Flumatinib (mesylate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.183907
FAM13A family with sequence similarity 13, member A 0.182392
ERRFI1 ERBB receptor feedback inhibitor 1 0.177835
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.150703
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.149366
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.148074
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.140997
CXCL8 chemokine (C-X-C motif) ligand 8 0.123285
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.118159
TRIO trio Rho guanine nucleotide exchange factor 0.107528
MYH9 myosin, heavy chain 9, non-muscle 0.106021
PTMA prothymosin, alpha 0.101163
STC1 stanniocalcin 1 0.0941981
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0889783
PGK1 phosphoglycerate kinase 1 0.087611
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0863078
JARID2 jumonji, AT rich interactive domain 2 0.0840183
FNDC3B fibronectin type III domain containing 3B 0.0803851
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0748685
NDRG1 N-myc downstream regulated 1 0.0713127
SPAG9 sperm associated antigen 9 0.0707245
NGLY1 N-glycanase 1 0.0641218
HILPDA hypoxia inducible lipid droplet-associated 0.0634346
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0619363
ASPH aspartate beta-hydroxylase 0.0618001
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0614009
LDHA lactate dehydrogenase A 0.0587581
UBA6 ubiquitin-like modifier activating enzyme 6 0.0564839
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0544556
ZNF292 zinc finger protein 292 0.0543034
ENO1 enolase 1, (alpha) 0.053635
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0535032
RNMT RNA (guanine-7-) methyltransferase 0.051446
NAMPT nicotinamide phosphoribosyltransferase 0.0507123
DDIT4 DNA-damage-inducible transcript 4 0.0500159
FLNB filamin B, beta 0.0498621
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0492373
TAC4 tachykinin 4 (hemokinin) 0.0491532
MIMS1 mitochondrial inner membrane scaffold 1 0.0477921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0477179
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0476485
USP3 ubiquitin specific peptidase 3 0.0473302
PRELID2 PRELI domain containing 2 0.0470625
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0468401
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0465344
RRM2 ribonucleotide reductase M2 0.0455506
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0453496
NUP58 nucleoporin 58 0.0452479
ATP13A3 ATPase type 13A3 0.0451301
PDIA3 protein disulfide isomerase family A, member 3 0.0450166
HPCAL1 hippocalcin-like 1 0.0431511
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0430497
DTNA dystrobrevin, alpha 0.0430149
HELZ helicase with zinc finger 0.042613
ADM adrenomedullin 0.0425452
PKM pyruvate kinase, muscle 0.0422948
SEPTIN9 septin 9 0.0421876
AMPD3 adenosine monophosphate deaminase 3 0.0416932
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0415081
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0408856
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406361
KDM3A lysine (K)-specific demethylase 3A 0.0401762
HOOK2 hook microtubule-tethering protein 2 0.0399643
HSPA8 heat shock 70kDa protein 8 0.0391514
RNF24 ring finger protein 24 0.0391502
PDE10A phosphodiesterase 10A 0.0387937
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0385091
CANX calnexin 0.0384223
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0382958
ARRDC3 arrestin domain containing 3 0.0380193
CD109 CD109 molecule 0.0377303
WDR45B WD repeat domain 45B 0.0377112
ANGPTL4 angiopoietin-like 4 0.0372637
KMT2E lysine (K)-specific methyltransferase 2E 0.0349249
PDIA6 protein disulfide isomerase family A, member 6 0.0344295
NAP1L1 nucleosome assembly protein 1-like 1 0.0343613
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0337447
SHB Src homology 2 domain containing adaptor protein B 0.033701
OGA O-GlcNAcase 0.033038
MYO1B myosin IB 0.0328023
DOT1L DOT1-like histone H3K79 methyltransferase 0.0322943
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.032214
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0316504
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0314133
BHLHE40 basic helix-loop-helix family, member e40 0.0313262
COL6A2 collagen, type VI, alpha 2 0.0312435
UGCG UDP-glucose ceramide glucosyltransferase 0.0309839
RAI1 retinoic acid induced 1 0.0309419
CLEC1B C-type lectin domain family 1, member B 0.0304088
RUNX1 runt-related transcription factor 1 0.030274
IRS2 insulin receptor substrate 2 0.0302314
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0300597
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0297655
FAM162A family with sequence similarity 162, member A 0.0294168
INSIG2 insulin induced gene 2 0.0290642
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0288485
RNF145 ring finger protein 145 0.028727
PDIA4 protein disulfide isomerase family A, member 4 0.0285998
