| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5287969 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Flavopiridol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP53 | tumor protein p53 | 3.62 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.27 |
| GLUL | glutamate-ammonia ligase | 1.18 |
| TAGLN | transgelin | 1.08 |
| METRN | meteorin, glial cell differentiation regulator | 1.07 |
| TDRD6 | tudor domain containing 6 | 1.06 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 1.03 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 1.01 |
| TPT1 | tumor protein, translationally-controlled 1 | 1.01 |
| HBA1 | hemoglobin, alpha 1 | 1.01 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 1.01 |
| PRG4 | proteoglycan 4 | 1.0 |
| S100A5 | S100 calcium binding protein A5 | 0.91 |
| CDK4 | cyclin-dependent kinase 4 | 0.9 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 0.89 |
| OTUD5 | OTU deubiquitinase 5 | 0.88 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 | 0.88 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.87 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | 0.87 |
| VTN | vitronectin | 0.86 |
| FHIT | fragile histidine triad | 0.86 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 0.85 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.82 |
| F2 | coagulation factor II (thrombin) | 0.81 |
| FN1 | fibronectin 1 | 0.8 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.79 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.78 |
| ACTL8 | actin-like 8 | 0.78 |
| AXL | AXL receptor tyrosine kinase | 0.78 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.77 |
| TMC4 | transmembrane channel-like 4 | 0.77 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.77 |
| CKM | creatine kinase, muscle | 0.77 |
| DCAF17 | DDB1 and CUL4 associated factor 17 | 0.76 |
| RNASE4 | ribonuclease, RNase A family, 4 | 0.75 |
| TK1 | thymidine kinase 1, soluble | 0.75 |
| AOC1 | amine oxidase, copper containing 1 | 0.75 |
| FAT2 | FAT atypical cadherin 2 | 0.74 |
| TSPAN4 | tetraspanin 4 | 0.73 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.73 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.73 |
| PRR11 | proline rich 11 | 0.73 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.72 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.72 |
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.72 |
| ELK1 | ELK1, member of ETS oncogene family | 0.71 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.71 |
| BOLA3 | bolA family member 3 | 0.71 |
| DNAH9 | dynein, axonemal, heavy chain 9 | 0.71 |
| CD81 | CD81 molecule | 0.7 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.69 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.69 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | 0.69 |
| GSTO2 | glutathione S-transferase omega 2 | 0.69 |
| PRAF2 | PRA1 domain family, member 2 | 0.69 |
| TTN | titin | 0.69 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.68 |
| ANKRD18B | ankyrin repeat domain 18B | 0.68 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.67 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.66 |
| CFAP36 | cilia and flagella associated protein 36 | 0.66 |
| TLCD4 | TLC domain containing 4 | 0.65 |
| PLEK | pleckstrin | 0.64 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | 0.64 |
| DHFR | dihydrofolate reductase | 0.64 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.64 |
| SGCE | sarcoglycan, epsilon | 0.64 |
| CRIP2 | cysteine-rich protein 2 | 0.64 |
| TPM2 | tropomyosin 2 (beta) | 0.64 |
| ACTBL2 | actin, beta-like 2 | 0.64 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.63 |
| BCL7C | B-cell CLL/lymphoma 7C | 0.63 |
| CDC37 | cell division cycle 37 | 0.62 |
| DPP7 | dipeptidyl-peptidase 7 | 0.61 |
| MYDGF | myeloid-derived growth factor | 0.61 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.61 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 0.61 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.6 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.6 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.6 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.6 |
| MTA1 | metastasis associated 1 | 0.6 |
| RHOD | ras homolog family member D | 0.59 |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 0.59 |
| PLCD3 | phospholipase C, delta 3 | 0.59 |
| GDA | guanine deaminase | 0.59 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.59 |
| CES2 | carboxylesterase 2 | 0.59 |
| RPLP2 | ribosomal protein, large, P2 | 0.58 |
| SUMO3 | small ubiquitin-like modifier 3 | 0.58 |
| ADIPOR1 | adiponectin receptor 1 | 0.58 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.58 |
| CPNE7 | copine VII | 0.58 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.58 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.58 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.58 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.58 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.58 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC25A | cell division cycle 25A | -5.46 |
