Fingolimod (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.07806
VEGFA vascular endothelial growth factor A 0.066511
TSC22D2 TSC22 domain family, member 2 0.0653464
HMGA1 high mobility group AT-hook 1 0.0617063
NDRG1 N-myc downstream regulated 1 0.0584156
RPS6 ribosomal protein S6 0.0511946
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0487554
C3 complement component 3 0.0433106
LY6E lymphocyte antigen 6 complex, locus E 0.0420405
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0402301
FNDC3B fibronectin type III domain containing 3B 0.0397773
RICTOR RPTOR independent companion of MTOR, complex 2 0.0394751
OXSR1 oxidative stress responsive 1 0.0393435
CCNL1 cyclin L1 0.0386393
RIMKLB ribosomal modification protein rimK-like family member B 0.0382637
KDM2A lysine (K)-specific demethylase 2A 0.0367957
UGCG UDP-glucose ceramide glucosyltransferase 0.0367696
ZSWIM6 zinc finger, SWIM-type containing 6 0.0367108
POTEF POTE ankyrin domain family, member F 0.0365282
DDIT4 DNA-damage-inducible transcript 4 0.0363306
RPS2 ribosomal protein S2 0.0361762
GOLGA4 golgin A4 0.0356243
KRT19 keratin 19, type I 0.0351703
SMOC1 SPARC related modular calcium binding 1 0.0344085
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0343876
UBE2H ubiquitin-conjugating enzyme E2H 0.0337844
LAMA4 laminin, alpha 4 0.0335997
PICALM phosphatidylinositol binding clathrin assembly protein 0.0334096
MYO1E myosin IE 0.033324
DSPP dentin sialophosphoprotein 0.0329168
FN1 fibronectin 1 0.0327333
YBX3 Y box binding protein 3 0.032602
EFHD2 EF-hand domain family, member D2 0.0317648
EPS8 epidermal growth factor receptor pathway substrate 8 0.0314793
PARD3 par-3 family cell polarity regulator 0.0307674
NPEPPS aminopeptidase puromycin sensitive 0.0305779
FTH1 ferritin, heavy polypeptide 1 0.0301612
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.029338
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0290581
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0290511
SVIL supervillin 0.028916
ERRFI1 ERBB receptor feedback inhibitor 1 0.0285636
JMJD1C jumonji domain containing 1C 0.0284045
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0281867
KMT2E lysine (K)-specific methyltransferase 2E 0.0281131
MAML2 mastermind-like 2 (Drosophila) 0.0279881
F3 coagulation factor III (thromboplastin, tissue factor) 0.0279228
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0277342
RIOK3 RIO kinase 3 0.0269861
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0268475
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0267156
RCOR1 REST corepressor 1 0.0266288
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0262784
AFF1 AF4/FMR2 family, member 1 0.0259989
MACF1 microtubule-actin crosslinking factor 1 0.0257819
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0256186
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0255726
GPBP1 GC-rich promoter binding protein 1 0.0255414
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0248416
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0245744
PPARD peroxisome proliferator-activated receptor delta 0.0245125
TRIO trio Rho guanine nucleotide exchange factor 0.0243855
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0239168
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0237815
JUP junction plakoglobin 0.0236477
ANXA1 annexin A1 0.0230978
AKAP12 A kinase (PRKA) anchor protein 12 0.0223464
IGFBP3 insulin-like growth factor binding protein 3 0.0222403
NAMPT nicotinamide phosphoribosyltransferase 0.0220613
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0218026
ITCH itchy E3 ubiquitin protein ligase 0.0217114
FXR1 fragile X mental retardation, autosomal homolog 1 0.0215852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0214485
RAB6A RAB6A, member RAS oncogene family 0.0214261
MUC4 mucin 4, cell surface associated 0.021325
ZNF292 zinc finger protein 292 0.0212775
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0206871
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0203631
SETD5 SET domain containing 5 0.0203456
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0203027
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0200783
LGALS3 lectin, galactoside-binding, soluble, 3 0.0200737
TMOD3 tropomodulin 3 (ubiquitous) 0.0198983
AKAP13 A kinase (PRKA) anchor protein 13 0.0198879
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0198201
RAB10 RAB10, member RAS oncogene family 0.0196012
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0192186
RLF rearranged L-myc fusion 0.0192121
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0189036
DLG1 discs, large homolog 1 (Drosophila) 0.0188986
BRD2 bromodomain containing 2 0.0188787
FAM3C family with sequence similarity 3, member C 0.0187114
SLMAP sarcolemma associated protein 0.0187025
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0185106
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0185023
FBXO11 F-box protein 11 0.0184217
