Fingolimod (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.098344
AKAP12 A kinase (PRKA) anchor protein 12 0.0939191
ERRFI1 ERBB receptor feedback inhibitor 1 0.0752427
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0678827
MT2A metallothionein 2A 0.0661204
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0637351
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0633887
MACF1 microtubule-actin crosslinking factor 1 0.0622163
POTEF POTE ankyrin domain family, member F 0.0621601
ELL2 elongation factor, RNA polymerase II, 2 0.060193
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0597843
MCL1 myeloid cell leukemia 1 0.0590388
SPAG9 sperm associated antigen 9 0.0589492
WAC WW domain containing adaptor with coiled-coil 0.0586692
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0578178
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0540591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.053547
ZFAND3 zinc finger, AN1-type domain 3 0.0528111
KTN1 kinectin 1 (kinesin receptor) 0.0518065
BIRC3 baculoviral IAP repeat containing 3 0.049689
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0494385
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0476193
APP amyloid beta (A4) precursor protein 0.0474852
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0469965
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0463207
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0449233
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0446056
TPD52 tumor protein D52 0.0444681
UBASH3B ubiquitin associated and SH3 domain containing B 0.0436272
RICTOR RPTOR independent companion of MTOR, complex 2 0.0433018
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0432204
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0425823
PDIA3 protein disulfide isomerase family A, member 3 0.0416658
ADAM17 ADAM metallopeptidase domain 17 0.0413118
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0412995
SMOC1 SPARC related modular calcium binding 1 0.0410792
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.041034
EEF2 eukaryotic translation elongation factor 2 0.0410302
CSNK1A1 casein kinase 1, alpha 1 0.0388903
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0387117
MYH9 myosin, heavy chain 9, non-muscle 0.0387108
TASOR2 transcription activation suppressor family member 2 0.0382507
KMT2E lysine (K)-specific methyltransferase 2E 0.0382276
GLG1 golgi glycoprotein 1 0.0375553
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0368472
BRD2 bromodomain containing 2 0.0365506
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0353943
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0352939
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0350595
CCNL1 cyclin L1 0.0346648
NCKAP1 NCK-associated protein 1 0.0345812
FTH1 ferritin, heavy polypeptide 1 0.034392
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0331708
COPA coatomer protein complex, subunit alpha 0.0331658
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0329711
RAB1A RAB1A, member RAS oncogene family 0.0320475
TM4SF1 transmembrane 4 L six family member 1 0.0319693
PKM pyruvate kinase, muscle 0.0317825
APLP2 amyloid beta (A4) precursor-like protein 2 0.031662
FMNL2 formin-like 2 0.0314471
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0310454
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0309872
PDIA6 protein disulfide isomerase family A, member 6 0.0307983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0304901
USP3 ubiquitin specific peptidase 3 0.0300997
GPBP1 GC-rich promoter binding protein 1 0.0299699
FXR1 fragile X mental retardation, autosomal homolog 1 0.0297171
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0297042
SUCO SUN domain containing ossification factor 0.0291912
RBM39 RNA binding motif protein 39 0.029031
SAMD4A sterile alpha motif domain containing 4A 0.0289093
MYOF myoferlin 0.0287515
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0286605
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.028581
WDR43 WD repeat domain 43 0.0284958
DOCK5 dedicator of cytokinesis 5 0.0283193
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282569
GGNBP2 gametogenetin binding protein 2 0.0282498
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0279036
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0277774
SEC23A Sec23 homolog A (S. cerevisiae) 0.0275581
USP34 ubiquitin specific peptidase 34 0.0274884
DENND4A DENN/MADD domain containing 4A 0.0274255
SEC31A SEC31 homolog A (S. cerevisiae) 0.0271001
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0269273
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0267085
IQGAP1 IQ motif containing GTPase activating protein 1 0.0266956
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.026666
CPNE8 copine VIII 0.0262905
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0261752
RAB2A RAB2A, member RAS oncogene family 0.025866
GLS2 glutaminase 2 (liver, mitochondrial) 0.0257451
CCL5 chemokine (C-C motif) ligand 5 0.0257435
DOCK4 dedicator of cytokinesis 4 0.0253656
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0252238
