Fingolimod (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.144559
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.1395
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0993802
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0956479
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0812329
POTEF POTE ankyrin domain family, member F 0.0794044
TSC22D2 TSC22 domain family, member 2 0.0791251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0790851
NAMPT nicotinamide phosphoribosyltransferase 0.0764483
ASPH aspartate beta-hydroxylase 0.0728059
NDRG1 N-myc downstream regulated 1 0.0653179
FNDC3B fibronectin type III domain containing 3B 0.0632798
FAM13A family with sequence similarity 13, member A 0.0575239
LAMC2 laminin, gamma 2 0.0525696
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.048173
HMGB2 high mobility group box 2 0.0472273
FXR1 fragile X mental retardation, autosomal homolog 1 0.0468675
ELL2 elongation factor, RNA polymerase II, 2 0.0458969
UBA6 ubiquitin-like modifier activating enzyme 6 0.0450988
ADAM9 ADAM metallopeptidase domain 9 0.0446473
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0446443
MYH9 myosin, heavy chain 9, non-muscle 0.0445239
RNF145 ring finger protein 145 0.0440417
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0428798
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.042862
ZNF292 zinc finger protein 292 0.0405528
CANX calnexin 0.0405084
MSN moesin 0.039764
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.037884
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0375572
TFG TRK-fused gene 0.0374452
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0372543
HSPA8 heat shock 70kDa protein 8 0.0367206
DSPP dentin sialophosphoprotein 0.0363746
MARCHF6 membrane associated ring-CH-type finger 6 0.0361639
TRIO trio Rho guanine nucleotide exchange factor 0.0354369
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0352844
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0348999
PAPOLA poly(A) polymerase alpha 0.0344151
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.032766
RAD21 RAD21 homolog (S. pombe) 0.0327089
KMT2E lysine (K)-specific methyltransferase 2E 0.0321949
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.032017
GRB10 growth factor receptor-bound protein 10 0.0318459
PCBP2 poly(rC) binding protein 2 0.0317152
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0316487
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0315183
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0313391
MATR3 matrin 3 0.0311782
SPAG9 sperm associated antigen 9 0.0308853
CCNL1 cyclin L1 0.0306194
TPM3 tropomyosin 3 0.0304762
RYBP RING1 and YY1 binding protein 0.0301563
GARS1 glycyl-tRNA synthetase 1 0.0301092
ARRDC3 arrestin domain containing 3 0.0299214
RBM39 RNA binding motif protein 39 0.0297006
USP3 ubiquitin specific peptidase 3 0.029631
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0290304
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0287983
CDC73 cell division cycle 73 0.0287868
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.02855
LDHA lactate dehydrogenase A 0.0285047
RLF rearranged L-myc fusion 0.0283677
BHLHE40 basic helix-loop-helix family, member e40 0.0275186
RPS2 ribosomal protein S2 0.0275119
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0272627
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0272411
NCKAP1 NCK-associated protein 1 0.0271945
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0257498
PGK1 phosphoglycerate kinase 1 0.0257457
EEF2 eukaryotic translation elongation factor 2 0.0257089
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.025593
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0253245
APLP2 amyloid beta (A4) precursor-like protein 2 0.0252762
CLINT1 clathrin interactor 1 0.0251388
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0245711
SSBP2 single-stranded DNA binding protein 2 0.0245032
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.024451
ANXA5 annexin A5 0.0242501
NUP58 nucleoporin 58 0.0240657
PTK2 protein tyrosine kinase 2 0.0240147
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0239782
DSG2 desmoglein 2 0.0238847
KDM3A lysine (K)-specific demethylase 3A 0.0238616
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0232873
CALR calreticulin 0.0232501
UBC ubiquitin C 0.0231976
WAC WW domain containing adaptor with coiled-coil 0.0227601
MEF2A myocyte enhancer factor 2A 0.0227262
YBX3 Y box binding protein 3 0.0226596
TOP1 topoisomerase (DNA) I 0.0222417
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0221921
RHEB Ras homolog enriched in brain 0.0220663
APP amyloid beta (A4) precursor protein 0.0219876
IQGAP1 IQ motif containing GTPase activating protein 1 0.0218364
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0217643
PDIA6 protein disulfide isomerase family A, member 6 0.0217376
