Flumatinib (mesylate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Flumatinib (mesylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.252362
ERRFI1 ERBB receptor feedback inhibitor 1 0.122015
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0968842
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0881357
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0875944
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0782903
ANXA1 annexin A1 0.0779361
NAP1L1 nucleosome assembly protein 1-like 1 0.0737286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0702742
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0691044
KDM3A lysine (K)-specific demethylase 3A 0.067521
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.064271
SET SET nuclear proto-oncogene 0.0637159
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.063415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0623543
XPO1 exportin 1 0.0620684
TPI1 triosephosphate isomerase 1 0.0594214
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0561856
RRM2 ribonucleotide reductase M2 0.0536582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0530489
SPTBN1 spectrin, beta, non-erythrocytic 1 0.052761
HSPA8 heat shock 70kDa protein 8 0.0509789
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0505319
TPM3 tropomyosin 3 0.0490642
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0487511
MYH9 myosin, heavy chain 9, non-muscle 0.04639
PGK1 phosphoglycerate kinase 1 0.0447387
KIF5B kinesin family member 5B 0.0441321
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0438067
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0424773
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0422001
CLTC clathrin, heavy chain (Hc) 0.0415347
PTMA prothymosin, alpha 0.0410408
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0409479
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0408876
ASPH aspartate beta-hydroxylase 0.040769
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0406187
HDGF hepatoma-derived growth factor 0.0403936
ZNF292 zinc finger protein 292 0.0401905
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.039817
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0393222
DST dystonin 0.0390161
CKAP5 cytoskeleton associated protein 5 0.038826
USP9X ubiquitin specific peptidase 9, X-linked 0.0387739
CSNK1A1 casein kinase 1, alpha 1 0.038257
IPO7 importin 7 0.0374252
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0372506
RPL3 ribosomal protein L3 0.0368772
EPHA6 EPH receptor A6 0.036812
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0361621
PDIA6 protein disulfide isomerase family A, member 6 0.0361598
ENO1 enolase 1, (alpha) 0.0358495
SRRM2 serine/arginine repetitive matrix 2 0.0347055
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0346778
EEF2 eukaryotic translation elongation factor 2 0.0344047
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0339138
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0334859
YEATS2 YEATS domain containing 2 0.0332569
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0329726
NCKAP1 NCK-associated protein 1 0.0324285
PUM2 pumilio RNA-binding family member 2 0.0323981
NFE2L1 nuclear factor, erythroid 2-like 1 0.0322852
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.032148
NAMPT nicotinamide phosphoribosyltransferase 0.0321205
FXR1 fragile X mental retardation, autosomal homolog 1 0.0320751
CPOX coproporphyrinogen oxidase 0.0318304
THOC1 THO complex 1 0.0318293
MED13L mediator complex subunit 13-like 0.0316983
PRELID2 PRELI domain containing 2 0.0313872
GASK1B golgi associated kinase 1B 0.031351
APP amyloid beta (A4) precursor protein 0.0310441
TBC1D5 TBC1 domain family, member 5 0.0310155
ARRDC3 arrestin domain containing 3 0.0306505
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0306186
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0304609
BRWD3 bromodomain and WD repeat domain containing 3 0.0301399
TPR translocated promoter region, nuclear basket protein 0.0301321
NUP58 nucleoporin 58 0.0299773
MGAT4C MGAT4 family, member C 0.0299267
TRIO trio Rho guanine nucleotide exchange factor 0.0297894
USP53 ubiquitin specific peptidase 53 0.0294982
DSPP dentin sialophosphoprotein 0.0293794
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0290302
TFG TRK-fused gene 0.0289359
RPL4 ribosomal protein L4 0.0288128
MKI67 marker of proliferation Ki-67 0.0282394
PNN pinin, desmosome associated protein 0.0281087
LDHA lactate dehydrogenase A 0.0281015
BIRC6 baculoviral IAP repeat containing 6 0.0278805
STAG2 stromal antigen 2 0.0278632
HLTF helicase-like transcription factor 0.0278323
EIF4B eukaryotic translation initiation factor 4B 0.0277119
WNK1 WNK lysine deficient protein kinase 1 0.0275482
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0274865
MACF1 microtubule-actin crosslinking factor 1 0.0274851
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0273911
