Flumatinib (mesylate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.220768
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.17506
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.171499
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.140763
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.107407
MSI2 musashi RNA-binding protein 2 0.101347
AKAP12 A kinase (PRKA) anchor protein 12 0.100522
SPAG9 sperm associated antigen 9 0.0850765
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0811843
MYH9 myosin, heavy chain 9, non-muscle 0.0810535
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0754863
GOLGA4 golgin A4 0.0738064
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0720207
FMNL2 formin-like 2 0.0708619
SPTBN1 spectrin, beta, non-erythrocytic 1 0.068713
KMT2E lysine (K)-specific methyltransferase 2E 0.0646664
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0623928
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0603381
NAMPT nicotinamide phosphoribosyltransferase 0.0589747
NGLY1 N-glycanase 1 0.0559186
FAM13A family with sequence similarity 13, member A 0.0553292
PGK1 phosphoglycerate kinase 1 0.0538005
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0537839
NAP1L1 nucleosome assembly protein 1-like 1 0.053063
FNDC3B fibronectin type III domain containing 3B 0.0527898
GARS1 glycyl-tRNA synthetase 1 0.05211
TPM3 tropomyosin 3 0.0515846
SREBF2 sterol regulatory element binding transcription factor 2 0.0515517
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.051367
CANX calnexin 0.0510263
SLC39A11 solute carrier family 39, member 11 0.0502326
KDM3A lysine (K)-specific demethylase 3A 0.0500127
PRELID2 PRELI domain containing 2 0.049461
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0486285
RPL3 ribosomal protein L3 0.0483995
VIM vimentin 0.0474915
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0463912
MMP12 matrix metallopeptidase 12 0.0457262
COPA coatomer protein complex, subunit alpha 0.0456076
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0439251
PDIA3 protein disulfide isomerase family A, member 3 0.0439049
CHD1 chromodomain helicase DNA binding protein 1 0.0436684
ESYT2 extended synaptotagmin-like protein 2 0.0435267
NFE2L1 nuclear factor, erythroid 2-like 1 0.0425796
IL1RAP interleukin 1 receptor accessory protein 0.0421247
SET SET nuclear proto-oncogene 0.0417413
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0416448
LDHA lactate dehydrogenase A 0.0415213
FLNA filamin A, alpha 0.0414242
YEATS2 YEATS domain containing 2 0.0406927
TFG TRK-fused gene 0.0400364
CENPF centromere protein F, 350/400kDa 0.0400287
HELZ helicase with zinc finger 0.0398746
PTMA prothymosin, alpha 0.0395567
RPS3 ribosomal protein S3 0.039048
OGA O-GlcNAcase 0.0384169
LINGO2 leucine rich repeat and Ig domain containing 2 0.0383772
CSDE1 cold shock domain containing E1, RNA-binding 0.0382962
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0381582
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0381332
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0378148
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0375259
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0375038
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0370468
UBA6 ubiquitin-like modifier activating enzyme 6 0.0367857
BRWD3 bromodomain and WD repeat domain containing 3 0.03652
ATP13A3 ATPase type 13A3 0.0364421
SETD5 SET domain containing 5 0.0362087
FLNB filamin B, beta 0.0361356
PMEL premelanosome protein 0.0358715
PLEC plectin 0.0356605
LAMP2 lysosomal-associated membrane protein 2 0.035459
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0350239
CAMTA1 calmodulin binding transcription activator 1 0.0346413
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0346029
UBE2O ubiquitin-conjugating enzyme E2O 0.0345649
SRRM2 serine/arginine repetitive matrix 2 0.0343019
NUP58 nucleoporin 58 0.0340801
ASPH aspartate beta-hydroxylase 0.0339879
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337482
ANLN anillin, actin binding protein 0.0336236
AFDN afadin, adherens junction formation factor 0.0336185
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0333409
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0332164
TRIM33 tripartite motif containing 33 0.0331371
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.03267
TPD52 tumor protein D52 0.0323054
RNF145 ring finger protein 145 0.0320667
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0319001
AFF4 AF4/FMR2 family, member 4 0.0316156
ARRDC3 arrestin domain containing 3 0.0316019
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0314058
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0311534
SRP54 signal recognition particle 54kDa 0.0309486
CALR calreticulin 0.0308525
ADAM17 ADAM metallopeptidase domain 17 0.0308468
AKAP10 A kinase (PRKA) anchor protein 10 0.030788
