Fingolimod (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.197516
LIMCH1 LIM and calponin homology domains 1 0.133642
MCL1 myeloid cell leukemia 1 0.104225
IGFBP3 insulin-like growth factor binding protein 3 0.0980004
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0929545
DST dystonin 0.0903192
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0863947
MYOF myoferlin 0.0839809
ASPH aspartate beta-hydroxylase 0.0757142
KYNU kynureninase 0.0754261
NAMPT nicotinamide phosphoribosyltransferase 0.071258
GDA guanine deaminase 0.0694793
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.068919
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0686203
TRIO trio Rho guanine nucleotide exchange factor 0.0675328
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.06388
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0637018
SAMD4A sterile alpha motif domain containing 4A 0.0634725
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0627924
ELL2 elongation factor, RNA polymerase II, 2 0.0618365
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0539312
PTEN phosphatase and tensin homolog 0.0527466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0503398
ESYT2 extended synaptotagmin-like protein 2 0.0488772
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.047525
PDE10A phosphodiesterase 10A 0.0472548
PSD3 pleckstrin and Sec7 domain containing 3 0.0468252
ERRFI1 ERBB receptor feedback inhibitor 1 0.0465438
MFF mitochondrial fission factor 0.0462009
PM20D1 peptidase M20 domain containing 1 0.0460526
COL4A6 collagen, type IV, alpha 6 0.043904
USP34 ubiquitin specific peptidase 34 0.0435163
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0432844
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0432072
MSN moesin 0.0428208
FNDC3B fibronectin type III domain containing 3B 0.0423009
NPAS2 neuronal PAS domain protein 2 0.0417993
BIRC6 baculoviral IAP repeat containing 6 0.041632
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0415843
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0410947
GOLGA4 golgin A4 0.0404803
COPA coatomer protein complex, subunit alpha 0.0404738
DNER delta/notch-like EGF repeat containing 0.0396636
COL8A1 collagen, type VIII, alpha 1 0.0394522
PCBP2 poly(rC) binding protein 2 0.0393807
FLNB filamin B, beta 0.038805
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0383963
FNDC3A fibronectin type III domain containing 3A 0.0379974
ITPRID2 ITPR interacting domain containing 2 0.0377905
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0373412
PYGL phosphorylase, glycogen, liver 0.0364833
DOCK4 dedicator of cytokinesis 4 0.0359282
TGFBR1 transforming growth factor, beta receptor 1 0.0357118
AVL9 AVL9 homolog (S. cerevisiase) 0.0342654
CTSC cathepsin C 0.034251
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0337167
GRAMD1B GRAM domain containing 1B 0.0336196
RTN4 reticulon 4 0.0334304
CSNK1A1 casein kinase 1, alpha 1 0.0329761
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0323992
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0323818
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0320598
SPAG9 sperm associated antigen 9 0.031539
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.031419
CANX calnexin 0.0313995
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0307734
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307719
GIGYF2 GRB10 interacting GYF protein 2 0.0304286
RGS2 regulator of G-protein signaling 2 0.0303651
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0299728
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0296148
NEK7 NIMA-related kinase 7 0.0294934
VMP1 vacuole membrane protein 1 0.0294404
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0292137
KMT2C lysine (K)-specific methyltransferase 2C 0.0292012
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290489
ZC3H11A zinc finger CCCH-type containing 11A 0.0289011
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0286149
NBAS neuroblastoma amplified sequence 0.0283398
SLC38A2 solute carrier family 38, member 2 0.0283209
CENPF centromere protein F, 350/400kDa 0.028184
MON2 MON2 homolog (S. cerevisiae) 0.0281708
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0280796
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0279489
CLTC clathrin, heavy chain (Hc) 0.0279388
PDIA6 protein disulfide isomerase family A, member 6 0.0276207
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0274471
NDRG1 N-myc downstream regulated 1 0.0274428
CARD16 caspase recruitment domain family, member 16 0.0269681
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0266709
PLCB4 phospholipase C, beta 4 0.0263989
SETX senataxin 0.0258193
NBEAL1 neurobeachin-like 1 0.025752
