| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It has been shown to exhibit antifungal activity. (Chemical Entities of Biological Interest Ontology, CHEBI_46081) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3365 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Fluconazole relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IPP | intracisternal A particle-promoted polypeptide | 1.55 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.06 |
| TCEANC2 | transcription elongation factor A (SII) N-terminal and central domain containing 2 | 0.63 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.6 |
| PEX13 | peroxisomal biogenesis factor 13 | 0.57 |
| TMEM64 | transmembrane protein 64 | 0.55 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.48 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.48 |
| TXNDC16 | thioredoxin domain containing 16 | 0.43 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.42 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.41 |
| LMO4 | LIM domain only 4 | 0.38 |
| ST5 | suppression of tumorigenicity 5 | 0.38 |
| PIP | prolactin-induced protein | 0.37 |
| ZC4H2 | zinc finger, C4H2 domain containing | 0.35 |
| KLHL5 | kelch-like family member 5 | 0.35 |
| PCNX1 | pecanex 1 | 0.35 |
| ZNF814 | zinc finger protein 814 | 0.35 |
| TROAP | trophinin associated protein | 0.34 |
| ADIRF | adipogenesis regulatory factor | 0.34 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.34 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.33 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.33 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.33 |
| ELK1 | ELK1, member of ETS oncogene family | 0.33 |
| DESI2 | desumoylating isopeptidase 2 | 0.33 |
| SFXN4 | sideroflexin 4 | 0.32 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.32 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.32 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.32 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 0.32 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.32 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.31 |
| XTBD1 | XRN2 binding domain containing 1 | 0.31 |
| SMTN | smoothelin | 0.3 |
| POMT2 | protein-O-mannosyltransferase 2 | 0.3 |
| MIEF2 | mitochondrial elongation factor 2 | 0.3 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.29 |
| YAE1 | YAE1 maturation factor of ABCE1 | 0.29 |
| SIRPA | signal-regulatory protein alpha | 0.29 |
| HMCES | 5-hydroxymethylcytosine (hmC) binding, ES cell-specific | 0.29 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.29 |
| TREX1 | three prime repair exonuclease 1 | 0.28 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | 0.28 |
| RNF141 | ring finger protein 141 | 0.28 |
| SUCO | SUN domain containing ossification factor | 0.28 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.27 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.27 |
| JRK | Jrk homolog (mouse) | 0.27 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.27 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.27 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.26 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.26 |
| PRKX | protein kinase, X-linked | 0.26 |
| DES | desmin | 0.26 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.26 |
| RGN | regucalcin | 0.26 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | 0.25 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.25 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.25 |
| MSH5 | mutS homolog 5 | 0.24 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | 0.24 |
| TUBB3 | tubulin, beta 3 class III | 0.24 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 0.24 |
| ZBED8L | ZBED8 like | 0.24 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | 0.24 |
| MCPH1 | microcephalin 1 | 0.24 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.23 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.23 |
| COMMD2 | COMM domain containing 2 | 0.23 |
| CCDC91 | coiled-coil domain containing 91 | 0.23 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.23 |
| ATG4D | autophagy related 4D, cysteine peptidase | 0.23 |
| ANK2 | ankyrin 2, neuronal | 0.23 |
| ZNF623 | zinc finger protein 623 | 0.23 |
| DBNL | drebrin-like | 0.23 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.23 |
| TRIM37 | tripartite motif containing 37 | 0.22 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.22 |
| R3HDM4 | R3H domain containing 4 | 0.22 |
| ETAA1 | Ewing tumor-associated antigen 1 | 0.22 |
| ZNF611 | zinc finger protein 611 | 0.22 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.22 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | 0.22 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.22 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 0.22 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.21 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.21 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.21 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.21 |
| CADPS | Ca++-dependent secretion activator | 0.21 |
| DCLRE1C | DNA cross-link repair 1C | 0.21 |
| MEF2A | myocyte enhancer factor 2A | 0.21 |
| KSR2 | kinase suppressor of ras 2 | 0.21 |
| HMCN1 | hemicentin 1 | 0.21 |
| SP140 | SP140 nuclear body protein | 0.21 |
| RAB26 | RAB26, member RAS oncogene family | 0.21 |
| KCNAB1 | potassium channel, voltage gated subfamily A regulatory beta subunit 1 | 0.21 |
