Fingolimod (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.14875
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.127952
NDRG1 N-myc downstream regulated 1 0.103034
ELL2 elongation factor, RNA polymerase II, 2 0.0927066
FTL ferritin, light polypeptide 0.0822163
PTMA prothymosin, alpha 0.0809497
NAMPT nicotinamide phosphoribosyltransferase 0.0737345
RBM39 RNA binding motif protein 39 0.0729928
MT2A metallothionein 2A 0.0649128
TRIO trio Rho guanine nucleotide exchange factor 0.0632051
CALD1 caldesmon 1 0.0615511
CD44 CD44 molecule (Indian blood group) 0.0594902
PKM pyruvate kinase, muscle 0.0582724
KMT2E lysine (K)-specific methyltransferase 2E 0.0543824
TRA2A transformer 2 alpha homolog (Drosophila) 0.052391
MYH9 myosin, heavy chain 9, non-muscle 0.0494606
FAM13A family with sequence similarity 13, member A 0.0492326
ARRDC3 arrestin domain containing 3 0.0492159
ADM adrenomedullin 0.0475403
TMSB10 thymosin beta 10 0.0463962
ZNF292 zinc finger protein 292 0.0460464
RPL11 ribosomal protein L11 0.0458164
RTN4 reticulon 4 0.0456986
MATR3 matrin 3 0.0454068
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0435054
MYOF myoferlin 0.0430721
FNDC3B fibronectin type III domain containing 3B 0.0419787
GPC6 glypican 6 0.0418484
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.04153
RAB1A RAB1A, member RAS oncogene family 0.041347
RPS6 ribosomal protein S6 0.0394659
KTN1 kinectin 1 (kinesin receptor) 0.0383001
MYO10 myosin X 0.0376336
SP100 SP100 nuclear antigen 0.0374051
PLAUR plasminogen activator, urokinase receptor 0.0371704
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0359946
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0358801
RNF145 ring finger protein 145 0.0350506
UGCG UDP-glucose ceramide glucosyltransferase 0.0345815
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0337165
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0334649
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0326107
MEF2A myocyte enhancer factor 2A 0.0323077
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.032301
RYBP RING1 and YY1 binding protein 0.0313731
SET SET nuclear proto-oncogene 0.0309003
S100A9 S100 calcium binding protein A9 0.0307691
FUS FUS RNA binding protein 0.0306374
RLF rearranged L-myc fusion 0.0304952
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0304723
CSNK1A1 casein kinase 1, alpha 1 0.0297886
NOP58 NOP58 ribonucleoprotein 0.0297716
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0284655
H3-3B H3.3 histone B 0.0284554
PCBP2 poly(rC) binding protein 2 0.0282816
SPAG9 sperm associated antigen 9 0.0278349
EGR1 early growth response 1 0.0277693
MSN moesin 0.0277137
DDIT4 DNA-damage-inducible transcript 4 0.0276821
CCNL1 cyclin L1 0.0276602
SBF2 SET binding factor 2 0.0276594
AKAP12 A kinase (PRKA) anchor protein 12 0.0276084
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.027161
ARID4B AT rich interactive domain 4B (RBP1-like) 0.026928
TXNIP thioredoxin interacting protein 0.0268693
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.02674
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0266852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0266509
ERBIN erbb2 interacting protein 0.0265335
PRRC2C proline-rich coiled-coil 2C 0.0265072
FMNL2 formin-like 2 0.026398
IFI44 interferon-induced protein 44 0.02627
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0260351
WDR43 WD repeat domain 43 0.026025
UBC ubiquitin C 0.0258811
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0257796
WTAP Wilms tumor 1 associated protein 0.0256969
ESYT2 extended synaptotagmin-like protein 2 0.0256249
FOSL1 FOS-like antigen 1 0.0253931
HILPDA hypoxia inducible lipid droplet-associated 0.025299
NF1 neurofibromin 1 0.0252986
UBE2B ubiquitin-conjugating enzyme E2B 0.0252338
ZNF148 zinc finger protein 148 0.0249852
RAB2A RAB2A, member RAS oncogene family 0.0248949
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0248421
EIF5B eukaryotic translation initiation factor 5B 0.0247935
YTHDC1 YTH domain containing 1 0.0247055
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0246949
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0244339
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0243021
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0242659
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0241829
RPS2 ribosomal protein S2 0.0239994
SLC35F5 solute carrier family 35, member F5 0.0238649
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0237287
CCNI cyclin I 0.023383
ANLN anillin, actin binding protein 0.0230816
B2M beta-2-microglobulin 0.0230612
PUM2 pumilio RNA-binding family member 2 0.0229083
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0228743

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.160067
