Fingolimod (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.210424
DLG1 discs, large homolog 1 (Drosophila) 0.178731
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.167479
DST dystonin 0.138183
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.116374
VIM vimentin 0.113654
TMSB4X thymosin beta 4, X-linked 0.102298
TMSB10 thymosin beta 10 0.0921523
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0885811
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0850524
TSC22D1 TSC22 domain family, member 1 0.0849509
ZDHHC14 zinc finger, DHHC-type containing 14 0.082195
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0793609
EHBP1 EH domain binding protein 1 0.0785337
ESYT2 extended synaptotagmin-like protein 2 0.0781775
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0780872
EFNA5 ephrin-A5 0.0776718
MYOF myoferlin 0.0740651
EPHA4 EPH receptor A4 0.0734506
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0727048
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0712701
ENO2 enolase 2 (gamma, neuronal) 0.0710747
CD44 CD44 molecule (Indian blood group) 0.0679168
APP amyloid beta (A4) precursor protein 0.067642
DOCK11 dedicator of cytokinesis 11 0.0668824
TNS3 tensin 3 0.0641713
HDAC9 histone deacetylase 9 0.0635397
FTL ferritin, light polypeptide 0.0633318
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0611849
POTEF POTE ankyrin domain family, member F 0.0595458
MINDY2 MINDY lysine 48 deubiquitinase 2 0.058575
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.05751
FNIP1 folliculin interacting protein 1 0.056867
ERRFI1 ERBB receptor feedback inhibitor 1 0.0561596
CSMD3 CUB and Sushi multiple domains 3 0.0550834
CADM2 cell adhesion molecule 2 0.0540905
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0540104
MBNL2 muscleblind-like splicing regulator 2 0.0533333
LDHA lactate dehydrogenase A 0.0528422
CANX calnexin 0.0527599
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0518398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512252
PIAS2 protein inhibitor of activated STAT, 2 0.0510635
RAB7A RAB7A, member RAS oncogene family 0.0507054
RNF213 ring finger protein 213 0.0491989
DNER delta/notch-like EGF repeat containing 0.0483816
RAD51B RAD51 paralog B 0.0471969
PTPRF protein tyrosine phosphatase, receptor type, F 0.0470396
FMNL2 formin-like 2 0.046569
YEATS2 YEATS domain containing 2 0.0465379
PGK1 phosphoglycerate kinase 1 0.046052
PLK2 polo-like kinase 2 0.0459908
ARHGAP5 Rho GTPase activating protein 5 0.0459647
CLIP2 CAP-GLY domain containing linker protein 2 0.0455092
LOXL2 lysyl oxidase-like 2 0.0441743
TXNIP thioredoxin interacting protein 0.0439956
TMEM123 transmembrane protein 123 0.0439457
EPB41 erythrocyte membrane protein band 4.1 0.0439166
WASF2 WAS protein family, member 2 0.043191
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0431098
ADAM10 ADAM metallopeptidase domain 10 0.0430308
SLK STE20-like kinase 0.042866
RUNX1 runt-related transcription factor 1 0.042353
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0422853
TP63 tumor protein p63 0.0414412
ENO1 enolase 1, (alpha) 0.0414157
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0411397
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0410411
TTC3 tetratricopeptide repeat domain 3 0.0407743
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0403169
PATJ PATJ crumbs cell polarity complex component 0.0400407
EXOC4 exocyst complex component 4 0.0398209
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0395055
MACF1 microtubule-actin crosslinking factor 1 0.0389685
GOLGA4 golgin A4 0.0385236
TIMP2 TIMP metallopeptidase inhibitor 2 0.0379452
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0376306
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0367504
WSB1 WD repeat and SOCS box containing 1 0.0358969
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0355327
DDIT4 DNA-damage-inducible transcript 4 0.0355048
LRRC49 leucine rich repeat containing 49 0.035299
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0350272
CALR calreticulin 0.0349006
PTK2 protein tyrosine kinase 2 0.0348704
SET SET nuclear proto-oncogene 0.0346526
MEF2A myocyte enhancer factor 2A 0.0340523
LYST lysosomal trafficking regulator 0.033794
ZMYND8 zinc finger, MYND-type containing 8 0.0331836
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0331677
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0329716
ZFP36L1 ZFP36 ring finger protein-like 1 0.0327898
NDRG1 N-myc downstream regulated 1 0.0327689
EGFR epidermal growth factor receptor 0.0325808
MAP4 microtubule-associated protein 4 0.0323749
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0317574
CD109 CD109 molecule 0.0316448
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0310893
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0302188
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0301176

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.170066
TM4SF1 transmembrane 4 L six family member 1 -0.103849
MT2A metallothionein 2A -0.0916026
