Fingolimod (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fingolimod (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fingolimod (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.0929174
NDRG1 N-myc downstream regulated 1 0.0757566
AKAP12 A kinase (PRKA) anchor protein 12 0.0577081
ATP13A3 ATPase type 13A3 0.0545159
FAM13A family with sequence similarity 13, member A 0.051138
ADM adrenomedullin 0.0500862
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.041329
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0376633
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364362
SPAG9 sperm associated antigen 9 0.0351282
ELL2 elongation factor, RNA polymerase II, 2 0.0340261
DST dystonin 0.0319601
LOXL2 lysyl oxidase-like 2 0.030952
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0300197
GOLGA4 golgin A4 0.0294878
GREM1 gremlin 1, DAN family BMP antagonist 0.0283096
ARHGAP21 Rho GTPase activating protein 21 0.0273745
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0265264
HILPDA hypoxia inducible lipid droplet-associated 0.0260215
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0259703
CLTC clathrin, heavy chain (Hc) 0.025926
FMNL2 formin-like 2 0.0248398
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.024834
SETD5 SET domain containing 5 0.0239586
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237804
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0236546
COL4A2 collagen, type IV, alpha 2 0.0235922
RICTOR RPTOR independent companion of MTOR, complex 2 0.0235367
COPB1 coatomer protein complex, subunit beta 1 0.0221536
COL4A1 collagen, type IV, alpha 1 0.0219862
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217326
FRMD6 FERM domain containing 6 0.0210434
TMF1 TATA element modulatory factor 1 0.0207882
RARS1 arginyl-tRNA synthetase 1 0.0203753
ESYT2 extended synaptotagmin-like protein 2 0.0200002
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0196567
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0195585
RAI14 retinoic acid induced 14 0.0193648
PDE4D phosphodiesterase 4D, cAMP-specific 0.0192571
TRIO trio Rho guanine nucleotide exchange factor 0.0190915
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0181719
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0178477
MORF4L2 mortality factor 4 like 2 0.0177368
KMT2E lysine (K)-specific methyltransferase 2E 0.0170833
CLINT1 clathrin interactor 1 0.0167326
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0166098
COPA coatomer protein complex, subunit alpha 0.0164819
VEGFA vascular endothelial growth factor A 0.0164095
LMAN1 lectin, mannose-binding, 1 0.0159336
GOLT1B golgi transport 1B 0.0156954
JARID2 jumonji, AT rich interactive domain 2 0.0156653
LCORL ligand dependent nuclear receptor corepressor-like 0.0152936
AKAP9 A kinase (PRKA) anchor protein 9 0.015278
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0150724
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0147666
SEC23A Sec23 homolog A (S. cerevisiae) 0.0145923
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0144955
LIMS1 LIM and senescent cell antigen-like domains 1 0.0143616
SEPTIN9 septin 9 0.0142711
CAVIN1 caveolae associated protein 1 0.0142397
MXI1 MAX interactor 1, dimerization protein 0.0141744
VEGFC vascular endothelial growth factor C 0.0139759
NGLY1 N-glycanase 1 0.0138508
SP3 Sp3 transcription factor 0.013633
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0135643
LOX lysyl oxidase 0.0135352
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0133979
SNX6 sorting nexin 6 0.013338
PDE8A phosphodiesterase 8A 0.0133279
BIRC6 baculoviral IAP repeat containing 6 0.0133252
RPS2 ribosomal protein S2 0.0133081
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0132296
FSTL1 follistatin-like 1 0.0132208
PICALM phosphatidylinositol binding clathrin assembly protein 0.0132156
DUSP10 dual specificity phosphatase 10 0.0131903
ARF4 ADP-ribosylation factor 4 0.0130394
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0128832
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0126617
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.012622
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0125141
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0124581
RNF145 ring finger protein 145 0.0124224
KMT2C lysine (K)-specific methyltransferase 2C 0.0124129
ASCC3 activating signal cointegrator 1 complex subunit 3 0.012369
RORA RAR-related orphan receptor A 0.0121638
SKIC3 SKI3 subunit of superkiller complex 0.0121404
UBA6 ubiquitin-like modifier activating enzyme 6 0.0121317
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0120525
B2M beta-2-microglobulin 0.0118963
SCAF11 SR-related CTD-associated factor 11 0.0118444
SRP54 signal recognition particle 54kDa 0.0118184
HDLBP high density lipoprotein binding protein 0.0117619
COL5A2 collagen, type V, alpha 2 0.0117184
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0116634
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0115726
RND3 Rho family GTPase 3 0.011569
RAB8B RAB8B, member RAS oncogene family 0.0115654
