| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flumatinib (mesylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flumatinib (mesylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.145541 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0845801 |
| TF | transferrin | 0.0844347 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0599894 |
| IGF2 | insulin-like growth factor 2 | 0.0577971 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0547123 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0546559 |
| PRELID2 | PRELI domain containing 2 | 0.0502143 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.049399 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0479172 |
| SDC4 | syndecan 4 | 0.0462575 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0411912 |
| AFDN | afadin, adherens junction formation factor | 0.0400662 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0397243 |
| RPL4 | ribosomal protein L4 | 0.0388139 |
| RPS12 | ribosomal protein S12 | 0.0384463 |
| PEG10 | paternally expressed 10 | 0.03838 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0376822 |
| DTNA | dystrobrevin, alpha | 0.0373307 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0361724 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0356341 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.035416 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0332776 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0325736 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0322737 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0312919 |
| KIF5B | kinesin family member 5B | 0.0312691 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0311897 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0309583 |
| FN1 | fibronectin 1 | 0.030475 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0289816 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0289461 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0279658 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0278559 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0277379 |
| RPL3 | ribosomal protein L3 | 0.0276959 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0274316 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0272701 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0271655 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0271654 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0271569 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0259502 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0258375 |
| MSI2 | musashi RNA-binding protein 2 | 0.0255478 |
| FMNL2 | formin-like 2 | 0.025436 |
| AHR | aryl hydrocarbon receptor | 0.0253172 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0249713 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0245699 |
| PHF3 | PHD finger protein 3 | 0.0241026 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0237045 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0235643 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0230256 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0228325 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0227073 |
| RPS3 | ribosomal protein S3 | 0.0226727 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0226026 |
| SMAP1 | small ArfGAP 1 | 0.0222861 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0222351 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0221083 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0217126 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0217117 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0216736 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0215874 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0215099 |
| MKI67 | marker of proliferation Ki-67 | 0.0212193 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0203958 |
| PEG3 | paternally expressed 3 | 0.0203183 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0201856 |
| FAM13A | family with sequence similarity 13, member A | 0.0201514 |
| LRRC1 | leucine rich repeat containing 1 | 0.0192113 |
| SBF2 | SET binding factor 2 | 0.0192036 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0191161 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0190288 |
| KIF1B | kinesin family member 1B | 0.0188098 |
| ANXA5 | annexin A5 | 0.0185861 |
| CENPF | centromere protein F, 350/400kDa | 0.0183511 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0181809 |
| PDZD8 | PDZ domain containing 8 | 0.0178695 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0177169 |
| ATRN | attractin | 0.017549 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0174391 |
| WWC2 | WW and C2 domain containing 2 | 0.017311 |
| CLIC1 | chloride intracellular channel 1 | 0.0168869 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0167806 |
| RNF145 | ring finger protein 145 | 0.016221 |
| HELZ | helicase with zinc finger | 0.016214 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0160118 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.0158436 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.015686 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0156713 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0155894 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0153317 |
| FNIP1 | folliculin interacting protein 1 | 0.0152181 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0151915 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0150927 |
| PDE8A | phosphodiesterase 8A | 0.0149815 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0146247 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.014622 |
| STK17A | serine/threonine kinase 17a | 0.0145009 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0144577 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.249059 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.213402 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.161976 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144038 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.108429 |
| RPS6 | ribosomal protein S6 | -0.107762 |
| EHBP1 | EH domain binding protein 1 | -0.102333 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.101602 |
| GPC6 | glypican 6 | -0.101204 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0932811 |
| APOA2 | apolipoprotein A-II | -0.0851483 |
| SVIL | supervillin | -0.0790862 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0758696 |
| MT2A | metallothionein 2A | -0.0724832 |
| FRMD5 | FERM domain containing 5 | -0.068171 |
| RBM39 | RNA binding motif protein 39 | -0.0664508 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0628139 |
| APOB | apolipoprotein B | -0.0601326 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0563516 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0555447 |
| RRBP1 | ribosome binding protein 1 | -0.0553685 |
| C3 | complement component 3 | -0.0549764 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0545327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0542981 |
| ITGAV | integrin, alpha V | -0.0538582 |
| FOXP1 | forkhead box P1 | -0.0532942 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0530429 |
| UBC | ubiquitin C | -0.0530267 |
| PARD3 | par-3 family cell polarity regulator | -0.0512527 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0500739 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0497464 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0496104 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.048637 |
| TMSB10 | thymosin beta 10 | -0.0485057 |
| RPS24 | ribosomal protein S24 | -0.0478322 |
| BCL2L1 | BCL2-like 1 | -0.0465 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0455086 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0451572 |
| JMJD1C | jumonji domain containing 1C | -0.0448057 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0446353 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0445204 |
| ENO1 | enolase 1, (alpha) | -0.044413 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0430423 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0427159 |
| B2M | beta-2-microglobulin | -0.0419488 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0417451 |
| VCL | vinculin | -0.0408301 |
| CP | ceruloplasmin (ferroxidase) | -0.0403301 |
| UBXN4 | UBX domain protein 4 | -0.0403064 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0403006 |
| RPL38 | ribosomal protein L38 | -0.0400312 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0388411 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0384494 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0381685 |
| RIGI | RNA sensor RIG-I | -0.0381448 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0377591 |
| ITGA1 | integrin, alpha 1 | -0.0374658 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0370835 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0361724 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0358537 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0358347 |
| RPS21 | ribosomal protein S21 | -0.0357599 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0357204 |
| MRTFA | myocardin related transcription factor A | -0.0351578 |
| RPS13 | ribosomal protein S13 | -0.0349756 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0347594 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0347448 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0341092 |
| USP34 | ubiquitin specific peptidase 34 | -0.0338993 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0333544 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332854 |
| RPLP0 | ribosomal protein, large, P0 | -0.0330148 |
| ACYP2 | acylphosphatase 2, muscle type | -0.0329554 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0328318 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0326993 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0324715 |
| RPLP2 | ribosomal protein, large, P2 | -0.0323319 |
| MX2 | MX dynamin-like GTPase 2 | -0.0322579 |
| RPLP1 | ribosomal protein, large, P1 | -0.032014 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0318088 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0317524 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0314278 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0310357 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.030873 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0308648 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0308131 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.030809 |
| PTCHD4 | patched domain containing 4 | -0.0307975 |
| H3-3B | H3.3 histone B | -0.0307864 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0306482 |
| FUS | FUS RNA binding protein | -0.0305854 |
| TRAM1 | translocation associated membrane protein 1 | -0.0305247 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0301993 |
| RUNX1 | runt-related transcription factor 1 | -0.0300256 |
| ATP10A | ATPase, class V, type 10A | -0.0300027 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0299402 |
| S100A9 | S100 calcium binding protein A9 | -0.0299263 |
| CTSB | cathepsin B | -0.0298629 |
| CFB | complement factor B | -0.029791 |
| FTL | ferritin, light polypeptide | -0.0295162 |