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0905577
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0704746
ZFAND3 zinc finger, AN1-type domain 3 -0.0470336
USP34 ubiquitin specific peptidase 34 -0.0468114
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0455634
EMP1 epithelial membrane protein 1 -0.0437469
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0428442
RTN4 reticulon 4 -0.0424179
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0408141
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0392834
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0380783
CDCP1 CUB domain containing protein 1 -0.0351514
TMEM41B transmembrane protein 41B -0.0342897
KMT2E lysine (K)-specific methyltransferase 2E -0.0341327
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0323274
ZEB1 zinc finger E-box binding homeobox 1 -0.0321215
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0301338
MT1X metallothionein 1X -0.027876
CFLAR CASP8 and FADD-like apoptosis regulator -0.0277066
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0267628
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0262024
PDE4D phosphodiesterase 4D, cAMP-specific -0.0260354
WDR26 WD repeat domain 26 -0.0254328
USP12 ubiquitin specific peptidase 12 -0.025313
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0250295
YBX3 Y box binding protein 3 -0.0250278
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -0.0240413
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0240152
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0231976
TPT1 tumor protein, translationally-controlled 1 -0.0231837
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0227144
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0226666
EREG epiregulin -0.0221903
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0218901
FERMT1 fermitin family member 1 -0.0216929
ERCC1 excision repair cross-complementation group 1 -0.0215892
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0215032
HSPA8 heat shock 70kDa protein 8 -0.0212476
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0211693
DIAPH3 diaphanous-related formin 3 -0.0207673
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0207056
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0206026
ARHGAP29 Rho GTPase activating protein 29 -0.0203709
RRM2 ribonucleotide reductase M2 -0.0203494
CHD7 chromodomain helicase DNA binding protein 7 -0.0202496
RECQL RecQ helicase-like -0.0200402
SMC4 structural maintenance of chromosomes 4 -0.0200194
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0199433
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0198988
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0195431
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.019419
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0193395
EXT1 exostosin glycosyltransferase 1 -0.0192852
SFPQ splicing factor proline/glutamine-rich -0.0191519
IL6ST interleukin 6 signal transducer -0.0187655
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0186741
SPRY4 sprouty homolog 4 (Drosophila) -0.0186082
AREG amphiregulin -0.0182748
SDC4 syndecan 4 -0.0179734
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0179073
IPO7 importin 7 -0.0177751
MT1E metallothionein 1E -0.0172106
MIS18BP1 MIS18 binding protein 1 -0.0170525
ZFAND6 zinc finger, AN1-type domain 6 -0.0170454
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0170055
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0169097
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.016823
TNPO1 transportin 1 -0.0166737
RASA2 RAS p21 protein activator 2 -0.0163886
MKI67 marker of proliferation Ki-67 -0.0163352
AHNAK AHNAK nucleoprotein -0.0160538
SPIDR scaffolding protein involved in DNA repair -0.0159355
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0159026
PLAUR plasminogen activator, urokinase receptor -0.0157741
SGO2 shugoshin 2 -0.0154999
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0154448
YAP1 Yes-associated protein 1 -0.0153228
PRDX1 peroxiredoxin 1 -0.0151498
GPHN gephyrin -0.0150902
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0150689
NCKAP1 NCK-associated protein 1 -0.0150577
GAN gigaxonin -0.0150287
MAPK8 mitogen-activated protein kinase 8 -0.0149716
ADAM17 ADAM metallopeptidase domain 17 -0.0149511
TMED5 transmembrane emp24 protein transport domain containing 5 -0.0148512
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.014815
PRKD3 protein kinase D3 -0.0148022
WWTR1 WW domain containing transcription regulator 1 -0.014762
NIPBL Nipped-B homolog (Drosophila) -0.014698
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0146583
FHL2 four and a half LIM domains 2 -0.0145855
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0145673
TJP1 tight junction protein 1 -0.0145243
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0145203
CENPE centromere protein E, 312kDa -0.0145031
CREB5 cAMP responsive element binding protein 5 -0.0144378
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0143759