Fingolimod (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

136 genes differentially expressed following the Fingolimod (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.230706
SPAG9 sperm associated antigen 9 0.132214
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.127796
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.117642
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.107035
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.100504
DST dystonin 0.0951433
STC1 stanniocalcin 1 0.0903748
GOLGA4 golgin A4 0.0895031
ERRFI1 ERBB receptor feedback inhibitor 1 0.0886702
ELL2 elongation factor, RNA polymerase II, 2 0.087575
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0849974
CANX calnexin 0.0817431
VIM vimentin 0.0808547
PRRC2C proline-rich coiled-coil 2C 0.0807803
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0746028
VMP1 vacuole membrane protein 1 0.0745811
FN1 fibronectin 1 0.0737633
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0719715
IGFBP3 insulin-like growth factor binding protein 3 0.0716394
GPC5 glypican 5 0.0713958
USP34 ubiquitin specific peptidase 34 0.066925
HMGA2 high mobility group AT-hook 2 0.0659805
NDRG1 N-myc downstream regulated 1 0.0659801
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0658822
RBM39 RNA binding motif protein 39 0.0598566
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0596172
RPS6 ribosomal protein S6 0.0572751
MON2 MON2 homolog (S. cerevisiae) 0.0571007
PDIA3 protein disulfide isomerase family A, member 3 0.0567245
NPAS2 neuronal PAS domain protein 2 0.0500407
TPT1 tumor protein, translationally-controlled 1 0.0491273
EFNA5 ephrin-A5 0.0483003
PKM pyruvate kinase, muscle 0.0480755
ASPH aspartate beta-hydroxylase 0.0436177
TXNRD1 thioredoxin reductase 1 0.0429397
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0411278
PDE4D phosphodiesterase 4D, cAMP-specific 0.0392983
EIF1 eukaryotic translation initiation factor 1 0.0384671
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.03529
ZFAND3 zinc finger, AN1-type domain 3 0.0323681
TRIO trio Rho guanine nucleotide exchange factor 0.0286299
OGA O-GlcNAcase 0.0266252
FNDC3B fibronectin type III domain containing 3B 0.0263167
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0262887
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251692
FTL ferritin, light polypeptide 0.0227206
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0191248
DSCAM Down syndrome cell adhesion molecule 0.0173951
PTMA prothymosin, alpha 0.0158198
SRPK2 SRSF protein kinase 2 0.013139
LDHA lactate dehydrogenase A 0.0109373
MYO1E myosin IE 0.0101085
MATR3 matrin 3 0.00915488
NIPBL Nipped-B homolog (Drosophila) 0.00876903
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00823082
WAC WW domain containing adaptor with coiled-coil 0.00521394
KMT2E lysine (K)-specific methyltransferase 2E 0.00510246
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0048649
TMSB10 thymosin beta 10 0.00468964
SBF2 SET binding factor 2 6.55746E-4
PDLIM5 PDZ and LIM domain 5 2.34474E-4

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.137227
SNX9 sorting nexin 9 -0.135572
RPS16 ribosomal protein S16 -0.133584
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.12179
MACF1 microtubule-actin crosslinking factor 1 -0.120266
ITGA6 integrin, alpha 6 -0.111354
NAV2 neuron navigator 2 -0.109254
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.102134
SRRM2 serine/arginine repetitive matrix 2 -0.0946232
CARD16 caspase recruitment domain family, member 16 -0.0869204
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0836132
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.078875
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0766677
STAG2 stromal antigen 2 -0.0763204
WASF2 WAS protein family, member 2 -0.07492
MAML2 mastermind-like 2 (Drosophila) -0.0725414
LMO7 LIM domain 7 -0.0715649
SPATA13 spermatogenesis associated 13 -0.0713396
RPLP2 ribosomal protein, large, P2 -0.0686388
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0650413
RPLP1 ribosomal protein, large, P1 -0.0649045
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0640179
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.059438
RPL26 ribosomal protein L26 -0.0593244
MYOF myoferlin -0.0567761
RPL23 ribosomal protein L23 -0.0535531
RBM25 RNA binding motif protein 25 -0.0527754
VCL vinculin -0.0485799
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0464189
ZBTB20 zinc finger and BTB domain containing 20 -0.0416643
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0396928
GMDS GDP-mannose 4,6-dehydratase -0.0386491
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0378992
MAML3 mastermind-like 3 (Drosophila) -0.0375344
CHD9 chromodomain helicase DNA binding protein 9 -0.0361241
RPL19 ribosomal protein L19 -0.0350799
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0349545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0342535
ANKRD11 ankyrin repeat domain 11 -0.0336848
LAMB3 laminin, beta 3 -0.0328224
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0307732
RPS19 ribosomal protein S19 -0.0287293
IGFBP5 insulin-like growth factor binding protein 5 -0.0265584
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0258466
BIRC6 baculoviral IAP repeat containing 6 -0.0244059
DSTN destrin (actin depolymerizing factor) -0.0230892
EZR ezrin -0.020704
RAB6A RAB6A, member RAS oncogene family -0.0205665
GPC6 glypican 6 -0.0200669
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0196032
PDE10A phosphodiesterase 10A -0.0178608
RPS8 ribosomal protein S8 -0.0175355
PARD3 par-3 family cell polarity regulator -0.0143185
RASA3 RAS p21 protein activator 3 -0.0137524
PSD3 pleckstrin and Sec7 domain containing 3 -0.0128107
PGK1 phosphoglycerate kinase 1 -0.012701
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0120726
PRELID2 PRELI domain containing 2 -0.0109335
RPL9 ribosomal protein L9 -0.0095445
JMJD1C jumonji domain containing 1C -0.00939823
EXT1 exostosin glycosyltransferase 1 -0.00929637
RPS27 ribosomal protein S27 -0.00889837
KDM5B lysine (K)-specific demethylase 5B -0.00885144
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00863635
MEF2A myocyte enhancer factor 2A -0.00828211
H3-3B H3.3 histone B -0.00717201
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00706774
ACTG1 actin gamma 1 -0.00559844
RSRC2 arginine/serine-rich coiled-coil 2 -0.00525327
SUCO SUN domain containing ossification factor -0.00413965
ANXA2 annexin A2 -0.00244252
RPL34 ribosomal protein L34 -0.001324
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -3.78517E-4
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -1.69507E-4