| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/107970 |
| Similar Terms | |
| Downloads & Tools |
196 proteins with high or low expression in Fingolimod relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.94 |
| DNAH9 | dynein, axonemal, heavy chain 9 | 1.87 |
| TMEM59 | transmembrane protein 59 | 1.63 |
| APOB | apolipoprotein B | 1.52 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.51 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.45 |
| PIP | prolactin-induced protein | 1.39 |
| ZNF543 | zinc finger protein 543 | 1.37 |
| LIMCH1 | LIM and calponin homology domains 1 | 1.35 |
| NCOA4 | nuclear receptor coactivator 4 | 1.31 |
| ITM2C | integral membrane protein 2C | 1.3 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.3 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 1.3 |
| NDFIP2 | Nedd4 family interacting protein 2 | 1.29 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 1.28 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 1.2 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 1.17 |
| IFITM3 | interferon induced transmembrane protein 3 | 1.14 |
| FDPS | farnesyl diphosphate synthase | 1.08 |
| MSMO1 | methylsterol monooxygenase 1 | 1.07 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.03 |
| PSAP | prosaposin | 1.02 |
| CD81 | CD81 molecule | 1.02 |
| ITM2B | integral membrane protein 2B | 1.02 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 1.01 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.0 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.98 |
| SQLE | squalene epoxidase | 0.93 |
| SET | SET nuclear proto-oncogene | 0.92 |
| AREG | amphiregulin | 0.91 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.89 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.89 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.88 |
| H1-0 | H1.0 linker histone | 0.87 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.86 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.85 |
| GINM1 | glycoprotein integral membrane 1 | 0.84 |
| RNF130 | ring finger protein 130 | 0.83 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.83 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.82 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.81 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.79 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.79 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.79 |
| IFNGR1 | interferon gamma receptor 1 | 0.78 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.77 |
| NOTCH3 | notch 3 | 0.74 |
| SDCBP | syndecan binding protein (syntenin) | 0.74 |
| RAB27B | RAB27B, member RAS oncogene family | 0.73 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.72 |
| APOE | apolipoprotein E | 0.71 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.71 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.7 |
| FASN | fatty acid synthase | 0.7 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.7 |
| XBP1 | X-box binding protein 1 | 0.69 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.69 |
| MVK | mevalonate kinase | 0.68 |
| TMEM248 | transmembrane protein 248 | 0.68 |
| TRIM2 | tripartite motif containing 2 | 0.68 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.68 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.67 |
| OSMR | oncostatin M receptor | 0.67 |
| LIPH | lipase, member H | 0.66 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.66 |
| HAS3 | hyaluronan synthase 3 | 0.65 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.65 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.65 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.64 |
| CTSL | cathepsin L | 0.64 |
| PLPP2 | phospholipid phosphatase 2 | 0.63 |
| RING1 | ring finger protein 1 | 0.63 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.63 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.62 |
| GPR108 | G protein-coupled receptor 108 | 0.62 |
| SQSTM1 | sequestosome 1 | 0.62 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 0.62 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.61 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.61 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.61 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.6 |
| LAMP1 | lysosomal-associated membrane protein 1 | 0.6 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.59 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.59 |
| SERINC1 | serine incorporator 1 | 0.59 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.58 |
| CD63 | CD63 molecule | 0.58 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.58 |
| PTDSS1 | phosphatidylserine synthase 1 | 0.58 |
| RPL30 | ribosomal protein L30 | 0.58 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.57 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.57 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.57 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.57 |
| LMF1 | lipase maturation factor 1 | 0.57 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | 0.57 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.57 |
