 shroom family member 3 0.0335553
PLAUR plasminogen activator, urokinase receptor 0.0326423
SRP54 signal recognition particle 54kDa 0.032592
BBX bobby sox homolog (Drosophila) 0.0325
CD2AP CD2-associated protein 0.0324057
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0321562
ZNF292 zinc finger protein 292 0.0321475
AREG amphiregulin 0.0320795

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.0900211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0746216
VCL vinculin -0.0543144
GMDS GDP-mannose 4,6-dehydratase -0.0489257
NALF1 NALCN channel auxiliary factor 1 -0.0486215
FHIT fragile histidine triad -0.0472333
PDE4D phosphodiesterase 4D, cAMP-specific -0.0456637
CEMIP cell migration inducing protein, hyaluronan binding -0.0444751
RAD51B RAD51 paralog B -0.0443624
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0375985
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0363025
ONECUT3 one cut homeobox 3 -0.0360185
SLC35F3 solute carrier family 35, member F3 -0.0348714
MAML3 mastermind-like 3 (Drosophila) -0.0343196
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0342605
ACTG1 actin gamma 1 -0.0299225
EGFR epidermal growth factor receptor -0.0289561
TMSB10 thymosin beta 10 -0.0288802
TRAPPC9 trafficking protein particle complex 9 -0.0284665
EXT1 exostosin glycosyltransferase 1 -0.0276139
DIAPH3 diaphanous-related formin 3 -0.026869
PTPRK protein tyrosine phosphatase, receptor type, K -0.0259233
LPP LIM domain containing preferred translocation partner in lipoma -0.0245493
HMGB1 high mobility group box 1 -0.0237469
LAMA4 laminin, alpha 4 -0.0228938
CCSER1 coiled-coil serine-rich protein 1 -0.0228016
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0227456
AHNAK AHNAK nucleoprotein -0.0216938
PSD3 pleckstrin and Sec7 domain containing 3 -0.0213043
PKP4 plakophilin 4 -0.021238
SAMD5 sterile alpha motif domain containing 5 -0.0210673
PDLIM5 PDZ and LIM domain 5 -0.0207252
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0204966
PCDH9 protocadherin 9 -0.0203628
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.019102
RPL23 ribosomal protein L23 -0.0191014
RPL35A ribosomal protein L35a -0.0190292
GREB1L growth regulation by estrogen in breast cancer-like -0.0190002
INTS6 integrator complex subunit 6 -0.0184672
NSD2 nuclear receptor binding SET domain protein 2 -0.0180473
ECT2 epithelial cell transforming 2 -0.017876
EXOC4 exocyst complex component 4 -0.0177615
PTPRB protein tyrosine phosphatase, receptor type, B -0.0175637
WWOX WW domain containing oxidoreductase -0.0175273
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0173426
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0172931
SMYD3 SET and MYND domain containing 3 -0.0170139
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0166995
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0165976
MBNL1 muscleblind-like splicing regulator 1 -0.0165973
LSAMP limbic system-associated membrane protein -0.0165876
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.0162058
NABP1 nucleic acid binding protein 1 -0.0160285
CFAP44 cilia and flagella associated protein 44 -0.0158819
MAML2 mastermind-like 2 (Drosophila) -0.0157315
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0155549
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0154589
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0154175
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0153102
SPIDR scaffolding protein involved in DNA repair -0.0152025
ANO1 anoctamin 1, calcium activated chloride channel -0.0150726
RABGAP1L RAB GTPase activating protein 1-like -0.0150531
SETX senataxin -0.0150522
PTPRG protein tyrosine phosphatase, receptor type, G -0.0149677
ZBTB20 zinc finger and BTB domain containing 20 -0.0148007
SCLT1 sodium channel and clathrin linker 1 -0.0146916
BICD1 bicaudal D homolog 1 (Drosophila) -0.0146884
TPM1 tropomyosin 1 (alpha) -0.0146151
THSD4 thrombospondin, type I, domain containing 4 -0.0144941
MTAP methylthioadenosine phosphorylase -0.0144684
RPL9 ribosomal protein L9 -0.0144656
TUBB tubulin, beta class I -0.0143053
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0142782
TPT1 tumor protein, translationally-controlled 1 -0.0141944
POF1B premature ovarian failure, 1B -0.0140293
GPR39 G protein-coupled receptor 39 -0.0137719
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0137169
CATSPERB catsper channel auxiliary subunit beta -0.0136976
F3 coagulation factor III (thromboplastin, tissue factor) -0.0136247
DENND1A DENN/MADD domain containing 1A -0.0135932
STPG4 sperm-tail PG-rich repeat containing 4 -0.0135907
HMGA2 high mobility group AT-hook 2 -0.0134929
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0134751
KIAA1549L KIAA1549-like -0.0132143
VWA8 von Willebrand factor A domain containing 8 -0.0132033
TUBB4B tubulin, beta 4B class IVb -0.0131978
UBAP2 ubiquitin associated protein 2 -0.0131968
COMMD10 COMM domain containing 10 -0.01317
MARCHF3 membrane associated ring-CH-type finger 3 -0.0131487
IGF1R insulin-like growth factor 1 receptor -0.0129968
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0129924
AEBP2 AE binding protein 2 -0.0127608
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0126237
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0126015
FUS FUS RNA binding protein -0.0124893
HDAC4 histone deacetylase 4 -0.0122473
CEP128 centrosomal protein 128kDa -0.0122416
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0122289
TENM3 teneurin transmembrane protein 3 -0.0122272
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0122213