BRWD1 bromodomain and WD repeat domain containing 1 0.0251286
FGA fibrinogen alpha chain 0.0250968
CHD1 chromodomain helicase DNA binding protein 1 0.0249167
TLN1 talin 1 0.0248794
TRA2A transformer 2 alpha homolog (Drosophila) 0.0247032

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.157347
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0952051
THSD4 thrombospondin, type I, domain containing 4 -0.0915575
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0774197
VIM vimentin -0.0728473
PTMA prothymosin, alpha -0.0665197
RPS21 ribosomal protein S21 -0.0659499
RPL23 ribosomal protein L23 -0.0592429
BASP1 brain abundant, membrane attached signal protein 1 -0.0563829
RPL19 ribosomal protein L19 -0.055691
TPT1 tumor protein, translationally-controlled 1 -0.0480952
GRAMD1B GRAM domain containing 1B -0.0471997
ACTG1 actin gamma 1 -0.0471118
RPS8 ribosomal protein S8 -0.0449257
RPLP1 ribosomal protein, large, P1 -0.0440303
S100A6 S100 calcium binding protein A6 -0.0431805
BICC1 BicC family RNA binding protein 1 -0.0420329
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0408594
CAVIN1 caveolae associated protein 1 -0.038985
ATP5F1E ATP synthase F1 subunit epsilon -0.0388826
RPL26 ribosomal protein L26 -0.0374427
RPL36 ribosomal protein L36 -0.0373014
LMNA lamin A/C -0.0367946
SLC38A2 solute carrier family 38, member 2 -0.0354019
S100A10 S100 calcium binding protein A10 -0.0345284
SRGN serglycin -0.0342184
ZBTB20 zinc finger and BTB domain containing 20 -0.0340406
NRG1 neuregulin 1 -0.0340271
RAB7A RAB7A, member RAS oncogene family -0.0333398
C15ORF48 chromosome 15 open reading frame 48 -0.0325471
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0324675
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0324084
OSMR oncostatin M receptor -0.0320184
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0311729
RPS19 ribosomal protein S19 -0.0306748
RPL18 ribosomal protein L18 -0.0304335
AHNAK AHNAK nucleoprotein -0.0301849
RPS12 ribosomal protein S12 -0.0301591
IER3 immediate early response 3 -0.0301273
RPLP2 ribosomal protein, large, P2 -0.0296746
IGFBP4 insulin-like growth factor binding protein 4 -0.0294785
HMGB1 high mobility group box 1 -0.029246
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.02879
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0278534
EHBP1 EH domain binding protein 1 -0.0277625
MSRB3 methionine sulfoxide reductase B3 -0.0276609
ROMO1 reactive oxygen species modulator 1 -0.0266189
RPLP0 ribosomal protein, large, P0 -0.0265735
EGR1 early growth response 1 -0.0265404
PDE4D phosphodiesterase 4D, cAMP-specific -0.0264148
SERF2 small EDRK-rich factor 2 -0.0262045
ASTN2 astrotactin 2 -0.0258213
PFN1 profilin 1 -0.0249548
RPS29 ribosomal protein S29 -0.0248924
COL4A5 collagen, type IV, alpha 5 -0.0244725
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0243454
MAML3 mastermind-like 3 (Drosophila) -0.0241791
RPS27A ribosomal protein S27a -0.0240411
PFDN2 prefoldin subunit 2 -0.0239049
HDAC9 histone deacetylase 9 -0.0238958
RPS6 ribosomal protein S6 -0.0238531
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0234473
RNF213 ring finger protein 213 -0.0234464
RPL35A ribosomal protein L35a -0.0233788
MYL12B myosin, light chain 12B, regulatory -0.0231074
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0229597
RAD21 RAD21 homolog (S. pombe) -0.0229261
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0229018
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0227169
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.0224021
S100A9 S100 calcium binding protein A9 -0.0223762
LGALS1 lectin, galactoside-binding, soluble, 1 -0.022023
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0219889
PCED1B PC-esterase domain containing 1B -0.0218062
THBS1 thrombospondin 1 -0.021761
HMGA1 high mobility group AT-hook 1 -0.021456
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0211517
RPL36AL ribosomal protein L36a-like -0.0209538
SOX4 SRY (sex determining region Y)-box 4 -0.0206635
KLF6 Kruppel-like factor 6 -0.0205668
HMGA2 high mobility group AT-hook 2 -0.0201705
RACK1 receptor for activated C kinase 1 -0.0198449
RPL12 ribosomal protein L12 -0.019696
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0194823
RABGAP1L RAB GTPase activating protein 1-like -0.0193372
RPL30 ribosomal protein L30 -0.0192994
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0187308
RPS16 ribosomal protein S16 -0.0186983
TBC1D5 TBC1 domain family, member 5 -0.0182572
NEGR1 neuronal growth regulator 1 -0.0182017
PA2G4 proliferation-associated 2G4, 38kDa -0.0181734
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0180482
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0179865
RPS24 ribosomal protein S24 -0.017828
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0177808
THSD7A thrombospondin, type I, domain containing 7A -0.0177367
RSL1D1 ribosomal L1 domain containing 1 -0.01772
NPR2 natriuretic peptide receptor 2 -0.0177191
ZMYND8 zinc finger, MYND-type containing 8 -0.0174549
PATJ PATJ crumbs cell polarity complex component -0.0174096