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0114778
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0114447
COG6 component of oligomeric golgi complex 6 0.0114356

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.211517
MMP1 matrix metallopeptidase 1 -0.0880868
NALF1 NALCN channel auxiliary factor 1 -0.0614494
INHBA inhibin, beta A -0.0565791
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0561051
TMSB10 thymosin beta 10 -0.0555227
PRKG1 protein kinase, cGMP-dependent, type I -0.0420205
UBC ubiquitin C -0.0388089
AHNAK AHNAK nucleoprotein -0.0357321
RPL23 ribosomal protein L23 -0.0320551
MT2A metallothionein 2A -0.0298965
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0294199
ENO1 enolase 1, (alpha) -0.029407
ASPH aspartate beta-hydroxylase -0.0285874
PTMA prothymosin, alpha -0.0283057
COL1A1 collagen, type I, alpha 1 -0.0279748
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0273617
HMGA2 high mobility group AT-hook 2 -0.0271707
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0267824
GLIS3 GLIS family zinc finger 3 -0.0262402
NAV2 neuron navigator 2 -0.0261433
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0248343
RPS27A ribosomal protein S27a -0.0242318
RPLP1 ribosomal protein, large, P1 -0.0235789
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0225012
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0206702
HLA-B major histocompatibility complex, class I, B -0.020604
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0205835
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0203693
PRRC2C proline-rich coiled-coil 2C -0.0199585
FLNA filamin A, alpha -0.0195839
RTN4 reticulon 4 -0.0194892
EEF2 eukaryotic translation elongation factor 2 -0.0191945
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0178182
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0177466
RPL37A ribosomal protein L37a -0.0171823
FN1 fibronectin 1 -0.0170546
ANKRD12 ankyrin repeat domain 12 -0.0169629
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0164821
ANTXR2 anthrax toxin receptor 2 -0.0164421
ACTG1 actin gamma 1 -0.0158944
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0157935
NAP1L1 nucleosome assembly protein 1-like 1 -0.0157864
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0155836
TPT1 tumor protein, translationally-controlled 1 -0.0153381
CD44 CD44 molecule (Indian blood group) -0.0152033
DOCK5 dedicator of cytokinesis 5 -0.0151899
PCBP2 poly(rC) binding protein 2 -0.0151377
RPLP2 ribosomal protein, large, P2 -0.0150975
MAML2 mastermind-like 2 (Drosophila) -0.0149306
RPL31 ribosomal protein L31 -0.014816
INTS6 integrator complex subunit 6 -0.0147829
RPL34 ribosomal protein L34 -0.0147486
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0146783
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0144093
FOXP1 forkhead box P1 -0.0143595
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0140253
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0137195
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0135147
IGF2R insulin-like growth factor 2 receptor -0.0135052
SLC38A2 solute carrier family 38, member 2 -0.0132462
PRELID2 PRELI domain containing 2 -0.012442
JUN jun proto-oncogene -0.0124152
SLIT2 slit homolog 2 (Drosophila) -0.0123805
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0123197
PKM pyruvate kinase, muscle -0.0122727
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0122413
TXNIP thioredoxin interacting protein -0.012216
FRMPD4 FERM and PDZ domain containing 4 -0.0121823
RPS3 ribosomal protein S3 -0.0121616
OXR1 oxidation resistance 1 -0.0121599
MCTP1 multiple C2 domains, transmembrane 1 -0.0120919
SOD2 superoxide dismutase 2, mitochondrial -0.0120466
ARHGAP22 Rho GTPase activating protein 22 -0.011884
CDK14 cyclin-dependent kinase 14 -0.0118299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0117885
ZNF638 zinc finger protein 638 -0.0117454
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0117274
ADGRB3 adhesion G protein-coupled receptor B3 -0.0116629
RPL9 ribosomal protein L9 -0.0116102
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0114312
RPL35A ribosomal protein L35a -0.0114128
RPL30 ribosomal protein L30 -0.0113723
AEBP2 AE binding protein 2 -0.0113528
TXNRD1 thioredoxin reductase 1 -0.0112985
HIPK2 homeodomain interacting protein kinase 2 -0.0112961
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0111745
SMYD3 SET and MYND domain containing 3 -0.0110806
ANK2 ankyrin 2, neuronal -0.0110557
EPAS1 endothelial PAS domain protein 1 -0.0110408
KIAA1549L KIAA1549-like -0.0109244
KDM4C lysine (K)-specific demethylase 4C -0.0108309
SPDYA speedy/RINGO cell cycle regulator family member A -0.0107546
ZBTB20 zinc finger and BTB domain containing 20 -0.0107321
LOC112694756 uncharaterized LOC112694756 -0.0104744
RPS12 ribosomal protein S12 -0.0102508
BCAS3 breast carcinoma amplified sequence 3 -0.0102129
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.0101845
CD59 CD59 molecule, complement regulatory protein -0.00975571
OSBPL8 oxysterol binding protein-like 8 -0.00959116