TIMP3 TIMP metallopeptidase inhibitor 3 -0.130377
COL6A3 collagen, type VI, alpha 3 -0.122484
AHNAK AHNAK nucleoprotein -0.119843
FN1 fibronectin 1 -0.113538
IGFBP3 insulin-like growth factor binding protein 3 -0.112235
HMGA2 high mobility group AT-hook 2 -0.096642
LOX lysyl oxidase -0.0909753
TGFBI transforming growth factor, beta-induced, 68kDa -0.0888252
CDH13 cadherin 13 -0.0862041
CALU calumenin -0.0671444
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.064404
NRXN3 neurexin 3 -0.062397
CXCL8 chemokine (C-X-C motif) ligand 8 -0.057288
COL6A2 collagen, type VI, alpha 2 -0.0551906
CANX calnexin -0.051416
F3 coagulation factor III (thromboplastin, tissue factor) -0.0490942
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0488393
EGFR epidermal growth factor receptor -0.0476348
PDE4D phosphodiesterase 4D, cAMP-specific -0.0474292
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0462478
STC1 stanniocalcin 1 -0.0459538
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0449011
HDLBP high density lipoprotein binding protein -0.0433541
AFF3 AF4/FMR2 family, member 3 -0.0424019
PRSS23 protease, serine, 23 -0.0420982
HLA-A major histocompatibility complex, class I, A -0.0409393
DNAH11 dynein, axonemal, heavy chain 11 -0.0409009
RAI14 retinoic acid induced 14 -0.0406672
SPDYA speedy/RINGO cell cycle regulator family member A -0.03978
ATXN1 ataxin 1 -0.0394611
SDC4 syndecan 4 -0.0390821
ZMYND8 zinc finger, MYND-type containing 8 -0.0383097
BIRC6 baculoviral IAP repeat containing 6 -0.0380272
HLA-B major histocompatibility complex, class I, B -0.0378312
SEC24D SEC24 family member D -0.0378308
SEC31A SEC31 homolog A (S. cerevisiae) -0.0374865
KAZN kazrin, periplakin interacting protein -0.0374134
INTS6 integrator complex subunit 6 -0.036969
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0367189
KMT2C lysine (K)-specific methyltransferase 2C -0.0364631
TNS3 tensin 3 -0.0361532
OSMR oncostatin M receptor -0.0360908
RAD51B RAD51 paralog B -0.0358982
VIM vimentin -0.0350068
COG6 component of oligomeric golgi complex 6 -0.0348884
COL5A1 collagen, type V, alpha 1 -0.0344736
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0343194
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0330287
AUTS2 autism susceptibility candidate 2 -0.032058
PRKCA protein kinase C, alpha -0.0312468
MYO9A myosin IXA -0.0311135
NAV1 neuron navigator 1 -0.0306958
GOLGB1 golgin B1 -0.0306356
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0305325
FBXO11 F-box protein 11 -0.0303722
PDLIM5 PDZ and LIM domain 5 -0.0301996
PDIA4 protein disulfide isomerase family A, member 4 -0.0301638
SMYD3 SET and MYND domain containing 3 -0.0298736
FBN1 fibrillin 1 -0.0298668
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0297796
WNT5A wingless-type MMTV integration site family, member 5A -0.0292298
VCL vinculin -0.0288684
DPYD dihydropyrimidine dehydrogenase -0.0284804
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0284403
HLA-C major histocompatibility complex, class I, C -0.0280696
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0278701
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0275176
FNIP1 folliculin interacting protein 1 -0.0274074
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0272977
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0271838
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0266506
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0264859
DNAAF9 dynein axonemal assembly factor 9 -0.0264194
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0262097
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0254366
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0249588
PRELID2 PRELI domain containing 2 -0.0248778
PDIA5 protein disulfide isomerase family A, member 5 -0.0245331
SOX5 SRY (sex determining region Y)-box 5 -0.0242096
PID1 phosphotyrosine interaction domain containing 1 -0.0241404
FKBP10 FK506 binding protein 10, 65 kDa -0.0240345
PSD3 pleckstrin and Sec7 domain containing 3 -0.0240135
COL6A1 collagen, type VI, alpha 1 -0.023985
TAS2R14 taste receptor, type 2, member 14 -0.0239016
CDK13 cyclin-dependent kinase 13 -0.023375
GPR173 G protein-coupled receptor 173 -0.0232473
DIAPH3 diaphanous-related formin 3 -0.0230633
CA12 carbonic anhydrase XII -0.0230508
FAF1 Fas (TNFRSF6) associated factor 1 -0.0229082
GOLM2 golgi membrane protein 2 -0.02276
TTC3 tetratricopeptide repeat domain 3 -0.0226824
AGO3 argonaute RISC catalytic component 3 -0.0226654
CHD9 chromodomain helicase DNA binding protein 9 -0.0226164
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0225601
PCNX4 pecanex 4 -0.0223918
BBS9 Bardet-Biedl syndrome 9 -0.0223882
BICD1 bicaudal D homolog 1 (Drosophila) -0.0223716
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0221725
HIP1 huntingtin interacting protein 1 -0.0218704