Flumatinib (mesylate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.14232
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.126602
MYH9 myosin, heavy chain 9, non-muscle 0.091551
PRELID2 PRELI domain containing 2 0.0781633
ARGLU1 arginine and glutamate rich 1 0.0691444
ERRFI1 ERBB receptor feedback inhibitor 1 0.0687306
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0669203
ASPH aspartate beta-hydroxylase 0.0651118
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.061756
SMAD3 SMAD family member 3 0.0606044
FAT1 FAT atypical cadherin 1 0.0596797
PGK1 phosphoglycerate kinase 1 0.058103
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0577782
RNF43 ring finger protein 43 0.0571244
RNF149 ring finger protein 149 0.0564668
SORBS1 sorbin and SH3 domain containing 1 0.0531596
ZMYM2 zinc finger, MYM-type 2 0.050935
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0498852
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0486394
BTBD9 BTB (POZ) domain containing 9 0.0450479
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0441466
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0440634
CTNND1 catenin (cadherin-associated protein), delta 1 0.0437276
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.041567
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0415144
PDIA3 protein disulfide isomerase family A, member 3 0.0407423
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0406162
HYOU1 hypoxia up-regulated 1 0.0399315
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0374868
ENO1 enolase 1, (alpha) 0.0367221
TM9SF2 transmembrane 9 superfamily member 2 0.0364746
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0364716
NRIP1 nuclear receptor interacting protein 1 0.0364318
EHF ets homologous factor 0.0362436
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0345025
IFNGR1 interferon gamma receptor 1 0.0336296
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0335456
LPP LIM domain containing preferred translocation partner in lipoma 0.033242
HELZ helicase with zinc finger 0.0328299
PDIA4 protein disulfide isomerase family A, member 4 0.0323753
YEATS2 YEATS domain containing 2 0.032183
RBM26 RNA binding motif protein 26 0.0316961
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.031053
NFE2L1 nuclear factor, erythroid 2-like 1 0.0295666
ESYT2 extended synaptotagmin-like protein 2 0.0290018
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.028752
KDM3A lysine (K)-specific demethylase 3A 0.0281815
XPO1 exportin 1 0.0280307
ARRDC3 arrestin domain containing 3 0.0274439
PFKP phosphofructokinase, platelet 0.027382
PHF3 PHD finger protein 3 0.0272009
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.027154
MXI1 MAX interactor 1, dimerization protein 0.0269551
DSPP dentin sialophosphoprotein 0.0269521
RAD23B RAD23 homolog B (S. cerevisiae) 0.0269432
ZDHHC20 zinc finger, DHHC-type containing 20 0.0267606
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0265596
MCTP2 multiple C2 domains, transmembrane 2 0.0264317
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0263644
MEF2A myocyte enhancer factor 2A 0.0262954
PDIA6 protein disulfide isomerase family A, member 6 0.0261623
HBS1L HBS1-like translational GTPase 0.0261317
CD46 CD46 molecule, complement regulatory protein 0.0260933
PLSCR2 phospholipid scramblase 2 0.0258778
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0257254
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0255347
TRERF1 transcriptional regulating factor 1 0.0254464
SRRM2 serine/arginine repetitive matrix 2 0.0252921
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0252665
RBM33 RNA binding motif protein 33 0.0252352
BRWD3 bromodomain and WD repeat domain containing 3 0.0252272
KMT2C lysine (K)-specific methyltransferase 2C 0.025033
MACF1 microtubule-actin crosslinking factor 1 0.0243114
PADI1 peptidyl arginine deiminase, type I 0.0241469
FNIP1 folliculin interacting protein 1 0.0240692
FNDC3B fibronectin type III domain containing 3B 0.0238377
TMED2 transmembrane emp24 domain trafficking protein 2 0.0237908
GOLGA4 golgin A4 0.0237735
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0236127
SREBF2 sterol regulatory element binding transcription factor 2 0.0235475
TTC3 tetratricopeptide repeat domain 3 0.0234309
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0234027
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0232891
MATR3 matrin 3 0.0232659
PKM pyruvate kinase, muscle 0.0232078
SFTPA2 surfactant protein A2 0.0231563
PDS5B PDS5 cohesin associated factor B 0.0231539
DNM2 dynamin 2 0.0228388
APOL1 apolipoprotein L, 1 0.0227863
ARHGAP5 Rho GTPase activating protein 5 0.0227339
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0222848
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0220809
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0220598
NCOR2 nuclear receptor corepressor 2 0.022043
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0215355
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0214843
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0214816
HPCAL1 hippocalcin-like 1 0.0214668
