Fingolimod (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.13304
ZEB1 zinc finger E-box binding homeobox 1 0.0542042
CPED1 cadherin-like and PC-esterase domain containing 1 0.0538393
RPS2 ribosomal protein S2 0.0533477
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0430497
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0398204
HSPA8 heat shock 70kDa protein 8 0.039769
INTS6 integrator complex subunit 6 0.0381633
ANXA1 annexin A1 0.0375032
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0352109
CAMTA1 calmodulin binding transcription activator 1 0.032518
NCOR1 nuclear receptor corepressor 1 0.031156
NAMPT nicotinamide phosphoribosyltransferase 0.0307645
SOX6 SRY (sex determining region Y)-box 6 0.0292634
GLI3 GLI family zinc finger 3 0.0281277
SDK1 sidekick cell adhesion molecule 1 0.0281237
EIF4A2 eukaryotic translation initiation factor 4A2 0.0280248
BMP10 bone morphogenetic protein 10 0.027597
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0275722
MYO5C myosin VC 0.0265809
RBM39 RNA binding motif protein 39 0.025067
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0248549
WNK1 WNK lysine deficient protein kinase 1 0.02457
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0243632
SSBP2 single-stranded DNA binding protein 2 0.0241317
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0235997
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0231674
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0227231
CDK13 cyclin-dependent kinase 13 0.022085
RPS18 ribosomal protein S18 0.0220253
CTBP2 C-terminal binding protein 2 0.0220083
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0219395
DENND1A DENN/MADD domain containing 1A 0.0217564
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0215359
CAMKMT calmodulin-lysine N-methyltransferase 0.0209851
NAV2 neuron navigator 2 0.0208086
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0207904
AEBP2 AE binding protein 2 0.0207553
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0204248
NIPBL Nipped-B homolog (Drosophila) 0.0202222
UBQLN1 ubiquilin 1 0.0198145
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.019382
KMT2E lysine (K)-specific methyltransferase 2E 0.0191732
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0188577
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0185939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0184637
PHF3 PHD finger protein 3 0.018458
H1-4 H1.4 linker histone, cluster member 0.0181458
FER1L6 fer-1-like family member 6 0.0178698
ELOVL5 ELOVL fatty acid elongase 5 0.0174314
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0173216
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0168202
ZSWIM6 zinc finger, SWIM-type containing 6 0.0166595
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0163653
KDM3A lysine (K)-specific demethylase 3A 0.0163255
CLIP2 CAP-GLY domain containing linker protein 2 0.0162583
TNRC6B trinucleotide repeat containing 6B 0.0162343
CUL3 cullin 3 0.016227
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0161719
CKAP5 cytoskeleton associated protein 5 0.0158596
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.015762
SENP6 SUMO1/sentrin specific peptidase 6 0.0156088
MAX MYC associated factor X 0.0154382
BMP2K BMP2 inducible kinase 0.0151239
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0150772
KDM4C lysine (K)-specific demethylase 4C 0.0149539
PDGFC platelet derived growth factor C 0.0148664
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.0147539
DIPK2A divergent protein kinase domain 2A 0.0146805
UBAP2 ubiquitin associated protein 2 0.0145215
IPO7 importin 7 0.0144366
MYOF myoferlin 0.0143126
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0141951
TRA2A transformer 2 alpha homolog (Drosophila) 0.0141656
KDM4B lysine (K)-specific demethylase 4B 0.0140463
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.0140164
HDAC9 histone deacetylase 9 0.0139946
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0139915
MSH4 mutS homolog 4 0.0138383
PNISR PNN-interacting serine/arginine-rich protein 0.0137839
DIAPH3 diaphanous-related formin 3 0.0136754
SETD2 SET domain containing 2 0.0135997
GLI2 GLI family zinc finger 2 0.0134926
EPS8 epidermal growth factor receptor pathway substrate 8 0.0134156
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0134088
CPNE1 copine I 0.0133538
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0133268
CORO1C coronin, actin binding protein, 1C 0.013275
RLF rearranged L-myc fusion 0.0130141
DENND5B DENN/MADD domain containing 5B 0.0130109
PDE10A phosphodiesterase 10A 0.0129922
SQSTM1 sequestosome 1 0.0129463
LCORL ligand dependent nuclear receptor corepressor-like 0.0129226
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0127254
CDC73 cell division cycle 73 0.0125105
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0124929
