Fingolimod (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.157789
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.102872
ELL2 elongation factor, RNA polymerase II, 2 0.0685608
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0669895
DLC1 DLC1 Rho GTPase activating protein 0.0661035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0601031
JMJD1C jumonji domain containing 1C 0.0598865
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0596993
PTK2 protein tyrosine kinase 2 0.0575571
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0570617
RPS2 ribosomal protein S2 0.054958
ZEB1 zinc finger E-box binding homeobox 1 0.054917
LAMB3 laminin, beta 3 0.0547137
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0505487
RBM39 RNA binding motif protein 39 0.0503548
TRIO trio Rho guanine nucleotide exchange factor 0.0501051
NUP58 nucleoporin 58 0.0497265
KDM3A lysine (K)-specific demethylase 3A 0.0494697
KMT2E lysine (K)-specific methyltransferase 2E 0.0484619
ZFAND3 zinc finger, AN1-type domain 3 0.0466312
MCTP1 multiple C2 domains, transmembrane 1 0.0452048
OGA O-GlcNAcase 0.0451088
RLF rearranged L-myc fusion 0.044178
PARD3 par-3 family cell polarity regulator 0.0438572
ZNF292 zinc finger protein 292 0.0430798
WAC WW domain containing adaptor with coiled-coil 0.0423602
NAMPT nicotinamide phosphoribosyltransferase 0.0408742
IARS1 isoleucyl-tRNA synthetase 1 0.0398979
RAD21 RAD21 homolog (S. pombe) 0.0393237
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0392895
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0389495
KMT2C lysine (K)-specific methyltransferase 2C 0.0388369
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0388212
TPD52 tumor protein D52 0.0386891
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0386635
RASA2 RAS p21 protein activator 2 0.038199
USP3 ubiquitin specific peptidase 3 0.0379272
OSBPL8 oxysterol binding protein-like 8 0.0378864
PRRC2C proline-rich coiled-coil 2C 0.0373261
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0370252
NIPBL Nipped-B homolog (Drosophila) 0.0367764
USP9X ubiquitin specific peptidase 9, X-linked 0.0367028
CHD1 chromodomain helicase DNA binding protein 1 0.0365233
DSCAM Down syndrome cell adhesion molecule 0.0364383
ATP13A3 ATPase type 13A3 0.036294
GOLGA4 golgin A4 0.036194
RUNX1 runt-related transcription factor 1 0.0355977
SET SET nuclear proto-oncogene 0.0350161
SRPK2 SRSF protein kinase 2 0.0344591
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0343123
BIRC6 baculoviral IAP repeat containing 6 0.0342684
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0340112
WDR43 WD repeat domain 43 0.0338091
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0334702
NCKAP1 NCK-associated protein 1 0.0334141
TEX10 testis expressed 10 0.0332123
KDM6A lysine (K)-specific demethylase 6A 0.0330742
MTDH metadherin 0.0329497
SBF2 SET binding factor 2 0.0328686
PUM2 pumilio RNA-binding family member 2 0.0328654
KAT6A K(lysine) acetyltransferase 6A 0.032448
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0324282
UBA6 ubiquitin-like modifier activating enzyme 6 0.0324162
SPRED2 sprouty-related, EVH1 domain containing 2 0.0319095
RSRC2 arginine/serine-rich coiled-coil 2 0.0318422
BBX bobby sox homolog (Drosophila) 0.0314898
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0313428
MAPK8 mitogen-activated protein kinase 8 0.03128
CANX calnexin 0.0311473
CORO1C coronin, actin binding protein, 1C 0.031054
SPAG9 sperm associated antigen 9 0.0302733
USP34 ubiquitin specific peptidase 34 0.0298253
BHLHE40 basic helix-loop-helix family, member e40 0.029815
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0295323
SCAF11 SR-related CTD-associated factor 11 0.0294454
FMNL2 formin-like 2 0.0291577
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0290416
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0288647
STC1 stanniocalcin 1 0.0288153
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0282051
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0281841
RBM33 RNA binding motif protein 33 0.0281297
FBXO11 F-box protein 11 0.0279905
NAP1L1 nucleosome assembly protein 1-like 1 0.0276482
PAPOLA poly(A) polymerase alpha 0.027567
TSC22D2 TSC22 domain family, member 2 0.0273839
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273491
MARCHF6 membrane associated ring-CH-type finger 6 0.0273162
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0271457
MATR3 matrin 3 0.0270464
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0270083
YEATS2 YEATS domain containing 2 0.0266519
CREB5 cAMP responsive element binding protein 5 0.0265381
FOXJ3 forkhead box J3 0.0264836
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0264597
CDK17 cyclin-dependent kinase 17 0.0264075
