Fingolimod (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.310214
ERRFI1 ERBB receptor feedback inhibitor 1 0.144037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.136495
TRIO trio Rho guanine nucleotide exchange factor 0.129965
FBL fibrillarin 0.10701
MYH9 myosin, heavy chain 9, non-muscle 0.10363
SEPTIN9 septin 9 0.0980762
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0931134
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0918303
SPAG9 sperm associated antigen 9 0.0875445
SMAD3 SMAD family member 3 0.0796939
MACF1 microtubule-actin crosslinking factor 1 0.0795137
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0759293
FNDC3B fibronectin type III domain containing 3B 0.0714516
AHNAK AHNAK nucleoprotein 0.066151
SFTPA2 surfactant protein A2 0.0619016
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0604918
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0601327
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0589749
PDE10A phosphodiesterase 10A 0.0575811
ANLN anillin, actin binding protein 0.0571341
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0563202
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0538751
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0536419
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0527051
MYOF myoferlin 0.0526444
JMJD1C jumonji domain containing 1C 0.0503743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0493027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0484974
FMNL2 formin-like 2 0.048124
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0472668
RPS2 ribosomal protein S2 0.0469835
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0469205
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0462009
CANX calnexin 0.0461224
APP amyloid beta (A4) precursor protein 0.0454548
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0451979
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0447508
NAV2 neuron navigator 2 0.0445741
APLP2 amyloid beta (A4) precursor-like protein 2 0.0443672
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0437853
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0435815
PGK1 phosphoglycerate kinase 1 0.0426982
AFAP1 actin filament associated protein 1 0.0422733
ANO6 anoctamin 6 0.041459
OGA O-GlcNAcase 0.0408711
ZCCHC7 zinc finger, CCHC domain containing 7 0.0402579
DST dystonin 0.0401457
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0400925
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0393607
BIRC3 baculoviral IAP repeat containing 3 0.0388948
VCL vinculin 0.0387289
CTBP2 C-terminal binding protein 2 0.0384829
PCBP2 poly(rC) binding protein 2 0.0383234
PICALM phosphatidylinositol binding clathrin assembly protein 0.0379724
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0378264
LARS1 leucyl-tRNA synthetase 1 0.0378215
AFDN afadin, adherens junction formation factor 0.0377378
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0377164
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0376883
TNS3 tensin 3 0.0375724
ADM adrenomedullin 0.0371734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370166
KDM3A lysine (K)-specific demethylase 3A 0.0359367
MATR3 matrin 3 0.0355805
ANKRD11 ankyrin repeat domain 11 0.0355744
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.035332
ENO1 enolase 1, (alpha) 0.0348118
FLNB filamin B, beta 0.0343588
COL18A1 collagen, type XVIII, alpha 1 0.034321
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0341772
RNF220 ring finger protein 220 0.0339454
ZNF638 zinc finger protein 638 0.0337525
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0336472
XPO1 exportin 1 0.0334695
SNX14 sorting nexin 14 0.033349
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0332785
BRD2 bromodomain containing 2 0.0330935
MSN moesin 0.0330852
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.032782
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0327408
SBF2 SET binding factor 2 0.032534
CDK19 cyclin-dependent kinase 19 0.0320918
PTK2 protein tyrosine kinase 2 0.031833
FXR1 fragile X mental retardation, autosomal homolog 1 0.031792
PKM pyruvate kinase, muscle 0.0313628
NUP98 nucleoporin 98kDa 0.0313383
CENPF centromere protein F, 350/400kDa 0.0311136
DDIT4 DNA-damage-inducible transcript 4 0.0308963
ESYT2 extended synaptotagmin-like protein 2 0.0307863
PUM2 pumilio RNA-binding family member 2 0.0306673
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0306468
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0304169
NCOR2 nuclear receptor corepressor 2 0.0303153
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0303022
PLEC plectin 0.0300492
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0299375
LDHA lactate dehydrogenase A 0.0292654
WNK1 WNK lysine deficient protein kinase 1 0.0292595