MACF1 microtubule-actin crosslinking factor 1 0.0124079
ZNF217 zinc finger protein 217 0.0124066
SMAD3 SMAD family member 3 0.0123855

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.300123
PKM pyruvate kinase, muscle -0.103729
TXNRD1 thioredoxin reductase 1 -0.0776403
RPL35A ribosomal protein L35a -0.0710193
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0689815
VCL vinculin -0.0638056
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0633419
FLNB filamin B, beta -0.0597635
POTEF POTE ankyrin domain family, member F -0.0570789
S100A4 S100 calcium binding protein A4 -0.0548119
ACTG1 actin gamma 1 -0.0541649
CCND1 cyclin D1 -0.0520459
EEF2 eukaryotic translation elongation factor 2 -0.0513354
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0504243
RTN4 reticulon 4 -0.0498126
PTMA prothymosin, alpha -0.0481901
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0450151
ARL4C ADP-ribosylation factor-like 4C -0.0438656
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.043167
PFN1 profilin 1 -0.042984
S100A6 S100 calcium binding protein A6 -0.0421635
STAT1 signal transducer and activator of transcription 1, 91kDa -0.041945
PRDX2 peroxiredoxin 2 -0.041442
RPS8 ribosomal protein S8 -0.040366
RPS6 ribosomal protein S6 -0.0401771
HSPB1 heat shock 27kDa protein 1 -0.0399446
ZBTB20 zinc finger and BTB domain containing 20 -0.0385122
RPLP0 ribosomal protein, large, P0 -0.0383413
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.038022
TJP1 tight junction protein 1 -0.0377201
RPLP1 ribosomal protein, large, P1 -0.0362094
TMSB10 thymosin beta 10 -0.0352442
TPT1 tumor protein, translationally-controlled 1 -0.0349329
IGF2 insulin-like growth factor 2 -0.0343955
ENO2 enolase 2 (gamma, neuronal) -0.033575
SMC3 structural maintenance of chromosomes 3 -0.0333344
EBNA1BP2 EBNA1 binding protein 2 -0.0331236
LDHA lactate dehydrogenase A -0.0329056
RHOA ras homolog family member A -0.0325104
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0322759
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0322701
TPM4 tropomyosin 4 -0.031485
RPS14 ribosomal protein S14 -0.0314329
RPS23 ribosomal protein S23 -0.0312901
RPLP2 ribosomal protein, large, P2 -0.0311063
HMGA1 high mobility group AT-hook 1 -0.0306394
RPS19 ribosomal protein S19 -0.0302386
SLC38A2 solute carrier family 38, member 2 -0.0297918
ENO1 enolase 1, (alpha) -0.0293696
SMIM44 small integral membrane protein 44 -0.0292912
RPL34 ribosomal protein L34 -0.0291495
CD47 CD47 molecule -0.0288263
MYL12B myosin, light chain 12B, regulatory -0.0284478
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0283415
LOC112694756 uncharaterized LOC112694756 -0.0280732
EGFR epidermal growth factor receptor -0.0277092
KPNB1 karyopherin (importin) beta 1 -0.0275397
PTMS parathymosin -0.0272271
HEG1 heart development protein with EGF-like domains 1 -0.0268351
RPL37A ribosomal protein L37a -0.0264535
GNAS GNAS complex locus -0.0263059
OSMR oncostatin M receptor -0.0259197
GCLM glutamate-cysteine ligase, modifier subunit -0.0257457
EXOC6B exocyst complex component 6B -0.0254237
RPS21 ribosomal protein S21 -0.0250825
CBX3 chromobox homolog 3 -0.0247344
S100A10 S100 calcium binding protein A10 -0.0245052
RPL27A ribosomal protein L27a -0.0243063
LOC102724023 ES1 protein homolog, mitochondrial -0.024234
DEK DEK proto-oncogene -0.0242112
SCAF11 SR-related CTD-associated factor 11 -0.0241864
B2M beta-2-microglobulin -0.0236503
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0235806
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0235172
RBM25 RNA binding motif protein 25 -0.0233805
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0233743
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0228628
RPL9 ribosomal protein L9 -0.0227537
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0226663
RPL31 ribosomal protein L31 -0.0223928
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.022297
RPL8 ribosomal protein L8 -0.0222189
SEPTIN11 septin 11 -0.0221127
RPL19 ribosomal protein L19 -0.0220688
BCAS3 breast carcinoma amplified sequence 3 -0.0216487
ATP5F1B ATP synthase F1 subunit beta -0.0215468
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0214807
TPI1 triosephosphate isomerase 1 -0.0214527
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209506
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0208968
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.020886
RPS24 ribosomal protein S24 -0.0208001
CCNL1 cyclin L1 -0.020714
RPL36A ribosomal protein L36a -0.0204622
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0204123
HLA-B major histocompatibility complex, class I, B -0.0201465
SRRM2 serine/arginine repetitive matrix 2 -0.0200961
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0200916
ADAM10 ADAM metallopeptidase domain 10 -0.0200776
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0200478