Flumatinib (mesylate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.156238
PGK1 phosphoglycerate kinase 1 0.140617
FN1 fibronectin 1 0.104274
STC1 stanniocalcin 1 0.100529
CXCL8 chemokine (C-X-C motif) ligand 8 0.100472
CD109 CD109 molecule 0.0843516
VIM vimentin 0.081589
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0720618
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0718426
EEF2 eukaryotic translation elongation factor 2 0.0643721
FAM13A family with sequence similarity 13, member A 0.0596818
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0511498
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0504904
RAD23B RAD23 homolog B (S. cerevisiae) 0.0493476
ZNF292 zinc finger protein 292 0.0492685
ESYT2 extended synaptotagmin-like protein 2 0.0483166
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0470641
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0459006
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0430215
CEMIP cell migration inducing protein, hyaluronan binding 0.0423971
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0411338
NUP58 nucleoporin 58 0.0406633
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0400838
COL6A2 collagen, type VI, alpha 2 0.038609
SNAP25 synaptosomal-associated protein, 25kDa 0.0385715
SET SET nuclear proto-oncogene 0.0383602
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0377478
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0371646
ANGPTL4 angiopoietin-like 4 0.0361498
UBA6 ubiquitin-like modifier activating enzyme 6 0.0352291
BHLHE40 basic helix-loop-helix family, member e40 0.0350591
MEF2A myocyte enhancer factor 2A 0.0342088
FMNL2 formin-like 2 0.0341196
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0338833
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.03376
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0336173
ZNF395 zinc finger protein 395 0.0335781
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0334131
FAM162A family with sequence similarity 162, member A 0.0333338
RPL4 ribosomal protein L4 0.0322233
RNF145 ring finger protein 145 0.0317113
FLNA filamin A, alpha 0.0314914
TFG TRK-fused gene 0.0311406
HILPDA hypoxia inducible lipid droplet-associated 0.0308816
ATP13A3 ATPase type 13A3 0.030619
RAB8B RAB8B, member RAS oncogene family 0.0304594
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0303649
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.0303469
NFE2L1 nuclear factor, erythroid 2-like 1 0.0301348
MMP2 matrix metallopeptidase 2 0.0299202
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0298591
RPS12 ribosomal protein S12 0.0298539
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0297943
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0296461
XPO1 exportin 1 0.0294623
TMEM178B transmembrane protein 178B 0.0288675
UBA5 ubiquitin-like modifier activating enzyme 5 0.0282912
ANXA2 annexin A2 0.0281738
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0279919
RAB18 RAB18, member RAS oncogene family 0.0278836
HOOK2 hook microtubule-tethering protein 2 0.0278233
NAP1L1 nucleosome assembly protein 1-like 1 0.027233
MYO1B myosin IB 0.0270538
USP3 ubiquitin specific peptidase 3 0.0269644
MKI67 marker of proliferation Ki-67 0.0267134
ELL2 elongation factor, RNA polymerase II, 2 0.0264053
HMGB2 high mobility group box 2 0.026228
INSIG2 insulin induced gene 2 0.0258897
UGCG UDP-glucose ceramide glucosyltransferase 0.0258301
KMT2E lysine (K)-specific methyltransferase 2E 0.0257429
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0256556
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0252971
ARRDC3 arrestin domain containing 3 0.0252792
CALR calreticulin 0.0251947
MATR3 matrin 3 0.0248582
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0245482
PREPL prolyl endopeptidase-like 0.0244095
SRRM2 serine/arginine repetitive matrix 2 0.0242411
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0239388
DDIT4 DNA-damage-inducible transcript 4 0.0237893
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0233925
PDE4D phosphodiesterase 4D, cAMP-specific 0.0232879
PLEC plectin 0.0231238
NAMPT nicotinamide phosphoribosyltransferase 0.0230613
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.022858
COPA coatomer protein complex, subunit alpha 0.0227515
NCKAP1 NCK-associated protein 1 0.0221846
ZEB2 zinc finger E-box binding homeobox 2 0.0221273
TOP2B topoisomerase (DNA) II beta 180kDa 0.0220487
CENPC centromere protein C 0.0219014
RPL5 ribosomal protein L5 0.0218691
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0217206
MYOF myoferlin 0.0214074
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.021331
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0212055
SPAG5 sperm associated antigen 5 0.0211028
RPS17 ribosomal protein S17 0.0210839
KIAA1217 KIAA1217 0.0210381
