| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flumatinib (mesylate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flumatinib (mesylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.150411 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.114853 |
| RPL3 | ribosomal protein L3 | 0.110951 |
| SET | SET nuclear proto-oncogene | 0.110802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.103646 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.088998 |
| RPL4 | ribosomal protein L4 | 0.0885342 |
| PGK1 | phosphoglycerate kinase 1 | 0.0708355 |
| FLNB | filamin B, beta | 0.0701925 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0697387 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0686928 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0682475 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0678445 |
| RPS12 | ribosomal protein S12 | 0.0618894 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0616579 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.060099 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0556761 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0555175 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0551653 |
| LAMB3 | laminin, beta 3 | 0.0550017 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0532668 |
| STC1 | stanniocalcin 1 | 0.0526804 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0523865 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0523372 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.051087 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0502394 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0501801 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0499252 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0421375 |
| NUP58 | nucleoporin 58 | 0.0416918 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0414511 |
| FLNA | filamin A, alpha | 0.0414472 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0408821 |
| TPM3 | tropomyosin 3 | 0.0407175 |
| XPO1 | exportin 1 | 0.0393796 |
| ENO1 | enolase 1, (alpha) | 0.0387532 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0385759 |
| NCKAP1 | NCK-associated protein 1 | 0.0385508 |
| RPSA | ribosomal protein SA | 0.0385269 |
| RPS2 | ribosomal protein S2 | 0.0383925 |
| CEP250 | centrosomal protein 250kDa | 0.038302 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0381277 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.037494 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0372653 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0362529 |
| ASPH | aspartate beta-hydroxylase | 0.0361904 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0361515 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0360595 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0359099 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0356567 |
| ATP13A3 | ATPase type 13A3 | 0.0356046 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0353083 |
| MTAP | methylthioadenosine phosphorylase | 0.0349152 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0345925 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0343995 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0337347 |
| CAPRIN2 | caprin family member 2 | 0.0333911 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0331446 |
| YEATS2 | YEATS domain containing 2 | 0.0328687 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.032808 |
| RPL37A | ribosomal protein L37a | 0.0323626 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0321621 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0318727 |
| H1-4 | H1.4 linker histone, cluster member | 0.0312081 |
| SBF2 | SET binding factor 2 | 0.0310693 |
| PTMA | prothymosin, alpha | 0.0310628 |
| NUDC | nudC nuclear distribution protein | 0.0310008 |
| HMGB2 | high mobility group box 2 | 0.0306171 |
| APP | amyloid beta (A4) precursor protein | 0.0306044 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0305257 |
| TTR | transthyretin | 0.0303034 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.030257 |
| ANXA5 | annexin A5 | 0.0301968 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0300881 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0299997 |
| SMYD3 | SET and MYND domain containing 3 | 0.029637 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0293502 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.029251 |
| RASA2 | RAS p21 protein activator 2 | 0.0290454 |
| HDGF | hepatoma-derived growth factor | 0.0290203 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0285942 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0285901 |
| PRELID2 | PRELI domain containing 2 | 0.0285016 |
| FHIT | fragile histidine triad | 0.0282592 |
| RPS18 | ribosomal protein S18 | 0.0282001 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0280933 |
| ACTN1 | actinin, alpha 1 | 0.0278679 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0276851 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 0.0275242 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0274137 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0273022 |
| RPL7 | ribosomal protein L7 | 0.0272848 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0270981 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.026666 |
| RBM33 | RNA binding motif protein 33 | 0.0266334 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0257423 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0256857 |
| RBM26 | RNA binding motif protein 26 | 0.0255508 |
