Fingolimod (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0968208
GOLGA4 golgin A4 0.0859914
RPS2 ribosomal protein S2 0.0750974
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0542775
DSCAM Down syndrome cell adhesion molecule 0.0507498
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0502981
TTC3 tetratricopeptide repeat domain 3 0.0434568
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0417935
RPL3 ribosomal protein L3 0.0383177
CANX calnexin 0.0379262
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0360002
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0353777
AKAP9 A kinase (PRKA) anchor protein 9 0.0348163
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0344822
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.034425
EPS8 epidermal growth factor receptor pathway substrate 8 0.0340723
ZFC3H1 zinc finger, C3H1-type containing 0.032503
TMF1 TATA element modulatory factor 1 0.032121
KMT2C lysine (K)-specific methyltransferase 2C 0.0317332
SETD5 SET domain containing 5 0.0311827
NKTR natural killer cell triggering receptor 0.0304687
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.030345
SRP54 signal recognition particle 54kDa 0.0297204
ESYT2 extended synaptotagmin-like protein 2 0.0291658
PCBP2 poly(rC) binding protein 2 0.0291343
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0279214
ZCCHC7 zinc finger, CCHC domain containing 7 0.0271373
GMDS GDP-mannose 4,6-dehydratase 0.0268877
SEC31A SEC31 homolog A (S. cerevisiae) 0.0263286
UBA6 ubiquitin-like modifier activating enzyme 6 0.0261461
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0257617
MON2 MON2 homolog (S. cerevisiae) 0.0257116
DSPP dentin sialophosphoprotein 0.0254653
JMY junction mediating and regulatory protein, p53 cofactor 0.0250503
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245141
COPA coatomer protein complex, subunit alpha 0.0240562
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0236595
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0231642
COG5 component of oligomeric golgi complex 5 0.0227415
KMT2E lysine (K)-specific methyltransferase 2E 0.0226834
PDIA3 protein disulfide isomerase family A, member 3 0.0225142
CLINT1 clathrin interactor 1 0.0224828
CALB1 calbindin 1, 28kDa 0.0223147
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0222449
GARS1 glycyl-tRNA synthetase 1 0.021954
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0217651
MED13L mediator complex subunit 13-like 0.0212354
PTEN phosphatase and tensin homolog 0.0211037
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0210741
BTBD9 BTB (POZ) domain containing 9 0.0208798
MLEC malectin 0.0207928
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0207673
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0207092
CSNK1A1 casein kinase 1, alpha 1 0.0205285
EIF4B eukaryotic translation initiation factor 4B 0.0204905
ZFAND3 zinc finger, AN1-type domain 3 0.0204538
PGM3 phosphoglucomutase 3 0.0203722
SEC24A SEC24 family member A 0.0202234
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0198108
GOLGB1 golgin B1 0.0197402
NIPBL Nipped-B homolog (Drosophila) 0.0197383
BIRC6 baculoviral IAP repeat containing 6 0.0197223
RPS18 ribosomal protein S18 0.0197014
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0196746
BRD2 bromodomain containing 2 0.0196482
USP3 ubiquitin specific peptidase 3 0.0194588
CALU calumenin 0.019325
CCPG1 cell cycle progression 1 0.0192033
NUP58 nucleoporin 58 0.0191402
MORF4L2 mortality factor 4 like 2 0.0189214
TRA2A transformer 2 alpha homolog (Drosophila) 0.0188873
GOLT1B golgi transport 1B 0.0188276
HSPA8 heat shock 70kDa protein 8 0.0187821
OGA O-GlcNAcase 0.0187474
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0186481
SUCO SUN domain containing ossification factor 0.0184588
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0182006
SEC24D SEC24 family member D 0.0180866
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.017881
DNM2 dynamin 2 0.0177226
SBF2 SET binding factor 2 0.0177208
ACBD3 acyl-CoA binding domain containing 3 0.0173269
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0172837
ZNF292 zinc finger protein 292 0.0172414
KDM2A lysine (K)-specific demethylase 2A 0.0171164
PAPOLA poly(A) polymerase alpha 0.0170502
RARS1 arginyl-tRNA synthetase 1 0.0170041
MINDY2 MINDY lysine 48 deubiquitinase 2 0.016937
USP34 ubiquitin specific peptidase 34 0.0169349
SLMAP sarcolemma associated protein 0.0168834
CDK13 cyclin-dependent kinase 13 0.0167808
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0167702
FXR1 fragile X mental retardation, autosomal homolog 1 0.0167373
VEGFA vascular endothelial growth factor A 0.0167295