ANO6 anoctamin 6 0.0262395
GARS1 glycyl-tRNA synthetase 1 0.0261418
RB1CC1 RB1-inducible coiled-coil 1 0.0259246
MYH9 myosin, heavy chain 9, non-muscle 0.0259169

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.102293
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0960142
RPL35A ribosomal protein L35a -0.0811427
TMSB10 thymosin beta 10 -0.059546
RPS8 ribosomal protein S8 -0.0479725
FTL ferritin, light polypeptide -0.0471655
RPL31 ribosomal protein L31 -0.0446803
RPS6 ribosomal protein S6 -0.0438671
RPL37A ribosomal protein L37a -0.042879
RPS13 ribosomal protein S13 -0.042295
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0418477
RPS19 ribosomal protein S19 -0.0415015
RPLP1 ribosomal protein, large, P1 -0.0405473
RPLP2 ribosomal protein, large, P2 -0.0402902
RPL9 ribosomal protein L9 -0.0401476
EGR1 early growth response 1 -0.0400744
RPS23 ribosomal protein S23 -0.0386028
RPL11 ribosomal protein L11 -0.0379312
RPS29 ribosomal protein S29 -0.0362914
RPL23 ribosomal protein L23 -0.0356401
RPS20 ribosomal protein S20 -0.0355594
RPL12 ribosomal protein L12 -0.0351882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0324902
TPT1 tumor protein, translationally-controlled 1 -0.0313578
RPL8 ribosomal protein L8 -0.0313242
PFN1 profilin 1 -0.0313214
RPS17 ribosomal protein S17 -0.0308872
POTEF POTE ankyrin domain family, member F -0.0297873
RPL7A ribosomal protein L7a -0.0289988
RPS15 ribosomal protein S15 -0.0277178
RPL30 ribosomal protein L30 -0.0271788
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0271657
ZNF438 zinc finger protein 438 -0.0271178
RPL34 ribosomal protein L34 -0.0264854
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0256284
RPL19 ribosomal protein L19 -0.0255017
RPS12 ribosomal protein S12 -0.0252175
RPL5 ribosomal protein L5 -0.0250231
HMGA1 high mobility group AT-hook 1 -0.0244722
RPS10 ribosomal protein S10 -0.0244138
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0242096
RPS14 ribosomal protein S14 -0.0227728
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0227144
VIM vimentin -0.0225895
RPL28 ribosomal protein L28 -0.0224521
RPLP0 ribosomal protein, large, P0 -0.0224191
RPS25 ribosomal protein S25 -0.0218852
EIF1 eukaryotic translation initiation factor 1 -0.021481
IFI6 interferon, alpha-inducible protein 6 -0.0213975
EEF2 eukaryotic translation elongation factor 2 -0.0212031
GLRX glutaredoxin (thioltransferase) -0.0209978
RPS24 ribosomal protein S24 -0.0208649
HMGA2 high mobility group AT-hook 2 -0.0206088
HLA-A major histocompatibility complex, class I, A -0.0203195
RPS27 ribosomal protein S27 -0.0202612
TUBB4B tubulin, beta 4B class IVb -0.0189567
RPL27 ribosomal protein L27 -0.0188511
ATP5F1B ATP synthase F1 subunit beta -0.0187354
RPL35 ribosomal protein L35 -0.0184402
RPS11 ribosomal protein S11 -0.0179831
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0179547
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0177484
RPS4X ribosomal protein S4, X-linked -0.0175442
ENO1 enolase 1, (alpha) -0.0175237
RPS21 ribosomal protein S21 -0.0169176
RPL10A ribosomal protein L10a -0.016886
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0167737
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0165912
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0162536
NABP1 nucleic acid binding protein 1 -0.0160456
RPL37 ribosomal protein L37 -0.0159515
IFITM2 interferon induced transmembrane protein 2 -0.0157024
EEF1G eukaryotic translation elongation factor 1 gamma -0.015143
RAD51B RAD51 paralog B -0.0148456
RPL36A ribosomal protein L36a -0.0146338
ISG15 ISG15 ubiquitin-like modifier -0.0144898
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0141196
RACK1 receptor for activated C kinase 1 -0.0140229
RPS27A ribosomal protein S27a -0.013597
RPS3 ribosomal protein S3 -0.0135615
RPS16 ribosomal protein S16 -0.0133258
RPS26 ribosomal protein S26 -0.0132004
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0131777
LDHB lactate dehydrogenase B -0.0131459
KPNB1 karyopherin (importin) beta 1 -0.0130983
RPL36AL ribosomal protein L36a-like -0.0130822
HMGB1 high mobility group box 1 -0.0130159
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0129671
TM4SF1 transmembrane 4 L six family member 1 -0.0129542
VDAC1 voltage-dependent anion channel 1 -0.0128801
GPC6 glypican 6 -0.0128636
HLA-B major histocompatibility complex, class I, B -0.0128459
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0125349
S100A2 S100 calcium binding protein A2 -0.0124582
G0S2 G0/G1 switch 2 -0.0123634
ENO2 enolase 2 (gamma, neuronal) -0.0122654
BPTF bromodomain PHD finger transcription factor -0.0122504
PRDX1 peroxiredoxin 1 -0.0122003
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0121327
PKM pyruvate kinase, muscle -0.0121236