RUNX1 runt-related transcription factor 1 0.0292113

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.200481
RPS16 ribosomal protein S16 -0.105045
TMSB10 thymosin beta 10 -0.0911466
MT2A metallothionein 2A -0.0619145
RPLP2 ribosomal protein, large, P2 -0.0597247
RPL35A ribosomal protein L35a -0.0590185
RPLP1 ribosomal protein, large, P1 -0.0417014
FTL ferritin, light polypeptide -0.0415949
RPS8 ribosomal protein S8 -0.0396958
RPS6 ribosomal protein S6 -0.037351
RPL12 ribosomal protein L12 -0.0340318
RPS19 ribosomal protein S19 -0.0336397
TM4SF1 transmembrane 4 L six family member 1 -0.0328999
RPS24 ribosomal protein S24 -0.0323026
RPLP0 ribosomal protein, large, P0 -0.0312176
RPL23 ribosomal protein L23 -0.0300889
RPL36A ribosomal protein L36a -0.0275092
RPL34 ribosomal protein L34 -0.0267394
TPT1 tumor protein, translationally-controlled 1 -0.0265316
CARD18 caspase recruitment domain family, member 18 -0.0260806
PFN1 profilin 1 -0.0257163
RTN4 reticulon 4 -0.025617
SLC38A2 solute carrier family 38, member 2 -0.0249571
RPS12 ribosomal protein S12 -0.0239204
RPS14 ribosomal protein S14 -0.023695
RPL9 ribosomal protein L9 -0.0236152
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0233568
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.023215
RPS13 ribosomal protein S13 -0.0226213
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0222095
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0216092
RPL31 ribosomal protein L31 -0.0207222
PERP PERP, TP53 apoptosis effector -0.020244
RPL21 ribosomal protein L21 -0.0200996
EIF1 eukaryotic translation initiation factor 1 -0.019879
ATP5F1E ATP synthase F1 subunit epsilon -0.0197676
OSMR oncostatin M receptor -0.0196527
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0194346
RPS27 ribosomal protein S27 -0.0192424
RPL19 ribosomal protein L19 -0.0192125
RPL11 ribosomal protein L11 -0.019135
VDAC1 voltage-dependent anion channel 1 -0.0189198
RPL36 ribosomal protein L36 -0.018465
EID2 EP300 interacting inhibitor of differentiation 2 -0.0183273
S100A6 S100 calcium binding protein A6 -0.0180211
RPL35 ribosomal protein L35 -0.0176494
RPS5 ribosomal protein S5 -0.0168986
RPS23 ribosomal protein S23 -0.0168021
CD44 CD44 molecule (Indian blood group) -0.0167144
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0165303
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0164037
ASTN2 astrotactin 2 -0.0161931
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0159071
IFITM3 interferon induced transmembrane protein 3 -0.0158515
RPL37 ribosomal protein L37 -0.015809
PHF14 PHD finger protein 14 -0.0156234
HMGB1 high mobility group box 1 -0.0156232
S100A10 S100 calcium binding protein A10 -0.015067
RPS17 ribosomal protein S17 -0.0149227
PDCD5 programmed cell death 5 -0.0149178
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0147695
RPL27A ribosomal protein L27a -0.0145231
ZBTB20 zinc finger and BTB domain containing 20 -0.0144684
RPS21 ribosomal protein S21 -0.0142687
MYL12B myosin, light chain 12B, regulatory -0.0140469
RPL30 ribosomal protein L30 -0.0139378
RPL26 ribosomal protein L26 -0.0139082
NDUFA4 NDUFA4, mitochondrial complex associated -0.0138953
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0136693
RPS27A ribosomal protein S27a -0.0136214
KLF6 Kruppel-like factor 6 -0.0135663
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0132676
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0132656
RPL32 ribosomal protein L32 -0.0131757
FTH1 ferritin, heavy polypeptide 1 -0.013061
COX6C cytochrome c oxidase subunit VIc -0.0130582
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0127225
RPL18 ribosomal protein L18 -0.0126204
EGR1 early growth response 1 -0.0125759
NACA nascent polypeptide-associated complex alpha subunit -0.0124787
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0124674
EIF3J eukaryotic translation initiation factor 3, subunit J -0.0123339
PNISR PNN-interacting serine/arginine-rich protein -0.0122412
RAB7A RAB7A, member RAS oncogene family -0.0122207
SON SON DNA binding protein -0.0120305
METTL15 methyltransferase like 15 -0.0119111
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0117221
RPS20 ribosomal protein S20 -0.0115264
RPL28 ribosomal protein L28 -0.0114236
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0114021
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0112395
RBM25 RNA binding motif protein 25 -0.0111784
TBCA tubulin folding cofactor A -0.0110937
ARHGAP29 Rho GTPase activating protein 29 -0.011057
N4BP2L2 NEDD4 binding protein 2-like 2 -0.011008
EIF5B eukaryotic translation initiation factor 5B -0.0107781
WWTR1 WW domain containing transcription regulator 1 -0.0107315
TPI1 triosephosphate isomerase 1 -0.0104022
CBX3 chromobox homolog 3 -0.0103356
COX5A cytochrome c oxidase subunit Va -0.0102706