| DUSP6 | dual specificity phosphatase 6 | -5.41 |
| CDCA4 | cell division cycle associated 4 | -5.35 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -4.82 |
| TRIB1 | tribbles pseudokinase 1 | -4.17 |
| CCDC112 | coiled-coil domain containing 112 | -3.99 |
| TGIF1 | TGFB-induced factor homeobox 1 | -3.94 |
| ZNF627 | zinc finger protein 627 | -3.88 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -3.68 |
| FBXO5 | F-box protein 5 | -3.57 |
| ZNF518A | zinc finger protein 518A | -3.57 |
| FOXD2 | forkhead box D2 | -3.57 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -3.56 |
| AREG | amphiregulin | -3.54 |
| FAM207A | family with sequence similarity 207, member A | -3.5 |
| MCL1 | myeloid cell leukemia 1 | -3.49 |
| RPS19BP1 | ribosomal protein S19 binding protein 1 | -3.47 |
| NRIP1 | nuclear receptor interacting protein 1 | -3.41 |
| GMNN | geminin, DNA replication inhibitor | -3.41 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -3.41 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -3.4 |
| CCDC59 | coiled-coil domain containing 59 | -3.36 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -3.36 |
| POLDIP3 | polymerase (DNA-directed), delta interacting protein 3 | -3.34 |
| CHTOP | chromatin target of PRMT1 | -3.25 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -3.23 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -3.2 |
| FYTTD1 | forty-two-three domain containing 1 | -3.17 |
| OSER1 | oxidative stress responsive serine-rich 1 | -3.17 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -3.16 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -3.14 |
| UTP11 | UTP11 small subunit processome component | -3.13 |
| SURF6 | surfeit 6 | -3.11 |
| FEM1C | fem-1 homolog c (C. elegans) | -3.1 |
| DUSP7 | dual specificity phosphatase 7 | -3.07 |
| CDC25B | cell division cycle 25B | -3.01 |
| MCM10 | minichromosome maintenance complex component 10 | -3.0 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -2.99 |
| GPBP1 | GC-rich promoter binding protein 1 | -2.98 |
| FNIP1 | folliculin interacting protein 1 | -2.97 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -2.93 |
| CCDC137 | coiled-coil domain containing 137 | -2.91 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.81 |
| ZNF385B | zinc finger protein 385B | -2.81 |
| KLF10 | Kruppel-like factor 10 | -2.8 |
| NOP53 | NOP53 ribosome biogenesis factor | -2.75 |
| TBX3 | T-box 3 | -2.74 |
| TRIB3 | tribbles pseudokinase 3 | -2.72 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.66 |
| NAGS | N-acetylglutamate synthase | -2.64 |
| KIAA1586 | KIAA1586 | -2.64 |
| JAG1 | jagged 1 | -2.63 |
| IER5L | immediate early response 5-like | -2.61 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.61 |
| PRSS8 | protease, serine, 8 | -2.55 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | -2.54 |
| CDC6 | cell division cycle 6 | -2.52 |
| RTL6 | retrotransposon Gag like 6 | -2.49 |
| PER1 | period circadian clock 1 | -2.49 |
| KLHL21 | kelch-like family member 21 | -2.49 |
| QKI | QKI, KH domain containing, RNA binding | -2.48 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -2.47 |
| GGNBP2 | gametogenetin binding protein 2 | -2.47 |
| AEN | apoptosis enhancing nuclease | -2.46 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -2.44 |
| SGO2 | shugoshin 2 | -2.42 |
| ZNF584 | zinc finger protein 584 | -2.42 |
| FBXO33 | F-box protein 33 | -2.41 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | -2.39 |
| RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | -2.37 |
| CCNF | cyclin F | -2.37 |
| CCDC77 | coiled-coil domain containing 77 | -2.37 |
| RPL7L1 | ribosomal protein L7-like 1 | -2.33 |
| JARID2 | jumonji, AT rich interactive domain 2 | -2.32 |
| AMOTL2 | angiomotin like 2 | -2.32 |
| ZNF526 | zinc finger protein 526 | -2.31 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -2.3 |
| WSB1 | WD repeat and SOCS box containing 1 | -2.29 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -2.29 |
| CDC20 | cell division cycle 20 | -2.29 |
| DIPK1B | divergent protein kinase domain 1B | -2.29 |
| GATA2 | GATA binding protein 2 | -2.28 |
| ZNF267 | zinc finger protein 267 | -2.27 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -2.27 |
| ZNF664 | zinc finger protein 664 | -2.27 |
| FBXO46 | F-box protein 46 | -2.26 |
| SPOP | speckle-type POZ protein | -2.25 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | -2.24 |
| ZNF770 | zinc finger protein 770 | -2.24 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -2.23 |
| ZNF766 | zinc finger protein 766 | -2.23 |
| KIFC1 | kinesin family member C1 | -2.22 |
| TRIM68 | tripartite motif containing 68 | -2.22 |
| CCNA2 | cyclin A2 | -2.2 |
| ZNF580 | zinc finger protein 580 | -2.2 |
| PRELID3B | PRELI domain containing 3B | -2.2 |
| VWA1 | von Willebrand factor A domain containing 1 | -2.2 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -2.19 |
| KLF13 | Kruppel-like factor 13 | -2.18 |
| NOP16 | NOP16 nucleolar protein | -2.18 |