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0203934
PCBP2 poly(rC) binding protein 2 0.0203153

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304409
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11566
COL1A1 collagen, type I, alpha 1 -0.09302
COL1A2 collagen, type I, alpha 2 -0.0866763
FTL ferritin, light polypeptide -0.0748079
EGR1 early growth response 1 -0.0728418
TMSB10 thymosin beta 10 -0.0725471
CLIC4 chloride intracellular channel 4 -0.0717126
TFPI2 tissue factor pathway inhibitor 2 -0.0713785
PSD3 pleckstrin and Sec7 domain containing 3 -0.0692885
POTEF POTE ankyrin domain family, member F -0.0658714
UBC ubiquitin C -0.0612778
ANKRD28 ankyrin repeat domain 28 -0.0585492
SEC31A SEC31 homolog A (S. cerevisiae) -0.0570409
IER3 immediate early response 3 -0.0561588
RRBP1 ribosome binding protein 1 -0.0546161
HM13 histocompatibility (minor) 13 -0.0542683
ZFAND3 zinc finger, AN1-type domain 3 -0.0510642
CALU calumenin -0.0501754
H1-0 H1.0 linker histone -0.0494372
CDH13 cadherin 13 -0.049234
GLIS3 GLIS family zinc finger 3 -0.0477165
ZEB1 zinc finger E-box binding homeobox 1 -0.0470381
RPS6 ribosomal protein S6 -0.0467278
GOLGB1 golgin B1 -0.0464954
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0459505
ZBTB20 zinc finger and BTB domain containing 20 -0.0457566
SETD5 SET domain containing 5 -0.0441973
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0441809
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0438584
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0436316
AHNAK AHNAK nucleoprotein -0.0435857
EXT1 exostosin glycosyltransferase 1 -0.042975
ZBTB38 zinc finger and BTB domain containing 38 -0.0428831
MT2A metallothionein 2A -0.0423622
ASPH aspartate beta-hydroxylase -0.0423058
NF1 neurofibromin 1 -0.0420903
TPT1 tumor protein, translationally-controlled 1 -0.0418162
RAB5A RAB5A, member RAS oncogene family -0.0415444
B2M beta-2-microglobulin -0.0412824
RAB7A RAB7A, member RAS oncogene family -0.0412292
IL1B interleukin 1, beta -0.0405066
USP34 ubiquitin specific peptidase 34 -0.0403012
CDCP1 CUB domain containing protein 1 -0.0402479
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0398927
TPM4 tropomyosin 4 -0.0396899
PTPRG protein tyrosine phosphatase, receptor type, G -0.0396095
RAB1A RAB1A, member RAS oncogene family -0.0390712
HDLBP high density lipoprotein binding protein -0.0386772
HLA-B major histocompatibility complex, class I, B -0.0379163
INTS6 integrator complex subunit 6 -0.0371769
MON2 MON2 homolog (S. cerevisiae) -0.0368173
DOCK5 dedicator of cytokinesis 5 -0.0366747
TRIP12 thyroid hormone receptor interactor 12 -0.0365486
MAP4 microtubule-associated protein 4 -0.0365207
GLG1 golgi glycoprotein 1 -0.0364192
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0363336
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0361057
TPM1 tropomyosin 1 (alpha) -0.0360127
DNAAF9 dynein axonemal assembly factor 9 -0.0359062
NDRG1 N-myc downstream regulated 1 -0.0353223
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0351916
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.035188
SLIT2 slit homolog 2 (Drosophila) -0.0348586
ARF4 ADP-ribosylation factor 4 -0.0348225
GSK3B glycogen synthase kinase 3 beta -0.0346531
RPS21 ribosomal protein S21 -0.034513
FAM20C family with sequence similarity 20, member C -0.0340152
NRP1 neuropilin 1 -0.0339323
TXNRD1 thioredoxin reductase 1 -0.0335403
HDAC8 histone deacetylase 8 -0.0332813
RBM39 RNA binding motif protein 39 -0.0332566
CDK13 cyclin-dependent kinase 13 -0.0332095
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0329239
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0328932
GARS1 glycyl-tRNA synthetase 1 -0.0326841
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0325975
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.032416
DSTN destrin (actin depolymerizing factor) -0.0321324
NKTR natural killer cell triggering receptor -0.0317817
SP100 SP100 nuclear antigen -0.0317476
MAP1B microtubule-associated protein 1B -0.031534
ZMYND8 zinc finger, MYND-type containing 8 -0.0315275
GCC2 GRIP and coiled-coil domain containing 2 -0.0315085
FBN1 fibrillin 1 -0.0314736
IARS1 isoleucyl-tRNA synthetase 1 -0.0314075
VDAC1 voltage-dependent anion channel 1 -0.0312522
VEGFA vascular endothelial growth factor A -0.0308371
BLZF1 basic leucine zipper nuclear factor 1 -0.0306609
NPAS2 neuronal PAS domain protein 2 -0.0306102
TCF12 transcription factor 12 -0.0303589
MCL1 myeloid cell leukemia 1 -0.029894
ATG7 autophagy related 7 -0.0298591
CANX calnexin -0.0296369
NCOA7 nuclear receptor coactivator 7 -0.0295501
ZNF609 zinc finger protein 609 -0.0294898
SENP5 SUMO1/sentrin specific peptidase 5 -0.0293261
PTMA prothymosin, alpha -0.0292565
COL6A1 collagen, type VI, alpha 1 -0.0292123
NBEA neurobeachin -0.0286606