| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flumatinib (mesylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flumatinib (mesylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.101716 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0919007 |
| EFNA5 | ephrin-A5 | 0.0808206 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.074721 |
| PGK1 | phosphoglycerate kinase 1 | 0.0712989 |
| VIM | vimentin | 0.0611744 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0608487 |
| PRELID2 | PRELI domain containing 2 | 0.057777 |
| RPL4 | ribosomal protein L4 | 0.0539197 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0519462 |
| MCL1 | myeloid cell leukemia 1 | 0.0478237 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0454203 |
| FLNA | filamin A, alpha | 0.0448024 |
| GPC6 | glypican 6 | 0.0418833 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0415808 |
| PTEN | phosphatase and tensin homolog | 0.0408083 |
| DNER | delta/notch-like EGF repeat containing | 0.0396488 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0395667 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0359332 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0353472 |
| PKM | pyruvate kinase, muscle | 0.0350579 |
| RPS12 | ribosomal protein S12 | 0.0341997 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0340068 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0337948 |
| CTBP2 | C-terminal binding protein 2 | 0.0337247 |
| RPL3 | ribosomal protein L3 | 0.0329664 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0312024 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0304957 |
| AUTS2 | autism susceptibility candidate 2 | 0.0303839 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0298122 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0295888 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0294672 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0284953 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.0284066 |
| CD44 | CD44 molecule (Indian blood group) | 0.0275881 |
| RAD51B | RAD51 paralog B | 0.0273024 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0266168 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0266121 |
| NHSL1 | NHS-like 1 | 0.0263476 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0263348 |
| FAM13A | family with sequence similarity 13, member A | 0.0261401 |
| LOC112694756 | uncharaterized LOC112694756 | 0.025792 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0255209 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0253386 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0253248 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0250196 |
| NUP58 | nucleoporin 58 | 0.0243736 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0240389 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0236568 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0235534 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0233968 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0231909 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.023107 |
| RPL37A | ribosomal protein L37a | 0.0230961 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0230648 |
| DTNA | dystrobrevin, alpha | 0.0230082 |
| NBAS | neuroblastoma amplified sequence | 0.0229771 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0228253 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0226866 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0224347 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0223683 |
| DST | dystonin | 0.0222746 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0222546 |
| DENND1A | DENN/MADD domain containing 1A | 0.0222259 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0220345 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0219017 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0217259 |
| APP | amyloid beta (A4) precursor protein | 0.0211875 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0210502 |
| COPA | coatomer protein complex, subunit alpha | 0.0210285 |
| SET | SET nuclear proto-oncogene | 0.0210167 |
| PYGL | phosphorylase, glycogen, liver | 0.0210006 |
| TPM3 | tropomyosin 3 | 0.0209958 |
| STC2 | stanniocalcin 2 | 0.0206109 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0202728 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0199765 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0197573 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0193084 |
| RIGI | RNA sensor RIG-I | 0.0192674 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0191185 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0191117 |
| FLNB | filamin B, beta | 0.0190978 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0190612 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0190561 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0189703 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0189535 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0188781 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0188406 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0188403 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0185071 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0184412 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.01844 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0182452 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0182059 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0181726 |
| HLA-A | major histocompatibility complex, class I, A | 0.0181254 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0180545 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0178918 |
| HDAC4 | histone deacetylase 4 | 0.0178711 |
| MSN | moesin | 0.0178148 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.285063 |
| TXNRD1 | thioredoxin reductase 1 | -0.163762 |
| GDA | guanine deaminase | -0.159099 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.15778 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.153683 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.132124 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.118277 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.111232 |
| FTL | ferritin, light polypeptide | -0.110284 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0963495 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0863303 |
| PTMA | prothymosin, alpha | -0.086101 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0830816 |
| RPS6 | ribosomal protein S6 | -0.0800631 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0665082 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.065374 |
| KYNU | kynureninase | -0.0653542 |
| RPL12 | ribosomal protein L12 | -0.0637516 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0614645 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0613615 |
| RPLP1 | ribosomal protein, large, P1 | -0.060928 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.059249 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.058456 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0544772 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0543514 |
| CANX | calnexin | -0.0521713 |
| RPLP0 | ribosomal protein, large, P0 | -0.0503336 |
| TNPO1 | transportin 1 | -0.0490518 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0487465 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0485413 |
| COL5A2 | collagen, type V, alpha 2 | -0.0480452 |
| NCOA7 | nuclear receptor coactivator 7 | -0.046951 |
| UBC | ubiquitin C | -0.0468564 |
| RGS2 | regulator of G-protein signaling 2 | -0.0459388 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0413367 |
| SRGN | serglycin | -0.0402277 |
| SMYD3 | SET and MYND domain containing 3 | -0.0401818 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0400562 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0398956 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0387518 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0383659 |
| TMSB10 | thymosin beta 10 | -0.0378895 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0376396 |
| NEK7 | NIMA-related kinase 7 | -0.0372018 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0369972 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0369373 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0368617 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0358862 |
| ASPH | aspartate beta-hydroxylase | -0.0358601 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0346487 |
| YBX3 | Y box binding protein 3 | -0.0336136 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.033504 |
| RAB10 | RAB10, member RAS oncogene family | -0.0332273 |
| PTGR1 | prostaglandin reductase 1 | -0.0331827 |
| NRCAM | neuronal cell adhesion molecule | -0.0329996 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0329522 |
| RPS24 | ribosomal protein S24 | -0.0329449 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0322056 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0316819 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0308933 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0308579 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0307853 |
| RBM39 | RNA binding motif protein 39 | -0.0307638 |
| IER3 | immediate early response 3 | -0.030572 |
| RPL23 | ribosomal protein L23 | -0.0298943 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0292784 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0291649 |
| RPL19 | ribosomal protein L19 | -0.0288947 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0284562 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0282973 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0277048 |
| RHEB | Ras homolog enriched in brain | -0.0273729 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0273344 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0273015 |
| TKT | transketolase | -0.0270293 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0269796 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0268323 |
| S100A10 | S100 calcium binding protein A10 | -0.0267893 |
| PRDX1 | peroxiredoxin 1 | -0.02677 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0265816 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0265322 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0262371 |
| RTN1 | reticulon 1 | -0.0261398 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0260271 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0257114 |
| MT2A | metallothionein 2A | -0.0255152 |
| GRAMD1B | GRAM domain containing 1B | -0.0254221 |
| RPL32 | ribosomal protein L32 | -0.0253156 |
| BMERB1 | bMERB domain containing 1 | -0.0252338 |
| CLU | clusterin | -0.0251516 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0251181 |
| RPS19 | ribosomal protein S19 | -0.0250376 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0248697 |
| TENM3 | teneurin transmembrane protein 3 | -0.0247386 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0246938 |
| B2M | beta-2-microglobulin | -0.0245373 |
| PCBP3 | poly(rC) binding protein 3 | -0.0244645 |
| NF1 | neurofibromin 1 | -0.024411 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0238099 |
| PHF20 | PHD finger protein 20 | -0.0237134 |
