| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flumatinib (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flumatinib (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120397 |
| FAM13A | family with sequence similarity 13, member A | 0.117615 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.102594 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0894835 |
| ASPH | aspartate beta-hydroxylase | 0.0695195 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0619899 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0600603 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0538717 |
| HELZ | helicase with zinc finger | 0.0531294 |
| PGK1 | phosphoglycerate kinase 1 | 0.052391 |
| HYOU1 | hypoxia up-regulated 1 | 0.0519545 |
| EGFR | epidermal growth factor receptor | 0.0514782 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0491339 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0476918 |
| ATP13A3 | ATPase type 13A3 | 0.0472983 |
| SPAG9 | sperm associated antigen 9 | 0.0462854 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0462143 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0455963 |
| TOP1 | topoisomerase (DNA) I | 0.0453314 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0438328 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0433842 |
| ARRDC3 | arrestin domain containing 3 | 0.0424259 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0418642 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0413627 |
| GRAMD1B | GRAM domain containing 1B | 0.0413109 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0407226 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0399056 |
| PDE8A | phosphodiesterase 8A | 0.0398603 |
| PTMA | prothymosin, alpha | 0.0394438 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0389875 |
| TPD52 | tumor protein D52 | 0.038804 |
| DTNA | dystrobrevin, alpha | 0.0379884 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0372119 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0371291 |
| PLEC | plectin | 0.0366935 |
| CES1 | carboxylesterase 1 | 0.0362736 |
| FNDC3B | fibronectin type III domain containing 3B | 0.036099 |
| LAMC2 | laminin, gamma 2 | 0.0360884 |
| RNF145 | ring finger protein 145 | 0.0354552 |
| NCKAP1 | NCK-associated protein 1 | 0.0353403 |
| NUP58 | nucleoporin 58 | 0.0351806 |
| HSPA8 | heat shock 70kDa protein 8 | 0.035002 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0343309 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0342058 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0339801 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0328709 |
| MKI67 | marker of proliferation Ki-67 | 0.0325548 |
| RUNX1 | runt-related transcription factor 1 | 0.0324329 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0323586 |
| UVRAG | UV radiation resistance associated | 0.0321702 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0319658 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0313656 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0310725 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0309938 |
| PYGL | phosphorylase, glycogen, liver | 0.0300255 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0299355 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0299132 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0297567 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0297397 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0295406 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0292873 |
| NGLY1 | N-glycanase 1 | 0.0290386 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0288833 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0283378 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0283328 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0280979 |
| RPL4 | ribosomal protein L4 | 0.0280188 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0279543 |
| TFG | TRK-fused gene | 0.0266171 |
| RPL3 | ribosomal protein L3 | 0.0262067 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0258235 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0257711 |
| USP3 | ubiquitin specific peptidase 3 | 0.0257291 |
| CUL3 | cullin 3 | 0.0255042 |
| SLMAP | sarcolemma associated protein | 0.0254905 |
| SMAD3 | SMAD family member 3 | 0.0253911 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0253491 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0251194 |
| ENO1 | enolase 1, (alpha) | 0.0249901 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0248812 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0246804 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0246748 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0246288 |
| YAP1 | Yes-associated protein 1 | 0.0244523 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0243391 |
| INSIG2 | insulin induced gene 2 | 0.0243039 |
| PTK2 | protein tyrosine kinase 2 | 0.024161 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0239251 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0236759 |
| MREG | melanoregulin | 0.0236685 |
| GPC6 | glypican 6 | 0.023566 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0234854 |
| NPTN | neuroplastin | 0.0234843 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0234405 |
| CPE | carboxypeptidase E | 0.0232308 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0231553 |
| APP | amyloid beta (A4) precursor protein | 0.0228402 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.022772 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.022707 |
| ANXA5 | annexin A5 | 0.0226551 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.330293 |
| TXNRD1 | thioredoxin reductase 1 | -0.171165 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.129069 |
| NDRG1 | N-myc downstream regulated 1 | -0.10389 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.101422 |
| EGR1 | early growth response 1 | -0.0850703 |
| TMSB10 | thymosin beta 10 | -0.0799949 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0793315 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0743723 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0668102 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0641976 |
| MT2A | metallothionein 2A | -0.0519292 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0494016 |
| OSMR | oncostatin M receptor | -0.0454687 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.044843 |
| FTL | ferritin, light polypeptide | -0.0414 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0403349 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0357087 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0353192 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0343532 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341852 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0331436 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0328213 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0298902 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0295201 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0288476 |
| LMO7 | LIM domain 7 | -0.0288427 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0279512 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0277812 |
| EMP1 | epithelial membrane protein 1 | -0.027037 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0265889 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0247568 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0232108 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0231542 |
| NABP1 | nucleic acid binding protein 1 | -0.0214742 |
| S100A11 | S100 calcium binding protein A11 | -0.0214394 |
| RPL35A | ribosomal protein L35a | -0.0211404 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.021086 |
| RPLP1 | ribosomal protein, large, P1 | -0.0209404 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0207223 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0203493 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0202551 |
| RPS6 | ribosomal protein S6 | -0.020195 |
| KRT7 | keratin 7, type II | -0.0201499 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.019966 |
| ACTG1 | actin gamma 1 | -0.0199036 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0198749 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0196896 |
| EZR | ezrin | -0.019612 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0195132 |
| STC1 | stanniocalcin 1 | -0.0193117 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0192201 |
| POTEF | POTE ankyrin domain family, member F | -0.0191771 |
| CSTB | cystatin B (stefin B) | -0.0188572 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.018733 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.018418 |
| AGR2 | anterior gradient 2 | -0.0181653 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0181026 |
| LDHA | lactate dehydrogenase A | -0.0179278 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0179191 |
| B2M | beta-2-microglobulin | -0.0178358 |
| S100A9 | S100 calcium binding protein A9 | -0.0174693 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.017376 |
| HLA-B | major histocompatibility complex, class I, B | -0.0172011 |
| CCND1 | cyclin D1 | -0.0172008 |
| GOLGB1 | golgin B1 | -0.0171249 |
| UBC | ubiquitin C | -0.0170677 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0170579 |
| HMGA1 | high mobility group AT-hook 1 | -0.0169593 |
| PER2 | period circadian clock 2 | -0.0169497 |
| MT1X | metallothionein 1X | -0.0169067 |
| GM2A | GM2 ganglioside activator | -0.0168373 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0167675 |
| SMIM14 | small integral membrane protein 14 | -0.0165746 |
| H1-0 | H1.0 linker histone | -0.0164208 |
| RPL34 | ribosomal protein L34 | -0.0162763 |
| EFNA5 | ephrin-A5 | -0.0162054 |
| TNS3 | tensin 3 | -0.0160988 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0160057 |
| ARF1 | ADP-ribosylation factor 1 | -0.0158836 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0158331 |
| NBEAL1 | neurobeachin-like 1 | -0.0157776 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0156657 |
| RPS21 | ribosomal protein S21 | -0.0155318 |
| MGAT4C | MGAT4 family, member C | -0.0153176 |
| FOSL1 | FOS-like antigen 1 | -0.0152945 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0152338 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0151872 |
| CCNK | cyclin K | -0.0151399 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0151092 |
| RPS24 | ribosomal protein S24 | -0.0149752 |
| HLA-A | major histocompatibility complex, class I, A | -0.0148254 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0147666 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0146083 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0144441 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.014318 |
| CST3 | cystatin C | -0.0142809 |
| IER3 | immediate early response 3 | -0.014277 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0141688 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0140791 |