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0166974
SLTM SAFB-like, transcription modulator 0.0166722
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0166655
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0166574
NCKAP1 NCK-associated protein 1 0.0166446
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0165481

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.188307
TPT1 tumor protein, translationally-controlled 1 -0.169654
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109835
RPL35A ribosomal protein L35a -0.0916286
TMSB10 thymosin beta 10 -0.0850348
RPS19 ribosomal protein S19 -0.0733628
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0711984
RPLP0 ribosomal protein, large, P0 -0.0697124
RPL34 ribosomal protein L34 -0.0668088
RPLP2 ribosomal protein, large, P2 -0.0659235
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0636434
RPS23 ribosomal protein S23 -0.0615886
RPS24 ribosomal protein S24 -0.0583702
RPL12 ribosomal protein L12 -0.0574829
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0539844
RPL31 ribosomal protein L31 -0.0538943
RPS8 ribosomal protein S8 -0.0518777
RPL26 ribosomal protein L26 -0.05157
HLA-B major histocompatibility complex, class I, B -0.0505491
RPL37A ribosomal protein L37a -0.0470253
RPS29 ribosomal protein S29 -0.0468445
RPS12 ribosomal protein S12 -0.0439848
RPS21 ribosomal protein S21 -0.0437118
RPS25 ribosomal protein S25 -0.0436155
RPL23 ribosomal protein L23 -0.0429068
RPS13 ribosomal protein S13 -0.0427733
RPS14 ribosomal protein S14 -0.0396863
IFI6 interferon, alpha-inducible protein 6 -0.039292
RPS6 ribosomal protein S6 -0.0390485
RPL37 ribosomal protein L37 -0.0389514
RPS27A ribosomal protein S27a -0.0385361
ACTG1 actin gamma 1 -0.038474
RPL11 ribosomal protein L11 -0.0375483
RPL9 ribosomal protein L9 -0.0365315
MYO1E myosin IE -0.0359989
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0356893
IER3 immediate early response 3 -0.0350553
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0349786
RPL32 ribosomal protein L32 -0.0344075
RPL36 ribosomal protein L36 -0.0340468
RIGI RNA sensor RIG-I -0.0337173
PDE4D phosphodiesterase 4D, cAMP-specific -0.0331722
RPS5 ribosomal protein S5 -0.0321631
RPS17 ribosomal protein S17 -0.0321285
CLDN4 claudin 4 -0.0320785
RPS3 ribosomal protein S3 -0.0319027
RPL19 ribosomal protein L19 -0.0315086
RPL30 ribosomal protein L30 -0.0298301
KRT18 keratin 18, type I -0.0298208
MX1 MX dynamin-like GTPase 1 -0.0294021
S100A10 S100 calcium binding protein A10 -0.0293372
TSPAN8 tetraspanin 8 -0.0287258
RPL27A ribosomal protein L27a -0.0286513
RPS11 ribosomal protein S11 -0.0281658
KLF6 Kruppel-like factor 6 -0.0279725
SP100 SP100 nuclear antigen -0.0277265
MT2A metallothionein 2A -0.0277027
PRSS3 protease, serine, 3 -0.0276484
ANXA2 annexin A2 -0.0273145
RPL28 ribosomal protein L28 -0.0271644
RPS20 ribosomal protein S20 -0.0270889
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0270843
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0269576
IFITM3 interferon induced transmembrane protein 3 -0.0269224
RPL8 ribosomal protein L8 -0.0269054
ACTN4 actinin, alpha 4 -0.0264113
RNF213 ring finger protein 213 -0.0260948
RPS16 ribosomal protein S16 -0.0260633
RPL36A ribosomal protein L36a -0.0258234
ISG15 ISG15 ubiquitin-like modifier -0.0256235
RPS15 ribosomal protein S15 -0.025182
DSG3 desmoglein 3 -0.0250438
F3 coagulation factor III (thromboplastin, tissue factor) -0.0246307
LAMA4 laminin, alpha 4 -0.0245575
S100A9 S100 calcium binding protein A9 -0.024439
RPL35 ribosomal protein L35 -0.0244361
RPL13A ribosomal protein L13a -0.0244013
PKP2 plakophilin 2 -0.0241221
VCL vinculin -0.0240545
KRT8 keratin 8, type II -0.0240029
RPS27 ribosomal protein S27 -0.0236126
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0234931
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0230697
EGR1 early growth response 1 -0.0228967
SERINC5 serine incorporator 5 -0.0228117
LAMB3 laminin, beta 3 -0.022777
S100A6 S100 calcium binding protein A6 -0.0225623
RPS4X ribosomal protein S4, X-linked -0.0220249
RPL5 ribosomal protein L5 -0.0218108
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0215192
PKM pyruvate kinase, muscle -0.021135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.020749
RACK1 receptor for activated C kinase 1 -0.0203005
C6ORF132 chromosome 6 open reading frame 132 -0.0200514
IFI27 interferon, alpha-inducible protein 27 -0.0199694
PLSCR1 phospholipid scramblase 1 -0.0199162
MUC13 mucin 13, cell surface associated -0.0197291
IFIH1 interferon induced with helicase C domain 1 -0.0195257
RPL38 ribosomal protein L38 -0.0193254
PTMA prothymosin, alpha -0.0189862