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0217049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0211151
NPEPPS aminopeptidase puromycin sensitive 0.0209811

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.117439
TMSB10 thymosin beta 10 -0.094291
PTMA prothymosin, alpha -0.0927071
RPL35A ribosomal protein L35a -0.0900333
ACTG1 actin gamma 1 -0.071941
TPT1 tumor protein, translationally-controlled 1 -0.0669502
EIF1 eukaryotic translation initiation factor 1 -0.051797
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0506954
EXT1 exostosin glycosyltransferase 1 -0.0498953
SAMD4A sterile alpha motif domain containing 4A -0.0490857
RPLP1 ribosomal protein, large, P1 -0.0483507
HLA-B major histocompatibility complex, class I, B -0.0454917
RPS8 ribosomal protein S8 -0.0452387
ZSWIM6 zinc finger, SWIM-type containing 6 -0.044255
RPS29 ribosomal protein S29 -0.04388
RPL34 ribosomal protein L34 -0.0413844
IFI27 interferon, alpha-inducible protein 27 -0.0412782
IFI6 interferon, alpha-inducible protein 6 -0.03857
RPL9 ribosomal protein L9 -0.0381805
RPL23 ribosomal protein L23 -0.0367891
RPS23 ribosomal protein S23 -0.0359429
RPLP2 ribosomal protein, large, P2 -0.0358206
RPS13 ribosomal protein S13 -0.0356174
RPL37A ribosomal protein L37a -0.0354071
IFITM3 interferon induced transmembrane protein 3 -0.0334074
ISG15 ISG15 ubiquitin-like modifier -0.033102
RPS19 ribosomal protein S19 -0.0330725
HLA-A major histocompatibility complex, class I, A -0.0326918
RPL31 ribosomal protein L31 -0.0320414
LPP LIM domain containing preferred translocation partner in lipoma -0.0315713
FBXO32 F-box protein 32 -0.0310673
EFNA5 ephrin-A5 -0.030733
VCL vinculin -0.0297033
VIM vimentin -0.02917
MYO1E myosin IE -0.028547
RPS27A ribosomal protein S27a -0.0283609
SOX4 SRY (sex determining region Y)-box 4 -0.0272713
CSTB cystatin B (stefin B) -0.0266991
RPS3 ribosomal protein S3 -0.0254913
RPS24 ribosomal protein S24 -0.0242001
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0239842
RPS25 ribosomal protein S25 -0.0239161
RPL37 ribosomal protein L37 -0.0239121
LIMCH1 LIM and calponin homology domains 1 -0.0236165
RPL36A ribosomal protein L36a -0.0231241
IFI16 interferon, gamma-inducible protein 16 -0.022951
GOLGB1 golgin B1 -0.022506
ARHGAP5 Rho GTPase activating protein 5 -0.0219204
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0215362
HLA-E major histocompatibility complex, class I, E -0.0212996
FBXO34 F-box protein 34 -0.0211864
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0211715
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0205753
S100A10 S100 calcium binding protein A10 -0.0203151
RPS27 ribosomal protein S27 -0.0202455
RPS10 ribosomal protein S10 -0.0200981
RPL28 ribosomal protein L28 -0.0200734
FNIP1 folliculin interacting protein 1 -0.0199012
SCFD1 sec1 family domain containing 1 -0.0198701
RPL38 ribosomal protein L38 -0.0194944
RPS12 ribosomal protein S12 -0.019429
ATXN1 ataxin 1 -0.0193956
RPS17 ribosomal protein S17 -0.0193792
RBM47 RNA binding motif protein 47 -0.0193621
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0193234
IFITM1 interferon induced transmembrane protein 1 -0.0192407
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0191253
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0191216
TBCA tubulin folding cofactor A -0.0188106
NIPBL Nipped-B homolog (Drosophila) -0.0186666
WSB1 WD repeat and SOCS box containing 1 -0.0185976
SACK1A scaffolding CK1 anchoring protein A -0.0185405
RPS16 ribosomal protein S16 -0.0185331
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0182979
S100A9 S100 calcium binding protein A9 -0.0182463
BLZF1 basic leucine zipper nuclear factor 1 -0.0180968
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0180319
ZBTB20 zinc finger and BTB domain containing 20 -0.0179858
INTS6 integrator complex subunit 6 -0.0177643
CAVIN1 caveolae associated protein 1 -0.0175066
RPS14 ribosomal protein S14 -0.0171571
RPL30 ribosomal protein L30 -0.0170759
MX2 MX dynamin-like GTPase 2 -0.016984
ENO2 enolase 2 (gamma, neuronal) -0.0168044
RNF213 ring finger protein 213 -0.0167984
ANKRD12 ankyrin repeat domain 12 -0.0166839
RPS21 ribosomal protein S21 -0.0164887
CDK13 cyclin-dependent kinase 13 -0.0164874
IFIH1 interferon induced with helicase C domain 1 -0.0164831
RPL19 ribosomal protein L19 -0.0164688
RPL36AL ribosomal protein L36a-like -0.0164614
RPL36 ribosomal protein L36 -0.0161782
CUX1 cut-like homeobox 1 -0.0161447
TTC3 tetratricopeptide repeat domain 3 -0.016089
CEP350 centrosomal protein 350kDa -0.0159461
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0159431
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.015873
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0157785
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0157487
RAB7A RAB7A, member RAS oncogene family -0.0157324