| APP | amyloid beta (A4) precursor protein | 0.56 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HPSE | heparanase | -1.11 |
| MB21D2 | Mab-21 domain containing 2 | -1.0 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.97 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.97 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.93 |
| MCOLN1 | mucolipin 1 | -0.9 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.83 |
| PLIN2 | perilipin 2 | -0.82 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.8 |
| SMN1 | survival of motor neuron 1, telomeric | -0.79 |
| NAAA | N-acylethanolamine acid amidase | -0.79 |
| AEN | apoptosis enhancing nuclease | -0.78 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | -0.76 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | -0.75 |
| MYO15B | myosin XVB | -0.74 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.74 |
| ZNF581 | zinc finger protein 581 | -0.73 |
| DPYD | dihydropyrimidine dehydrogenase | -0.71 |
| POC1B | POC1 centriolar protein B | -0.7 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -0.69 |
| PRKX | protein kinase, X-linked | -0.68 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.67 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.65 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.64 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.63 |
| RFK | riboflavin kinase | -0.62 |
| CCN1 | cellular communication network factor 1 | -0.62 |
| ZNF814 | zinc finger protein 814 | -0.62 |
| S100PBP | S100P binding protein | -0.62 |
| ADCY5 | adenylate cyclase 5 | -0.62 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.61 |
| VAMP4 | vesicle-associated membrane protein 4 | -0.61 |
| SYTL3 | synaptotagmin-like 3 | -0.61 |
| AMOTL2 | angiomotin like 2 | -0.6 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.59 |
| ZNRD1 | zinc ribbon domain containing 1 | -0.59 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -0.59 |
| RFT1 | RFT1 homolog (S. cerevisiae) | -0.59 |
| CCDC167 | coiled-coil domain containing 167 | -0.58 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.58 |
| KIF1B | kinesin family member 1B | -0.57 |
| FNIP1 | folliculin interacting protein 1 | -0.56 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.55 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.55 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | -0.54 |
| TSPAN31 | tetraspanin 31 | -0.54 |
| COQ4 | coenzyme Q4 | -0.54 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.52 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.51 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.51 |
| ZXDC | ZXD family zinc finger C | -0.51 |
| PICK1 | protein interacting with PRKCA 1 | -0.51 |
| DNA2 | DNA replication helicase/nuclease 2 | -0.51 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -0.5 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.5 |
| E4F1 | E4F transcription factor 1 | -0.5 |
| ODC1 | ornithine decarboxylase 1 | -0.5 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.49 |
| YAP1 | Yes-associated protein 1 | -0.49 |
| TRIB3 | tribbles pseudokinase 3 | -0.49 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.48 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.48 |
| TMEM14C | transmembrane protein 14C | -0.48 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.48 |
| UPP1 | uridine phosphorylase 1 | -0.48 |
| NMU | neuromedin U | -0.48 |
| CEP72 | centrosomal protein 72kDa | -0.47 |
| STK33 | serine/threonine kinase 33 | -0.47 |
| MED12L | mediator complex subunit 12-like | -0.47 |
| C5ORF34 | chromosome 5 open reading frame 34 | -0.47 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.47 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | -0.46 |
| DONSON | downstream neighbor of SON | -0.46 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -0.46 |
| THG1L | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) | -0.46 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.46 |
| ZNF76 | zinc finger protein 76 | -0.46 |
| MIS12 | MIS12 kinetochore complex component | -0.46 |
| ZWILCH | zwilch kinetochore protein | -0.46 |
| MRPL54 | mitochondrial ribosomal protein L54 | -0.46 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.45 |
| IMMT | inner membrane protein, mitochondrial | -0.45 |
| PLEC | plectin | -0.45 |
| UBL5 | ubiquitin-like 5 | -0.45 |
| CMC1 | C-x(9)-C motif containing 1 | -0.45 |
| ZNF142 | zinc finger protein 142 | -0.45 |
| MYCBP | MYC binding protein | -0.45 |
| TIGD5 | tigger transposable element derived 5 | -0.45 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | -0.44 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.44 |
| TMEM39A | transmembrane protein 39A | -0.43 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.43 |
| SURF2 | surfeit 2 | -0.43 |
| PRMT1 | protein arginine methyltransferase 1 | -0.43 |
| MT1X | metallothionein 1X | -0.43 |
| GPSM2 | G-protein signaling modulator 2 | -0.43 |
| POMP | proteasome maturation protein | -0.43 |
| TYK2 | tyrosine kinase 2 | -0.43 |