| MNT | MAX network transcriptional repressor | 0.21 |
| ABITRAM | actin binding transcription modulator | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PALM3 | paralemmin 3 | -0.75 |
| PAH | phenylalanine hydroxylase | -0.51 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.46 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.42 |
| ROGDI | rogdi homolog (Drosophila) | -0.4 |
| KIAA1109 | KIAA1109 | -0.39 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.36 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.35 |
| NAV2 | neuron navigator 2 | -0.34 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.33 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | -0.32 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.3 |
| TMEM59 | transmembrane protein 59 | -0.29 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.29 |
| PITX2 | paired-like homeodomain 2 | -0.29 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | -0.29 |
| TM2D3 | TM2 domain containing 3 | -0.28 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.28 |
| ONECUT2 | one cut homeobox 2 | -0.27 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.27 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.27 |
| TBC1D13 | TBC1 domain family, member 13 | -0.27 |
| LAMA3 | laminin, alpha 3 | -0.27 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.27 |
| FAM120C | family with sequence similarity 120C | -0.26 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.26 |
| FBXO44 | F-box protein 44 | -0.26 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | -0.26 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.26 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.25 |
| ANGPTL4 | angiopoietin-like 4 | -0.25 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.25 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | -0.24 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.24 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.24 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -0.24 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.23 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.23 |
| TCTEX1D2 | Tctex1 domain containing 2 | -0.23 |
| FHIT | fragile histidine triad | -0.23 |
| FTL | ferritin, light polypeptide | -0.22 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | -0.22 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | -0.22 |
| MAGEA6 | melanoma antigen family A6 | -0.22 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.22 |
| C12ORF4 | chromosome 12 open reading frame 4 | -0.22 |
| RNF13 | ring finger protein 13 | -0.22 |
| ZNF263 | zinc finger protein 263 | -0.21 |
| ZNF264 | zinc finger protein 264 | -0.21 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.21 |
| HMBOX1 | homeobox containing 1 | -0.21 |
| CD63 | CD63 molecule | -0.21 |
| TEP1 | telomerase-associated protein 1 | -0.21 |
| SLC35B1 | solute carrier family 35, member B1 | -0.2 |
| TTPA | tocopherol (alpha) transfer protein | -0.2 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.2 |
| LYRM2 | LYR motif containing 2 | -0.2 |
| CDC37 | cell division cycle 37 | -0.2 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.2 |
| RNF111 | ring finger protein 111 | -0.2 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.2 |
| TMEM120A | transmembrane protein 120A | -0.19 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.19 |
| HLA-F | major histocompatibility complex, class I, F | -0.19 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -0.19 |
| FN1 | fibronectin 1 | -0.19 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.19 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.19 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.19 |
| METTL4 | methyltransferase like 4 | -0.19 |
| TTC31 | tetratricopeptide repeat domain 31 | -0.19 |
| ZSWIM3 | zinc finger, SWIM-type containing 3 | -0.18 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.18 |
| SGSM1 | small G protein signaling modulator 1 | -0.18 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.18 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | -0.18 |
| TSKU | tsukushi, small leucine rich proteoglycan | -0.18 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.18 |
| RNF149 | ring finger protein 149 | -0.18 |
| NRXN3 | neurexin 3 | -0.18 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.18 |
| KIAA1210 | KIAA1210 | -0.18 |
| RCAN3 | RCAN family member 3 | -0.17 |
| C12ORF73 | chromosome 12 open reading frame 73 | -0.17 |
| INAVA | innate immunity activator | -0.17 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.17 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.17 |
| TRIM15 | tripartite motif containing 15 | -0.17 |
| TTN | titin | -0.17 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.17 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -0.17 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.17 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.17 |
| CFAP57 | cilia and flagella associated protein 57 | -0.17 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.17 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.17 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | -0.17 |
| NTAN1 | N-terminal asparagine amidase | -0.17 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.17 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | -0.17 |