ZFC3H1 zinc finger, C3H1-type containing 0.0253821
NRCAM neuronal cell adhesion molecule 0.024976
USP9X ubiquitin specific peptidase 9, X-linked 0.0248894
ARHGAP29 Rho GTPase activating protein 29 0.0248452
KMT2E lysine (K)-specific methyltransferase 2E 0.0247269
KTN1 kinectin 1 (kinesin receptor) 0.0247071
LAMA1 laminin, alpha 1 0.0246952

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.150645
VIM vimentin -0.124359
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.117594
RPLP1 ribosomal protein, large, P1 -0.107993
PDE4D phosphodiesterase 4D, cAMP-specific -0.104561
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0938965
PTMA prothymosin, alpha -0.0914784
TMSB10 thymosin beta 10 -0.0898287
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0836319
RPS24 ribosomal protein S24 -0.0834536
NALF1 NALCN channel auxiliary factor 1 -0.0803583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0802004
RPL35A ribosomal protein L35a -0.0755024
CDH13 cadherin 13 -0.0718301
RPS8 ribosomal protein S8 -0.0715677
FTL ferritin, light polypeptide -0.0658537
RPL26 ribosomal protein L26 -0.0609934
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0585548
RPL12 ribosomal protein L12 -0.0582555
RPL37A ribosomal protein L37a -0.0579486
RPL31 ribosomal protein L31 -0.0579014
RPS6 ribosomal protein S6 -0.0561052
RPLP0 ribosomal protein, large, P0 -0.0558707
RPL34 ribosomal protein L34 -0.0529518
RPS19 ribosomal protein S19 -0.0523554
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0523091
COL5A2 collagen, type V, alpha 2 -0.048444
RPS27A ribosomal protein S27a -0.0482048
FN1 fibronectin 1 -0.0468728
LSAMP limbic system-associated membrane protein -0.046704
RPL9 ribosomal protein L9 -0.0463564
RPL36A ribosomal protein L36a -0.0460554
RPL23 ribosomal protein L23 -0.0458574
RPL19 ribosomal protein L19 -0.0456753
RPLP2 ribosomal protein, large, P2 -0.0454175
RPL38 ribosomal protein L38 -0.043635
RPS12 ribosomal protein S12 -0.0435324
SMYD3 SET and MYND domain containing 3 -0.0429549
SOX4 SRY (sex determining region Y)-box 4 -0.0400939
RPL37 ribosomal protein L37 -0.0398422
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0395868
RPS3 ribosomal protein S3 -0.0387046
NAP1L1 nucleosome assembly protein 1-like 1 -0.0386605
RPS14 ribosomal protein S14 -0.037979
RPS29 ribosomal protein S29 -0.0371968
RPS23 ribosomal protein S23 -0.0369054
RPS27 ribosomal protein S27 -0.0360016
RPS25 ribosomal protein S25 -0.0358121
HLA-B major histocompatibility complex, class I, B -0.035663
RPS21 ribosomal protein S21 -0.0356194
S100A10 S100 calcium binding protein A10 -0.0353442
RPL13A ribosomal protein L13a -0.0339694
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0334226
RPL11 ribosomal protein L11 -0.0329848
RPS4X ribosomal protein S4, X-linked -0.0326159
RPL35 ribosomal protein L35 -0.0324555
RPS16 ribosomal protein S16 -0.0322268
ACTG1 actin gamma 1 -0.0321046
RPL7A ribosomal protein L7a -0.0307912
RPS17 ribosomal protein S17 -0.0307136
TENM3 teneurin transmembrane protein 3 -0.0296344
RPL27 ribosomal protein L27 -0.0288672
PTPRM protein tyrosine phosphatase, receptor type, M -0.0286141
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0282732
IER3 immediate early response 3 -0.0279405
RPL36 ribosomal protein L36 -0.0274482
NCKAP5 NCK-associated protein 5 -0.0273177
RACK1 receptor for activated C kinase 1 -0.0268707
AKR1C1 aldo-keto reductase family 1, member C1 -0.0257583
PRKN parkin RBR E3 ubiquitin protein ligase -0.0253638
PCDH9 protocadherin 9 -0.0253203
RPS13 ribosomal protein S13 -0.0245169
TTC28 tetratricopeptide repeat domain 28 -0.0242016
ENO1 enolase 1, (alpha) -0.023601
RPL39 ribosomal protein L39 -0.0235552
MAP7 microtubule-associated protein 7 -0.0234344
RPL5 ribosomal protein L5 -0.022917
RPL30 ribosomal protein L30 -0.022714
RPS28 ribosomal protein S28 -0.0225297
DNAH14 dynein, axonemal, heavy chain 14 -0.0219421
CADM2 cell adhesion molecule 2 -0.0219024
GNAS GNAS complex locus -0.0218089
KPNB1 karyopherin (importin) beta 1 -0.0210433
TENM2 teneurin transmembrane protein 2 -0.0204182
RPL27A ribosomal protein L27a -0.0203629
TMSB4X thymosin beta 4, X-linked -0.0201644
HMGB1 high mobility group box 1 -0.0201247
WARS1 tryptophanyl-tRNA synthetase 1 -0.0200604
RPL4 ribosomal protein L4 -0.019996
RPS20 ribosomal protein S20 -0.0194259
S100A6 S100 calcium binding protein A6 -0.0194012
RPL8 ribosomal protein L8 -0.0192145
RPL28 ribosomal protein L28 -0.0190596
RHOB ras homolog family member B -0.0189562
OASL 2'-5'-oligoadenylate synthetase-like -0.0187209
RPS10 ribosomal protein S10 -0.0186807
RPL32 ribosomal protein L32 -0.0186145
RANBP17 RAN binding protein 17 -0.0185505
UNC5D unc-5 homolog D (C. elegans) -0.0183149
AHNAK AHNAK nucleoprotein -0.0181128