| MCL1 | myeloid cell leukemia 1 | 0.0255042 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0253946 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.210187 |
| ACTG1 | actin gamma 1 | -0.125394 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.120302 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.117159 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107348 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0974541 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0968661 |
| EGR1 | early growth response 1 | -0.0888498 |
| RPS6 | ribosomal protein S6 | -0.0861916 |
| RPL8 | ribosomal protein L8 | -0.0858959 |
| HDAC9 | histone deacetylase 9 | -0.0850262 |
| HMGA1 | high mobility group AT-hook 1 | -0.0845422 |
| FRMD6 | FERM domain containing 6 | -0.0805038 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0804881 |
| RPLP1 | ribosomal protein, large, P1 | -0.0752165 |
| NABP1 | nucleic acid binding protein 1 | -0.0723326 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0708722 |
| FTL | ferritin, light polypeptide | -0.0681759 |
| RPS21 | ribosomal protein S21 | -0.0655578 |
| TXNRD1 | thioredoxin reductase 1 | -0.0590557 |
| POTEF | POTE ankyrin domain family, member F | -0.0587722 |
| MT2A | metallothionein 2A | -0.0583402 |
| INTS6 | integrator complex subunit 6 | -0.0570535 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0567771 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.056713 |
| JMJD1C | jumonji domain containing 1C | -0.056522 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.055884 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0534357 |
| ERBIN | erbb2 interacting protein | -0.0488379 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0487798 |
| FBXO11 | F-box protein 11 | -0.04683 |
| RPLP0 | ribosomal protein, large, P0 | -0.0460428 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0460132 |
| RPL12 | ribosomal protein L12 | -0.045636 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.045156 |
| RPL32 | ribosomal protein L32 | -0.0439781 |
| RPS19 | ribosomal protein S19 | -0.0433031 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0416405 |
| RPL34 | ribosomal protein L34 | -0.0416144 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0407566 |
| PARD3 | par-3 family cell polarity regulator | -0.0406747 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0402459 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0401259 |
| S100A9 | S100 calcium binding protein A9 | -0.0401192 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0394091 |
| B2M | beta-2-microglobulin | -0.0388759 |
| ZNF438 | zinc finger protein 438 | -0.0387944 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0383637 |
| RTN4 | reticulon 4 | -0.0356639 |
| TMSB10 | thymosin beta 10 | -0.0353582 |
| RPS15 | ribosomal protein S15 | -0.0350858 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0349511 |
| RPL36 | ribosomal protein L36 | -0.0345622 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.0344583 |
| RPL35A | ribosomal protein L35a | -0.0343549 |
| SGMS2 | sphingomyelin synthase 2 | -0.0339787 |
| RPL28 | ribosomal protein L28 | -0.0335818 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0335559 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.032636 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.032582 |
| FUS | FUS RNA binding protein | -0.0317448 |
| RPS16 | ribosomal protein S16 | -0.0309852 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.030499 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0300285 |
| RPLP2 | ribosomal protein, large, P2 | -0.0299819 |
| PFN1 | profilin 1 | -0.0299626 |
| MTDH | metadherin | -0.0297704 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0295296 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0293474 |
| JUN | jun proto-oncogene | -0.0293325 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0290989 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0290494 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.029004 |
| BRD2 | bromodomain containing 2 | -0.0289146 |
| RCOR1 | REST corepressor 1 | -0.028427 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0283558 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282546 |
| NAV3 | neuron navigator 3 | -0.0279321 |
| RPL35 | ribosomal protein L35 | -0.0279131 |
| RUNX1 | runt-related transcription factor 1 | -0.0274708 |
| TMEM263 | transmembrane protein 263 | -0.0273686 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.0271509 |
| DIAPH3 | diaphanous-related formin 3 | -0.0270807 |
| USP3 | ubiquitin specific peptidase 3 | -0.0267559 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.026645 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0266101 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0264202 |
| SP100 | SP100 nuclear antigen | -0.0261665 |
| CCDC88A | coiled-coil domain containing 88A | -0.0259916 |
| BRD4 | bromodomain containing 4 | -0.0256977 |
| AHI1 | Abelson helper integration site 1 | -0.0255778 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0255019 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0251004 |
| HLA-A | major histocompatibility complex, class I, A | -0.0248205 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0245274 |
| CCNI | cyclin I | -0.0244815 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0243921 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0243465 |
| RPS24 | ribosomal protein S24 | -0.0243178 |
| RPS23 | ribosomal protein S23 | -0.0240648 |