BCAR3 breast cancer anti-estrogen resistance 3 0.0183042
ESYT2 extended synaptotagmin-like protein 2 0.0182302
GOLT1B golgi transport 1B 0.0180538
ENO2 enolase 2 (gamma, neuronal) 0.017956

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.138593
UBC ubiquitin C -0.0915502
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0750532
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0689248
RPS27A ribosomal protein S27a -0.064483
LAMB3 laminin, beta 3 -0.0633966
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0602342
TPT1 tumor protein, translationally-controlled 1 -0.0577614
KRT8 keratin 8, type II -0.0505731
KRT7 keratin 7, type II -0.0453081
EMP1 epithelial membrane protein 1 -0.0444866
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0414171
TMSB10 thymosin beta 10 -0.0412331
HLA-E major histocompatibility complex, class I, E -0.0386383
CANX calnexin -0.0383005
RPL23 ribosomal protein L23 -0.0374943
PCLO piccolo presynaptic cytomatrix protein -0.0368928
EEF2 eukaryotic translation elongation factor 2 -0.0337154
THBS1 thrombospondin 1 -0.0328914
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0327417
JUN jun proto-oncogene -0.0325702
TPM4 tropomyosin 4 -0.0323702
RPS24 ribosomal protein S24 -0.0319577
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0305188
KRT17 keratin 17, type I -0.0290716
RPS3 ribosomal protein S3 -0.0267252
VCL vinculin -0.0266385
EGR1 early growth response 1 -0.0262258
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.02564
DEK DEK proto-oncogene -0.0253664
ACTN4 actinin, alpha 4 -0.024676
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.024553
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0241483
PLSCR1 phospholipid scramblase 1 -0.0231846
LDHA lactate dehydrogenase A -0.022194
RPS8 ribosomal protein S8 -0.0214066
HLA-B major histocompatibility complex, class I, B -0.0213358
SDC4 syndecan 4 -0.0210351
AMOTL2 angiomotin like 2 -0.0204297
HLA-C major histocompatibility complex, class I, C -0.0203828
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0202101
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0198445
CD44 CD44 molecule (Indian blood group) -0.0196485
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0196441
RPL30 ribosomal protein L30 -0.0195787
RACK1 receptor for activated C kinase 1 -0.0195376
ETV6 ets variant 6 -0.0193877
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0193826
CEP95 centrosomal protein 95kDa -0.0193609
RPS12 ribosomal protein S12 -0.0193552
TM4SF1 transmembrane 4 L six family member 1 -0.0192489
PLAT plasminogen activator, tissue -0.0191363
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0190887
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0189041
PCBP2 poly(rC) binding protein 2 -0.0186523
RPLP1 ribosomal protein, large, P1 -0.0185393
VIM vimentin -0.0183284
MYH9 myosin, heavy chain 9, non-muscle -0.0182666
ENO1 enolase 1, (alpha) -0.0182636
ACTG1 actin gamma 1 -0.0180907
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0178402
NUP214 nucleoporin 214kDa -0.0175481
FNIP1 folliculin interacting protein 1 -0.0175161
ARB2A ARB2 cotranscriptional regulator A -0.0174597
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0174027
SMC4 structural maintenance of chromosomes 4 -0.0172776
RPL9 ribosomal protein L9 -0.0169058
TMSB4X thymosin beta 4, X-linked -0.0166229
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0163696
EXOC6B exocyst complex component 6B -0.0163585
CDK12 cyclin-dependent kinase 12 -0.0163105
RBM25 RNA binding motif protein 25 -0.0162884
RAD21 RAD21 homolog (S. pombe) -0.0159808
SENP5 SUMO1/sentrin specific peptidase 5 -0.0158819
ANXA2 annexin A2 -0.0158264
INHBA inhibin, beta A -0.0152746
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0152167
CALR calreticulin -0.0151242
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0149599
MCL1 myeloid cell leukemia 1 -0.0145496
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0145382
NCOA7 nuclear receptor coactivator 7 -0.0143575
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0143391
ATAD2 ATPase family, AAA domain containing 2 -0.0143307
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0141599
CALU calumenin -0.0141245
TRAPPC9 trafficking protein particle complex 9 -0.0140492
KDM3A lysine (K)-specific demethylase 3A -0.0140017
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0139559
RPL4 ribosomal protein L4 -0.0138651
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0138049
RPL34 ribosomal protein L34 -0.0136932
UBASH3B ubiquitin associated and SH3 domain containing B -0.0136497
BPTF bromodomain PHD finger transcription factor -0.013596
FLNA filamin A, alpha -0.013469
LOC112694756 uncharaterized LOC112694756 -0.0134393
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0133229
SMYD3 SET and MYND domain containing 3 -0.0133089
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0131529
PRELID2 PRELI domain containing 2 -0.0130025