SSR1 signal sequence receptor, alpha 0.0214354
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0213698

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.203493
LMO7 LIM domain 7 -0.1871
EZR ezrin -0.136411
FOS FBJ murine osteosarcoma viral oncogene homolog -0.123362
STAT1 signal transducer and activator of transcription 1, 91kDa -0.117508
MACC1 metastasis associated in colon cancer 1 -0.108107
EPSTI1 epithelial stromal interaction 1 (breast) -0.107442
B2M beta-2-microglobulin -0.100107
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0940798
LOC102724023 ES1 protein homolog, mitochondrial -0.0923949
RAB7A RAB7A, member RAS oncogene family -0.0923282
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.087327
RIGI RNA sensor RIG-I -0.0834398
ZMYND8 zinc finger, MYND-type containing 8 -0.0832047
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0829278
PLSCR1 phospholipid scramblase 1 -0.0815834
MYO1E myosin IE -0.0815397
IRF1 interferon regulatory factor 1 -0.0807097
JUN jun proto-oncogene -0.0763232
CCNL1 cyclin L1 -0.0763012
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0733396
MX1 MX dynamin-like GTPase 1 -0.0712374
TMC5 transmembrane channel-like 5 -0.0709389
LYZ lysozyme -0.0698008
MX2 MX dynamin-like GTPase 2 -0.0684882
SPATA13 spermatogenesis associated 13 -0.0659986
H1-0 H1.0 linker histone -0.0641337
SQSTM1 sequestosome 1 -0.0636046
SP100 SP100 nuclear antigen -0.0618493
PERP PERP, TP53 apoptosis effector -0.0612502
ANXA2 annexin A2 -0.0600012
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0569329
VMP1 vacuole membrane protein 1 -0.0567494
GMDS GDP-mannose 4,6-dehydratase -0.0558351
GOLGB1 golgin B1 -0.0541579
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0538978
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0536367
LCN2 lipocalin 2 -0.0521962
ITPKC inositol-trisphosphate 3-kinase C -0.0501658
UBC ubiquitin C -0.0496985
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0481681
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0478702
ZFP36L1 ZFP36 ring finger protein-like 1 -0.047645
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0471629
EXT1 exostosin glycosyltransferase 1 -0.0469702
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0455949
XAF1 XIAP associated factor 1 -0.0444236
DDIT3 DNA-damage-inducible transcript 3 -0.0436922
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0433688
NAMPT nicotinamide phosphoribosyltransferase -0.0432508
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0427092
PHACTR4 phosphatase and actin regulator 4 -0.0422114
BLZF1 basic leucine zipper nuclear factor 1 -0.0419078
PATJ PATJ crumbs cell polarity complex component -0.0414787
IGFBP3 insulin-like growth factor binding protein 3 -0.041217
GCC2 GRIP and coiled-coil domain containing 2 -0.0411325
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.040406
PMP22 peripheral myelin protein 22 -0.0403558
ARF4 ADP-ribosylation factor 4 -0.0403522
SEC31A SEC31 homolog A (S. cerevisiae) -0.0396375
EPHB2 EPH receptor B2 -0.0383015
ITGA6 integrin, alpha 6 -0.0380803
FOXP1 forkhead box P1 -0.0376113
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0372576
RABGAP1L RAB GTPase activating protein 1-like -0.0370499
PTMA prothymosin, alpha -0.0366043
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0364636
SOD2 superoxide dismutase 2, mitochondrial -0.0356983
SPDYA speedy/RINGO cell cycle regulator family member A -0.0355099
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0354716
TPT1 tumor protein, translationally-controlled 1 -0.0350233
ATF6 activating transcription factor 6 -0.0349724
HM13 histocompatibility (minor) 13 -0.0347021
APOL6 apolipoprotein L, 6 -0.0345901
MCU mitochondrial calcium uniporter -0.0344601
TRIM2 tripartite motif containing 2 -0.0339475
RBM47 RNA binding motif protein 47 -0.0338932
UFM1 ubiquitin-fold modifier 1 -0.0337658
TJP1 tight junction protein 1 -0.032837
HLA-B major histocompatibility complex, class I, B -0.0325776
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0325671
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.032467
UGDH UDP-glucose 6-dehydrogenase -0.0321183
FTH1 ferritin, heavy polypeptide 1 -0.0320613
SAMD4A sterile alpha motif domain containing 4A -0.0319089
STAT2 signal transducer and activator of transcription 2, 113kDa -0.0316308
LAP3 leucine aminopeptidase 3 -0.0312432
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0308026
IFI27 interferon, alpha-inducible protein 27 -0.0305524
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0305195
TM4SF1 transmembrane 4 L six family member 1 -0.0301284
FTL ferritin, light polypeptide -0.0301274
OASL 2'-5'-oligoadenylate synthetase-like -0.0300021
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0298634
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0296526
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0295383
NCKAP5 NCK-associated protein 5 -0.0293003
MCTP1 multiple C2 domains, transmembrane 1 -0.028918
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283772
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0281101