| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flumatinib (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flumatinib (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.144437 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.132053 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.131584 |
| TPM3 | tropomyosin 3 | 0.0865582 |
| VIM | vimentin | 0.078498 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0771421 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0767823 |
| APP | amyloid beta (A4) precursor protein | 0.0756192 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.075032 |
| TPD52 | tumor protein D52 | 0.0743549 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0721203 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0684068 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0666394 |
| FMNL2 | formin-like 2 | 0.0665767 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0652693 |
| PTMA | prothymosin, alpha | 0.0638458 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0636775 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0615093 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0610535 |
| KIF5B | kinesin family member 5B | 0.0605614 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0604874 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0603599 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0595662 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0564344 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0535875 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0535018 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0532723 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.050353 |
| RPL3 | ribosomal protein L3 | 0.0495757 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.048987 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0487665 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.048643 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0482511 |
| CALR | calreticulin | 0.0475797 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0471325 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0443636 |
| NUP58 | nucleoporin 58 | 0.0440812 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0435807 |
| RTN4 | reticulon 4 | 0.0434722 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0428192 |
| FNBP1L | formin binding protein 1-like | 0.0427091 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0426613 |
| PFDN2 | prefoldin subunit 2 | 0.0424418 |
| PKM | pyruvate kinase, muscle | 0.0423939 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0423169 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0416553 |
| HYOU1 | hypoxia up-regulated 1 | 0.0409965 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0409532 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0407607 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.040454 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0402552 |
| PLS3 | plastin 3 | 0.0393437 |
| HDGF | hepatoma-derived growth factor | 0.0389 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.038865 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0388566 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0385498 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0383396 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0382151 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0381771 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0377118 |
| RPL4 | ribosomal protein L4 | 0.0376818 |
| ANXA1 | annexin A1 | 0.0375267 |
| MATR3 | matrin 3 | 0.0374038 |
| ENO1 | enolase 1, (alpha) | 0.0370906 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0370535 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0364339 |
| RNF145 | ring finger protein 145 | 0.036364 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0358423 |
| ECT2 | epithelial cell transforming 2 | 0.0355435 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0350704 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0350697 |
| CHN1 | chimerin 1 | 0.0347616 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0344751 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0343379 |
| WDR43 | WD repeat domain 43 | 0.0339457 |
| ASPH | aspartate beta-hydroxylase | 0.0333671 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0322099 |
| SEPTIN7 | septin 7 | 0.0320807 |
| TPI1 | triosephosphate isomerase 1 | 0.0320556 |
| FLNB | filamin B, beta | 0.0316916 |
| YME1L1 | YME1-like 1 ATPase | 0.0316891 |
| USP3 | ubiquitin specific peptidase 3 | 0.0314827 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0311756 |
| RBM39 | RNA binding motif protein 39 | 0.0308615 |
| CANX | calnexin | 0.030621 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0304935 |
| NCKAP1 | NCK-associated protein 1 | 0.0304277 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0302014 |
| ANXA5 | annexin A5 | 0.0301864 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0300382 |
| SET | SET nuclear proto-oncogene | 0.0299336 |
| RRM2 | ribonucleotide reductase M2 | 0.0297225 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0296645 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0295924 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0295404 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0295355 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0295095 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0292172 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0291981 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0291359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.228662 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.160392 |
| MT2A | metallothionein 2A | -0.120589 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.115734 |
| FTL | ferritin, light polypeptide | -0.0845116 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.07985 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0719869 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0710055 |
| EGR1 | early growth response 1 | -0.0501869 |
| IER3 | immediate early response 3 | -0.0492838 |
| TXNRD1 | thioredoxin reductase 1 | -0.0488683 |
| GRAMD1B | GRAM domain containing 1B | -0.0480849 |
| RPL35A | ribosomal protein L35a | -0.047529 |
| BICC1 | BicC family RNA binding protein 1 | -0.0458928 |
| OSMR | oncostatin M receptor | -0.042989 |
| WWOX | WW domain containing oxidoreductase | -0.0422362 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0401007 |
| TMSB10 | thymosin beta 10 | -0.0398345 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.03893 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0370937 |
| GLIS3 | GLIS family zinc finger 3 | -0.0366768 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0336748 |
| IGF2 | insulin-like growth factor 2 | -0.032733 |
| RPLP1 | ribosomal protein, large, P1 | -0.0323176 |
| NNMT | nicotinamide N-methyltransferase | -0.0309843 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0291665 |
| RPS24 | ribosomal protein S24 | -0.0290002 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0286659 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0285596 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0282704 |
| RPS15 | ribosomal protein S15 | -0.0275476 |
| RPS21 | ribosomal protein S21 | -0.0273695 |
| POTEF | POTE ankyrin domain family, member F | -0.0266236 |
| NRG1 | neuregulin 1 | -0.0260187 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0257744 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0255588 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0248396 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0240484 |
| NABP1 | nucleic acid binding protein 1 | -0.0231995 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0227613 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0226612 |
| RPS19 | ribosomal protein S19 | -0.0223822 |
| RPL11 | ribosomal protein L11 | -0.0223711 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0221521 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0210685 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0207595 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0206196 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0202539 |
| EFNA5 | ephrin-A5 | -0.0200772 |
| RPL28 | ribosomal protein L28 | -0.0200085 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0200075 |
| RPS6 | ribosomal protein S6 | -0.0196994 |
| USP34 | ubiquitin specific peptidase 34 | -0.0195218 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0194487 |
| FHIT | fragile histidine triad | -0.0193391 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0192641 |
| NAV3 | neuron navigator 3 | -0.0191811 |
| RPS8 | ribosomal protein S8 | -0.0188286 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0187968 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0184943 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0183012 |
| MCL1 | myeloid cell leukemia 1 | -0.0182575 |
| RPS16 | ribosomal protein S16 | -0.0180485 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0179471 |
| MT1X | metallothionein 1X | -0.0179416 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0178133 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0176133 |
| HMGB1 | high mobility group box 1 | -0.0175874 |
| NTN4 | netrin 4 | -0.0174892 |
| RPL31 | ribosomal protein L31 | -0.0173926 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0171708 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0170052 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0167018 |
| RPL8 | ribosomal protein L8 | -0.0165923 |
| RPL34 | ribosomal protein L34 | -0.0164977 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0164563 |
| METTL15 | methyltransferase like 15 | -0.0160203 |
| AK1 | adenylate kinase 1 | -0.0158175 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0156259 |
| HLA-B | major histocompatibility complex, class I, B | -0.0156155 |
| RPL38 | ribosomal protein L38 | -0.0154388 |
| TASOR2 | transcription activation suppressor family member 2 | -0.015333 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0152926 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0151962 |
| TBCK | TBC1 domain containing kinase | -0.0150825 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0150356 |
| RUNX1 | runt-related transcription factor 1 | -0.0150321 |
| KYNU | kynureninase | -0.0149965 |
| FOSL1 | FOS-like antigen 1 | -0.0149674 |
| RPS23 | ribosomal protein S23 | -0.0149539 |
| ATM | ATM serine/threonine kinase | -0.0148423 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0146973 |
| RAD51B | RAD51 paralog B | -0.0145963 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0145094 |
| ZNF804A | zinc finger protein 804A | -0.0145025 |
| SVIL | supervillin | -0.0144815 |
| PFN1 | profilin 1 | -0.0144782 |
| CDK12 | cyclin-dependent kinase 12 | -0.0144432 |
| RPS5 | ribosomal protein S5 | -0.0143603 |
| SEC23IP | SEC23 interacting protein | -0.0142768 |