RLF rearranged L-myc fusion 0.0285769
LIMS1 LIM and senescent cell antigen-like domains 1 0.0284003

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195887
HMGA2 high mobility group AT-hook 2 -0.179476
EXT1 exostosin glycosyltransferase 1 -0.0867424
IGF2 insulin-like growth factor 2 -0.0714502
EGR1 early growth response 1 -0.0711325
COL6A1 collagen, type VI, alpha 1 -0.0655418
ACTG1 actin gamma 1 -0.0624976
VIM vimentin -0.0612144
TPT1 tumor protein, translationally-controlled 1 -0.0611868
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0604124
CD44 CD44 molecule (Indian blood group) -0.0603264
BICD1 bicaudal D homolog 1 (Drosophila) -0.0569136
FN1 fibronectin 1 -0.0568084
CLMP CXADR-like membrane protein -0.0504029
RAI14 retinoic acid induced 14 -0.0455796
ANKRD28 ankyrin repeat domain 28 -0.0447679
COL5A1 collagen, type V, alpha 1 -0.0444151
NAV1 neuron navigator 1 -0.0418009
COL1A1 collagen, type I, alpha 1 -0.0392737
OSMR oncostatin M receptor -0.0373968
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0357382
ZBTB20 zinc finger and BTB domain containing 20 -0.0352079
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0336527
RPL35A ribosomal protein L35a -0.032846
BPTF bromodomain PHD finger transcription factor -0.0324094
RPS6 ribosomal protein S6 -0.0321808
TENM2 teneurin transmembrane protein 2 -0.0316374
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0310789
CAVIN1 caveolae associated protein 1 -0.0308087
EGFR epidermal growth factor receptor -0.0305001
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0304181
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0303451
GLIS3 GLIS family zinc finger 3 -0.0293589
MAP4 microtubule-associated protein 4 -0.0291108
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0289511
TPM1 tropomyosin 1 (alpha) -0.0281132
TMSB10 thymosin beta 10 -0.0277873
ENO2 enolase 2 (gamma, neuronal) -0.027712
CAPN2 calpain 2, (m/II) large subunit -0.0274838
RPS13 ribosomal protein S13 -0.0270154
GOLGB1 golgin B1 -0.0268962
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0268638
MYO10 myosin X -0.0266419
TBCA tubulin folding cofactor A -0.0265179
AGRN agrin -0.0261688
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0256842
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0252342
ARHGAP22 Rho GTPase activating protein 22 -0.0250959
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0249149
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0246408
CUX1 cut-like homeobox 1 -0.0246023
CCND1 cyclin D1 -0.0245009
RPLP1 ribosomal protein, large, P1 -0.0241647
CDH13 cadherin 13 -0.0238483
RPL38 ribosomal protein L38 -0.023538
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0235335
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0229848
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0223287
PTPRG protein tyrosine phosphatase, receptor type, G -0.0222965
MT1E metallothionein 1E -0.0222096
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0219054
RPS24 ribosomal protein S24 -0.0218252
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0215375
ACTN4 actinin, alpha 4 -0.0214476
AGO3 argonaute RISC catalytic component 3 -0.0212376
EXOC6B exocyst complex component 6B -0.0208714
PCNX4 pecanex 4 -0.020813
TCF12 transcription factor 12 -0.0202071
EHBP1 EH domain binding protein 1 -0.0200813
PTPRK protein tyrosine phosphatase, receptor type, K -0.0199595
IGFBP3 insulin-like growth factor binding protein 3 -0.0197118
RAB7A RAB7A, member RAS oncogene family -0.0196016
MRC2 mannose receptor, C type 2 -0.0195775
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0195407
NALF1 NALCN channel auxiliary factor 1 -0.0193313
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0193191
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0190975
VCL vinculin -0.0189555
ZFAND3 zinc finger, AN1-type domain 3 -0.0189027
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.0189025
POTEF POTE ankyrin domain family, member F -0.0187315
TPM4 tropomyosin 4 -0.0187313
RAB31 RAB31, member RAS oncogene family -0.0185943
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.018182
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0181125
ZBTB38 zinc finger and BTB domain containing 38 -0.0180828
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0180269
NRP1 neuropilin 1 -0.0179726
MED13 mediator complex subunit 13 -0.0179076
SEC31A SEC31 homolog A (S. cerevisiae) -0.0178211
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0177165
MBD5 methyl-CpG binding domain protein 5 -0.0172915
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0172839
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.017253
FOXP1 forkhead box P1 -0.0171438
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0170466
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0169844
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0168948
FMN1 formin 1 -0.0168654
IL11 interleukin 11 -0.0166971