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0306646
LEF1 lymphoid enhancer-binding factor 1 0.0305867
KAZN kazrin, periplakin interacting protein 0.0304544

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254907
MT2A metallothionein 2A -0.166949
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.122483
FMN1 formin 1 -0.114282
TMSB10 thymosin beta 10 -0.0843273
ICAM1 intercellular adhesion molecule 1 -0.0706337
CCND1 cyclin D1 -0.0699397
POTEF POTE ankyrin domain family, member F -0.0672612
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0570221
TM4SF1 transmembrane 4 L six family member 1 -0.0558536
MT1X metallothionein 1X -0.0556028
FRMD5 FERM domain containing 5 -0.0523413
RPS6 ribosomal protein S6 -0.0516344
FRMD4A FERM domain containing 4A -0.0493089
FTL ferritin, light polypeptide -0.0489611
RPLP1 ribosomal protein, large, P1 -0.0461939
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0449688
NRG3 neuregulin 3 -0.0439954
RPS13 ribosomal protein S13 -0.0437062
RUNX1 runt-related transcription factor 1 -0.043667
RPS21 ribosomal protein S21 -0.0431741
NLGN1 neuroligin 1 -0.0429145
SQSTM1 sequestosome 1 -0.0420595
ZBTB20 zinc finger and BTB domain containing 20 -0.040193
TXNRD1 thioredoxin reductase 1 -0.0392607
BPTF bromodomain PHD finger transcription factor -0.0371805
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0366694
RPL35A ribosomal protein L35a -0.0365579
APOD apolipoprotein D -0.0353986
RPL38 ribosomal protein L38 -0.0331111
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0325919
RPS23 ribosomal protein S23 -0.0320709
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0320649
ANKRD28 ankyrin repeat domain 28 -0.030905
RPLP2 ribosomal protein, large, P2 -0.0304093
HLA-B major histocompatibility complex, class I, B -0.0296994
S100A9 S100 calcium binding protein A9 -0.0291078
COMMD10 COMM domain containing 10 -0.0290699
BICD1 bicaudal D homolog 1 (Drosophila) -0.0287685
RPL32 ribosomal protein L32 -0.0284778
LINC02798 long intergenic non-protein coding RNA 2798 -0.0277911
TFPI2 tissue factor pathway inhibitor 2 -0.027659
VDAC1 voltage-dependent anion channel 1 -0.0275914
TOB2 transducer of ERBB2, 2 -0.0275903
TPT1 tumor protein, translationally-controlled 1 -0.0270573
HDAC9 histone deacetylase 9 -0.0269886
RPL34 ribosomal protein L34 -0.0259686
RPL19 ribosomal protein L19 -0.0259283
ZNFX1 zinc finger, NFX1-type containing 1 -0.0255594
NDRG1 N-myc downstream regulated 1 -0.0254772
EGR1 early growth response 1 -0.0249016
RPS29 ribosomal protein S29 -0.0247647
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0243973
TP63 tumor protein p63 -0.0241673
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0238946
RPS19 ribosomal protein S19 -0.0237978
FOXP1 forkhead box P1 -0.0237774
PCNX4 pecanex 4 -0.0237571
RPL27 ribosomal protein L27 -0.0235055
IFI6 interferon, alpha-inducible protein 6 -0.0233735
CD44 CD44 molecule (Indian blood group) -0.0232528
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0229835
S100A10 S100 calcium binding protein A10 -0.0226661
HLA-A major histocompatibility complex, class I, A -0.0225186
RASAL2 RAS protein activator like 2 -0.0224668
PLSCR1 phospholipid scramblase 1 -0.0223635
CYB5R3 cytochrome b5 reductase 3 -0.022209
PRRC2B proline-rich coiled-coil 2B -0.0221271
TAPBP TAP binding protein (tapasin) -0.0217927
TBCA tubulin folding cofactor A -0.0217605
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0217428
RPS14 ribosomal protein S14 -0.021736
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0216244
CDK6 cyclin-dependent kinase 6 -0.0215414
RPL31 ribosomal protein L31 -0.0214966
TUBB4B tubulin, beta 4B class IVb -0.0214539
CEMIP2 cell migration inducing hyaluronidase 2 -0.0214209
SOX6 SRY (sex determining region Y)-box 6 -0.021353
RIGI RNA sensor RIG-I -0.0211934
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0211631
WNT2B wingless-type MMTV integration site family, member 2B -0.0210868
IFI44L interferon-induced protein 44-like -0.0208292
IFIH1 interferon induced with helicase C domain 1 -0.0207617
RPS15 ribosomal protein S15 -0.0207416
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0205593
IFI16 interferon, gamma-inducible protein 16 -0.0202047
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0199812
ACTG1 actin gamma 1 -0.0197458
RNF213 ring finger protein 213 -0.0195793
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0195335
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0195109
MYO9A myosin IXA -0.0195088
MAML2 mastermind-like 2 (Drosophila) -0.0194743
FER fer (fps/fes related) tyrosine kinase -0.0193543
RPL28 ribosomal protein L28 -0.019319
AGO2 argonaute RISC catalytic component 2 -0.0192319
SHISA5 shisa family member 5 -0.0183292
RPL9 ribosomal protein L9 -0.0182425
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0181309
SVIL supervillin -0.0179029