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0269663
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0269536
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0265553
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0263336

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239118
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.232795
TMSB10 thymosin beta 10 -0.156396
AREG amphiregulin -0.146087
NLGN1 neuroligin 1 -0.0992051
FTL ferritin, light polypeptide -0.0833806
EGR1 early growth response 1 -0.082775
RAB7A RAB7A, member RAS oncogene family -0.0665845
ZBTB20 zinc finger and BTB domain containing 20 -0.0650399
PDE4D phosphodiesterase 4D, cAMP-specific -0.0643186
RPL35A ribosomal protein L35a -0.0625124
CCN2 cellular communication network factor 2 -0.0602425
SLC38A2 solute carrier family 38, member 2 -0.0592359
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0530587
RPS6 ribosomal protein S6 -0.0520561
ATP5F1B ATP synthase F1 subunit beta -0.0481207
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0478549
CELF2 CUGBP, Elav-like family member 2 -0.0451663
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0447035
NABP1 nucleic acid binding protein 1 -0.044296
RPLP1 ribosomal protein, large, P1 -0.0422007
PFN1 profilin 1 -0.0415327
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0411401
PCDH7 protocadherin 7 -0.0399556
CNRIP1 cannabinoid receptor interacting protein 1 -0.0394084
CMIP c-Maf inducing protein -0.0390813
DPYD dihydropyrimidine dehydrogenase -0.0384399
RASAL2 RAS protein activator like 2 -0.0375858
VIM vimentin -0.0369287
RPS23 ribosomal protein S23 -0.0369246
RPLP2 ribosomal protein, large, P2 -0.0357001
MARCHF4 membrane associated ring-CH-type finger 4 -0.0355906
ZNF804A zinc finger protein 804A -0.0354485
HMGA2 high mobility group AT-hook 2 -0.0348082
ZSWIM6 zinc finger, SWIM-type containing 6 -0.034057
RPL12 ribosomal protein L12 -0.0339026
MYL12B myosin, light chain 12B, regulatory -0.0333151
POTEF POTE ankyrin domain family, member F -0.033029
RPS19 ribosomal protein S19 -0.0324096
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0323104
ANKRD28 ankyrin repeat domain 28 -0.0315995
RPS13 ribosomal protein S13 -0.0302849
CCND1 cyclin D1 -0.0299098
RPS21 ribosomal protein S21 -0.0292944
RPL28 ribosomal protein L28 -0.0286711
RPL38 ribosomal protein L38 -0.0273999
TPT1 tumor protein, translationally-controlled 1 -0.0273421
RPL34 ribosomal protein L34 -0.0270183
EHBP1 EH domain binding protein 1 -0.0268359
JMJD1C jumonji domain containing 1C -0.026823
HSPB1 heat shock 27kDa protein 1 -0.0265512
RPL23 ribosomal protein L23 -0.0265015
BPTF bromodomain PHD finger transcription factor -0.0262298
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0259883
LOC102724023 ES1 protein homolog, mitochondrial -0.0255477
ANKRD12 ankyrin repeat domain 12 -0.0254175
RPL36 ribosomal protein L36 -0.0253823
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0251168
RPL19 ribosomal protein L19 -0.0248756
MAP1B microtubule-associated protein 1B -0.0242213
TSC22D2 TSC22 domain family, member 2 -0.0238831
EDARADD EDAR-associated death domain -0.0237442
RPS29 ribosomal protein S29 -0.0237246
TBCA tubulin folding cofactor A -0.0236356
RPS16 ribosomal protein S16 -0.0234171
RPS24 ribosomal protein S24 -0.0231616
RPLP0 ribosomal protein, large, P0 -0.0229301
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0229158
DDIT3 DNA-damage-inducible transcript 3 -0.0226652
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0226033
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0225896
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0222951
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0221345
EDN1 endothelin 1 -0.0219662
RPS15 ribosomal protein S15 -0.0219459
PHF14 PHD finger protein 14 -0.0217444
ATF6 activating transcription factor 6 -0.0214859
RPL32 ribosomal protein L32 -0.0214534
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.0206007
RPS5 ribosomal protein S5 -0.0205833
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0204645
TEAD4 TEA domain family member 4 -0.0203074
HMGA1 high mobility group AT-hook 1 -0.0200925
MSRB3 methionine sulfoxide reductase B3 -0.0198273
TGM2 transglutaminase 2 -0.0193757
INTS6 integrator complex subunit 6 -0.0189223
RIMS2 regulating synaptic membrane exocytosis 2 -0.0189095
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0188465
ATN1 atrophin 1 -0.0187506
ANKRD17 ankyrin repeat domain 17 -0.0184705
RTN4 reticulon 4 -0.0184003
RPL5 ribosomal protein L5 -0.0182121
RPL11 ribosomal protein L11 -0.018154
ERBIN erbb2 interacting protein -0.0180028
NCEH1 neutral cholesterol ester hydrolase 1 -0.0179947
CCDC88A coiled-coil domain containing 88A -0.0178341
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0176707
LATS2 large tumor suppressor kinase 2 -0.0176502
CSMD3 CUB and Sushi multiple domains 3 -0.0175419
RPL27 ribosomal protein L27 -0.0172522